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Evaluation on the efficacy and safety of Chinese herbal medication Xifeng Dingchan Pill in treating Parkinson's disease: study protocol of a multicenter, open-label, randomized active-controlled trial

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Journal of Integrative Medicine 2013年第4期11卷 285-290页

作者： Jie Zhang Yun-zhi Ma Xiao-ming Shen Department of cerebropathy Dongzhimen Hospital Beijing University of Chinese Medicine Department of cerebropathy the First Affiliated Hospital Henan University of Traditional Chinese Medicine

BACKGROUND： Parkinson＇s disease （PD） is a complicated disease, commonly diagnosed among the elderly, which leads to degeneration of the central nervous system. It presently lacks an effective therapy for its complex pathogenesis. Adverse effects from Western drug-based medical intervention prevent long-term adherence to these therapies in many patients. Traditional Chinese medicine （TCM） has long been used to improve the treatment of PD by alleviating the toxic and adverse effects of Western drug-based intervention. Therefore, the aim of this study is to evaluate the efficacy and safety of Xifeng Dingchan Pill （XFDCP）, a compound traditional Chinese herbal medicine, taken in conjunction with Western medicine in the treatment of PD patients at different stages in the progression of the disease. METHODS AND DESIGN： This is a multicenter, randomized controlled trial. In total, 320 patients with early- （n = 160） and middle-stage PD （n = 160） will be enrolled and divided evenly into control and trial groups. Of the 160 patients with early-stage PD, the trial group （n = 80） will be given XFDCP, and the control group （n = 80） will be given Madopar. Of the 160 patients with middle-stage PD, the trial group （n = 80） will be given XFDCP combined with Madopar and Piribedil, and the control group （n = 80） will be given Madopar and Piribedil. The Unified Parkinson＇s Disease Rating Scale scores, TCM symptoms scores, quality of life, change of Madopar＇s dosage and the toxic and adverse effects of Madopar will be observed during a 3-month treatment period and through a further 6-month follow-up period. DISCUSSION： It is hypothesized that XFDCP, combined with Madopar and Piribedil, will have beneficial effects on patients with PD. The results of this study will provide evidence for developing a comprehensive therapy regimen, which can delay the progress of the disease and improve the quality of life for PD patients in different stages. TRIAL REGISTRATION： This trial has been registe

关键词： Parkinson disease levodopa drugs, Chinese herbal drug toxicity randomized controlled trial clinical protocols

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Pinellia Total Alkaloids Modulate the GABAergic System in Hippocampal Formation on Pilocarpine-Induced Epileptic Rats

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Chinese Journal of Integrative Medicine 2020年第2期26卷 138-145页

作者： DENG Chu-xin WU Zhi-bing CHEN Yi YU Zheng-miao The First Clinical Medical School Guangzhou University of Chinese MedicineGuangzhou(510406)China cerebropathy Center The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou(510406)China

Objective:To investigate the neuromodulatory effect of pinellia total alkaloids(PTA)on the gamma-aminobutyric acidergic(GABAergic)system in epileptic rats,and preliminarily evaluate the anti-epileptic effect of ***:Ninety-one male Sprague-Dawley rats were randomized to a control group(n=17)or an epileptic group(n=74)using computer-generated random *** epilepticus(SE)was induced with pilocarpine in the epileptic *** rats that survived SE were randomly divided into 4 groups,namely an epilepsy group(n=13),a topiramate(TPM,60 mg/kg)group(n=12),a high-dose PTA(800 mg/kg)group(n=12),and a low-dose PTA(400 mg/kg)group(n=10).Treatments were given intragastrically once daily for 14 *** control group and epilepsy group received normal *** recurrent seizures(SRSs)were monitored 8-h daily for 7 days after ***,the hippocampal formation tissues were *** level was measured using enzyme-linked immunosorbent *** and mRNA expression levels of glutamate decarboxylase 65(GAD65),GABA transporter-1(GAT-1),GABA transaminase(GABA-T),and GABAA receptor(GABAAR)α4,α5,γ2 andδsubunits were measured using Western-blotting analysis and quantitative polymerase chain ***:PTA lowered the incidence and frequency of SRS(both doses *** TPM group,P>0.05).Compared with the epilepsy group,PTA increased the levels of GABA(both doses P<0.01)and GAD65(mRNA,800 mg/kg,P<0.01),and suppressed the levels of GAT-1(mRNA,800 mg/kg,P<0.01;400 mg/kg,P<0.05),GABA-T(mRNA,both doses P<0.01),and GABAARδsubunit(protein,800 mg/kg,P<0.05)andγ2 subunit(protein,both doses P<0.01).PTA upregulated the low-expressed mRNA levels of GABAARα5 subunit(400 mg/kg,P<0.01),δsubunit(800 mg/kg,P<0.05),andγ2 subunit(400 mg/kg,P<0.05).Conclusions:PTA regulated the GABAergic system through modulating GABA levels and the expression levels of GAD65,GAT-1,GABA-T,and GABAARα4,α5,γ2 andδ*** may exert antiepileptic effects on the pilocarpine-

