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Effectiveness of infliximab after adalimumab failure in Crohn's disease

World Journal of Gastroenterology 2012年第37期18卷 5219-5224页

作者： María Chaparro Montserrat Andreu Manuel Barreiro-de Acosta Esther García-Planella Elena Ricart Eugeni Domènech María Esteve Olga Merino Pilar Nos Mireia Pealva Javier P Gisbert department of Gastroenterology Hospital Universitario de La PrincesaInstituto de Investigación Princesa(IP)and Centro de Investigación Biomédica en Red de Enfermedades Hepáticasy Digestivas(CIBEREHD)28006 MadridSpain Americio 17 portal E 2℃28021 Madrid department of Gastroenterology Hospital del Mar department of Gastroenterology Hospital Clínico Universitario de Santiago department of Gastroenterology Hospital Santa Creui Sant Pau department of Gastroenterology Hospital ClínicBarcelonaand Centro de Investigación Biomédica en Red de Enfermedades Hepáticasy Digestivas department of Gastroenterology Hospital Germans Triasi Pujol and Centro de Investigación Biomédica en Red de Enfermedades Hepáticasy Digestivas(CIBEREHD) department of Gastroenterology Hospital Mutua de Terrassa department of Gastroenterology Hospital de Cruces department of Gastroenterology Hospital Universitario La Fe and Centro de Investigación Biomédica en Red de Enfermedades Hepáticasy Digestivas(CIBEREHD) department of Gastroenterology Hospital de Bellvitge department of Gastroenterology Hospital Universitario de La PrincesaInstituto de Investigación Princesa(IP)and Centro de Investigación Biomédica en Red de Enfermedades Hepáticasy Digestivas(CIBEREHD)

AIM:To evaluate the effectiveness of infliximab as a second-line therapy in Crohn's disease patients after adalimumab failure. METHODS:A historical cohort study in a community-based gastroenterology practice evaluated Crohn's disease patients treated with infliximab (induction plus maintenance) after adalimumab failure. Patients were identified using a large Spanish database (ENEIDA). RESULTS:We included 15 Crohn's disease patients who received infliximab after adalimumab failure. Five patients discontinued adalimumab due to loss of response, 3 due to adverse events and 7 due to partial response. After infliximab therapy was started, all patients who had interrupted adalimumab due to loss of efficacy regained response. All patients who discontinued adalimumab due to adverse events responded to infliximab and maintained this response; one of these patients had an uneventful course on infliximab, but 2 developed adverse events. None of the 7 patients who interrupted adalimumab due to partial response reached remission with infliximab. CONCLUSION:Switching from adalimumab to infliximab may be useful in patients who develop adverse effects or loss of response, however, the benefit of infliximab in primary nonresponders was not established.

关键词：单抗胃肠病学队列研究开关频率患者治疗数据库西班牙

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Approach to early-onset colorectal cancer:Clinicopathological,familial,molecular and immunohistochemical characteristics

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World Journal of Gastroenterology 2010年第29期16卷 3697-3703页

作者： Jose Perea Edurne Alvaro Yolanda Rodríguez Cristina Gravalos Eva Sánchez-Tomé Barbara Rivera Francisco Colina Pablo Carbonell Rogelio González-Sarmiento Manuel Hidalgo Miguel Urioste department of Surgery Hospital Universitario 12 de Octubre department of Pathology Hospital Universitario 12 de Octubre Medical Oncology Hospital Universitario 12 de Octubre Human Genetics Group Human Cancer Genetics ProgramSpanish National Cancer Centre Molecular Genetics Unit Centro de Bioquímicay Genética ClínicaHospital Virgen de la Arrixaca department of Medicine Medicine SchoolSalamanca University

AIM:To characterize clinicopathological and familial features of early-onset colorectal cancer(CRC) and compare features of tumors with and without microsatellite instability(MSI).METHODS:Forty-five patients with CRC aged 45 or younger were included in the *** information,a three-generation family history,and tumor samples were *** status was analyzed and mismatch repair genes were examined in the MSI *** were included in a tissue microarray and an immunohistochemical study was carried out with a panel of selected ***:Early onset CRC is characterized by advanced stage at diagnosis,right colon location,low-grade of differentiation,mucin production,and presence of *** forms represent at least 21% of ***-one percent of patients who died during followup showed a lack of expression of cyclin E,which could be a marker of poor prognosis.β-catenin expression was normal in a high percentage of ***:Early-onset CRC has an important familial component,with a high proportion of tumors showing microsatellite *** E might be a poor prognosis factor.

