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Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults

Journal of Sport and Health Science 2024年第3期13卷 409-418页

作者： Jérémy Raffin yves Rolland Annelise Genoux Guillaume Combes Mikael Croyal Bertrand Perret Sophie Guyonnet Bruno Vellas Laurent O.Martinez Philipe de Souto Barreto For the MAPT/dSA Group Institut du Vieillissement Gérontopôle de ToulouseCentre Hospitalo-Universitaire de ToulouseToulouse 31000France centre d'Epidémiologie et de Recherche en Santédes Populations UnitéMixte de Recherche 1295Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse-III-Paul-SabatierToulouse 31000France LimitAging Team Institut des Maladies Métaboliques et CardiovasculairesUnitéMixte de Recherche 1297Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse III-Paul SabatierToulouse 31432France Service de Biochimie Pôle de biologieHôpital de PurpanCentre Hospitalo-Universitaire de ToulouseToulouse 31300France L'Institut du Thorax Institut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France BioCore US16Structure Fédérative de Recherche BonamyInstitut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Plate-forme de spectrométrie de masse Centre de Recherche en Nutrition HumaineOuestNantes 44000France 不详

Background:Adenosine triphosphatase inhibitory factor 1(IF1)is a key protein involved in energy ***1 has been linked to various agerelated diseases,although its relationship with physical activity(PA)remains ***,the apolipoprotein A-I(apoA-I),a PA-modulated lipoprotein,could play a role in this relationship because it shares a binding site with IF1 on the cell-surface ATP *** examined here the associations between chronic PA and plasma IF1 concentrations among older adults,and we investigated whether apoA-I mediated these ***:In the present work,1096 healthy adults(63.8%females)aged 70 years and over who were involved in the Multidomain Alzheimer Prevention Trial study were ***1 plasma concentrations(square root of ng/mL)were measured at the 1-year visit of the Multidomain Alzheimer Prevention Trial,while PA levels(square root of metabolic equivalent task min/week)were assessed using questionnaires administered each year from baseline to the 3-year *** linear regressions were performed to investigate the associations between the first-year mean PA levels and IF1 *** analyses were conducted to examine whether apoA-I mediated these *** linear regressions were carried out to investigate whether the 1-year visit IF1 concentrations predicted subsequent changes in ***:Multiple linear regressions indicated that first-year mean PA levels were positively associated with IF1 concentrations(B=0.021;SE=0.010;p=0.043).Mediation analyses revealed that about 37.7%of this relationship was mediated by apoA-I(B_(ab)=0.008;SE=0.004;p=0.023).Longitudinal investigations demonstrated that higher concentrations of IF1 at the 1-year visit predicted a faster decline in PA levels over the subsequent 2 years(time×IF1:B=0.148;SE=0.066;p=0.025).Conclusion:This study demonstrates that regular PA is associated with plasma IF1 concentrations,and it suggests that apoA-I partly med

关键词： Aging Apolipoprotein Bioenergetics Exerkine Mitochondria

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Antiviral effect of polyphenol rich plant extracts on herpes simplex virus type 1

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Food Science and Human Wellness 2018年第1期7卷 91-101页

作者： Sayed A.El-Toumy Josline Y.Salib Walaa A.El-Kashak Christel Marty Gilles Bedoux Nathalie Bourgougnon Chemistry of Tannins department National Research CentreDokki12622 CairoEgypt Chemistry of Natural Compounds department National Research CentreDokki12622 CairoEgypt centre de rechercheet d’enseignement yves coppens Campus de TohannicBP 57356017 VannesFrance

Evaluation of the anti-herpetic activity of 25 Egyptian plants extracts was investigated in vitro in this *** antiviral activity against Herpes Simplex Virus type 1(HSV-1)was done on Vero cell lines by cell *** two plants extracts;namely Euphorbia coopire(Euphorbiaceae)and Morus alba(Moraceae)showed potent anti-herpetic activity and six other extracts showed moderate *** contrast,a bioassay monitored phytochemical exploration of these two plants led to the isolation of pure flavonoid *** antiviral activity of the isolated compounds was also examined,among which seven pure compounds namely;7-galloyl catechin,gallic acid,kaempferol 3-O-β-(6″-O-galloyl)-glucopyranoside,quercetin 3-O-β-(6″-O-galloyl)-glucopyranoside,curcumin,quercetin and kaempferol exhibited significant inhibition.

