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Organic and Inorganic Mercury in Biological Samples of Flouresecent Lamp Industries Workers and Health Risks

Biomedical and Environmental sciences 2020年第2期33卷 89-102页

作者： Nayab GUL Sardar KHAN Abbas KHAN Javed NAWAB Adnan SARWAR Nida GUL Climate Change centre The University of AgriculturePeshawar 25120Pakistan Department of Environmental sciences University of PeshawarPeshawar 25120Pakistan Drug Control Administration Government of Khyber PakhtunkhwaHealth DepartmentPeshawar 25120Pakistan Department of Environmental sciences Abdul Wali Khan University MardanPeshawar 25120Pakistan Pak International Medical College and research Institute HayatabadPeshawar 25120Pakistan

Objective The present study aims to investigate the concentrations of Hg and its aspects methyl mercury(Me-Hg)and inorganic mercury(I-Hg)in the biological samples(BSs)of fluorescent lamp industries workers(FLIWs).Methodology Different BSs including red blood cells(RBCs),plasma,urine,hair and nails were collected from the workers exposed to Hg and unexposed persons were selected as control group to measure both the T-Hg concentration as well as its species in different biological samples through quantitative *** data was collected through questionnaire *** The mean concentrations of T-Hg(31.9μg/L),Me-Hg(27.7μg/L),and I-Hg(5.36μg/L)in RBCs were found significantly(P<0.001)higher among the workers(n=40)as compared to the control group(n=40).Similarly the mean Hg concentrations in plasma,urine,hair and nails were also significantly higher among the workers than the control *** statistical relation between Hg concentration and demographic characteristics observed that workers experience and fish consumption has increased the Hg concentration while age,weight and smoking found no significant effect on Hg concentration in the *** The study observed that the workers were highly exposed to high concentration of Hg and they are at a high health risk.

关键词： Mercury Health risk Fluorescent lamp industries Regression Demographic characteristics Biological samples

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Poly-hydroxylated bile acids and their prognostic roles in Alagille syndrome

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World Journal of Pediatrics 2023年第7期19卷 652-662页

作者： Meng-Xuan Wang Jun Han Teng Liu Ren-Xue Wang Li-Ting Li Zhong-Die Li Jun-Cong Yang Lang-Li Liu Yi Lu Xin-Bao XieJing-Yu Gong Shi-Yu Lei Zhang Victor Ling J Jian-She Wang Department of Pediatrics Jinshan Hospital of Fudan UniversityShanghai 201508China The Center for Pediatric Liver Diseases Children's Hospital of Fudan UniversityShanghai 201102China University of Victoria-Genome BC Proteomics centre and Division of Medical sciences VictoriaBritish ColumbiaCanada BC Cancer research centre VancouverBritish ColumbiaCanadaDepartment of PediatricsJinshan Hospital of Fudan UniversityShanghai 201508China Institutes of Biomedical sciences Fudan UniversityShanghai 201199China Shanghai Key Laboratory of Birth Defect Shanghai 201102China

Background The liver manifestations of Alagille syndrome(ALGS)are highly variable,and factors affecting its prognosis are poorly *** asked whether the composition of bile acids in ALGS patients with good clinical outcomes differs from that in patients with poor outcomes and whether bile acids could be used as prognostic *** Blood for bile acid profiling was collected from genetically confirmed JAG1-associated ALGS patients before one year of age.A good prognosis was defined as survival with native liver and total bilirubin(TB)607.69 nmol/L was associated with native liver survival[hazard ratio:13.03,95%confidence interval(CI):(2.662-63.753),P=0.002].Conclusions We identified two poly-hydroxylated bile acids as liver prognostic biomarkers of ALGS *** hydroxylation of bile acids may result in better clinical outcomes.

