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Molecular plant 2016年第1期9卷 182-186页

作者： Rebecca Dautel XuNa Wu Michael Heunemann WaltraudX. Schulze Klaus Harter Department of plant Physiology Center for Plant Molecular Biology (ZMBP) University of T&uuml bingen Auf der Morgenstelle 32 72076 T&uuml bingen Germany Department of Plant Systems Biology University of Hohenheim 70593 Stuttgart Germany

Cytokinins are N^6-substituted adenine derivatives that are involved in the regulation of numerous aspects of plant growth and development. These include the control of cell division, leaf senescence, apical dominance, sink^source relationship, vascular and embryonic development, and apical meristem activity （Kieber and Schaller, 2014）. In addition, there is increasing evidence for the function of cytokinins in abiotic stress responses （Zwack and Rashotte, 2015）.

关键词： CYTOKININ PHOSPHOPROTEOMICS

Is the mission to identify all the human proteins achievable? —Commenting on the human proteome draft maps

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Science China(life Sciences) 2014年第10期57卷 1039-1040页

作者： CHANG ZengYi GU LiangCai center for Protein Science State Key Laboratory of Protein and Plant Gene Studies School of Life Sciences Center for History and Philosophy of Science Peking University Department of Genetics Harvard Medical School

Unveiling the structure and function of all the proteins a human body produces is undoubtedly a key task for us to better understand ourselves. Although a mission difficult to achieve, this apparently becomes more feasible upon the determination of the DNA sequence of the whole human genome, which was predicted to encode a total of 20,000-25,000 proteins [1]. Recent efforts of direct （de novo） protein isolation and peptide sequencing, mainly using liquid chromatography-tandem mass spectrometry （LC-MS/ MS） and in-depth bioinformatics analyses, led to the apparent identification of over 17,000 proteins from large sets of human tissues, cell lines and body fluids [2,3].

关键词：人类蛋白质组 DNA序列 LC-MS 地图人类基因组串联质谱法蛋白分离液相色谱

Elevated nitrogen and co-evolution history with competitors shape the invasion process of Galinsoga quadriradiata

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Journal of plant Ecology 2024年第4期17卷 9-22页

作者： Wen-Gang Zhang Xing-Jiang Song Laís Petri Gang Liu Xiao-Yan Chen Rui-Ling Liu Fang-Fang Huang Jia-Bin Zou Zhi-Hong Zhu College of life Sciences Shaanxi Normal UniversityXi’an 710119China School for Environment and Sustainability University of MichiganAnn ArborMI 48109USA Research center for UAV Remote Sensing Shaanxi Normal UniversityXi’an 710119China Changqing Teaching&Research Base of Ecology Shaanxi Normal UniversityXi’an 710119China Guangdong Provincial Key Laboratory of Silviculture Protection and UtilizationGuangdong Academy of ForestryGuangzhou 510520China

Invasive plants usually experience population differentiation as they expand from their initial invasive range to the ***,invasive plants usually encounter competitors which shared different co-evolutionary histories with *** factors may lead to varying responses of invasive plant populations to elevated nitrogen deposition during ***,this issue has received limited attention in prior *** address these challenges,we conducted a greenhouse experiment to investigate how population differentiation of Galinsoga quadriradiata interacts with the presence of various competitors in response to increased nitrogen *** types(new or old that shared short or long co-evolutionary history with the invader,respectively)were set to compete with the invasive central and edge populations under different nitrogen addition *** from the central population of ***,originating from the initial invasion range,showed greater total mass,reproduction and interspecific competitiveness compared with the edge *** addition improved growth and reproductive performance in both populations,and the central population had a stronger response compared with the edge *** performance of *** was inhibited more effectively by old competitors than new *** results indicate that population differentiation occurs in terms of growth and competitiveness during the range expansion of ***,with the central population exhibiting superior ***-evolutionary history with competitors is considered unfavorable for invasive plants in this *** results highlight the combined effects of population differentiation in invasive species and their co-evolution history with competitors in the context of global change factors.