关键词： Egyptian plants Anti-HSV-1 Polyphenols Vero cell

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Incidence and Management of Occupational Blood Exposure (OBE) among Medical Students at the University of Bangui

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Occupational diseases and Environmental Medicine 2024年第2期12卷 68-77页

作者： Hermione dahlia Mossoro-Kpinde Caleb Koyambenguia yves Kpangba Mangbé Saint Calvaire Henri diemer Ministè re du Travail de l&#8217Emploi de la Protection Sociale et de la Formation Professionnelle Bangui Central African Republic dé partement de Sant&#233 Publique &#224 la Facult&#233 des Sciences de la Sant&#233 de l&#8217Universit&#233 de Bangui Bangui Central African Republic centre Hospitalier Universitaire de l’ Amiti&#233 Sino-Centrafricaine de Bangui Bangui Central African Republic département de Formation Continue à la Faculté des Sciences de la Santé de l’Université de Bangui Bangui Central African Republic

Introduction: Like healthcare workers, medical students are also exposed to a risk of accidental contamination during their hospital internships. However, they do not benefit from prevention services in the same way as workers in this sector, although they actively participate in the routine care provided to patients in the various hospital departments. The objective of our study is to determine the incidence of these accidents and their medical and administrative management among these victims (medical students) not classified in the category of workers. Materials and Method: This was a cross-sectional study carried out over three months from January 15 to March 14, 2023. The study population consisted of all medical students at the Faculty of Health Sciences at the University of Bangui. Regularly enrolled students from 2nd to 7th year, on placement in hospitals in the Central African Republic and who gave their informed consent were included. data were collected through a self-administered questionnaire. Results: A cross-sectional study was carried out among medical students concerning the incidence and management of accidents involving exposure to blood in the Central African Republic. Of the 254 students included, three (9%) had already been correctly vaccinated against the viral hepatitis B virus, 198 (77.9%) reported still having access to personal protective equipment, 133 students (52.4%) reported being victims of OBE in the past 12 months. The main types of OBE were stings (62%), followed by liquid splashes (32%) and cuts (6%). Among the 133 victims, 92.9% carried out immediate hand disinfection or abundant eye washing, 41.9% obtained the serology of the source patient and 37% reported the accident to their supervisor. Conclusion: It is important that students benefit from better prevention and management of these accidents.

关键词： Incidence of Blood Exposure Accidents Medical Student Treatment Bangui

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Cost of Medical Treatment for Primary Open-Angle Glaucoma in Relation to Patients’ Income and Its Impact on the Prognosis of the disease, in Bouaké University Hospital

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Open Journal of Ophthalmology 2024年第1期14卷 8-17页

作者： yves Ouattara Liliane Ella Godé Zana diabaté Franck Hermann Koffi Mamadou Korka diallo Philippe Emile France Koffi Bilé diomandé François Gossé Ibrahim Abib diomandé Ophthalmology department of Bouaké University Hospital (CHU de Bouaké) Bouaké C&#244te d’Ivoire

Introduction: Medical treatment for POAG is continuous and lifelong treatment. The aim of this study was to evaluate the relationship between the cost of this treatment and patients’ income and the impact of this relationship on treatment compliance. Materials and Methods: Prospective cross-sectional study with a descriptive aim covering sociodemographic data, average incomes, and direct and indirect costs of treatment of 57 patients followed for POAG during the period from January 1, 2012, to december 31, 2016 (5 years). Results: The patients were aged 25 to 77 years (mean = 54.4 years) with a male predominance (sex ratio = 1.5). Retirees were the most represented (26.32%), followed by workers in the informal sector (14.04%) and housewives (12.28%). Patients who had an annual income less than or equal to 900,000 CFA francs (€1370.83) per year represented 56.14% and those who did not have health coverage represented 57.89%. The treatment was monotherapy (64.91%), dual therapy (31.58%) or triple therapy (3.05%) and the average ratio of “annual cost of treatment to annual income” was 0.56 with for maximum 2.23 and 0.02 as minimum. Patients who considered the cost of treatment unbearable for their income represented 78.95%. Conclusion: Prevention of blindness due to glaucoma requires early detection but also the establishment of health coverage mechanisms to improve compliance with medical treatment. In addition, consideration should be given to the development of glaucoma surgery in our country, the indication of which could be the first intention in certain patients, considering for those patients, the geographical and financial accessibility of medical treatment. .

