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decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： Hui Li Laurent Seugnet department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina centre de recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

Reevaluating health metrics:Unraveling the limitations of disabilityadjusted life years as an indicator in disease burden assessment

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World Journal of Methodology 2025年第1期15卷 14-19页

作者： Ariel Beresniak Dominique Bremond-Gignac Danielle Dupont Gerard Duru Data Mining International Geneva 1216Switzerland department of Ophtalmology Necker-Enfants Malades University HospitalAP-HPParis-CitéUniversityINSERMUMRS1138Team 17From Physiopathology of Ocular Diseases to Clinical DevelopmentSorbonne Paris CitéUniversityCentre de Recherche des CordeliersParis 75015France Data Mining America Montreal H2YCanada

In 1993,the World Bank released a global report on the efficacy of health promotion,introducing the disability-adjusted life years(DALY)as a novel *** DALY,a composite metric incorporating temporal and qualitative data,is grounded in preferences regarding disability *** review delineates the algorithm used to calculate the value of the proposed DALY synthetic indicator and elucidates key methodological challenges associated with its *** contrast to the quality-adjusted life years approach,derived from multi-attribute utility theory,the DALY stands as an independent synthetic indicator that adopts the assumptions of the Time Trade Off utility technique to define Disability *** to rely on no mathematical or economic theory,DALY users appear to have exempted themselves from verifying whether this indicator meets the classical properties required of all indicators,notably content validity,reliability,specificity,and *** DALY concept emerged primarily to facilitate comparisons of the health impacts of various diseases globally within the framework of the Global Burden of Disease initiative,leading to numerous publications in international *** widespread adoption,the DALY synthetic indicator has prompted significant methodological concerns since its inception,manifesting in inconsistent and non-reproducible *** the substantial diffusion of the DALY indicator and its critical role in health impact assessments,a reassessment is *** reconsideration is imperative for enhancing the robustness and reliability of public health decisionmaking processes.

关键词： Disability adjusted life years Cost-utility analyses Outcome research Public health Burden of disease

Blockchain software patterns for the design of decentralized applications:A systematic literature review

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Blockchain(Research and Applications) 2022年第2期3卷 25-38页

作者： Nicolas Six Nicolas Herbaut Camille Salinesi centre de recherche en Informatique Universite Paris 1 Pantheon-Sorbonne75231 ParisFrance

A software pattern is a reusable solution to address a commonly occurring problem within a given context when designing *** patterns is a common practice for software architects to ensure software *** pattern collections have been proposed for a large number of application ***,because of the technology's recentness,there are only a few available collections with a lack of extensive testing in industrial blockchain *** is also difficult for software architects to adequately apply blockchain patterns in their applications,as it requires deep knowledge of blockchain *** a systematic literature review,this paper has identified 120 unique blockchain-related patterns and proposes a pattern taxonomy composed of multiple categories,built from the extracted pattern *** purpose of this collection is to map,classify,and describe all the available patterns across the literature to help readers make adequate decisions regarding blockchain pattern *** study also shows potential applications of those patterns and identifies the relationships between blockchain patterns and other non-blockchain software patterns.

关键词： Blockchain Software patterns Software design Smart contracts

Variation of Transition Characteristics in a Wall Jet

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Journal of Thermal Science 2003年第2期12卷 167-170页

作者： Marie-Francoise Scibilia centre National de la recherche Scientifique ParisFrance

The characteristics of a laminar wall jet submitted to different configurations have been experimentally explored in order to obtain a better knowledge of transition modifications,In fact different parameters can accelerate or delay the transition using a smooth or rough surface,heated or not,submitted to vibrations or not .In this study,significant effects can be *** has been possible to measure the beginning of growth rates of disturbance amplitude using a wind tunnel and comparing the results with the linear stability theory.

关键词： wall jet transition acoustic vibration heat transfer turbulence roughness.

Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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Neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative Neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

A New Triassic Primitive Ichthyosaur from Yuanan, South China

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Acta Geologica Sinica(english Edition) 2013年第3期87卷 672-677页

作者： CHen Xiaohong P. Martin SANdeR CHenG Long WANG Xiaofeng Wuhan centre of China Geological Survey Steinmann-Institut für Geologie Mineralogie und Palontologie Universitt Bonn

Based on the systematic study of two fossil skeleton specimens collected from the top of the third member of the marine Lower Triassic Jialingjiang Formation of Yuanan, Hubei Province, South China, a new Early Triassic primitive ichthyosaur Chaohusaurus zhang]iawanensis sp. nov. is reported and described. The beds yielding the type material are correlated with the Neospathodus homeri-N, triangularis Conodont zone. The new taxon is most similar to Chaohusaurus geishanensis Young and Dong, 1972 in the shape and configuration of the scapula, forefin, pelvic girdle and hindfin, presacral vertebral count and well-developed caudal peak, but distinguished from the latter by its larger size, the position of the pineal foramen in the centre of the parietal, the occurrence of a larger calcaneum in hindfin and the first sacral rib with distal expansion. The new species exhibits common features of primitive ichthyosaurs such as：（1） the prefrontal has an antero-dorsal shelf projecting towards the orbit; （2） the upper temporal fenestra is small; （3） the postorbital and the squamosal meet laterally to the upper temporal fenestra; and （4） cylindrical centra. However, more derived ichthyosaur characters are seen with the frontal separated from the orbital dorsal margin by the contact of the prefrontal and postfrontal, which offer new clues to the early radiation of ichthyosaurs.

关键词： vertebrate paleontology reptilian ichthyosauria Lower Triassic (Spathian) Hubei Province

Noncanonical antibody strategy for broad and potent neutralization of influenza virus

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Cellular & Molecular Immunology 2021年第7期18卷 1615-1617页

作者： Jordan D.Dimitrov centre de recherche des Cordeliers INSERMSorbonne UniversitéUniversitéde ParisF-75006ParisFrance

Pathogens with high levels of genetic variability,such as HIV-1 and influenza virus,evade the immune system by constantly changing their proteins vulnerable to neutralization by antibodies Consequently,these highly evolvable viruses are notoriously elusive targets for *** rare cases,infection of humans with HIV-1 or influenza virus results in production of antibodies that can neutralize a very broad spectrum of viral *** antibodies are referred to as broadly neutralizing.

关键词： influenza antibodies neutral

Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-Juan Mario Villa Irene Benito-Cuesta Lara Ordónez-Gutiérrez Francisco Wandosell Centro de Biología Molecular“Severo Ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter