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Phenolic profile， antioxidant properties， and beneficial gut microbiota associated with freeze dried Lycium ruthenicum

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food Science and Human Wellness 2024年

作者： Jing Huang Xueni Fan Xin Li Dingmei Dai Wenjie Huang Dong Ruan Shijuan Yan Xiaodan Huang School of Public Health， Lanzhou University Guangdong Key Laboratory for Crop Germplasm Resources Preservation and Utilization， Agro-biological Gene Research center， Guangdong Academy of Agricultural Sciences Institute of Animal Science， Guangdong Academy of Agricultural Sciences， Key Laboratory of Animal Nutrition and Feed Science in South China， Ministry of agriculture and Rural Affairs， State Key Laboratory of Livestock and Poultry Breeding， Guangdong Key Laboratory of Animal Breeding and Nutrition

Black wolfberry (Lycium ruthenicum) is enriched in phytochemical metabolites which can benefit human health. However， few studies have examined the effects of different fruit drying methods on its polyphenol content， antioxidant activity， and anti-inflammatory activity. In addition， whether and how consuming dried black wolfberry affects gut microbiota has not been reported. Here， we assessed the phytochemical profile and bioactivities of black wolfberry dried through different methods， and subsequently characterized changes in human fecal microbiota associated with freeze-dried black wolfberry in vitro. The results showed that freeze-dried samples retained higher total polyphenols (49.68 ± 1.62) mg GAE/g， tannins (38.64 ± 1.35) mg GAE/g， and proanthocyanidins (3.35 ± 0.30) mg/g compared to sun drying or hot air drying (P < 0.05)， and exhibited higher antioxidant and anti-inflammatory activities. In bioreactor fermentations of human fecal inoculum， freeze-dried black wolfberry was associated with increased species richness and alpha diversity. At the genus level， fermentations treated with black wolfberry had higher abundance of Lactic Acid Bacteria including Lactococcus， Bifidobacterium， Lactobacillus， Pediococcus and Weissella， as well as butyrate-producing bacteria compared to the untreated samples， suggesting enrichment for taxa associated with a healthy gut microbiome. In addition， the black wolfberry treatment group had higher levels of short-chain fatty acids， which was consistent with PICRUSt2 inference. This study defines an optimal method for black wolfberry preservation to retain the beneficial compounds， and provides a foundation for further exploration of its potential benefits for human gut microbiota.

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Revealing the Effects of Pore Size and Geometry on the Mechanical Properties of Graphene Nanopore Using the Atomistic Finite Element Method

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Acta Mechanica Solida Sinica 2019年第1期32卷 81-92页

作者： Prapasiri Pongprayoon Attaphon Chaimanatsakun Department of Chemistry Faculty of ScienceKasetsart UniversityChatuchakBangkok 10900Thailand center for advanced studies in Nanotechnology for Chemical Food and Agricultural IndustriesKU Institute for Advanced StudiesKasetsart UniversityBangkok 10900Thailand Computational Biomodelling Laboratory for Agricultural Science and Technology(CELAST) Kasetsart UniversityBangkok 10900Thailand Department of Mechanical Engineering Faculty of Engineering at SrirachaKasetsart UniversityTungsukhlaSrirachaChonburi 20230Thailand

Graphene nanopore has been extensively employed in nanoscale sensing devices due to its outstanding *** understanding of its mechanical properties at nanoscale is crucial for sensing *** this work,the mechanical proper ties of graphene nanopore are t hus investigated using the atomistic finite element met *** graphene models with different pore shapes(circle(CR),horizontal rec tangle(RH),vertical rec tangle(RV)and square(SQ))in sub-5nm size,which could be successfully fabricated experimentally,have been studied *** force normal to a pore rim is applied to mimic the impact force due to a fluid *** expected,the strength of nanoholed graphene is pore size *** pore size results in the reduction in its str *** bet ween different pore shapes with comparable sizes,the order of pore st rength is CR>RH>RV>*** addition,two different corner st rue tu res(V-like or zigzag and C-like or armchair corners)are observed,where the V-like st rue ture causes higher tensile ***,we find that the highest tensile stress is produced at the corner in all *** finding suggests the corners as an origin of pore *** results of RH and RV highlight the impact of a direction of pore orientation on mechanical *** a long side of a pore along the zigzag direction gains more tensile stress,while aligning on an armchair side causes a *** only the pore geometry and size,but also the pore orientation is crucial for defining the mechanical properties of nanopores.

