体外受精移植前应用预防性抗生素疗法(阿莫西林+克拉维酸)无益:随机研究结果

作     者：Peikrishvili R Evrard B Pouly J.-L Janny L 侯巍 

作者机构：Centre de Fecondation In-Vitro Polyclinique Philippe-Marcombes 13 boulevard Charles-de-G aulle 63033 Clermont-Ferrand France 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2005年第1卷第5期

页      面：61-62页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

主　　题：预防性抗生素 体外受精 随机研究 克拉维酸 着床率 取卵 卵母细胞 显微注射 流产率 晚期流产 

摘      要：Objectives. We studied the implantation rate during IVF cycles according to th e prescription or not of antibiotics. Materials and methods. During a 5-month p eriod all the patients aged less than 38 years were randomized into two groups a ccording to an independent personal variable. In group 1 amoxicilline +clavuian ic acid 1g/125mg were administrated from the ovum pick-up day for 6 days. In th e group 2 no antibiotic treatment was administered. Results. The two groups were identical for all the criteria (type of stimulation, IVF/ICSI report, indicatio ns, average age). The average number of collected oocytes, obtained embryos and transferred embryos was similar in the two groups. The implantation rate per tra nsfer was similar in the two groups (36.9%versus 36.5%; P0.95). The pregnancy loss rate (biological pregnancy, early and late miscarriages or extra uterine p regnancy) was increased in a non significant manner (P=0.15) in the group with a ntibiotic: 33.3%(16/48) versus 20.8%(11/53) in the group without antibiotic. C onclusion. This prospective randomised study leads us not to recommend this anti biotic prescription at the time of the embryo transfer during in vitro fertilisation attempt.