Antiviral effect of polyphenol rich plant extracts on herpes simplex virus type 1

作     者：Sayed A.El-Toumy Josline Y.Salib Walaa A.El-Kashak Christel Marty Gilles Bedoux Nathalie Bourgougnon 

作者机构：Chemistry of Tannins DepartmentNational Research CentreDokki12622 CairoEgypt Chemistry of Natural Compounds DepartmentNational Research CentreDokki12622 CairoEgypt Centre de Rechercheet d’enseignement Yves CoppensCampus de TohannicBP 57356017 VannesFrance 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2018年第7卷第1期

页      面：91-101页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学] 

基　　金：The authors thank the Academy of Scientific Research&Technology(ASRT Egypt)and Centre de Recherchéet d’enseignement Yves Coppens Campus de Tohannic BP 573 56017 Vannes(France)for supporting this study within the IMHOTEP program(Project No.EGY/FR 8-013) 

主　　题：Egyptian plants Anti-HSV-1 Polyphenols Vero cell 

摘      要：Evaluation of the anti-herpetic activity of 25 Egyptian plants extracts was investigated in vitro in this *** antiviral activity against Herpes Simplex Virus type 1(HSV-1)was done on Vero cell lines by cell *** two plants extracts;namely Euphorbia coopire(Euphorbiaceae)and Morus alba(Moraceae)showed potent anti-herpetic activity and six other extracts showed moderate *** contrast,a bioassay monitored phytochemical exploration of these two plants led to the isolation of pure flavonoid *** antiviral activity of the isolated compounds was also examined,among which seven pure compounds namely;7-galloyl catechin,gallic acid,kaempferol 3-O-β-(6″-O-galloyl)-glucopyranoside,quercetin 3-O-β-(6″-O-galloyl)-glucopyranoside,curcumin,quercetin and kaempferol exhibited significant inhibition.