关键词： Early onset colorectal cancer Microsatellite instability Lynch syndrome Microsatellite stable colorectal cancer

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Historical fluxes of metal and metalloids in an aquatic ecosystem affected by land-use change and mining activities in northwestern Mexico

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International Journal of Sediment Research 2023年第5期38卷 724-738页

作者： Ochoa-Contreras Roberto Jara-Marini Martín Enrique Ruiz-Fernández Ana Carolina Sanchez-Cabeza Joan Albert Meza-Figueroa Diana Pérez-Bernal Libia Hascibe Posgrado en Ciencias Centro de Investigación en Alimentación y Desarrollo Unidad Hermosillo 2. Centro de Investigación en Alimentación y Desarrollo Unidad Hermosillo Unidad Acad emica Mazatlán Instituto de Ciencias del Mar y Limnología Universidad Nacional Autónoma de M exico departamento de Geología División de Ciencias Exactas y Naturales Universidad de Sonora Rosales y Encinas

Freshwater reservoirs are essential owing because of their ecological, economic, and social *** are particularly vulnerable to contamination, as of metal and metalloids, derived from anthropogenic activities like mining. The temporal variations in trace element concentrations(arsenic(As),mercury(Hg), chromium(Cr), copper(Cu), nickel(Ni), lead(Pb), and zinc(Zn)), enrichment, fluxes, and possible sources were evaluated by studying two sediment cores from the la Angostura(ANG) Reservoir(northwest Mexico), using210Pb geochronology. The enrichment factors showed from null to minor enrichment for most elements, but moderate to severe enrichment of mercury(Hg). Most trace element concentrations had a detrital origin, and notable Hg concentration increases since the past decade were associated with severe drought periods, likely resulting from wildfires. The observed sediment concentrations of As and Hg can cause adverse effects on biota in the ecosystem since they are above the probable effect level(PEL). development of strategies for metal attenuation in this reservoir is recommended and metals should be controlled until specific ecotoxicological studies are performed.

关键词： Aquatic ecosystems ~(210)Pb geochronology Mining activities Metals Metalloids Enrichment factors

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Insights into myelin dysfunction in schizophrenia and bipolar disorder

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World Journal of Psychiatry 2022年第2期12卷 264-285页

作者： Marcela Valdés-Tovar Alejandra Monserrat Rodríguez-Ramírez Leslye Rodríguez-Cárdenas Carlo E Sotelo-Ramírez Beatriz Camarena Marco Antonio Sanabrais-Jiménez Héctor Solís-Chagoyán Jesús Argueta Germán Octavio López-Riquelme departamento de Farmacogenética Subdirección de Investigaciones ClínicasInstituto Nacional de Psiquiatría Ramón de la Fuente MuñizMexico City 14370Mexico departamento de Farmacogenética Instituto Nacional de Psiquiatría Ramón de la Fuente MuñizMexico City 14370Mexico Doctorado en Biología Experimental Universidad Autónoma Metropolitana-IztapalapaMexico City 09340Mexico laboratorio de Neurofarmacología Instituto Nacional de Psiquiatría Ramón de la Fuente MuñizMexico City 14370Mexico laboratorio de Socioneurobiología Centro de Investigación en Ciencias CognitivasUniversidad del Estado de MorelosCuernavaca 62209MorelosMexico