关键词： Nanopores Atomistic finite element Graphene nanopores Nanosensors

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Machine Learning Models for Genetic Risk Assessment of Infants with Non-syndromic Orofacial Cleft

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Genomics, Proteomics & Bioinformatics 2018年第5期16卷 354-364页

作者： Shi-Jian Zhang Peiqi Meng Jieni Zhang Peizeng Jia Jiuxiang Lin Xiangfeng Wang Feng Chen Xiaoxing Wei Beijing advanced Innovation center for food Nutrition and Human Health College of Agronomy and Biotechnology China Agricultural University Department of Orthodontics & Central Laboratory Peking University School and Hospital of Stomatology State Key Laboratory of Plateau Ecology and agriculture Medical College of Qinghai University

The isolated type of orofacial cleft, termed non-syndromic cleft lip with or without cleft palate(NSCL/P), is the second most common birth defect in China, with Asians having the highest incidence in the world. NSCL/P involves multiple genes and complex interactions between genetic and environmental factors, imposing difficulty for the genetic assessment of the unborn fetus carrying multiple NSCL/P-susceptible variants. Although genome-wide association studies(GWAS)have uncovered dozens of single nucleotide polymorphism(SNP) loci in different ethnic populations, the genetic diagnostic effectiveness of these SNPs requires further experimental validation in Chinese populations before a diagnostic panel or a predictive model covering multiple SNPs can be built. In this study, we collected blood samples from control and NSCL/P infants inHan and Uyghur Chinese populations to validate the diagnostic effectiveness of 43 candidate SNPs previously detected using GWAS. We then built predictive models with the validated SNPs using different machine learning algorithms and evaluated their prediction performance. Our results showed that logistic regression had the best performance for risk assessment according to the area under curve. Notably, defective variants in MTHFR and RBP4, two genes involved in folic acid and vitamin A biosynthesis, were found to have high contributions to NSCL/P incidence based on feature importance evaluation with logistic regression. This is consistent with the notion that folic acid and vitamin A are both essential nutritional supplements for pregnant women to reduce the risk of conceiving an NSCL/P baby. Moreover, we observed a lower predictive power in Uyghur than in Han cases, likely due to differences in genetic background between these two ethnic ***, our study highlights the urgency to generate the HapMap for Uyghur population and perform resequencing-based screening of Uyghur-specific NSCL/P markers.

关键词： Orofacial cleft Genetic risk Folic acid Vitamin A Nutritional intervention

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Essential oils as alternatives to antibiotics in swine production

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Animal Nutrition 2018年第2期4卷 126-136页

作者： Faith A.Omonijo Liju Ni Joshua Gong Qi Wang Ludovic Lahaye Chengbo Yang Department of Animal Science University of Manitoba Shanghai Lab-Animal Research center Guelph food Research Centre Agriculture and Agri-Food Canada Jefo Nutrition Inc.

This review article summarizes the efficacy, feasibility and potential mechanisms of the application of essential oils as antibiotic alternatives in swine *** there are numerous studies demonstrating that essential oils have several properties, such as antimicrobial, antioxidative and antiinflammatory effects, feed palatability enhancement and improvement in gut growth and health, there is still a need of further investigations to elucidate the mechanisms underlying their *** the past,the results has been inconsistent in both laboratory and field studies because of the varied product compositions, dosages, purities and growing stages and conditions of *** minimal inhibitory concentration(MIC) of essential oils needed for killing enteric pathogens may not ensure the optimal feed intake and the essential oils inclusion cost may be too high in swine *** the lipophilic and volatile nature of essential oils, there is a challenge in effective delivery of essential oils within pig gut and this challenge can partially be resolved by microencapsulation and *** effects of essential oils on inflammation, oxidative stress, microbiome, gut chemosensing and bacterial quorum sensing(QS) have led to better production performance of animals fed essential oils in a number of *** has been demonstrated that essential oils have good potential as antibiotic alternatives in feeds for swine *** combination of different essential oils and other compounds(synergistic effect) such as organic acids seems to be a promising approach to improve the efficacy and safety of essential oils in ***-throughput systems technologies have been developed recently,which will allow us to dissect the mechanisms underlying the functions of essential oils and facilitate the use of essential oils in swine production.