关键词： Alagille syndrome Bile acid profile Poly-hydroxylated bile acids Prognostic biomarkers

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Modulating intestinal mucus barrier for nanoparticles penetration by surfactants

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Asian Journal of pharmaceutical sciences 2019年第5期14卷 543-551页

作者： Xin Zhang Wei Dong Hongbo Cheng Meixia Zhang Yongqiang Kou Jian Guan Qiaoyu Liu Mingyue Gao Xiuhua Wang ShiruiMao School of Pharmacy Shenyang Pharmaceutical UniversityShenyang110016China Laboratory of Metabolic Disease research and Drug Development China Medical UniversityShenyang110122China

Improving peroral delivery efficiency is always a persistent goal for both small-molecule and macromolecular drug development. However,intestinal mucus barrier which greatly impedes drug-loaded nanoparticles penetration is commonly overlooked. Therefore,in this study,taking fluorescent labeled PLGA(poly(lactic-co-glycolic acid)) nanoparticles as a tool,the influence of anionic and nonionic surfactants on mucus penetration ability of nanoparticles and their mucus barrier regulating ability were studied. The movement of PLGA nanoparticles in mucus was tracked by multiple particles tracking method(MPT).Alteration of mucus properties by addition of surfactants was evaluated by rheology and morphology study. Rat intestinal villus penetration study was used to further evaluate penetration enhancement of nanoparticles. The effective diffusivities of the nanoparticles in surfactants pretreated mucus were increased by 2–3 times and the mucus barrier regulating capacity was also surfactant type dependent. Sodium dodecyl sulfate(SDS) increased the complex viscosity and viscoelastic properties of mucus,but poloxamer presented a decreased trend. Tween 80 maintained the rheological property of the mucus. With the mucus barrier regulated by surfactants,the penetration of nanoparticles in intestinal villus was obviously increased. In summary,the mucus penetration ability of nanoparticles could be enhanced by altering mucus microenvironment with surfactants. Tween 80 which largely retains the original mucus rheology and morphology properties may be a promising candidate for facilitating nanoparticle penetration through the mucus barrier with good safety profile.

关键词： Mucus barrier Mucus modulating agents Rheology PLGA nanoparticles Surfactants

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Application of plant DNA metabarcoding of lake sediments for monitoring vegetation compositions on the Tibetan Plateau

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Science China Earth sciences 2024年第11期67卷 3594-3609页

作者： Kai WU Kai LI Weihan JIA Kathleen RSTOOF-LEICHSENRING Ulrike HERZSCHUH Jian NI Mengna LIAO Fang TIAN College of Life sciences Zhejiang Normal UniversityJinhua 321004China Polar Terrestrial Environmental Systems research Group Alfred Wegener Institute Helmholtz Centre for Polar and Marine ResearchPotsdam 14473Germany Institute of Environmental Science and Geography University of PotsdamPotsdam 14476Germany Institute of Biochemistry and Biology University of PotsdamPotsdam 14476Germany College of Resource Environment and Tourism Capital Normal UniversityBeijing 100048China

Benefiting from the rapid development of environmental DNA(eDNA) technologies, sedimentary DNA(sedDNA)emerges as a promising tool for monitoring plant compositions in remote regions. The Tibetan Plateau(TP), renowned for its harsh environment and numerous ponds and lakes, presents a potentially demanding region for the application of sedDNA on vegetation investigations. Here, we used the g and h universal primers for the P6 loop region of the chloroplast trn L(UAA)intron to amplify plant DNA in surface sediments from 59 ponds and small lakes on the southwestern TP. The applicability and limitations of using plant DNA metabarcoding for modern vegetation monitoring and palaeo-vegetation reconstructions have been assessed by comparing sedDNA, pollen, and vegetation survey data. Our results showed that plant DNA metabarcoding recorded 186 terrestrial taxa, of which 30.1% can be identified at the species level. The plant sedDNA approach can effectively disclose the dominant plant taxa(including Asteraceae, Cyperaceae and Poaceae) and significant vegetation assemblages in the vicinity of the investigated sites. The number of taxa and taxonomic resolution of plant sedDNA exceeded that of pollen analysis(75 taxa detected, 5.3% can be identified at species level). Unlike pollen that retains a broad spectrum of regional plant signals(including Pinus and Artemisia), plant sedDNA mirrors very local plants, underscoring its utility in local vegetation monitoring and reconstructions. To conclude, plant DNA metabarcoding of(small) lake sediments warrant increased attention in the future for local vegetation monitoring and reconstructions on the TP.