关键词： Pineilia total alkaloids Pineilia ternata gamma-aminobutyric acidergic agents seizure epilepsy

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Mortality and recurrence of vascular disease among stroke patients treated with combined TCM therapy

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Journal of Traditional Chinese Medicine 2012年第2期32卷 173-178页

作者：赵晓峰苏世君国云红王舒 Institute of Acupuncture and Moxibustion the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Tianjin Key Laboratory of Acupuncture and Moxibustion Sciences Key Unit of cerebropathy Acupuncture Therapy of State Administration of Traditional Chinese Medicine

OBJECTIVE:To confirm the long-term outcomes of stroke patients and determine predicting factors for death,recurrence of vascular events and poor outcome(either recurrence or death) after the use of combined TCM ***:This was a retrospective hospital-based cohort study and was performed in the First Affiliated hospital of Tianjin University of Traditional Chinese Medicine in *** subjects with stroke consecutively admitted to an inpatient ward of the Acupuncture Department from January 1,2008,to December 31,2008 were retrospectively followed through one *** main outcomes were either a recurrence of vascular events,,mortality or *** factors were recorded from medical *** regression models were used to analyze *** following independent variables were used:age,gender,hypertension,ischemic heart disease,atrial fibrillation,diabetes mellitus,carotid arterial lesions and history of ***:Four-hundred and five patients were *** 1-year mortality rate was 11.11%.23.70% of the patients had a recurrent vascular event,and 30.86% suffered a poor *** logistic regression analysis found that previous stroke,and advanced age were predictors of death within one year,Recurrence of vascular events was associated with carotid arterial lesions,history of diabetes and previous ***-term poor outcome was predicted by advanced age,history of diabetes,and previous ***:Age,previous stroke,carotid arterial lesions and diabetes history seem to have different impacts on the three outcomes within one *** findings provide important data for planning future hospital register studies of stroke patients in TCM hospitals.

关键词： Stroke Acupuncture Traditional Chinese medicine Mortality Recurrence Risk factors

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Optimal stimulation parameters for Renzhong (DU 26) electro-acupuncture for improving motor function in a rat model of middle cerebral artery occlusion

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Neural Regeneration Research 2011年第12期6卷 929-934页

作者： Lin Han Shu Wang Jinquan Ma Wenping Yao Yan Shen Xuemin Shi Acupuncture Institute of First Affiliated hospital Tianjin University of Traditional Chinese Medicine Tianjin 300193 China Key Laboratory of cerebropathy Acupuncture Therapy of State Administration of Traditional Chinese Medicine Tianjin Key Laboratory of Acupuncture and Moxibustion Tianjin 300193 China

The selection of electro-acupuncture parameters remains poorly unified between clinical studies. The present study observed the effects of electro-acupuncturing Renzhong （DU 26） with different stimulation parameters on motor function recovery following middle artery occlusion injury in rats. Results showed an optimal stimulation parameter for Renzhong electro-acupuncture that was low frequency and mild current （2 Hz, 1 mA） significantly improved cortical excitability and conductive function, and promoted recovery in a rat model of motor function in middle artery occlusion. Frequency had a greater impact than current or interaction, and played a critical role in electro-acupuncture therapy.

关键词： electro-acupuncture acupoint middle artery occlusion injury motor-evoked potential stimulation parameters orthogonal design

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Mechanism of action of Zhuyu Annao pill in mice with cerebral intrahemorrhage based on TLR4

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Asian Pacific Journal of Tropical Medicine 2016年第11期9卷 1072-1077页

作者： Wei Chen Yue-Qiang Hu Ling-Fei Jiang Lin Wu First cerebropathy Unit.First Affiliated hospital of Guangxi University of Chinese Medicine Key Laboratory of Guangxi Basic Chinese Medicine Postgraduate Department Guangxi University of Chinese Medicine Science Experiment Center Guangxi University of Chinese Medicine

