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体外受精移植前应用预防性抗生素疗法(阿莫西林+克拉维酸)无益:随机研究结果

世界核心医学期刊文摘（妇产科学分册） 2005年第5期1卷 61-62页

作者： Peikrishvili R Evrard B Pouly J.-L Janny L 侯巍 centre de fecondation in-vitro Polyclinique Philippe-Marcombes 13 boulevard Charles-de-G aulle 63033 Clermont-Ferrand France

Objectives. We studied the implantation rate during IVF cycles according to th e prescription or not of antibiotics. Materials and methods. During a 5-month p eriod all the patients aged less than 38 years were randomized into two groups a ccording to an independent personal variable. In group 1 amoxicilline +clavuian ic acid 1g/125mg were administrated from the ovum pick-up day for 6 days. In th e group 2 no antibiotic treatment was administered. Results. The two groups were identical for all the criteria (type of stimulation, IVF/ICSI report, indicatio ns, average age). The average number of collected oocytes, obtained embryos and transferred embryos was similar in the two groups. The implantation rate per tra nsfer was similar in the two groups (36.9%versus 36.5%; P>0.95). The pregnancy loss rate (biological pregnancy, early and late miscarriages or extra uterine p regnancy) was increased in a non significant manner (P=0.15) in the group with a ntibiotic: 33.3%(16/48) versus 20.8%(11/53) in the group without antibiotic. C onclusion. This prospective randomised study leads us not to recommend this anti biotic prescription at the time of the embryo transfer during in vitro fertilisation attempt.

关键词：预防性抗生素体外受精随机研究克拉维酸着床率取卵卵母细胞显微注射流产率晚期流产

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AZF microdeletions and partial deletions of AZFc region on the Y chromosome in Moroccan men

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Asian Journal of Andrology 2007年第5期9卷 674-678页

作者： Laila Imken Brahim El Houate Abdelaziz Chafik Halima Nahili Redouane Boulouiz Omar Abidi Elbakkay Chadli Noureddine Louanjli Abdelouhab Elfath Mohammed Hassar Ken McElreavey Abdelhamid Barakat Hassan Rouba Human Genetic and Cytogenetic Unit Research Department Pasteur Institute of Morocco Ezzahraoui 20100 CasablancaMorocco Laboratory of Anthropogenetic and Biostatistic University Chouaib Doukkali 299 Eljadida 24000 Morocco In vitro fecondation Center 40 Rue Prince Moulay Abedelah 20 000 Casablanca Morocco Reproduction Fertility and Population Unit Developmental Biology Department Pasteur Institute 25 Rue Docteur Roux Paris France

Aim： To evaluate for the first time the frequency of Y chromosome microdeletions and the occurrence of the partial deletions of AZFc region in Moroccan men, and to discuss the clinical significance of AZF deletions. Methods： We screened Y chromosome microdeletions and partial deletions of the AZFc region of a consecutive group of infertile men （n = 149） and controls （100 fertile men, 76 normospermic men）. AZFa, AZFb, AZFc and partial deletions of the AZFc region were analyzed by polymerase chain reaction （PCR） according to established protocols. Results： Among the 127 infertile men screened for microdeletion, four subjects were found to have microdeletions： two AZFc deletions and two AZFb＋AZFc deletions. All the deletions were found only in azoospermic subjects （4/48, 8.33%）. The overall AZFc deletion frequency was low （4/127, 3.15%）. AZF microdeletions were not observed in either oligoasthenoteratozoospermia （OATS） or the control. Partial deletions of AZFc （gr/gr） were observed in a total of 7 of the 149 infertile men （4.70%） and 7 partial AZFc deletions （gr/gr） were found in the control group （7/176, 3.98%）. In addition, two b2/b3 deletions were identified in two azoospermic subjects （2/149, 1.34%） but not in the control group. Conclusion： Our results suggest that the frequency of Y chromosome AZF microdeletions is elevated in individuals with severe spermatogenic failure and that gr/gr deletions are not associated with spermatogenic failure.

关键词： Y microdeletions haplogroups gr/gr infertility bi-allelic markers

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