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Neural Regeneration Research 2024年第10期19卷 2189-2201页

作者： Jesus Amo-Aparicio Charles A.Dinarello Ruben Lopez-Vales department of Medicine University of ColoradoAuroraCOUSA Institute of Neurosciences and Department Cell BiologyPhysiology and ImmunologyUniversitat Autònoma de BarcelonaBellaterraSpain centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud Carlos ⅢSpain

Metabolism is a fundamental process by which biochemicals are broken down to produce energy(catabolism) or used to build macromolecules(anabolism). Metabolism has received renewed attention as a mechanism that generates molecules that modulate multiple cellular responses. This was first identified in cancer cells as the Warburg effect, but it is also present in immunocompetent cells. Studies have revealed a bidirectional influence of cellular metabolism and immune cell function, highlighting the significance of metabolic reprogramming in immune cell activation and effector functions. Metabolic processes such as glycolysis, oxidative phosphorylation, and fatty acid oxidation have been shown to undergo dynamic changes during immune cell response, facilitating the energetic and biosynthetic demands. This review aims to provide a better understanding of the metabolic reprogramming that occurs in different immune cells upon activation, with a special focus on central nervous system disorders. Understanding the metabolic changes of the immune response not only provides insights into the fundamental mechanisms that regulate immune cell function but also opens new approaches for therapeutic strategies aimed at manipulating the immune system.

关键词： central nervous system fatty acid oxidation glycolysis inflammation macrophage metabolism microglia neurodegeneration oxidative phosphorylation

Role of hyperfine mixing in b→c semileptonic decays of doubly-heavy baryons

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Chinese Physics C 2010年第9期34卷 1488-1490页

作者： C.Albertus E.Hernández J.Nieves departamento de física fundamental e IUffyM Universidad de Salamanca Instituto de física Corpuscular (IfIC) Centro Mixto CSIC-Universidad de ValenciaInstitutos de Investigación de Paterna

We analyze the effects of hyperfine mixing in b → c semileptonic decays of doubly heavy *** qualitatively confirm the results by *** and *** in ***.A,2009,24： 2401– 2413,finding that mixing has a great impact on those ***,predictions without mixing differ by a factor of 2 and this discrepancy translates to the mixed case where large differences in decay widths are observed between the two calculations.

关键词： doubly-heavy baryons semileptonic decay hyperfine mixing

Semileptonic bc to cc and bb to bc baryon decays and heavy quark spin symmetry

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Chinese Physics C 2010年第9期34卷 1364-1367页

作者： J.Nieves J.M.flynn E.Hernández Instituto de física corpuscular (IfIC) Centro Mixto Universidad de Valencia-CSICInstitutos de Investigación de Paterna School of Physics and Astronomy University of Southampton departamento de física fundamental e IUffyM Universidad de Salamanca

We study the semileptonic decays of the lowest-lying bc baryons to the lowest-lying cc baryons （Ξ （＊） bc → Ξ （＊） cc and Ω （＊） bc → Ω （＊） cc ）,in the limit m b,m c Λ QCD and close to the zero recoil *** separate heavy quark spin symmetries make it possible to describe all these decays using a single form *** also show how these constraints can be used to test the validity of different quark model *** to bc baryon decays are also discussed.

关键词： heavy quark spin symmetry semileptonic decays constituent quark modelsIf

Effective Interaction force between an Electric Charge and a Magnetic Dipole and Locality (or Nonlocality) in Quantum Effects of the Aharonov–Bohm Type

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Chinese Physics Letters 2021年第3期38卷 39-43页

作者： Gianfranco Spavieri George T.Gillies Miguel Rodriguez Maribel Perez centro de física fundamental Facultad de CienciasUniversidad de Los AndesMérida 5101Venezuela department of Mechanical and Aerospace Engineering University of VirginiaCharlottesvilleVA 22904USA departamento de física Facultad de Ciencia y TecnologíaUniversidad de CaraboboNaguanagua 2001Venezuela Carrera de Ingeniería Ambiental Facultad de IngenieríaUniversidad Nacional de ChimborazoRiobamba 100150Ecuador

Classical electrodynamics foresees that the effective interaction force between a moving charge and a magnetic dipole is modified by the time-varying total momentum of the interaction fields. We derive the equations of motion of the particles from the total stress-energy tensor, assuming the validity of Maxwell’s equations and the total momentum conservation law. Applications to the effects of Aharonov–Bohm type show that the observed phase shift may be due to the relative lag between interfering particles caused by the effective local force.

关键词： force. momentum interaction

Rheological properties and concentration evolution of thickened tailings under the coupling effect of compression and shear

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 862-876页

作者： Aixiang Wu Zhenqi Wang Zhuen Ruan Raimund Bürger Shaoyong Wang Yi Mo Key Laboratory of the Ministry of Education of China for High-efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China Shunde Innovation School University of Science and Technology BeijingFoshan 528399China CI2MA and departamento de Ingeniería Matemática Facultad de Ciencias Físicas y MatemáticasUniversidad de ConcepciónCasilla 160-CConcepciónChile School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China China Railway Construction Tongguan Investment Co. Ltd.Tongling 244000China

Cemented paste backfill(CPB)is a key technology for green mining in metal mines,in which tailings thickening comprises the primary link of CPB ***,difficult flocculation and substandard concentrations of thickened tailings often *** rheological properties and concentration evolution in the thickened tailings remain ***,traditional indoor thickening experiments have yet to quantitatively characterize their rheological *** experiment of flocculation condition optimization based on the Box-Behnken design(BBD)was performed in the study,and the two response values were investigated:concentration and the mean weighted chord length(MWCL)of ***,optimal flocculation conditions were *** addition,the rheological properties and concentration evolution of different flocculant dosages and ultrafine tailing contents under shear,compression,and compression-shear coupling experimental conditions were tested and *** results show that the shear yield stress under compression and compression-shear coupling increases with the growth of compressive yield stress,while the shear yield stress increases slightly under *** order of shear yield stress from low to high under different thickening conditions is shear,compression,and compression-shear *** compression and compression-shear coupling,the concentration first rapidly increases with the growth of compressive yield stress and then slowly increases,while concentration increases slightly under *** order of concentration from low to high under different thickening conditions is shear,compression,and compression-shear ***,the evolution mechanism of the flocs and drainage channels during the thickening of the thickened tailings under different experimental conditions was revealed.

关键词： thickened tailings compression-shear coupling compressive yield stress shear yield stress concentration

Scientific guidelines for preclinical research on potentised preparations manufactured according to current pharmacopoeias-the PrePoP guidelines

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Journal of Integrative Medicine 2024年第5期22卷 533-544页

作者： Alexander L.Tournier Leoni V.Bonamin Susann Buchheim-Schmidt Steven Cartwright Christoph Dombrowsky Paul Doesburg Carla Holandino Maria Olga Kokornaczyk Everine Bvan de Kraats Jesús Antonio López-Carvallo Papiya Nandy JoséManuel Mazón-Suástegui fateme Mirzajani Bernard Poitevin Claudia Scherr Karin Thieves Sandra Würtenberger Stephan Baumgartner Institute of Complementary and Integrative Medicine University of Bern3010 BernBernSwitzerland Institute of Integrative Medicine Witten/Herdecke University58455 WittenNorth Rhine–WestphaliaGermany Homeopathy Research Institute London SW74EFUnited Kingdom Graduate Program on Environmental and Experimental Pathology Paulista UniversitySão Paulo 01504-000São PauloBrazil department of Medical Science Deutsche Homöopathie-Union DHU-Arzneimittel GmbH&Co.KG76227 KarlsruheBaden-WürttembergGermany Cherwell Laboratory for fundamental Research in Homeopathy Oxford OX28NUOxforeshireUnited Kingdom Society for Cancer Research Hiscia Research Institute4144 ArlesheimBaselSwitzerland Laboratório Multidisciplinar de Ciências farmacêuticas Universidade Federal do Rio de JaneiroRio de Janeiro 21941-902Rio de JaneiroBrazil World Water Community Rotterdam 3029AKthe Netherlands departamento de Acuicultura Facultad de Ciencias del MarUniversidad Católica del Norte1790437 CoquimboElquiChile Centre for Interdisciplinary Research and Education KolkataWest Bengal 700068West BengalIndia Laboratorio de Homeopatía Acuícola y Semillas Marinas Centro de Investigaciones Biológicas del NoroesteLa Paz 23096Baja California SurMexico Protein Research Center Shahid Beheshti UniversityTehran ***Iran department of Medical Laboratory Science College of ScienceKnowledge University44001 ErbilErbilIraq SociétéSavante d’Homéopathie 75009 ParisFrance Sola Salus Institute for Homeopathic Research52511 GeilenkirchenNorth Rhine–WestphaliaGermany Scientific Society for Homeopathy 06366 KöthenSaxony-AnhaltGermany

