Mechanobiology of the cell surface:Probing its remodeling dynamics using membrane tether pulling assays with optical tweezers
作者机构：Centro Nacional de Biologia Estrutural e Bioimagem-CENABIOUniversidade Federal do Rio de JaneiroRio de Janeiro21941-902Brazil Programa de Pós-graduação em Ciências Biológicas BiofísicaInstituto de Biofísica Carlos Chagas FilhoUniversidade Federal do Rio de JaneiroRio de Janeiro21941-902Brazil Programa de Pós-graduação Multidisciplinar em Física AplicadaInstituto de FísicaUniversidade Federal do Rio de JaneiroRio de Janeiro21941-972Brazil Instituto de Ciências BiomédicasUniversidade Federal do Rio de JaneiroRio de Janeiro21941-902Brazil Programa de Pós-graduação em BiotecnologiaInstituto de Ciências BiológicasUniversidade Federal do AmazonasManaus69067-005Brazil
出 版 物：《BIOCELL》 (生物细胞（英文）)
年 卷 期：2022年第46卷第9期
页 面：2009-2013页
核心收录：
学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by the Brazilian agencies Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior(CAPES)–Financial Code 001,Fundação de AmparoàPesquisa do Estado do Rio de Janeiro(FAPERJ) Fundação de AmparoàPesquisa do Estado do Amazonas(FAPEAM) Instituto Nacional de Ciência e Tecnologia de Fluidos Complexos(INCT-FCx)together with Fundação de AmparoàPesquisa do Estado de São Paulo(FAPESP).BP was supported by a JCNE grant from FAPERJ
主 题：Cell surface architecture Actin cortex Membrane-cytoskeleton complex Optical tweezers Tether extraction
摘 要：Mammalian cell surfaces consist of the plasma membrane supported by an underneath cortical ***,these structures can control not only the shape of cells but also a series of cellular functions ranging from migration and division to exocytosis,endocytosis and ***,the cell surface is capable of exerting and reacting to mechanical *** viscoelastic properties,especially membrane tension and bending modulus,are fundamental parameters involved in these *** viewpoint summarizes our current knowledge on how to measure the viscoelastic properties of cell surfaces employing optical tweezers-based tether assays,paving the way for a better understanding of how cells react to external mechanical forces,with a glance on their remodeling dynamics and possible consequences on downstream cellular processes.
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