Schizophrenia and bipolar disorder are disabling psychiatric disorders with a worldwide prevalence of approximately 1%.Both disorders present chronic and deteriorating prognoses that impose a large burden,not only on patients but also on society and health *** mental illnesses share several clinical and neurobiological traits;of these traits,oligodendroglial dysfunction and alterations to white matter(WM)tracts could underlie the disconnection between brain regions related to their symptomatic *** is mainly composed of heavily myelinated axons and glial *** internodes are discrete axon-wrapping membrane sheaths formed by oligodendrocyte *** ensheathment allows fast and efficient conduction of nerve impulses through the nodes of Ranvier,improving the overall function of neuronal *** and precisely synchronized nerve impulse conduction through fibers that connect distant brain structures is crucial for higher-level functions,such as cognition,memory,mood,and *** cellular and subcellular anomalies related to myelin and oligodendrocytes have been found in postmortem samples from patients with schizophrenia or bipolar disorder,and neuroimaging techniques have revealed consistent alterations at the macroscale connectomic level in both *** this work,evidence regarding these multilevel alterations in oligodendrocytes and myelinated tracts is discussed,and the involvement of proteins in key functions of the oligodendroglial lineage,such as oligodendrogenesis and myelination,is *** molecular components of the axo-myelin unit could be important targets for novel therapeutic approaches to schizophrenia and bipolar disorder.

关键词： Myelin sheath Oligodendroglia Schizophrenia Bipolar disorder White matter

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Abiotic drivers shape seed inputs and outputs in a tropical wetland on Croton trinitatis population

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Ecological Processes 2022年第1期11卷 65-77页

作者： Francielli Bao Arnildo Pott Pedro Manuel Villa centro de Avaliação da Biodiversidade Pesquisa e Conservação do Cerrado(CBC)Instituto Chico Mendes de Conservação da Biodiversidade(ICMBio)BrasíliaDF 70670-350Brazil Programa de Pós-Graduação em Biologia Vegetal Instituto de BiociênciasUniversidade Federal de Mato Grosso do SulCampo GrandeMS 79070-900Brazil Programa de Pós-Graduacão em Botânica Departamento de Biologia VegetalUniversidade Federal de ViçosaViçosaMG 36570-900Brazil Fundación para la Conservación de la Biodiversidad Mérida 7101Venezuela

Background:Predicting how natural and anthropogenic drivers shape different ecological indicators,such as plant populations along environmental gradients,can be a relevant tool for establishing management and conservation criteria of tropical *** aimed to assess the effects of seasonal flood disturbance,type of grasslands and topographical conditions on Croton trinitatis population distribution in a tropical ***:The study was carried out in a seasonally flooded grassland(Central-West Brazil).We conducted samplings of soil on the dry and flood hydrophases of the *** took the samples in eight seasonal ponds,with 1 km interval between *** were marked during the flood period,observing the water level,one in the lowest zone,in the middle of the pond=low(ca.60 cm deep),one at the pond edge=mid(ca.30 cm deep)and one in the higher zone,on the external part=high(ca.1 cm deep).Results:The results showed that the topography,seasonality,and types of grassland determine differences in the abundance patterns of adult plants and seedlings,and seed bank and seed *** abiotic factors can shape plant population-related ecological processes and patterns,with outputs(germination and predation)and inputs(local dispersion and from neighbouring areas)of proportional seeds for the population maintenance in this ***:We emphasize the importance of these findings,to show that abiotic factors are not the only ones to be considered in ecological studies of distribution and structuring of populations in habitats with extreme seasonal events.

关键词： Environmental filter Flood disturbance Pantanal Population ecology Seasonal change Seed predation Seedling Soil seed bank

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Exclusion of tourist species from assemblages in ecological studies:a methodological approach using spiders

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Ecological Processes 2022年第1期11卷 825-844页

作者： María Florencia Nadal Alda González Gilberto Avalos Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Buenos AiresArgentina laboratorio de Biología de los Artrópodos Facultad de Ciencias Exactas y Naturales y AgrimensuraUniversidad Nacional del NordesteAvenida Libertad 54703400 CorrientesArgentina centro de Estudios Parasitológicos y de Vectores(CEPAVE-UNLP) Boulevard 120 s/n(e/60-64)1900 La PlataArgentina