Objective Pharmacopoeias regulate the manufacture of potentised pharmaceutical preparations used in different branches of complementary and integrative *** physicochemical properties and biological activity of these preparations are often investigated in preclinical research,yet no guidelines for experimental research currently exist in this *** present PrePoP guidelines aim to provide recommendations to promote high-quality,statistically sound,and reproducible preclinical research on potentised *** Input was gathered from researchers nominated by the relevant scientific societies using a simplified delphi consensus approach covering the most relevant aspects of basic research methodology in the field including appropriate controls,sample preparation and handling,and *** three rounds of feedback,a consensus was finally reached on the most important aspects and considerations for conducting high-quality research on potentised *** We present a series of recommendations on a range of topics including experimental controls,system stability,blinding and randomisation,environmental influences,and procedures for the preparation of potentised samples and controls,and we address some specific challenges of this research *** This expert consensus process resulted in a robust set of methodological guidelines for research on potentised preparations and provides a valuable framework that will inform and improve the quality of subsequent research in this emerging field.

关键词： Research guidelines fundamental research Basic research Complementary and integrative medicine Potentisation Potentised preparations

frequency stabilization of C-band semiconductor lasers through a SiN photonic integrated circuit

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Photonics Research 2024年第8期12卷 1619-1626页

作者： ALESSANDRO BRUGNONI ALI EMRE KAPLAN VALERIO VITALI KYLE BOTTRILL MICHELE RE PERIKLIS PETROPOULOS COSIMO LACAVA ILARIA CRISTIANI Photonics Group Department of ElectricalComputer and Biomedical EngineeringUniversity of PaviaPavia 27100Italy Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK Huawei Technologies Italia S.r.l Centro direzionale MilanoSegrate 20054Italy

Integrated semiconductor lasers represent essential building blocks for integrated optical components and circuits and their stability in frequency is fundamental for the development of numerous frontier applications and engineering *** dense optical circuits are considered,the stability of integrated laser sources can be impaired by the thermal cross-talk generated by the action of neighboring components,leading to a deterioration of the long-term system performance(on the scale of seconds).In this work we show the design and the experimental characterization of a silicon nitride photonic integrated circuit(PIC)that is able to frequency stabilize 16semiconductor lasers,simultaneously.A stabilized 50 GHz-spaced two-channel system is demonstrated through the detection of the related beating note and the stability of the resulting waveform is characterized via the use of artificially induced thermal cross-talk stimuli.

关键词： stabilization stability impaired

Mechanobiology of the cell surface:Probing its remodeling dynamics using membrane tether pulling assays with optical tweezers

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BIOCELL 2022年第9期46卷 2009-2013页

作者： JULIANA SOARES DOUGLAS G.fREITAS PEDRO S.LOURENÇO JEfTE fARIAS BRUNO PONTES centro Nacional de Biologia Estrutural e Bioimagem-CENABIO Universidade Federal do Rio de JaneiroRio de Janeiro21941-902Brazil Programa de Pós-graduação em Ciências Biológicas Biofísica Instituto de Biofísica Carlos Chagas FilhoUniversidade Federal do Rio de JaneiroRio de Janeiro21941-902Brazil Programa de Pós-graduação Multidisciplinar em física Aplicada Instituto de FísicaUniversidade Federal do Rio de JaneiroRio de Janeiro21941-972Brazil Instituto de Ciências Biomédicas Universidade Federal do Rio de JaneiroRio de Janeiro21941-902Brazil Programa de Pós-graduação em Biotecnologia Instituto de Ciências BiológicasUniversidade Federal do AmazonasManaus69067-005Brazil

Mammalian cell surfaces consist of the plasma membrane supported by an underneath cortical ***,these structures can control not only the shape of cells but also a series of cellular functions ranging from migration and division to exocytosis,endocytosis and ***,the cell surface is capable of exerting and reacting to mechanical *** viscoelastic properties,especially membrane tension and bending modulus,are fundamental parameters involved in these *** viewpoint summarizes our current knowledge on how to measure the viscoelastic properties of cell surfaces employing optical tweezers-based tether assays,paving the way for a better understanding of how cells react to external mechanical forces,with a glance on their remodeling dynamics and possible consequences on downstream cellular processes.

