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In-vitro Synthesis and Activity Identification of Antimicrobial Peptide from Aspergillus granifolium

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Agricultural Biotechnology 2020年第2期9卷 35-38页

作者： Huihui CAO Lei WANG Yan WANG Yanhua YAN Xiaonan SONG Yu ZHOU Tangshan Food and Drug Comprehensive Testing center Tangshan 063000China Hebei Agricultural Products Quality and Safety Testing Innovation center Tangshan 063000China Tangshan Institute of Industrial Technology for Functional Agricultural Products Tangshan 063000China

[Objectives] This study was conducted to investigate the control effect of antimicrobial peptides to peanut aflatoxin contamination and achieve the purpose of biological control of peanut aflatoxin.[Methods]bioinformatics methods were applied to screen antimicrobial peptides with strong antifungal activity in the antimicrobial peptide database and analyze their secondary structures and bacteriostatic characteristics,and the candidated peptide was then artificially synthesized,expressed and purified and detected for in-vitro activity.[Results] The antimicrobial peptide(AFP1) which was screened from Aspergillus granifolium exhibited strong antimicrobial activity against Aspergillus *** inhibition rate of crude AFP1 at 3 mg/ml reached 58% for gram-positive bacteria,52% for gram-negative bacteria,and 62% for ***.[Conclusions]This study provides a new approach for the prevention and control of various plant diseases including peanut disease,and a new idea for the biological prevention and control of plant diseases.

关键词： Peanut Antimicrobial peptide Aspergillus granifolium Anti-fungal activity Bacteriostatic activity detection

Fungal diversity notes 1–110:taxonomic and phylogenetic contributions to fungal species

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Fungal Diversity 2015年第3期72卷 1-197页

作者： Jian Kui Liu Kevin D.Hyde E.B.Gareth Jones Hiran A.Ariyawansa Darbhe J.Bhat Saranyaphat Boonmee Sajeewa S.N.Maharachchikumbura Eric H.C.McKenzie Rungtiwa Phookamsak Chayanard Phukhamsakda Belle Damodara Shenoy Mohamed A,Abdel-Wahab Bart Buyck Jie Chen K.W.Thilini Chethana Chonticha Singtripop Dong Qin Dai Yu Cheng Dai Dinushani ADaranagama Asha J.Dissanayake Mingkwan Doilom Melvina J.D’souza Xin Lei Fan Ishani DGoonasekara Kazuyuki Hirayama Sinang Hongsanan Subashini C.Jayasiri Ruvishika S.Jayawardena Samantha C.Karunarathna Wen Jing Li Ausana Mapook Chada Norphanphoun Ka Lai Pang Rekhani H.Perera Derek Peršoh Umpava Pinruan Indunil CSenanayake Sayanh Somrithipol Satinee Suetrong Kazuaki Tanaka Kasun M.Thambugala Qing Tian Saowaluck Tibpromma Danushka Udayanga Nalin N.Wijayawardene Dhanuska Wanasinghe Komsit Wisitrassameewong Xiang Yu Zeng Faten AAbdel-Aziz Slavomir Adamčík Ali H.Bahkali Nattawut Boonyuen Timur Bulgakov Philippe Callac Putarak Chomnunti Katrin Greiner Akira Hashimoto Valerie Hofstetter Ji Chuan Kang David Lewis Xing Hong Li Xing Zhong Liu Zuo Yi Liu Misato Matsumura Peter E.Mortimer Gerhard Rambold Emile Randrianjohany Genki Sato Veera Sri-Indrasutdhi Cheng Ming Tian Annemieke Verbeken Wolfgang von Brackel Yong Wang Ting Chi Wen Jian Chu Xu Ji Ye Yan Rui Lin Zhao Erio Camporesi Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouChina Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanChina Institute of Excellence in Fungal Research and School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Botany and Microbiology King Saudi UniversityRiyadhSaudi Arabia Manaaki Whenua Landcare Research Private Bag 92170AucklandNew Zealand Formerly Department of Botany Goa UniversityGoaIndia No.128/1–J Azad Housing SocietyCurcaGoa VelhaIndia Muséum national d’histoire naturelle Dépt.Systématique etévolutionUMR 720575005 ParisFrance Institute of Microbiology&Beijing Key Laboratory for Forest Pest Control Beijing Forestry UniversityPO Box 61Beijing 100083China Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesNo.9 of Shu Guang Hua Yuan Zhong LuHaidian DistrictBeijing 10097China The Key Laboratory for Silviculture and Conservation of Ministry of Education Beijing Forestry UniversityBeijing 100083China Mycology University of BayreuthUniversitätsstraße 3095440 BayreuthGermany The United Graduate School of Agricultural Sciences Iwate University18-8 Ueda 3 chomeMorioka 020-8550Japan Apple Experiment Station Aomori Prefectural Agriculture and Forestry Research Center24 FukutamiBotandairaKuroishiAomori 036-0332Japan Department of Plant Protection Agroscope Changins-Wadenswil Research Station ACWRte de Duiller1260 NyonSwitzerland Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Department of Botany Faculty of ScienceSohag UniversitySohagEgypt Institute of Botany Slovak Academy of SciencesDúbravskácesta 984523 BratislavaSlovakia Hirosaki University Bleakwood262 CR 3062NewtonTexas 75966USA Faculty of Agriculture and Life Sciences Hirosaki University3 Bunkyo-choHirosakiAomori