关键词： Galinsoga quadriradiata central population edge population interspecific competition population differentiation elevated nitrogen

Global patterns and ecological drivers of taxonomic and phylogenetic endemism in angiosperm genera

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plant Diversity 2024年第2期46卷 149-157页

作者： Hong Qian Brent D.Mishler Jian Zhang Shenhua Qian Research and Collections center Illinois State Museum1011 East Ash StreetSpringfieldIL 62703USA University and Jepson Herbaria Department of Integrative BiologyUniversity of CaliforniaBerkeleyCA 94720-2465USA center for Global Change and Complex Ecosystems Zhejiang Tiantong Forest Ecosystem National Observation and Research StationSchool of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment Ministry of EducationChongqing UniversityChongqing 400045China

Endemism of lineages lies at the core of understanding variation in community composition among geographic regions because it reflects how speciation,extinction,and dispersal have influenced current ***,we investigated geographic patterns and ecological drivers of taxonomic and phylogenetic endemism of angiosperm genera across the *** identify centers of paleo-endemism and neo-endemism of angiosperm genera,and show that they are mostly located in the Southern Hemisphere in tropical and subtropical regions,particularly in Asia and *** categories of phylogenetic endemism centers can be differentiated using current climate *** climate,historical climate change,and geographic variables together explained~80%of global variation in taxonomic and phylogenetic endemism,while 42-46%,1%,and 15%were independently explained by these three types of variables,*** our findings show that past climate change,current climate,and geography act together in shaping endemism,which are consistent with the findings of previous studies that higher temperature and topographic heterogeneity promote *** study showed that many centers of phylogenetic endemism of angiosperms,including regions in Amazonia,Venezuela,and west-central tropical Africa that have not previously been identified as biodiversity hotspots,are missed by taxon-based measures of endemism,indicating the importance of including evolutionary history in biodiversity assessment.

关键词： Angiosperm Current climate Endemism Historical climate change Topographic heterogeneity

Recurrent genome duplication events likely contributed to both the ancient and recent rise of ferns^FA

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Journal of Integrative plant biology 2020年第4期62卷 433-455页

作者： Chien-Hsun Huang Xinping Qi Duoyuan Chen Ji Qi Hong Ma Ministry of Education Key Laboratory of Biodiversity Sciences and Ecological Engineering and State Key Laboratory of Genetic Engineering Collaborative Innovation Center for Genetics and DevelopmentInstitute of Plant BiologyInstitute of Biodiversity SciencesCenter for Evolutionary BiologySchool of Life SciencesFudan UniversityShanghai 200433China Department of biology The Huck Institutes of the Life SciencesThe Pennsylvania State UniversityUniversity ParkUniversity ParkPA 16802USA

Ferns, the second largest group of vascular plants, originated ~400 mil ion years ago(Mya). They became dominant in the ancient Earth landscape before the angiosperms and are stil important in current *** ferns have exceptional y high chromosome numbers,possibly resulting from whole-genome duplications(WGDs).However, WGDs have not been investigated molecularly across fern diversity. Here we detected and dated fern WGDs using a phylogenomic approach and by calculating synonymous substitution rates(Ks). We also investigated a possible correlation between proposed WGDs and shifts in species diversification rates. We identified 19 WGDs: three ancient events along the fern phylogenetic backbone that are shared by 66%–97% of extant ferns, with additional lineage-specific WGDs for eight orders, providing strongevidence for recurring genome duplications across fern evolutionary history. We also observed similar Ks peak values for more than half of these WGDs, with multiple WGDs occurring close to the Cretaceous(~145–66 Mya). Despite the repeated WGD events, the biodiversity of ferns declined during the Cretaceous, implying that other factors probably contributed to the floristic turnover from ferns to angiosperms. This study provides molecular evidence for recurring WGDs in ferns and offers important clues to the genomic evolutionary history of ferns.

关键词： likely Cretaceous backbone

CRISPR-Mediated Engineering across the Central Dogma in plant biology for Basic Research and Crop Improvement

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Molecular plant 2021年第1期14卷 127-150页

作者： Dibyajyoti Pramanik Rahul Mahadev Shelake Mi Jung Kim Jae-Yean Kim Division of Applied life Science(BK21 Four Program) Plant Molecular Biology and Biotechnology Research CenterGyeongsang National UniversityJinju 52828Korea These authors contributed equally to this article

The central dogma(CD)of molecular biology is the transfer of genetic information from DNA to RNA to *** CD processes governing genetic flow include the cell cycle,DNA replication,chromosome packaging,epigenetic changes,transcription,posttranscriptional alterations,translation,and posttranslational *** CD processes are tightly regulated in plants to maintain genetic integrity throughout the life cycle and to pass genetic materials to next *** of various CD processes involved in gene regulation will accelerate crop improvement to feed the growing world *** technology enables programmable editing of CD processes to alter DNA,RNA,or protein,which would have been impossible in the ***,an overview of recent advancements in CRISPR tool development and CRISPR-based CD modulations that expedite basic and applied plant research is ***,CRISPR applications in major thriving areas of research,such as gene discovery(allele mining and cryptic gene activation),introgression(de novo domestication and haploid induction),and application of desired traits beneficial to farmers or consumers(biotic/abiotic stress-resilient crops,plant cell factories,and delayed senescence),are ***,the global regulatory policies,challenges,and prospects for CRISPR-mediated crop improvement are discussed.

关键词： central dogma CRISPR crop improvement gene regulation genome editing

Evolution and protein interactions of AP2 proteins in Brassicaceae： Evidence linking development and environmental responses

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Journal of Integrative plant biology 2016年第6期58卷 549-563页

作者： Liping Zeng Yue Yin Chenjiang You Qianli Pan Duo Xu Taijie Jin Bailong Zhang Hong Ma Ministry of Education Key Laboratory of Biodiversity and Ecological Engineering Institute of Plant Biology Institute of Biodiversity SciencesCenter for Evolutionary Biology School of Life Sciences Fudan University Shanghai 200433 China Institutes of Biomedical Sciences Fudan University Shanghai 200433 China

plants have evolved a large number of transcription factors（TF）, which are enriched among duplicate genes,highlighting their roles in complex regulatory networks. The APETALA2/EREBP-like genes constitute a large plant TF family and participate in development and stress responses. To probe the conservation and divergence of AP2/EREBP genes,we analyzed the duplication patterns of this family in Brassicaceae and identified interacting proteins of representative Arabidopsis AP2/EREBP proteins. We found that many AP2/EREBP duplicates generated early in Brassicaceae history were quickly lost, but many others were retained in all tested Brassicaceae species, suggesting early functional divergence followed by persistent conservation. In addition,the sequences of the AP2 domain and exon numbers were highly conserved in rosids. Furthermore, we used 16 *** AP2/EREBP proteins as baits in yeast screens and identified 1,970 potential AP2/EREBP-interacting proteins,with a small subset of interactions verified in planta. Many AP2 genes also exhibit reduced expression in an antherdefective mutant, providing a possible link to developmental regulation. The putative AP2-interacting proteins participate in many functions in development and stress responses,including photomorphogenesis, flower development, pathogenesis, drought and cold responses, abscisic acid and auxin signaling. Our results present the AP2/EREBP evolution patterns in Brassicaceae, and support a proposed interaction network of AP2/EREBP proteins and their putative interacting proteins for further study.