关键词： Sedimentary DNA(sedDNA) Metabarcoding Pollen Vegetation composition Tibetan Plateau

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Use of nanoscale metals in poultry diet as a mineral feed additive

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Animal Nutrition 2020年第2期6卷 185-191页

作者： Еlena Sizova Sergey Miroshnikov Svyatoslav Lebedev Boris Usha Sergey Shabunin Federal research centre of Biological Systems and Agrotechnologies of the Russian Academy of sciences Orenburg460000Russia Orenburg State University Orenburg460018Russia Moscow State University of Food Production Moscow125080Russia Federal State Budget Scientific Institute(All-Russian Veterinary research Institute of Pathology Pharmacology and Therapy)Voronezh394087Russia

The research was aimed at studying the efficiency of a nanoscale alloy of copper(Cu) and zinc(Zn) to be used as a mineral additive for feeding broiler chickens,compared to inorganic and organic forms of these *** studies of the blood serum were performed using an automated *** mineral composition was determined by atomic emission and mass spectrometry(MS-ISP),The study was performed on broiler chickens of cross Smena 7(n=72) in the conditions of a *** were3 treatment groups with 24 chickens in *** the inorganic form of mineral supplements with the nanosized alloy resulted in a positive productive effect,with a tendency to increasing the content of serum *** nano scale form of metals improved(P <0.05) the activity of *** the same time,the liver micro structure of experimental groups is similar to that of the *** was a moderate plethora and poor polymorphoncellular infiltration around the interlobular triads with a clear morphological orga nization of the stromal and parenchymal co mponents of the ***,the lack of oxidative stress was confirmed by the dynamics of catalase(CT),total superoxide dismutase(TSOD) and malondialdehyde(MDA) levels,and the concentrations of which did not exceed the reference level Replacing Cu and Zn sulfates with the nanoscale alloy(group 1) and organic form(group 2) of these elements in the diet of broiler chickens was accompanied by the increasing pool of these elements in the organisms at the end of the *** was accumulated throughout the experiment in experimental group 1,compared to the reference,with the maximum difference in the liver of 36.5%(P ≤ 0.05),in the feathers 2.5 times(P ≤ 0.01).Assessment of the Zn level dynamics in the feathers revealed a well noticeable tendency to reducing its concentrations during the experiment in all *** the background of feeding a nanoscale alloy,Zn concentration in the liver exceeded th

关键词： Broiler chicken Feeding Mineral supplement Nanoscale metal

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Orthogonal assays for the identification of inhibitors of the single-stranded nucleic acid binding protein YB-1

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Acta Pharmaceutica Sinica B 2019年第5期9卷 997-1007页

作者： Alexander J.Trevarton Yan Zhou Dehua Yang Gordon W.Rewcastle Jack U.Flanagan Antony Braithwaite Peter R.Shepherd Cristin G.Print Ming-Wei Wang Annette Lasham Department of Molecular Medicine and Pathology University of AucklandAucklandNew Zealand The National Center for Drug Screening and the CAS Key Laboratory of Receptor research Shanghai Institute of Materia MedicaChinese Academy of Sciences(CAS)Shanghai201203China Auckland Cancer Society research centre AucklandNew Zealand Maurice Wilkins centre for Molecular Biodiscovery University of AucklandAucklandNew Zealand Department of Pathology Dunedin School of MedicineUniversity of OtagoDunedinNew Zealand Maurice Wilkins centre for Molecular Biodiscovery University of OtagoDunedinNew Zealand School of Pharmacy Fudan UniversityShanghai201203China

