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Are type IV pili involved in <i>Vibrio anguillarum</i>virulence towards sea bass (<i>Dicentrarchus labrax</i>L.) larvae?

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Agricultural Sciences 2013年第6期4卷 30-38页

作者： Ingeborg Frans Pieter Busschaert Kristof Dierckens Chris W. Michiels Kris A. Willems Bart Lievens Peter Bossier Hans Rediers centre for Food and Microbial Technology M2S KU Leuven Leuven Belgium Laboratory for Process Microbial Ecology and Bioinspirational Management (PME&BIM) Thomas More Mechelen Campus De Nayer Department of Microbial and Molecular Systems (M2S) KU Leuven Association Sint-Katelijne-Waver Belgium Scientia Terrae Research Institute Sint-Katelijne-Waver Belgium Laboratory for Process Microbial Ecology and Bioinspirational Management (PME&BIM) Thomas More Mechelen Campus De Nayer Department of Microbial and Molecular Systems (M2S) KU Leuven Association Sint-Katelijne-Waver Belgium Scientia Terrae Research Institute Sint-Katelijne-Waver Belgium Centre for Food and Microbial Technology M2S KU Leuven Leuven Belgium Laboratory of Aquaculture & Artemia Reference Center Department of Animal Production Ghent University Ghent Belgium Laboratory of Aquaculture & Artemia Reference Center Department of Animal Production Ghent University Ghent Belgium

Vibrio anguillarum, an important bacterial fish pathogen, expresses a variety of virulence factors contributing to its ability to cause vibriosis in fish. Many virulence factors of this pathogen remain however unknown. For example, a type IV pilus system was previously reported to be potentially involved in the virulence of this bacterium but no experimental evidence was reported yet. In this study, complete genome sequencing of V. anguillarum strain VIB15, shown to be highly virulent towards sea bass (Dicen- trarchus labrax L.) larvae, revealed the presence of a PilA pilin. A V. anguillarum VIB15 pilA mutant was constructed and the pathogenicity of this mutant was assessed in a gnotobiotic sea bass system developed for virulence screening. Our results suggest that the V. anguillarum pilA gene is not crucial for virulence towards sea bass larvae. Possibly, another type IV pilus system identified in V. anguillarum, showing homology to the mannose-sensitive hemagglutinin pilin of Vibrio cholerae, may complement the pilA mutation. Alternatively, the type IV pilus system has a role in infection of juvenile or adult fish, rather than in the larval phase. As such, further research is required to unravel the potential role of type IV pili in V. anguillarum virulence.

关键词： Virulence Vibrio anguillarum Fish Pathogen Type IV Pili

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抗狂犬病VHH和疫苗用于暴露后处置显著提高小鼠对致死性狂犬病感染的保护作用

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中华实验和临床病毒学杂志 2017年第5期31卷 408-408页

作者： Sanne Terryn Aurelie Francart Heidi Rommelaere 吕新军唐浏英 National Reference centre of Rabies Viral Diseases Scientific Institute of Public Health (WIV-ISP) Brussels Belgium. Laboratory of Virology Department of Virology Parasitology and Immunology Faculty of Veterinary Medicine Ghent University Ghent Belgium. Ablynx NV Ghent Belgium.

狂犬病暴露后处置需要在暴露后尽快使用抗狂犬病免疫球蛋白和狂犬病疫苗。由于抗狂犬病免疫球蛋白昂贵且稀缺，可以持续生产的更加廉价的替代品有现实需求。此前，我们研发了针对狂犬病病毒糖蛋白的可以有效中和狂犬病病毒的VHH。

关键词：抗狂犬病狂犬病疫苗暴露后保护作用致死性免疫球蛋白感染小鼠

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蚯蚓(Eiseniafetida)细胞色素P450及抗氧化酶系对环境浓度苯并(a)芘的响应

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农业环境科学学报 2009年第2期28卷 337-342页

作者：王磊宋玉芳张薇陈朗 David Freestone M Leigh Ackland 中国科学院沈阳应用生态研究所辽宁沈阳110016 中国科学院研究生院北京100049 沈阳农业大学土地与环境学院辽宁沈阳110161 centre for Cellular and Molecular Biology School of Life and Environmental SciencesDeakin UniversityMel-bourne 3125Australia

以赤子爱胜蚓(Eisenia fetida)为供试生物,草甸棕壤为供试土壤,以蚯蚓微粒体细胞色素P450含量、抗氧化酶系以及谷胱甘肽转移酶活性为指标,进行了土壤中苯并(a)芘[B(a)P]暴露与酶活性的量-效关系研究。结果表明,在接近沈抚灌区实地污染状... 详细信息