关键词： APETALA2 EREBP evolution Brassicaceae protein interaction

Towards understanding abscisic acid-mediated leaf senescence

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Science China(life Sciences) 2015年第5期58卷 506-508页

作者： LIANG Chengzhen CHU Chengcai State Key Laboratory of plant Genomics and National center for plant Gene Research (Beijing) Institute of Genetics and Developmental Biology Chinese Academy of Sciences

senescence is a necessary part of most complex organisms that controlled by many complicated genetic programs. However, unlike animals and humans, leaf senescence has a great impact on nutrient recycling from source to sink to promote reproductive success, thus has strong adaptive advantages in plants. Therefore, from the agricultural point of view, understanding the process of leaf senescence is extremely important for the breeding of higher-yielding crop with optimized nutritional qualities.

关键词：叶片衰老脱落酸介导植物适应性组成部分遗传程序养分循环品质育种

Gene Network Analysis and Functional Studies of senescence-associated Genes Reveal Novel Regulators of Arabidopsis Leaf senescence

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Journal of Integrative plant biology 2012年第8期54卷 526-539页

作者： Zhonahai Li Jinying Peng Xing Wen Hongwei Guo State Key Laboratory of Protein and plant Gene Research College of Life SciencesPeking UniversityPeking-Tsinghua Center for Life SciencesBeijing 100871China

plant leaf senescence has been recognized as the last phase of plant development, a highly ordered process regulated by genes known as senescence associated genes （SAGs）. However, the function of most of SAGs in regulating leaf senescence as well as regulators of those functionally known SAGs are still unclear. We have previously developed a curated database of genes potentially associated with leaf senescence, the Leaf senescence Database （LSD）. In this study, we built gene networks to identify common regulators of leaf senescence in Arabidopsis thaliana using promoting or delaying senescence genes in LSD. Our results demonstrated that plant hormones cytokinin, auxin, nitric oxide as well as small molecules, such as Ca2＋, delay leaf senescence. By contrast, ethylene, ABA, SA and JA as well as small molecules, such as oxygen, promote leaf senescence, altogether supporting the idea that phytohormones play a critical role in regulating leaf senescence. Functional analysis of candidate SAGs in LSD revealed that a WRKY transcription factor WRKY75 and a Cys2/His2-type transcription factor AZF2 are positive regulators of leaf senescence and loss-of-function of WRKY75 or AZF2 delayed leaf senescence. We also found that silencing of a protein phosphatase, AtMKP2, promoted early senescence. Collectively, LSD can serve as a comprehensive resource for systematic study of the molecular mechanism of leaf senescence as well as offer candidate genes for functional analyses.

关键词： Arabidopsis leaf senescence SAG phytohormone systems biology.

Metochalcone induces senescence-associated secretory phenotype via JAK2/STAT3 pathway in breast cancer

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Oncology Research 2024年第5期32卷 943-953页

作者： JIANBO ZHOU FENG WAN BIN XIAO XIN LI CHENG PENG FU PENG Department of Pharmacology West China School of PharmacySichuan UniversityChengduChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduChina Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologySichuan UniversityChengduChina Chengdu No.1 Pharmaceutical Co. Ltd.PengzhouChina Chengdu Push Bio-Technology Co. Ltd.ChengduChina

Breast and lung cancers are the leading causes of mortality and most frequently diagnosed cancers in women and men,respectively,*** the antitumor activity of chalcones has been extensively studied,the molecular mechanisms of isoliquiritigenin analog 2',4',4-trihydroxychalcone(metochalcone;TEC)against carcinomas remain less well *** this study,we found that TEC inhibited cell proliferation of breast cancer BT549 cells and lung cancer A549 cells in a concentration-dependent *** induced cell cycle arrest in the S-phase,cell migration inhibition in vitro,and reduced tumor growth in ***,transcriptomic analysis revealed that TEC modulated the activity of the JAK2/STAT3 and P53 *** triggered the senescence-associated secretory phenotype(SASP)by repressing the JAK2/STAT3 *** mechanism of metochalcone against breast cancer depended on the induction of SASP via deactivation of the JAK2/STAT3 pathway,highlighting the potential of chalcone in senescence-inducing therapy against carcinomas.

关键词： Metochalcone Breast cancer Lung cancer SASP JAK2/STAT3