关键词： Essential oils Organic acids Medium chain fatty acids Inflammation Oxidative stress Pigs

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Exogenous Application of Thiourea Ameliorates Salt Stress Effects by Alleviation of Oxidative Damage in Hybrid Maize

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Journal of Agricultural Science and Technology(A) 2016年第4期6卷 220-231页

作者： Tayyaba Sanaullah Abdul Wahid Bushra Sadia Asma Hanif Nazimah Maqbool Taskeen Arshad Zohra Kabir Department of Botany University of Agriculture Faisalabad'38040 Pakistan U.S.-Pakistan center for advanced studies in agriculture and food Security (USPCAS-AFS) University of Agriculture Faisalabad38040 Pakistan

Salinity is the most damaging factor towards crop production. The aim of this study was to investigate the possible role of thiourea in salinity tolerance. These experiments were carried out on two maize hybrids （DK6789 and 33M15） using the optimized thiourea level （400 μM） in autumn and spring seasons, and the growth and physiological attributes were observed. Salt stress caused a substantial suppression of growth, and damaging effects were observed, as reduction in shoot and root length, their fresh and dry weights, decreased root number and shoot/root ratio, increased accumulation of H202, malondialdehyde （MDA） in root and shoot tissues, and enhancement in activities of some key antioxidant enzymes （catalase, peroxidase and superoxide dismutase） with altered ascorbate peroxidase level in leaves of both maize hybrids. Medium supplemented thiourea was found to be very effective in improving growth may be due to decreased H202, MDA and further enhanced the activities of antioxidants with higher accumulation of ascorbate peroxidase under control and saline conditions. Salinity tolerance induced by thiourea was superior in the spring than in autumn grown maize. From the changes in the growth and physiological attributes of maize, it can be concluded that thiourea application has a great potential to alleviate the deteriorating effects of salt stress on maize and is recommended for improving growth in marginally to moderately saline soils.

关键词： Salinity thiourea malondialdehyde H202 maize.

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Earth Map:A Novel Tool for Fast Performance of advanced Land Monitoring and Citation:Morales C,DiazAS,Climate Assessment Climate Assessment

Journal of Remote Sensing

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Journal of Remote Sensing 2023年第1期3卷 1-18页

作者： Carmen Morales Alfonso Sanchez-Paus Diaz Daniel Dionisio Laura Guarnieri Giulio Marchi Danae Maniatis Danilo Mollicone food and agriculture Organization of the United Nations 00153 RomeItaly

Earth Map(https://***/)is an innovative and free application developed by the food and agriculture Organization of the United Nations that was designed in the framework of the food and agriculture Organization of the United Nations-Google partnership and facilitates the visualization,processing,and analysis ofland and climate *** Map makes petabytes of multitemporal,multiscale,multiparametric,and quasi-real-time satellite imagery and geospatial datasets available to any user thanks to the power of Google Earth Engine(https://***/)and a point-and-click graphical user *** are further complemented with more planetary-scale analytical capabilities so that global and local changes and trends on Earth's surface can be easily detected,quantified,and *** does not require users to master coding techniques,thereby avoiding bottlenecks in terms of technical capacities of nonexpert *** ultimately paves the way for countries,research institutes,farmers,and members of the general public to access critical knowledge to develop science-based policy interventions,leverage investments,and sustain *** provide a full overview of Earth Map's software architecture,design,features,and *** illustrate the possible applications of the tool,different examples are presented including a few case studies that show how quick historical analysis of environmental and climate parameters can be performed and research questions *** examples demonstrate that Earth Map is a comprehensive and user-friendly tool for land monitoring and climate assessment and that it has the potential to be used to assess land use,land use change,climate change impacts,and natural disasters.