以赤子爱胜蚓(Eisenia fetida)为供试生物,草甸棕壤为供试土壤,以蚯蚓微粒体细胞色素P450含量、抗氧化酶系以及谷胱甘肽转移酶活性为指标,进行了土壤中苯并(a)芘[B(a)P]暴露与酶活性的量-效关系研究。结果表明,在接近沈抚灌区实地污染状况B(a)P(0.1～***-1)暴露下,第1、3、7以及第14d取样时,P450和SOD有较好的响应:SOD在第1、3d显著升高,而在第7、14d时降低;P450总体表现为低浓度B(a)P诱导下降低,高浓度下升高的趋势。CAT、POD以及GST的敏感性相对较差。比照其他4个指标,蚯蚓P450的敏感性更为优异,具有较好的应用前景。指标敏感性总体表现为:P450>SOD>CAT/POD>GST。

关键词：土壤蚯蚓 P450 抗氧化酶系苯并(a)芘[B(a)P]

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澜沧江和怒江流域的气候变化及其对径流的影响

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气候变化研究进展 2017年第4期13卷 356-365页

作者：刘苏峡丁文浩莫兴国王盛刘昌明罗贤何大明 Sagar Ratna Bajracharya Arun Bhakta Shrestha Nand Kishor Agrawal 中国科学院地理科学与资源研究所陆地水循环及地表过程重点实验室北京100101 中国科学院大学资环学院/中丹学院北京100049 云南大学昆明650091 International centre for Integrated Mountain Development Kathmandu 100023Nepal

采用VIP(Vegetation Interface Processes)模型和HIMS(Hydro-Informatic Modeling system)模型,模拟分析了1957—2012年澜沧江和怒江流域(简称两江流域)水资源量的演变。根据CMIP5 RCP2.6,RCP4.5和RCP8.5情景预测,模拟了2030年代和2050年代流域水资源的变化。研究发现,过去50年间,两江流域的气温都呈升高趋势,但海拔较高的上游地区升幅大于下游。年总降水量的变化趋势不明显,但春季降水增加趋势明显。两江流域年总水资源量为650亿~850亿m^3,水资源总量长期变化趋势不明显,其中澜沧江的波动性(1.884,最大与最小之比)大于怒江。空间上水资源量呈现北低-南高的格局。在未来,两江流域气温仍呈增加趋势,降水呈增加趋势,径流呈增加趋势,空间变异性趋小,但较强的季节性变化对水资源安全仍具有较大的挑战性。

关键词：径流气温降水 VIP模型 HIMS模型

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ANALGESIC ACTIVITY OF HAWTHORN SEED EXTRACT

ANALGESIC ACTIVITY OF HAWTHORN SEED EXTRACT

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第十五届国际药理学大会

作者： Can Ozgur Demir Umide Ozturk Nilgun Ozturk Yusuf Anadolu Unv Plant Drag and Scientific Research Centre 26470 EskisehirTURKEY. Anadolu Univ.Fac.Pharmacy Dept.Pharmacology 26470 Eskisehir TURKEY. Anadolu Univ.Fac.Pharmacy Dept.O Pharmacognosy 26470 Eskisehir TURKEY. Anadolu Univ.Fac.Pharmacy Dept.Pharmacology 26470 Eskisehir TURKEY.

＜正＞ Hawthorn （Crataegus monogyna, Rosaceae） extracts are among the most popular herbal medicinal products in the U. S. A. and various European countries. Hawthorn has been used for its several pharmacological effects more than 700 years as a folk medicine. Although various pharmacological activities of Hawthorn have been reported previously,to the best of our knowledge,there have been no reports related to its analgesic action. Here we aimed to investigate the analgesic activity of plant seed extract. Analgesic activity of morphine （2 mg/kg） and the extract （1 - 1000 mg/kg） were measured by tail - clip and tail - immersion tests. Naloxone （5 mg/kg） was used as opioid antagonist. In tail clip tests. 10 - 1000 mg/kg doses of the extract showed analgesic activity,whereas its 1mg/ kg dose did not. Naloxone antagonized its analgesic effect. No analgesic activity was observed in tailimmersion test. LD50 value of the extract was estimated higher than 1000 mg/ kg. Being important for the development of new analgesic drugs,this is the first report for the analgesic activity of Hawthorn seeds possibly due to endogenous opioid system. However,further studies are necessary.