This paper is a compilation of notes on 110 fungal taxa,including one new family,10 new genera,and 76 new species,representing a wide taxonomic and geographic *** new family,Paradictyoarthriniaceae is introduced based on its distinct lineage in Dothideomycetes and its unique *** family is sister to Biatriosporaceae and *** new genera are Allophaeosphaeria(Phaeosphaeriaceae),Amphibambusa(Amphisphaeriaceae),Brunneomycosphaerella(Capnodiales genera incertae cedis),Chaetocapnodium(Capnodiaceae),Flammeascoma(Anteagloniaceae),Multiseptospora(Pleosporales genera incertae cedis),Neogaeumannomyces(Magnaporthaceae),Palmiascoma(Bambusicolaceae),Paralecia(Squamarinaceae)and Sarimanas(Melanommataceae).The newly described species are the Ascomycota Aliquandostipite manochii,Allophaeosphaeria dactylidis,***,Alternaria cesenica,Amphibambusa bambusicola,Amphisphaeria sorbi,Annulohypoxylon thailandicum,Atrotorquata spartii,Brunneomycosphaerella laburni,Byssosphaeria musae,Camarosporium aborescentis,***,***,Chaetocapnodium siamensis,Chaetothyrium agathis,Colletotrichum sedi,Conicomyces pseudotransvaalensis,Cytospora berberidis,***,Diaporthe thunbergiicola,Diatrype palmicola,Dictyosporium aquaticum,***,***,Didymella cirsii,Dinemasporium nelloi,Flammeascoma bambusae,Kalmusia italica,***,Keissleriella sparticola,Lauriomyces synnematicus,Leptosphaeria ebuli,Lophiostoma pseudodictyosporium,***,Lophiotrema eburnoides,Montagnula graminicola,Multiseptospora thailandica,Myrothecium macrosporum,Natantispora unipolaris,Neogaeumannomyces bambusicola,Neosetophoma clematidis,***,Oxydothis atypica,Palmiascoma gregariascomum,Paraconiothyrium nelloi,***,Paradictyoarthrinium tectonicola,Paralecia pratorum,Paraphaeosphaeria spartii,Pestalotiopsis digitalis,***,***,Phaeoisaria pseudoclematidis,Phragmocapnias philippinensis,Pseudocamarosporium cotinae,Pseudocercospora tam