关键词： Primary Open-Angle Glaucoma Treatment Cost Medical Treatment Income Blindness

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Fatty Acid Composition of Hazelnut Kernel Oil from Coula edulis Collected in the Republic of Congo

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Food and Nutrition Sciences 2024年第4期15卷 290-297页

作者： Josiane Enzonga Yoca Jean Paul Latran Ossoko yves Okandza Michel didace Mvoula Tsieri Laboratoire de Contrô le et Qualit&#233 des Aliments de l&#8217Ecole Nationale Sup&#233rieure d&#8217Agronomie et de Foresterie Universit&#233 Marien NGOUABI Brazzaville Congo Université Denis Sassou NGUESSO Brazzaville Congo

Coula edulis is non-timber forest product (NTFP) used in Africa for its hazelnuts, which contain edible seeds with a demonstrated nutritional potential. However, there have been very few scientific studies of this species in the Republic of Congo. Thus, the aim of the current study was therefore to determine the fatty acid composition of the oil extracted from Coula edulis hazelnut seeds collected at random in the Republic of Congo. The oil was extracted using the Soxhlet method and its fatty acid composition was determined by gas chromatography. The extracted oil from Coula edulis hazelnut kernels is rich in monounsaturated fatty acids (95.28%), particularly oleic acid (94.5%), which classifies it as an oleic oil and gives it interesting nutritional and therapeutic properties. On the other hand, saturated fatty acids (4.15%) and polyunsaturated fatty acids (0.35%) are not well represented. Its low poly-unsaturated fatty acid content makes it more stable when stored at room temperature.

关键词： Coula edulis Fatty Acids Oil Seeds Hazelnuts Republic of Congo NTFP

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Why implantation of bio-loggers may improve our understanding of how animals cope within their natural environment

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Integrative Zoology 2019年第1期14卷 48-64页

作者： Marie-Amélie FORIN-WIART Manfred R.ENSTIPP Yvon LE MAHO yves HANdRICH Universitéde Strasbourg CNRSIPHCDépartement EcologiePhysiologie et EthologieUMR 7178StrasbourgFrance centre d’Etudes Biologiques de Chizé CNRSUMR 7372Villiers en BoisFrance centre Scientifique de Monaco Département de Biologie PolaireMonaco

Bio-loggers are miniaturized autonomous devices that record quantitative data on the state of free-ranging ani-mals(***,position and physiology)and their natural *** is especially relevant for spe-cies where direct visual observation is difficult or ***,ongoing technical development allows the monitoring of numerous parameters in an increasing range of species over extended ***,the ex-ternal attachment of devices might affect various aspects of animal performance(energetics,thermoregulation,foraging as well as social and reproductive behavior),which ultimately affect *** attachment might also increase entanglement risk and the conspicuousness of animals,leaving them more vulnerable to *** contrast,implantation of devices can mitigate many of these undesirable effects and might be prefera-ble,especially for long-term studies,provided that the many challenges associated with surgical procedures can be *** may then allow us to gather data that would be impossible to obtain otherwise and thereby may provide new and ecologically relevant insights into the life of wild ***,we:(i)discuss the pros and cons of attachment methods;(ii)highlight recent field studies that used implanted bio-loggers to address eco-physiological questions in a wide range of species;and(iii)discuss logger implantation in light of ethical considerations.

关键词： behavior bio-logging device implantation eco-physiology long-term deployment

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Phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos

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Asian Pacific Journal of Tropical Biomedicine 2018年第11期8卷 554-564页

作者： Zalilawati Mat Rashid Abdul M. Ali Philippe douzenel Nathalie Bourgougnon Khozirah Shaari Yosie Andriani Tengku Sifzizul Tengku Muhammad Habsah Mohamad Faculty of Bioresources and Food Industry Universiti Sultan Zainal Abidin Besut Campus School of Agriculture Science & Biotechnology Universiti Sultan Zainal Abidin Besut Campus Faculté des Sciences et Sciences de l'Ingénieur (UFR SSI) Centre Yves Coppens Université Européenne de Bretagne Campus de Tohannic - BP 573 LBCM Université Européenne de Bretagne Campus de Tohannic BP573 Laboratory of Natural Products Institute of Bioscience Universiti Putra Malaysia Institute of Marine Biotechnology University Malaysia Terengganu Mengabang Telipot

Objective: To investigate phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos. Methods: Fatty acid methyl ester was analyzed by gas chromatography-flame ionization detector. Antioxidant activity was determined using 2,2-diphenyl-picrylhydrazyl radical scavenging assay and total phenolics content by Folin-Ciocalteu procedure. Vero cells viability was evaluated using methyl thiazole tetrazolium and the inactivation of herpes simplex virus type 1 by neutral red uptake assay. p-Hydroxybenzamide isolated by column chromatography was characterized by utilizing nuclear magnetic resonance spectroscopy and electron impact mass spectrometry. Results: The chloroform, ethyl acetate and methanol extracts of Aaptos aaptos produced higher portions of straight-chain saturated fatty acid, while hexane extract mainly consisted of unsaturated fatty acid. The five majors of fatty acid methyl ester were identified as behenic acid, cis-10-heptadecenoic acid and cis-10-pentadecenoic acids, palmitic acid and tricosanoic acid. In addition, among all organic extracts, chloroform extract inactivated herpes simplex virus type 1 while exhibited weak cytotoxic activity against normal Vero cells and also exhibited strong cytotoxic activity on HL-60, MCF-7, K562, CEM-SS and WEHI-3 B cells. A phenolic compound, p-hydroxybenzamide was also isolated from the sponge. Conclusions: Aaptos aaptos could be a source to derive the potential antiviral and anticancer agents. However, further studies are needed to determine the mechanism involved in the process.