关键词： Cell surface architecture Actin cortex Membrane-cytoskeleton complex Optical tweezers Tether extraction

Variability and trends of near-surface wind speed over the Tibetan Plateau:The role played by the westerly and Asian monsoon

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Advances in Climate Change Research 2024年第3期15卷 525-536页

作者： Gang-feng ZHANG Cesar AZORIN-MOLINA deliang CHEN Tim RMCVICAR Jose AGUIJARRO Kai-Qiang deNG Lorenzo MINOLA Jaeyeon LEE Seok-Woo SON Heng MA Pei-Jun SHI State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijing 100875China Engineering Center of desertification and Blown-Sand Control of Ministry of Education Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Key Laboratory of Environmental Change and Natural Disaster of Ministry of Education Beijing Normal UniversityBeijing 100875China centro de Investigaciones Sobre desertificaci'on Consejo Superior de Investigaciones Cientı'ficas(CIDECSIC-UV-Generalitat alenciana)ClimateAtmosphere and Ocean Laboratory(Climatoc-Lab)Moncada 46113Spain Regional Climate Group Department of Earth SciencesUniversity of GothenburgGothenburg 40530Sweden CSIRO Environment CanberraACT 2600Australia Australian Research Council Centre of Excellence for Climate Extremes CanberraACT 2600Australia State Meteorological Agency Balearic Islands OfficePalma de Mallorca 07015Spain School of Atmospheric Sciences Sun Yat-sen UniversityZhuhai 519082China Interuniversity department of Regional and Urban Studies and Planning(DIST) Politecnico and University of TurinTurin 10125Italy School of Earth and Environmental Sciences Seoul National UniversitySeoul 08826South Korea Atmospheric and Oceanic Sciences Program Princeton UniversityPrinceton NJ 08544USA Geophysical fluid Dynamics Laboratory NOAAPrinceton NJ 08544USA

Near-surface wind speed exerts profound impacts on many environmental issues,while the long-term(≥60 years)trend and multidecadal variability in the wind speed and its underlying causes in global high-elevation and mountainous areas(e.g.,Tibetan Plateau)remain largely ***,by examining homogenized wind speed data from 104 meteorological stations over the Tibetan Plateau for 1961-2020 and ERA5 reanalysis datasets,we investigated the variability and long-term trend in the near-surface wind speed and revealed the role played by the westerly and Asian *** results show that the homogenized annual wind speed displays a decreasing trend(-0.091 m s^(−1)per decade,pdecade,pdecade,pdecadal variability of wind speed,which manifested in an prominent increase in 1961-1970,a sustained decrease in 1970-2002,and a consistent increase in *** observed decadal variations are likely linked to large-scale atmospheric circulation,and the correlation analysis unveiled a more important role of westerly and East Asian winter monsoon in modulating near-surface wind changes over the Tibetan *** potential physical processes associated with westerly and Asian monsoon changes are in concordance with wind speed change,in terms of overall weakened horizontal air flow(i.e.,geostrophic wind speed),declined vertical thermal and dynamic momentum transfer(i.e.,atmospheric stratification thermal instability and vertical wind shear),and varied Tibetan Plateau *** indicates that to varying degrees these processes may have contributed to the changes in near-surface wind speed over the Tibetan *** study has implications for wind power production and soil wind erosion prevention in the Tibetan Plateau.

关键词： Tibetan Plateau Wind speed decadal change Atmospheric circulation Physical processes

Pressure-induced evolution of stoichiometries and electronic structures of host-guest Na-B compounds

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Matter and Radiation at Extremes 2023年第6期8卷 101-110页

作者： Zixuan Guo Xing Li Aitor Bergara Shicong Ding Xiaohua Zhang Guochun Yang State Key Laboratory of Metastable Materials Science&Technology and Key Laboratory for Microstructural Material Physics of Hebei Province School of ScienceYanshan UniversityQinhuangdao 066004China departamento de física and EHU-Quantum Center Universidad del País Vasco-Euskal Herriko UnibertsitateaUPV/EHU48080 BilbaoSpain Donostia International Physics Center(DIPC) 20018 DonostiaSpain centro de física de Materiales CfM Centro Mixto CSIC-UPV/EHU20018 DonostiaSpain

Superionic and electride behaviors in materials,which induce a variety of exotic physical properties of ions and electrons,are of great importance both in fundamental research and for practical ***,their coexistence in hot alkali-metal borides has not been *** this work,we apply first-principles structure search calculations to identify eight Na-B compounds with host-guest structures,which exhibit a wide range of building blocks and interesting properties linked to the Na/B *** the known borides,Na-rich Na9B stands out as the composition with the highest alkali-metal content,featuring vertex-and face-sharing BNa16 ***,it exhibits electride characteristics and transforms into a superionic electride at 200 GPa and 2000 K,displaying unusual Na atomic diffusion behavior attributed to the modulation of the interstitial anion *** demonstrates semiconductor behavior in the solid state,and metallic properties associated with Na 3p/3s states in the superionic and liquid *** the other hand,B-rich NaB7,consisting of a unique covalent B framework,is predicted to exhibit low-frequency phonon-mediated superconductivity with a T_(c) of 16.8 K at 55 *** work advances the understanding of the structures and properties of alkali-metal borides.

关键词： alkali structures compounds