关键词： Hawthorn Crataegus analgesia

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营养素度量法的应用:慢性疾病预防饮食中的潜在角色以及核心营养素度量体系的可行性

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营养健康新观察 2014年第1期 37-38页

作者： G Sacks M Rayner L Stockley P Scarborough W Snowdon B Swinburn 刘轶群 Deakin Population Health Deakin University British Heart Foundation Health Promotion Research Group Department of Public HealthUniversity of Oxford Pacific Research centre for the Prevention of Obesity and Non-communicable Diseases(C-POND) Fiji School of Medicine

背景/目的:大量不同的营养素度量模型被提出但只有少量营养素度量法的应用被评估验证。本论文旨在描述营养素度量法的应用在慢性疾病饮食(DRCD)中的潜在角色,以及考虑核心营养素度量体系的可行性,哪一个可以被改进从而加强特定国家中多... 详细信息

背景/目的:大量不同的营养素度量模型被提出但只有少量营养素度量法的应用被评估验证。本论文旨在描述营养素度量法的应用在慢性疾病饮食(DRCD)中的潜在角色,以及考虑核心营养素度量体系的可行性,哪一个可以被改进从而加强特定国家中多重潜在应用的基础。方法:市场营销中的4‘P'(产品、促销、地点和价格)被作为一个框架去识别和区分营养素度量法的潜在应用。逻辑通路的提出可被适用于评估营养素度量干预对行为改变、饮食改变以及慢病饮食效果改变的潜在影响。核心营养素度量体系的可行性可用于评估不同模型设计策略的影响以及不同目的的适宜性。结果和结论:使用营养素度量法作为干预慢病饮食策略的一部分具有巨大的空间。核心营养素度量体系作为各种应用的基础是可以减少差异以及缩小监管机构、制造商和消费者的混乱。并且它作为公共元素并被合并为核心体系的一部分也是可行的,例如,标准评分法、营养素的核心体系、食物成分和清晰的食物分类,以及额外的专用标准应用。无论如何,在一个系统的发展和实施过程中需要与几个特定国家的背景和技术性因素相协调。

关键词：营养素度量法慢性疾病饮食应用

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乳腺癌患者健康效用值测量研究

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中国卫生经济 2016年第3期35卷 21-24页

作者：徐喜卿王珉李顺平陈钢山东大学卫生管理与政策研究中心卫生部卫生经济与政策研究重点实验室济南250012 山东省青岛市市立医院(东院区) 山东青岛266011 Australia Flinders University Flinders centre for Innovation in Cancer

目的：采用EQ-5D-5L量表对乳腺癌患者进行健康效用值的测量,为今后开展乳腺癌临床治疗的成本-效用分析提供方法借鉴和基础数据支持。方法：采用EQ-5D-5L量表对621名乳腺癌患者进行面对面问卷调查。结果：用EQ-5D-5L量表测量的乳腺癌患... 详细信息

目的：采用EQ-5D-5L量表对乳腺癌患者进行健康效用值的测量,为今后开展乳腺癌临床治疗的成本-效用分析提供方法借鉴和基础数据支持。方法：采用EQ-5D-5L量表对621名乳腺癌患者进行面对面问卷调查。结果：用EQ-5D-5L量表测量的乳腺癌患者的平均健康效用值为0.83±0.16（95%可信区间为0.82-0.85,中位数为0.87）;被调查患者的教育程度、家庭收入以及治疗方案会对健康效用值产生一定影响。结论：采用EQ-5D-5L量表对乳腺癌患者进行健康效用值的测量具有重要研究价值,应加快研制适用中国人群的EQ-5D-5L量表的效用值积分体系。

关键词：乳腺癌健康效用 EQ-5D-5L量表

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Towards a Theoretical Framework of Autonomous systems Underpinned by Intelligence and systems Sciences

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IEEE/CAA Journal of Automatica Sinica 2021年第1期8卷 52-63页

作者： Yingxu Wang Ming Hou Konstantinos NPlataniotis Sam Kwong Henry Leung Edward Tunstel Imre JRudas Ljiljana Trajkovic International Institute of Cognitive Informatics and Cognitive Computing Department of Electrical and Computer EngineeringSchulich School of Engineering and Hotchkiss Brain InstituteUniversity of CalgaryCalgary T2N 1N4Canada Toronto Research centre Defence Research&Development CanadaToronto M3K 2C9Canada Department of Electrical&Computer Engineering University of TorontoToronto M5S3G4Canada Department of Computer Science City University of Hong KongHong KongChina Department of Electrical and Computer Engineering Schulich School of EngineeringUniversity of CalgaryCalgary T2N 1N4Canada Autonomous&Intelligent systems Department United Technologies Research CenterCT 06108 USA University Research&Innovation Center(EKIK) Óbuda UniversityBudapest H-1034Hungary School of Engineering Science Simon Fraser UniversityBurnaby V5A 1S6Canada