Background:The exclusion of tourist species from samples is important to avoid bias in community ***,in practice,this is a very difficult *** commonly used methods by researchers,when the habitat of the species is not known,have several shortcomings:first,they exclude not only pseudo-rare species but also genuinely rare species;second,the results obtained with those methods depend on the abundance of the sampling;and third,they follow very subjective *** aims of this study were:(i)to propose a methodology to detect and exclude habitat-tourist species from the database used to carry out analyses in community ecology studies,(ii)to evaluate how the presence of habitat-tourist species affects the richness estimates,and(iii)to assess the effect of including juvenile spiders in the detection of tourist species and the effect of removing them from the richness ***:When the adult+juvenile dataset was considered,twenty-one habitat-tourist species were detected:8 in forest foliage,11 in forest leaf litter,and 2 in *** habitat-tourist species were considered with this dataset,richness overestimation was significant in foliage and in leaf litter,and the final slopes of the richness estimation curves were significantly steeper in leaf *** only the adult dataset was considered,eight habitat-tourist species were detected:3 in forest foliage,4 in forest leaf litter,and just one in *** inclusion of habitat-tourist species in this dataset showed an overestimation of richness,but this was not ***:The proposed methodology contributes to solving the problem of tourist species,which was recognized as one of the great problems in biodiversity *** study showed that common estimators overestimate species richness when habitat-tourist species are included,leading to erroneous ***,this research showed that the inclusion of juveniles(***)could improve the analysis outputs be

关键词： Pseudo-rare species Richness estimation Indicator value Habitat

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Conventional type 1 dendritic cells protect against age-related adipose tissue dysfunction and obesity

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Cellular & Molecular Immunology 2022年第2期19卷 260-275页

作者： Elena Hernández-García Francisco J.Cueto Emma C.L.Cook Ana Redondo-Urzainqui Sara Charro-Zanca Iñaki Robles-Vera Ruth Conde-Garrosa Ivana Nikolić Guadalupe Sabio David Sancho Salvador Iborra department of Immunology Ophthalmology and ENTSchool of MedicineUniversidad Complutense de MadridMadrid 28040Spain centro Nacional de Investigaciones Cardiovasculares(CNIC) Madrid 28029Spain

Conventional dendritic cells(cDCs)scan and integrate environmental cues in almost every tissue,including exogenous metabolic *** cDCs are critical in maintaining immune balance,their role in preserving energy homeostasis is ***,we showed that Batf3-deficient mice lacking conventional type 1 DCs(cDC1s)had increased body weight and adiposity during *** led to impaired energy expenditure and glucose tolerance,insulin resistance,dyslipidemia,and liver ***1 deficiency caused adipose tissue inflammation that was preceded by a paucity of NK1.1+invariant NKT(iNKT)***,among antigen-presenting cells,cDC1s exhibited notable induction of IFN-γproduction by iNKT cells,which plays a metabolically protective role in lean adipose ***3L treatment,which expands the dendritic cell(DC)compartment,mitigated diet-induced obesity and hyperlipidemia in a Batf3-dependent *** effect was partially mediated by NK1.1+*** results reveal a new critical role for the cDC1-iNKT cell axis in the regulation of adipose tissue homeostasis.

关键词： dendritic Cells NKT Obesity ageing FLT3L

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Clinical characteristics and type of antithrombotic treatment in a Spanish cohort of elderly patients with atrial fibrillation according to dependency, frailty and cognitive impairment

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Journal of Geriatric Cardiology 2018年第4期15卷 268-274页

作者： Jose Maria Mostaza Manuel Jesús Romero Jiménez Fernando José Ruiz laiglesia José Antonio Díaz Peromingo Manuel Beltrán Robles Ernesto Guevara Sierra Ana Santander Bilbao Carmen Suárez Hospital Carlos III Madrid Spain Hospital Infanta Elena Huelva Spain Hospital Clínico universitario Lozano Blesa Zaragoza Spain Complejo Hospitalario universitario de Santiago Santiago de Compostela Spain Hospital Virgen del Camino Sanlucar-Cádiz Spain centro Socio-Sanitario Vallparadís Terrassa Spain Hospital de Basurto Bilbao Spain Hospital universitario de la Princesa Madrid Spain

根据相关性，脆弱和认知缺陷与 atrial 纤维性颤动(AF ) 考虑老病人的临床的侧面和管理的 BackgroundAvailable 数据是少见的。学习的目的是根据相关性分析 biodemographic 数据，临床的侧面和 antithrombotic 治疗，吗在***部分的老 AF... 详细信息