关键词： Aaptos aaptos Fatty acid p-Hydroxybenzamide Antioxidant Cytotoxicity Antivirus

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Vortex　Simulation　of　Axisymmetrical　Flows　in　Cylindrical　***：Application　to　Pipes　Incorporating　an　Orifice　Plate

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Journal of Thermal Science 1995年第4期4卷 221-228页

作者： André Giovannini yves Gagnon Université Paul Sabatier and centre d’études et de recherches de Toulouse Toulouse France Université de Moncton Campus d’Edmundston Edmundston Canada

The Random Vortex Method extended to an azisymmetrical flow is used in the study of the flow field inside pipes incorporating an orifice plate with different contraction ratios and different inlet velocity profiles. Three test-cases, each having experimental measurements available in the literature, are studied. In particular, instantaneous and average velocity fields along with the turbulent statistics for high Reynolds number flows are computed and compared to the corresponding experimental *** comparisons show the ability and the citations of the method. The results of the numerical simulations are used in the physical analysis of the flow fields and thus allow for a better understanding of the dynamics of the flow in pipes incorporating an orifice plate.

关键词： orifice plate axisymmetrical flows vorticity.

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deep-UV fluorescence lifetime imaging microscopy

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Photonics Research 2015年第5期3卷 283-288页

作者： Christiaan J.de Jong Alireza Lajevardipour Mindaugas Gecevicius Martynas Beresna Gediminas Gervinskas Peter G.Kazansky yves Bellouard Andrew H.A.Clayton Saulius Juodkazis centre for Micro-Photonics Faculty of Science Engineering and Technology Swinburne University of Technology department of Mechanical Engineering Eindhoven University of Technology Optoelectronics Research centre University of Southampton Melbourne centre for Nanofabrication Ecole Polytechnique Fédérale de Lausanne Rue de la Maladiére 71b Center for Nanotechnology King Abdulaziz University

A novel fluorescence lifetime imaging microscopy(FLIM) working with deep UV 240–280 nm wavelength excitations has been developed. UV-FLIM is used for measurement of defect-related fluorescence and its changes upon annealing from femtosecond laser-induced modifications in fused silica. This FLIM technique can be used with microfluidic and biosamples to characterize temporal characteristics of fluorescence upon UV excitation, a capability easily added to a standard microscope-based FLIM. UV-FLIM was tested to show annealing of the defects induced by silica structuring with ultrashort laser pulses. Frequency-domain fluorescence measurements were converted into the time domain to extract long fluorescence lifetimes from defects in silica.

关键词： UV deep-UV fluorescence lifetime imaging microscopy

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Natural history, treatment and prevention of hepatitis C recurrence after liver transplantation: Past, present and future

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World Journal of Gastroenterology 2014年第32期20卷 11069-11079页

作者： Jérme dumortier Olivier Boillot Jean-yves Scoazec Unité de Transplantation Hépatique-Fédération des Spécialités digestives HCL H?pital Edouard Herriot 69437 Lyon France Olivier Boillot Jean-Yves Scoazec Université Claude Bernard Lyon 1 69437 Lyon France Service d’Anatomie et Cytologie Pathologiques HCL H?pital Edouard Herriot 69437 Lyon France

Hepatitis C virus(HCV)-related liver disease, including cirrhosis and hepatocellular carcinoma is the main indication for liver transplantation(LT) worldwide. Posttransplant HCV re-infection is almost universal and results in accelerated progression from acute hepatitis to chronic hepatitis, and liver cirrhosis. Comprehension and treatment of recurrent HCV infection after LT have been major issues for all transplant hepatologists and transplant surgeons for the last decades. The aim of this paper is to review the evolution of our knowledge on the natural history of HCV recurrence after LT, including risk factors for disease progression, and antiviral therapy. We will focus our attention on possible ways(present and future) to improve the final longterm results of LT for HCV-related liver disease.

关键词： Hepatitis C Liver transplantation Recurrence Fibrosis Treatment

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