Autonomous systems are an emerging AI technology functioning without human intervention underpinned by the latest advances in intelligence,cognition,computer,and systems *** paper explores the intelligent and mathematical foundations of autonomous *** focuses on structural and behavioral properties that constitute the intelligent power of autonomous *** explains how system intelligence aggregates from reflexive,imperative,adaptive intelligence to autonomous and cognitive intelligence.A hierarchical intelligence model(HIM)is introduced to elaborate the evolution of human and system intelligence as an inductive *** properties of system autonomy are formally analyzed towards a wide range of applications in computational intelligence and systems *** paradigms of autonomous systems including brain-inspired systems,cognitive robots,and autonomous knowledge learning systems are *** in autonomous systems will pave a way towards highly intelligent machines for augmenting human capabilities.

关键词： Autonomous systems(AS) cognitive systems computational intelligence engineering paradigms intelligence science intelligent mathematics

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Global diversity and taxonomy of the Inonotus linteus complex（Hymenochaetales,Basidiomycota）:Sanghuangporus ***.,Tropicoporus excentrodendri and T guanacastensis *** ***.,and 17 new combinations

Global diversity and taxonomy of the Inonotus linteus comple...

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第十二届海峡两岸真菌学学术研讨会

作者： Zhou,Li-Wei Vlasak,Josef Decock,Cony Assefa,Addisu Stenlid,Jan Abate,Dawit Wu,Sheng-Hua Dai,Yu-Cheng State Key Laboratory of Forest and Soil Ecology Institute of Applied EcologyChinese Academy of Sciences Biology centre of the Academy of Sciences of the Czech Republic Mycotheque de l'Universite catholique de Louvain(MUCL BCCMTM)Earth and Life Institute-Microbiology (ELIM)Universite catholique de LouvainCroix du Sud 2 bte L7.05.061348 Louvain-la-NeuveBelgium

＜正＞Although Inonotus linteus complex is placed in the genus Inonotus,its perennial basidiocarps with a dimitic hyphal system,at least in the trama,distinguish the complex from other species in the genus,which have an annual habit and a monomitic hyphal *** species number of Inonotus linteus complex has been increased in China and tropical America in recent ***,

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Quantum state and process tomography via adaptive measurements

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Science China(Physics,Mechanics & Astronomy) 2016年第10期59卷 25-32页

作者： HengYan Wang WenQiang Zheng NengKun Yu KeRen Li DaWei Lu Tao Xin Carson Li ZhengFeng Ji David Kribs Bei Zeng XinHua Peng JiangFeng Du Hefei National Laboratory for Physical Sciences at Microscale and Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Department of Applied Physics Zhejiang University of TechnologyHangzhou 310023China Institute for Quantum Computing University of WaterlooWaterloo N2L 3G1Canada 4Department of Mathematics&Statistics University of GuelphGuelph N1G 2W1Canada centre for Quantum Computation&Intelligent systems Faculty of Engineering and Information TechnologyUniversity of Technology SydneySydney NSW 2007Australia State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing 100084China Department of Physics University of GuelphGuelph N1G 2W1Canada State Key Laboratory of Computer Science Institute of SoftwareChinese Academy of SciencesBeijing 100190China Canadian Institute for Advanced Research Toronto M5G 1Z8Canada

We investigate quantum state tomography(QST) for pure states and quantum process tomography(QPT) for unitary channels via adaptive measurements. For a quantum system with a d-dimensional Hilbert space, we first propose an adaptive protocol where only 2d. 1 measurement outcomes are used to accomplish the QST for all pure states. This idea is then extended to study QPT for unitary channels, where an adaptive unitary process tomography(AUPT) protocol of d2+d.1measurement outcomes is constructed for any unitary channel. We experimentally implement the AUPT protocol in a 2-qubit nuclear magnetic resonance system. We examine the performance of the AUPT protocol when applied to Hadamard gate, T gate(/8 phase gate), and controlled-NOT gate,respectively, as these gates form the universal gate set for quantum information processing purpose. As a comparison, standard QPT is also implemented for each gate. Our experimental results show that the AUPT protocol that reconstructing unitary channels via adaptive measurements significantly reduce the number of experiments required by standard QPT without considerable loss of fidelity.

关键词： quantum tomography state reconstruction nuclear magnetic resonance

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