We have previously shown that high expression of the nucleic acid binding factor YB-1 is strongly associated with poor prognosis in a variety of cancer types. The 3-dimensional protein structure of YB-1 has yet to be determined and its role in transcriptional regulation remains elusive. Drug targeting of transcription factors is often thought to be difficult and there are very few published high-throughput screening approaches. YB-1 predominantly binds to single-stranded nucleic acids, adding further difficulty to drug discovery. Therefore, we have developed two novel screening assays to detect compounds that interfere with the transcriptional activation properties of YB-1, both of which may be generalizable to screen for inhibitors of other nucleic acid binding molecules. The first approach is a cell-based luciferase reporter gene assay that measures the level of activation of a fragment of the E2 F1 promoter by YB-1. The second approach is a novel application of the Alpha Screen system, to detect interference of YB-1 interaction with a single-stranded DNA binding site. These complementary assays examine YB-1 binding to two discrete nucleic acid sequences using two different luminescent signal outputs and were employed sequentially to screen 7360 small molecule compounds leading to the identification of three putative YB-1 inhibitors.

关键词： Cancer YB-1 Luciferase Alpha Screen Transcription factor Single-stranded DNA

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Organizational ambidexterity, open innovation and innovation outputs: How do followers and low-flyer EU countries innovate?

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International Journal of Innovation Studies 2024年第2期8卷 186-235页

作者： Joao Leitao Sonia de Brito Dina Pereira Faculty of Social and Human sciences NECE-Research Unit in Business SciencesUniversity of Beira Interior6200-001CovilhaPortugal research Unit in Business sciences(NECE) University of Beira InteriorCovilhaPortugal centre for Management Studies of Instituto Superior Tecnico(CEG-IST) University of Lisbon1649-004LisboaPortugal Instituto de Ciencias Sociais ICsUniversity of Lisbon1649-004LisboaPortugal

This study analyses the role played by organizational ambidexterity and open innovation in innovation outputs,considering business units with different levels of technological intensity(medium-high and high tech,and medium-low and low tech)for countries with different inno-vation *** countries considered in this paper are i)Estonia and Slovenia as innovation followers;i)Slovakia,Hungary,Spain,Czech Republic,Italy,Portugal,Norway,and Croatia as moderate innovators;and ii)Bulgaria,Lithuania and Romania as modest *** the empirical approach,the research hypotheses arise from the literature review and are tested using secondary data collected from the Community Innovation Survey(CIS)*** conceptual model is tested using the logistic regression method,which indicates suitable accuracy and reliability for empirical testing *** evidence reveals that for innovation followers,ambidexterity has a greater influence on the practice of eco-innovation,marketing innovation,and product *** moderate innovators,ambidexterity has a greater influence on the practice of product innovation,process innovation,and *** modest in-novators,ambidexterity has a greater influence on the practice of product innovation,process innovation,and *** regard to open innovation,for innovation followers,this has a negative influence on product innovation in medium-high and high-tech *** moderate innovators,open innovation has a greater influence in process,organizational,and *** the case of modest innovators,open innovation is more significant for innovation outputs in product,organizational,and marketing *** is not always positively related to innovation outputs.

关键词： Organizational ambidexterity CIS Cooperation Open innovation Public innovation policies

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THE COMPARISON OF SURFACE AIR TEMPERATURE IN CHINA BETWEEN GCM MODEL CLIMATE AND OBSERVED CLIMATE

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Journal of Geographical sciences 1992年第2期 58-82页

作者： Wei-Chyung Wang Zhang Yi Institute of Geography,CAS Atmospheric Science research centre State University of New York at Albany

In the presentstudy,we compare the observed surface air temperature in China with those simulated from the NCAR general circulation *** results indicate that1 x CO2model climate is similar to observation climate over China,especially in the eastern partof *** model summer temperature calculated is in better agreement,but winter is *** mean temperature differences between model climate and observed climate of summer,autumn,winter and spring are 1.08℃,1.16℃,1.85℃and 1.26℃*** annual mean temperature difference is 1.12℃.