关键词： Ascomycota Basidiomycota Global Taxonomy Initiative Phylogeny Taxonomy

Science:推翻常规认知! 科学家发现树突细胞或许源于特殊祖细胞

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现代生物医学进展 2017年第22期17卷 I0001-I0001页

作者： Peter See,* Singapore Immunology Network (SIgN) A*STAR 8A Biomedical Grove Immunos Building Level 4 Singapore 138648 Singapore.Program in Emerging Infectious Disease Duke-NUS Medical School 8 College Road 169857 Singapore.Genomics and Immunoregulation Life and Medical Sciences (LIMES) Institute University of Bonn 32115 Bonn Germany.Institute of Cellular Medicine Newcastle University Newcastle UK.Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn 53175 Bonn Germany.Institut Curie Paris Sciences et Lettres (PSL) Research University INSERM U 932 F-75005 Paris France.Department of Pediatrics Academic Medical Centre University of Amsterdam Amsterdam Netherlands.Department of Anatomical Pathology Singapore General Hospital Singapore.Department of Health Promotion Board (HPB) and Transplant Surgery Singapore General Hospital Singapore.Department of Microbiology and Immunology Yong Loo Lin School of Medicine National University of Singapore Singapore.Singapore Health Services Flow Cytometry Core Platform 20 College Road The Academia Discovery Tower Level 10 Singapore 169856 Singapore.Department of Reproductive Medicine Division of Obstetrics and Gynaecology KK Women’s and Children’s Hospital Singapore.Cancer and Stem Cell Biology Program Duke-NUS Graduate Medical School Singapore.Experimental Fetal Medicine Group Yong Loo Lin School of Medicine National University of Singapore Singapore.Humanized Mouse Unit Institute of Molecular and Cell Biology (IMCB) A*STAR Singapore.Myeloid Cell Biology Life and Medical Sciences (LIMES) Institute University of Bonn 53115 Bonn Germany.

树突细胞是机体免疫力的”门卫”，其能够帮助机体有效检测并且开启抵御外来病原体或异物的免疫力，截止到目前为止，研究者认为树突细胞的亚型是从一种共同的祖细胞分化而来；近日，一项刊登在国际杂志science上的研究报告中，来自新加... 详细信息

树突细胞是机体免疫力的”门卫”，其能够帮助机体有效检测并且开启抵御外来病原体或异物的免疫力，截止到目前为止，研究者认为树突细胞的亚型是从一种共同的祖细胞分化而来；近日，一项刊登在国际杂志science上的研究报告中，来自新加坡ASTAR研究所等机构的研究人员通过研究发现，人类机体的免疫细胞或许是从特殊的祖细胞衍生而来，相关研究或为后期开发新型疫苗并且优化疫苗提供了新的线索。

关键词：树突细胞祖细胞科学家机体免疫力细胞分化研究人员免疫细胞后期开发

MetaDP: a comprehensive web server for disease prediction of 16S rRNA metagenomic datasets

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Biophysics Reports 2016年第Z2期2卷 106-115页

作者： Xilin Xu Aiping Wu Xinlei Zhang Mingming Su Taijiao Jiang Zhe-Ming Yuan Hunan Provincial Key Laboratory for Biology and Control of Plant Diseases and Insect Pests Hunan Agricultural University center for Systems Medicine Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & Peking Union Medical College Suzhou Institute of Systems Medicine Suzhou Geneworks Technology Company Limited Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & Peking Union Medical College

High-throughput sequencing-based metagenomics has garnered considerable interest in recent *** methods and tools have been developed for the analysis of metagenomic data. However, it is still a daunting task to install a large number of tools and complete a complicated analysis, especially for researchers with minimal bioinformatics backgrounds. To address this problem, we constructed an automated software named Meta DP for 16 S r RNA sequencing data analysis, including data quality control, operational taxonomic unit clustering, diversity analysis, and disease risk prediction ***, a support vector machine-based prediction model for intestinal bowel syndrome(IBS)was built by applying Meta DP to microbial 16 S sequencing data from 108 children. The success of the IBS prediction model suggests that the platform may also be applied to other diseases related to gut microbes, such as obesity, metabolic syndrome, or intestinal cancer, among others(http://***:7001/).