根据相关性，脆弱和认知缺陷与 atrial 纤维性颤动(AF ) 考虑老病人的临床的侧面和管理的 BackgroundAvailable 数据是少见的。学习的目的是根据相关性分析 biodemographic 数据，临床的侧面和 antithrombotic 治疗，吗在***部分的老 AF 和学习在 75 年与 3 个月在 *** 在内部药部门出席了的口头的抗凝剂对待的连续 AF 病人执行了的多中心的脆弱和认知缺陷 837 总计病人( 83.0 ???????????????????吗???????????????????￡？？

关键词：缺陷分析西班牙纤维性临床颤动治疗特征和类型

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Metabolism of tissue macrophages in homeostasis and pathology

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Cellular & Molecular Immunology 2022年第3期19卷 384-408页

作者： Stefanie K.Wculek Gillian Dunphy Ignacio Heras-Murillo Annalaura Mastrangelo David Sancho Immunobiology laboratory Centro Nacional de Investigaciones Cardiovasculares(CNIC)Melchor Fernández Almagro 3Madrid28029Spain

Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and anabolism to generate cellular energy and structural *** emerging field of immunometabolism highlights the importance of cellular metabolism for the maintenance and activities of immune *** are embryo-or adult bone marrow-derived leukocytes that are key for healthy tissue homeostasis but can also contribute to pathologies such as metabolic syndrome,atherosclerosis,fibrosis or *** metabolism has largely been studied in ***,different organs contain diverse macrophage populations that specialize in distinct and often tissue-specific *** context specificity creates diverging metabolic challenges for tissue macrophage populations to fulfill their homeostatic roles in their particular microenvironment and conditions their response in pathological ***,we outline current knowledge on the metabolic requirements and adaptations of macrophages located in tissues during homeostasis and selected diseases.

关键词： Tissue macrophages metabolism homeostasis pathology tissue regeneration

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Intraplaque injections of hyaluronic acid for the treatment of stable-phase Peyronie’s disease:a retrospective single-center experience

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Asian Journal of Andrology 2024年第3期26卷 268-271页

作者： Simone Cilio Roberto la Rocca Giuseppe Celentano Claudio Marino Massimiliano Creta Gianluigi Califano Celeste Manfredi Giorgio Ivan Russo Afonso Morgado Marco Falcone Marco Capece YAU Working Group Sexual and Reproductive Health department of Neurosciences Reproductive Sciences and OdontostomatologyUrology UnitUniversity of Naples“Federico II”Naples 80131Italy Urology Unit Department of WomenChild and General and Specialized Surgery“Luigi Vanvitelli”UniversityNaples 80131Italy Urology Section Department of SurgeryUniversityof CataniaCatania 95131Italy department of Urology Centro Hospitalar Universitário São JoãoPorto 4200-319Portugal Urology Clinic-A.O.U.“Cittàdella Salute edella Scienza”-Molinette Hospital University of TurinTurin 10100Italy 不详

Peyronie’s disease(PD)is a condition of penile connective tissue affecting up to 10%of men *** the complexity ofits management,nonsurgical treatments,such as intraplaque injections,are gaining *** current literature shows dataon the efficacy of intraplaque injections of hyaluronic acid(HA)mainly in acute-phase ***,data on injections of HA instable-phase PD are *** for this retrospective study were derived from a prospectively maintained database of privatepatients presenting at a private medical practice affiliated to the University of Naples“Federico II”(Naples,Italy)with stable-phasePD between January 2020 and March *** underwent a standard protocol of three injections,each administered at atwo-week *** the intervals,patients performed vacuum device therapy,penile stretching,and modeling *** compiled the Peyronie’s Disease Questionnaire(PDQ)and Global Assessment of Peyronie’s Disease(GAPD)at baselineand 2 weeks after the third injection.A penile Doppler ultrasound was performed 2 weeks after the last injection to record thefinal ***,we recruited 62 patients with stable-phase PD and a mean(±standard deviation[s.d.])curvature of52.7°(±9.7°).After 6 weeks,eight(12.9%)patients did not experience any curvature *** remaining 54 patientshad a final mean(±s.d.)curvature of 40.3°(±9.1°)with Pdemonstrated that after three injections of HA administered according to the adopted protocol,patientswith stable-phase PD could experience significant improvements in penile curvature,and physical and psychological consequencesof the disease without significantly relevant side effects.

关键词： hyaluronic acid intraplaque injection Peyronie’s disease stable-phase therapy

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