关键词： model climate observed climate spatial-climate equation

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Traditional medical uses of Drimia species in terms of phytochemistry,pharmacology and toxicology

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Journal of Traditional Chinese Medicine 2017年第1期37卷 124-139页

作者： Mahbubeh Bozorgi Gholamreza Amin Maryam Shekarchi Roja Rahimi Department of Traditional Pharmacy School of Traditional MedicineTehran University of Medical SciencesTehran ***Iran pharmaceutical sciences research Center Teh-ran University of Medical SciencesTehran ***Iran Department of Pharmacognosy Faculty of PharmacyTehran University of Medical SciencesTehran ***Iran Food and Drug Laboratory research Center and Food and Drug Control Laboratories MOH and METehran ***Iran

Drimia genus includes plants that used from ancient time for various ailments such as dropsy, respiratory ailment, bone and joint complications,skin disorders, epilepsy and cancer. Toxic properties of some Drimia species also were noted by ancient scientists and these plants have been traditionally used for rat control. Bufadienolides have been identified as the main constituents in the genus of Drimia. Phenolics, sterols, protein and some of other phytochemicals have been also isolated from these plants. Pharmacological and clinical studies have strongly approved their effect on cardiovascular system. Extracts and compounds isolated from Drimia species showed biological activities such as antibacterial, antifungal, antiviral, antioxidant, anti-inflammatory and insecticidal effects throughseveral in vivo and in vitro studies. Moreover, cytotoxic and antitumor activities which may be related to bufadienolide content of these plants have been considered by many researchers. Traditional therapeutic values of these plants for treating respiratory and rheumatic ailments as well as skin disorders are needed to be validated through more researches. Toxic effects of these plants and isolated compounds have been investigated through several in vivo studies. Drimia plants and their isolated compounds have narrow therapeutic index, so patients should be prohibited from applying these plants without medical supervision and should be informed about the main intoxication symptoms before starting treatment. Moreover, interaction of Drimia plants with other constituents of traditional herbal mixtures as well as chemical and biological modalities for reducing toxicity of bufadienolide compounds can be subjected for future studies.

关键词： Urginea Ethnopharmacology Toxicolo-gy Cardiac glycosides

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MODEL STUDY OF THE EFFECT OF SOIL NO EMISSIONS ON SURFACE OZONE

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Acta meteorologica Sinica 2002年第4期16卷 470-480页

作者：韩志伟胡非张美根朱江 State Key Laboratory of Atmospheric Boundary Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeiiing 100029China Frontier research System for Global Change Kanagawa 236-0061Japan International centre for Climate and Environmental sciences Institute of Atmospheric Physics.Chinese Academy of SciencesBeijing 100029China

The effect of soil NO emissions on surface ozone in autumn in East China has been studied by using TCTM(Troposphere Chemical Transport Model)with the input of meteorological variables from *** chemical mechanism for ozone variation caused by soil emissions has also been *** model results reveal that soil NO emissions are important to regional ozone formation and distribution and the effect of soil NO emissions shows spatial *** over most areas in northern China decreases with maximum average decrement reaching 5 ppb while it increases over most areas of central and southern China with maximum average increment reaching 7 ppb caused by soil NO *** situation of ozone variation is mainly determined by nonlinear photochemical *** the low NOx areas(≤3 ppb),ozone increases as NOx increases;for the high NOx areas(>3 ppb),ozone decreases as NOx *** effect of soil NO emissions on ozone depends on the transition value and NOx concentrations.

关键词： model study soil NO emissions ozone photochemical mechanism transition value

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