Conventional type 1 dendritic cells protect against age-related adipose tissue dysfunction and obesity

作     者：Elena Hernández-García Francisco J.Cueto Emma C.L.Cook Ana Redondo-Urzainqui Sara Charro-Zanca Iñaki Robles-Vera Ruth Conde-Garrosa Ivana Nikolić Guadalupe Sabio David Sancho Salvador Iborra 

作者机构：Department of ImmunologyOphthalmology and ENTSchool of MedicineUniversidad Complutense de MadridMadrid 28040Spain Centro Nacional de Investigaciones Cardiovasculares(CNIC)Madrid 28029Spain 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2022年第19卷第2期

页      面：260-275页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：Work in the S.I.laboratory is funded by the Spanish Ministerio de Ciencia,Innovación(MICINN),Agencia Estatal de Investigación(AEI)and Fondo Europeo de Desarrollo Regional(FEDER),RTI2018-094484-BI00,and RYC-2016-19463.EHG is the recipient of an FPI fellowship(PRE2019-087509)from the Spanish Ministry of Science and Innovation.Work in the DS laboratory is funded by the CNIC the European Research Council(ERC-2016-Consolidator Grant 725091) the MICINN,AEI and FEDER(PID2019-108157RB) Comunidad de Madrid(B2017/BMD-3733 Immunothercan-CM) Atresmedia(Constantes y Vitales prize) and FundacióLa Maratóde TV3(201723).Work in the G.S.laboratory receives funding from the European Union’s Seventh Framework Programme(FP7/2007-2013)under grant agreement n°ERC 260464,EFSD/Lilly European Diabetes Research Programme GS,2017 Leonardo Grant for Researchers and Cultural Creators,BBVA Foundation(Investigadores-BBVA-2017)IN_BBM_BAS_0066,MINECO-FEDER SAF2016-79126-R,EUIN2017-85875,Comunidad de Madrid IMMUNOTHERCAN-CM S2010/BMD-2326 and B2017/BMD-3733 and Fundación AECC.IN receives funding from EFSD/Lilly(2019),EFSD Rising star(2019),and JdC-Incorporation(IJC2018-035390-I) The CNIC is supported by the Instituto de Salud Carlos III(ISCIII),the MICINN,and the Pro CNIC Foundation 

主　　题：Dendritic Cells NKT Obesity ageing FLT3L 

摘      要：Conventional dendritic cells(cDCs)scan and integrate environmental cues in almost every tissue,including exogenous metabolic *** cDCs are critical in maintaining immune balance,their role in preserving energy homeostasis is ***,we showed that Batf3-deficient mice lacking conventional type 1 DCs(cDC1s)had increased body weight and adiposity during *** led to impaired energy expenditure and glucose tolerance,insulin resistance,dyslipidemia,and liver ***1 deficiency caused adipose tissue inflammation that was preceded by a paucity of NK1.1+invariant NKT(iNKT)***,among antigen-presenting cells,cDC1s exhibited notable induction of IFN-γproduction by iNKT cells,which plays a metabolically protective role in lean adipose ***3L treatment,which expands the dendritic cell(DC)compartment,mitigated diet-induced obesity and hyperlipidemia in a Batf3-dependent *** effect was partially mediated by NK1.1+*** results reveal a new critical role for the cDC1-iNKT cell axis in the regulation of adipose tissue homeostasis.