关键词： 16S rRNA Disease prediction Intestinal bowel syndrome Metagenomics

Identification of Novel Nonsense RPGR Variant Causing Mild X-Linked Cone-Rod Dystrophy and Myopia

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Case Reports in Clinical Medicine 2022年第10期11卷 422-434页

作者： Kunka Kamenarova Sylvia Cherninkova Kalina Mihova Rosen Georgiev Yana Nikolaeva Radka Kaneva Molecular Medicine center Department of Medical Chemistry and Biochemistry Medical Faculty Medical University—Sofia Sofia Bulgaria Laboratory of Genomic Diagnostics Department of Medical Chemistry and Biochemistry Medical Faculty Medical University—Sofia Sofia Bulgaria Clinic of Nervous diseases University Hospital “Alexandrovska” Sofia Bulgaria Clinic of Eye Diseases University Hospital “Alexandrovska” Sofia Bulgaria Eye Clinic “Vision” Sofia Bulgaria

Background: Mutations in the RPGR gene are associated with rod-cone or cone-rod dystrophy, the latter associated with mutations at the distal end. Cone-rod dystrophy (CRD) is a subgroup of hereditary retinal disorders characterized by the primary degeneration of cone photoreceptors often followed by progressive loss of rod photoreceptors in the peripheral visual field. Purpose: The aim of this study was to describe the milder CRD phenotype associated with a novel pathogenic variant c.1905 + 223C > T (p.Q710X) found in RPGR which results in shortening of the photoreceptor specific isoform RPGR ORF15. Method: An 11-year-old boy with symptoms of CRD and two female relatives were referred for detailed ophthalmic examinations. Genetic testing was performed by next-generation sequencing of clinical exome followed by Sanger sequencing for segregation analysis. Results: Genetic analysis identified a novel variant in ORF15 of the RPGR gene (c.1905 + 223C > T, p.Q710X) in the proband considered as pathogenic according to the American College of Medical Genetics and genomics (ACMG) standards. Segregation study identified the mutation in a heterozygous state in the mother and her sister. Detailed ophthalmological examination revealed slightly reduced color vision and scattered grayish point-like deposits in the posterior pole of the fundus in the male patient. All mutation carriers were myopic. Conclusion: We report a novel pathogenic RPGR variant in a Bulgarian patient with clinical features compatible with the CRD diagnosis. This condition is inherited as an X-linked dominant trait in its familial form presenting with a mild CRD phenotype in the male hemizygous proband and a moderate to high myopia in the female heterozygous carriers.

关键词： Cone-Rod Dystrophy Myopia RPGR Novel Mutation

Research progress of individualized precision treatment for pancreatic cancer

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Precision Medicine Research 2020年第4期2卷 165-170页

作者： Yong Tang Department of Pancreatic Neoplasms Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for Cancer/Tianjin Key Laboratory of Cancer Prevention and Treatment/Tianjin Clinical Medical Research Center for Malignant TumorsTianjin 300060China

Currently,there is the extremely poor prognosis for pancreatic *** the continuous development of various technologies,the long-term survival rate is not improved *** the rapid development of genomics and biotechnology,the concept of tumor precision treatment has attracted much *** sequencing technology and biomarker detection have been used to deeply explore the mechanism of the occurrence and development of pancreatic cancer and applied it to clinical diagnosis and treatment,making it possible for patients to carry out individualized precision treatment for pancreatic ***-factor analysis combined with meaningful biological indicators is more helpful to determine individualized diagnosis and treatment *** paper summarizes the research results in the above aspects.