Objective:To explore the protective effect and possible mechanism of action of Zhuyu Annao pill in mice with intracerebral hemorrhage(ICH).Methods:Sixty mice were divided into the control group,hemorrhage group,drug-treated group(after hemorrhage),TLR4-knockout hemorrhage group and TLR4-knockout hemorrhage + drug-treated group(after hemorrhage) with 12 in each *** of autologous ICH was established in all *** drilling and 12 h of fasting,models in the control group hemorrhage group and TLR4-knockout hemorrhage group were all drenched with 10 mL/kg distilled water by intragastric *** in the drug-treated group and TLR4-knockout hemorrhage + drugtreated group were drenched with 6.25 g/kg of Zhuyu Annao *** groups were treated for 7 *** scoring method was used to measure the neurological defect scores and determine the brain water contents of all groups;ELISA was employed to detect the inflammatory factor interleukin(IL)-6,tumor necrosis factor- α(TNF- α) and IL-1β in brain tissues;and Western blot was applied to test the expression quantities of apoptotic protein Bax and anti-apoptotic protein Bcl-2 in brain ***:At day 3 and7,compared with the hemorrhage group,the neurological defect scores of the drug-treated group,TLR4-knockout hemorrhage group and TLR4-knockout hemorrhage + drug-treated group decreased significantly(P<0.05) Compared with the hemorrhage group,the brain water contents of the drug-treated group,TLR4-knockout hemorrhage group and TLR4-knockout hemorrhage + drug-treated group reduced significantly(P<0.05) Compared with the hemorrhage group,the inflammatory factor IL-6,TNF-α and IL-1β of the drug-treated group,TLR4-knockout hemorrhage group and TLR4-knockout hemorrhage + drug-treated group decreased significantly(P<0.05).Compared with the hemorrhage group,the expression of apoptotic protein Bax of the drug-treated group,TLR4-knockout hemorrhage group and TLR4-knockout hemorrhage+ drug-treated group de

关键词： Zhuyu Annao pill Intacerebral hemorrhage TLR4 Gene knockout Mechanism

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Orthogonal design to sift the optimal parameter of Neiguan acupuncture for cerebral infarction

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Neural Regeneration Research 2013年第28期8卷 2641-2648页

作者： Yanan Zhang Sha Yang Xiaonong Fan Shu Wang Nina He Lingxin Li Ding Luo Xuemin Shi First Teaching hospital of Tianjin University of Traditional Chinese Medicine Acupuncture and Moxibustion Research Institute of Tianjin University of Traditional Chinese Medicine Key Laboratory of cerebropathy Acupuncture Therapy of State Administration of Traditional Chinese Medicine Tianjin Key Laboratory of Acupuncture & Moxibustion Science Three-level Laboratory of Acupuncture Dose-Effect Relationship State Administration of Traditional Chinese Medicine Wuhai hospital of Traditional Chinese Medicine Department of Rehabilitation Medicine West China Medical SchoolWest China Hospital Sichuan University Postgraduate School Tianjin University of Traditional Chinese Medicine

The individual difference and non-repeatability in acupuncture have not only restricted the devel- opment of acupuncture, but have also affected the specificity of acupoints. The present study used instruments to control needle depth, lifting and thrusting frequency, and the duration of acupuncture. Effects of the quantified acupuncture were observed at Neiguan （PC6） with different stimulation parameters. A frequency of 1, 2, or 3 Hz and duration of 5, 60, or 180 seconds were used to observe cerebral blood flow and ratio of infarct volume recovery. Results showed that stimulation at Neiguan with a frequency of 1 Hz and long duration of 180 seconds or 2/3 Hz and long duration of 5/60 seconds significantly increased cerebral blood flow and decreased the ratio of infarct volume. In- teractions between frequency and duration play a critical role in quantified acupuncture therapy.

关键词： neural regeneration acupoint quantified acupuncture Neiguan middle artery occlusion injury lift-ing and thrusting method orthogonal design lifting and thrusting frequency acupuncture duration grants-supported paper neuroregeneration

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Therapeutic effects of different durations of acupuncture on rats with middle cerebral artery occlusion

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Neural Regeneration Research 2015年第1期10卷 159-164页

作者： Chao Zhang Yan Wen Xiao-nong Fan Guang Tian Xue-yi Zhou Shi-zhe Deng Zhi-hong Meng First Teaching hospital of Tianjin University of Traditional Chinese Medicine Post-graduate School Tianjin University of Traditional Chinese Medicine Acupuncture and Moxibustion Research Institute of Tianjin University of Traditional Chinese Medicine Key Laboratory of cerebropathy Acupuncture Therapy of State Administration of Traditional Chinese Medicine Tianjin Key Laboratory of Acupuncture & Moxibustion Science Three-level Laboratory of Acupuncture Dose-Effect Relationship State Administration of Traditional Chinese Medicine

Acupuncture is regarded as an effective therapy for cerebral ischemia. Different acupuncture ma- nipulations and durations may result in different therapeutic effects. In the present study, the Neig uan （PC6） acupoint of rats with occluded middle cerebral arteries was needled at a fixed frequency （3 Hz） with different durations, i.e., 5, 60 and 180 seconds under a twisting-rotating acupuncture method. Results showed that different durations of acupuncture had different therapeutic effects, with 60 seconds yielding a better therapeutic effect than the other two groups. This duration of treatment demonstrated rapid cerebral blood flow, encouraging recovery of neurological function, and small cerebral infarct volume. Experimental findings indicated that under 3 Hz frequency, the treatment of needling Neiguan for 60 seconds is effective for ischemic stroke.