关键词： Earth Map thereby

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Intercalation assembly of kojic acid into Zn-Ti layered double hydroxide with antibacterial and whitening performances

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Chinese Chemical Letters 2019年第4期30卷 919-923页

作者： Xin-Rui Wang Hui-Min Cheng Xue-Wei Gao Wei Zhou Shu-Jing Li Xue-Li Cao Dongpeng Yan Beijing advanced Innovation center for food Nutrition and Human Health Beijing Technology and Business University Department of Chemistry Beijing Normal University

A melanin synthesis inhibitor and bacteriostatic agent, kojic acid(KA) has been intercalated into Zn-Ti layered double hydroxide(LDH) by an anion-exchange reaction. The structure and the thermal stability of the samples were characterized by XRD, FT-IR, TG-DTA and SEM. The study of KA release from ZnTi-KALDH in phosphate buffered solution(pH 5) implies that ZnTi-KA-LDH is a better controlled release system than pure KA. Meanwhile, the mechanisms of slow release were assessed by using four commonly kinetic models. The antimicrobial activity of ZnTi-KA-LDH was tested against three kinds of bacteria. The inhibition of L-dopa oxidation was tested to verify its skin whitening effect. The studies suggest that the kojic acid intercalated LDHs has the potential application as a safely functional composite in cosmetic.

关键词： Layered double hydroxide Kojic acid Intercalation Slow release Antimicrobial Tyrosinase

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Silencing of Transposable Elements by piRNAs in Drosophila:An Evolutionary Perspective

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Genomics, Proteomics & Bioinformatics 2017年第3期15卷 164-176页

作者： Shiqi Luo Jian Lu State Key Laboratory of Protein and Plant Gene Research Center for BioinformaticsCollege of Life Sciences and Peking-Tsinghua Center for Life SciencesPeking University Beijing advanced Innovation center for food Nutrition and Human Health College of Food Science and Nutritional EngineeringChina Agricultural University

Transposable elements （TEs） are DNA sequences that can move within the genome. TEs have greatly shaped the genomes, transcriptomes, and proteomes of the host organisms through a variety of mechanisms. However, TEs generally disrupt genes and destabilize the host genomes, which substantially reduce fitness of the host organisms. Understanding the genomic distribution and evolutionary dynamics of TEs will greatly deepen our understanding of the TE-mediated bio- logical processes. Most TE insertions are highly polymorphic in Drosophila melanogaster, providing us a good system to investigate the evolution of TEs at the population level. Decades of theoretical and experimental studies have well established ＂transposition-selection＂ population genetics model, which assumes that the equilibrium between TE replication and purifying selection determines the copy number of TEs in the genome. In the last decade, P-element-induced wimpy testis （PIW1）- interacting RNAs （piRNAs） were demonstrated to be master repressors of TE activities in Droso- phila, The discovery of piRNAs revolutionized our understanding of TE repression, because it reveals that the host organisms have evolved an adaptive mechanism to defend against TE invasion. Tremendous progress has been made to understand the molecular mechanisms by which piRNAs repress active TEs, although many details in this process remain to be further explored. The inter- action between piRNAs and TEs well explains the molecular mechanisms underlying hybrid dysge- nesis for the IoR and P-M systems in Drosophila, which have puzzled evolutionary biologists for decades. The piRNA repression pathway provides us an unparalleled system to study the co-evolutionary process between parasites and host organisms.