关键词： Pancreatic cancer Precision treatment Molecular typing Multiple-factor analysis

Understanding and modeling human traits and diseases:Insights from the comparative genomics resources of Zoonomia

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The Innovation 2023年第4期4卷 5-6页

作者： Maosen Ye Deng-Feng Zhang Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650201China Kunming College of Life Science University of Chinese Academy of SciencesKunming 650204China center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650204China National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility) Kunming Institute of ZoologyChinese Academy of SciencesKunming 650107China KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunming 650201China

Understanding the genetic architecture of complex human traits and diseases is one of the major aims of biomedical *** research,such as genome-wide association studies(GWASs)of large-scale,wellphenotyped cohorts,has identified tens of thousands of genomic variants associated with human traits and *** remaining challenge is how to translate the statistical association of genomic loci to biological mechanisms and clinical strategies.

关键词： diseases clinical translate

Large-scale genome-wide scans do not support petaloid toenail as a Mendelian trait

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Journal of Genetics and genomics 2016年第12期43卷 702-704页

作者： Manfei Zhang Sijie Wu Juan Zhang Yajun Yang Jingze Tan Haijuan Guan Yu Liu Kun Tang Jean Krutmann Shuhua Xu Li Jin Yaqun Guan Hui Li Sijia Wang Ministry of Education Key Laboratory of Contemporary Anthropology Collaborative Innovation Center for Genetics and DevelopmentSchool of Life SciencesFudan UniversityShanghai 200438China Chinese Academy of Sciences Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China Fudan-Taizhou Institute of Health Sciences Taizhou 225300China IUF-Leibniz Research Institute for Environmental Medicine Dusseldorf 40225Germany School of Life Science and Technology Shanghai Tech UniversityShanghai 200031China Department of Biochemistry and Molecular Biology Preclinical Medicine CollegeXinjiang Medical UniversityUrumqi 830011China

Petaloid toenail, or accessory nail of the fifth toe, is a physical trait characterized by the presence of an additional tiny toenail on the small toe. Since it can occasionally cause disfigurement and tenderness while wearing tight shoes or walking, standard surgical matricectomy is often carried out to repair the petaloid toenail （Chi and Wang, 2004）. Chinese legends recorded petaloid toenails as a trait unique to Han Chinese （Gao, 2010）, but population- based studies are largely absent.

关键词： meta mode than

ZFN,TALEN and CRISPR-Cas9 mediated homology directed gene insertion in Arabidopsis:A disconnect between somatic and germinal cells

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Journal of Genetics and genomics 2018年第12期45卷 681-684页

作者： Qiwei Shan Nicholas J.Baltes Paul Atkins Elida R. Kirkland Yong Zhang Joshua A.Ballet Levi G.Lowder Aimee A.Malzahn John C.Haugner Ⅲ Burckhard Seelig Daniel F. Voytas Yiping Qi Department of Genetics Cell Biology & Development and Center for Genome EngineeringUniversity of MinnesotaMinneapolisMN 55455USA Department of Biology East Carolina UniversityGreenvilleNC 27858USA Department of Biotechnology School of Life Sciences and Technology University of Electronic Science and Technology of ChinaChengdu 610054China Minnesota Supercomputing Institute University of Minnesota MinneapolisMN 55455USA Department of Plant Science and Landscape Architecture University of MarylandCollege ParkMD 20742USA Department of Biochemistry Molecular Biology and Biophysics University of MinnesotaMinneapolisMN 55455USA BioTechnology Institute University of MinnesotaSt.PaulMN 55108 USA Institute for Bioscience and Biotechnology Research University of MarylandRockvilleMD 20850USA

Breakthroughs in the generation of programmable sequence-specific nucleases (SSNs), such as zinc finger nucleases (ZFNs),TAL effector nucleases (TALENs) and the RNA-directed nuclease CRISPR-associated protein 9 (Cas9), have greatly increased the ease of plant genome engineering (Voytas, 2013; Malzahn et al.,2017). Programmable SSNs introduce a DNA double-strand break

关键词： ZFN,TALEN and CRISPR-Cas9 mediated homology directed gene insertion in Arabidopsis GUS A disconnect between somatic and germinal cells