关键词： nerve regeneration middle cerebral artery occlusion manipulation Neiguan cerebralinfarction volume twisting-rotating method duration frequency cerebral blood flow neural regeneration

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Infectious Microbes & Diseases 2023年第3期5卷 120-126页

作者： Fei-Xiang Liu Zi-Bei Dong Min Zhao Ya-Hui Gao Xiang Li Ya-Nan Jiang Yi-Ming Li Yu-Xin Zheng Zhen Wang Yan-Chen Feng Ya-Li Liu cerebropathy hospital The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouChina The First Clinical Medical School Henan University of Chinese MedicineZhengzhouChina State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Research Units of Infectious Disease and Microecology Chinese Academy ofMedical SciencesHangzhouChina Traditional ChineseMedicine(Zhong Jing)School Henan University of Chinese MedicineZhengzhouChina.

Coronavirus disease 2019(COVID-19)has affected the quality of sleep for various populations,causing anxiety and depression ***-19–related insomnia(COVIDRI)appears to be more common in certain populations,including females,urban residents and other individuals who reside in high-risk COVID-19–related areas,lack higher socioeconomic and educational levels,have a history of underlying mental illness,have no access to social support and work,or have been mandated for *** vulnerable pop-ulations,pregnant women,adolescents and children are more likely to suffer from anxiety and depression,which leads to irregular sleep-wake cycles and significantly poor sleep *** in COVID-19 patients is associated with decreased immune levels,ex-cessive psychological stress and severe *** COVIDRI incidence and severity among frontline healthcare workers is high,espe-cially among females and those working in isolation wards and intensive care *** factors related to COVIDRI for college students during home study are stress from upcoming graduation,disharmonious family relationships and inadaptability to online *** military personnel,anxiety and depression are the main causes of poor sleep *** on the characteristics of different popula-tions,active Chinese and Western medications,non-drug therapy,psychological counseling and suitable sleep management are vital measures to strengthen immunity,alleviate insomnia and limit recurrence.

关键词： COVID-19 insomnia anxiety depression.

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Acupuncture for stroke cohort construction:a protocol describing a multicenter,prospective,real-world cohort construction study

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TMR Non-Drug Therapy 2023年第1期6卷 14-21页

作者： Gui-Ping Li Shu Wang Fan Xu Lin-Na Wu Chen Yang Hao-Long Guo Li Li Sha Yang Hui-Yan Shi Department of Acupuncture and Moxibustion First Teaching Hospital of Tianjin University of Traditional Chinese MedicineNational Clinical Research Center for Chinese Medicine Acupuncture and MoxibustionTianjin 300381China Department of Acupuncture and Moxibustion Tianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin 300120China Key Laboratory of cerebropathy Acupuncture Therapy of State Administration of Traditional Chinese Medicine Tianjin 300381China

Background:Acupuncture for stroke has been endorsed by the World Health Organization,and the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2018 lists acupuncture for stroke as a Level II recommendation with Level B *** efficacy of acupuncture in the treatment of acute ischaemic stroke needs to be approved by more high-quality ***,there are currently no real-world studies of acupuncture for ***:Stroke patients who meet the study criteria and are hospitalized from February 2021 to March 2022 in 23 medical institutions across China,including the First Teaching hospital of Tianjin University of Chinese *** number of patients planned to be recruited is 3,*** to the impact of COVID-19,we have applied to the competent authorities for an extension(recruit patients until December 2022).Basic patient information and treatment information will be registered at admission,at discharge,and on the following dates after the onset of the disease:90±7 days,180±7 days,and 360±7 days after the onset of the *** a database for statistical ***:This study proposes to conduct a prospective cohort study of acupuncture intervention for stroke in a real-world medical *** of the effect pattern of acupuncture intervention on the recovery of neurological function system and swallowing disorder in stroke *** the long-term effects of acupuncture intervention for stroke and recurrence of cardiovascular and cerebrovascular events.

关键词： stroke acupuncture cohort studies real-world multicenter

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