关键词： Transposable element piRNA Hybrid dysgenesis Evolution Drosophila

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Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3661-3679页

作者： Baolong Liu Phuong Linh Nguyen Han Yu Xingzhi Li Huiren Wang Tram Gia Bao Nguyen Prakash Kumar Sahoo Meghna Sur Jay Reddy Sarah Sillman Stephen D.Kachman Bara Altartouri Guoqing Lu Sathish Kumar Natarajan Mahesh Pattabiraman Jiujiu Yu Department of Nutrition and Health Sciences University of Nebraska-LincolnLincolnNE 68583USA Shaanxi Key Laboratory of Molecular Biology for agriculture College of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Department of Nutrition Case Western Reserve UniversityClevelandOH 44106USA School of Veterinary Medicine and Biomedical Sciences University of Nebraska-LincolnLincolnNE 68583USA Department of Statistics University of Nebraska-LincolnLincolnNE 68583USA center for Biotechnology University of Nebraska-LincolnLincolnNE 68588USA Department of Biology University of Nebraska OmahaOmahaNE 68182USA Department of Chemistry University of Nebraska-KearneyKearneyNE 68849USA

Non-alcoholic steatohepatitis(NASH),an advanced form of non-alcoholic fatty liver disease(NAFLD),has emerged as the leading cause of liver failure and related ***,no medication is specifically approved to treat NAFLD or *** we report that oral administration of honey vesiclelike nanoparticles(H-VLNs)to naturally aged mice protects the liver from NASH development.H-VLNs are dominantly taken up by Kupffer cells in the liver and suppress hepatic chronic inflammation and further development of fibrosis and nodule formation in aged *** their reported antiinflammasome function,H-VLNs are found to inhibit the transcriptional activities of C-JUN and nuclear factor-kappa B(NF-κB).MicroRNAs miR5119 and miR5108 and phenolic compound luteolin in H-VLNs are identified in suppressing both the C-JUN and NF-kB ***,oral intake of H-VLNs represents a promising new user-friendly modality to prevent the development of NASH.

关键词： Honey Extracellular vesicles Exosomes Nanoparticles microRNAs Aging Inflammation Non-alcoholic steatohepatitis

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Organic-inorganic hybrid fluorescent sensor thin films of rhodamine B embedded Ag-SBA 15 for selective recognition of Hg(Ⅱ)ions in water

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Chinese Chemical Letters 2017年第7期28卷 1399-1405页

作者： Banupriya Cinnasamy Srinivasan Krishnan Rajasekar Aruliah Murugan Kadarkarai Giovanni Benelli Dinakaran Kannaiyan Department of Chemistry Thiruvalluvar UniversityVellore632115India Department of Biotechnology Thiruvalluvar UniversityVellore632115India Department of Zoology Bharathiar UniversityCoimbatore641046India Department of agriculture Food and EnvironmentUniversity of PisaPisa 56124Italy TheBioRobotics Institute Sant'Anna School of Advanced StudiesPontedera 56025Italy

Nowadays, the rapid and effective detection of low doses of heavy metal pollutants in contaminated water is a timely challenge in environmental pollution research. In this study, a rapid and highly sensitive assay for the detection of Hg^2＋based on quenching of metal-enhanced fluorescence of rhodamine B（RB）has been fabricated. RB and silver nanoparticle were incorporated into the mesoporous siliceous framework spin cast on a quartz glass through post-synthetic incorporation method. The morphology and crystallinity of mesoporous structure and Ag nanoparticle were characterized by transmission electron microscopy and X-ray diffraction analyses. Photoluminescence assays on the hybrid thin film of RB-Ag-SBA15 showed a high enhancement when compared to the intensity of silver free SBA15-RB in the wavelength of 575 nm. The fluorescence of RB-Ag-SBA15 thin film decreased gradually with the increase in the concentration of Hg^2＋and the detection limits were 10.54 nmol/L. Furthermore, the fluorescence intensity increased linearly with the concentration of Hg^2＋in the range from 1.0 ×10^-8mol/L to10× 10^-8mol/L, with a response time of a few seconds. In addition, this system offers a high selectivity over interfering cations such as Cd^2＋ and Pb^2＋. Overall, we have developed an optical assay having a wellordered mesoporous SBA15 containing Ag-RBfor selective detection of Hg^2＋in aqueous solution. The scheme combines the advantages of specific binding interactions between Hg^2＋and RB molecule and optical emission properties of RB. The method is suitable for a single-shot and irreversible analytical assay in a quartz glass/microtiter plate.

关键词： Mercury sensor Metal enhanced fluorescence Rhodamine B Ag nanoparticles SBA15 Fluorescence quenching

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