检索结果-南通市图书馆

Vasoactive intestinal polypeptide (VIP) corrects chronic inflammatory response syndrome (CIRS) acquired following exposure to water-damaged buildings

引用

Health 2013年第3期5卷 396-401页

作者： Ritchie C. Shoemaker Dennis House James C. Ryan center for research on biotoxin associated illnesses Pocomoke City USA Proteogenomics LLC Vero Beach USA

Exposure in water-damaged buildings (WDB) to airborne bioaerosols including metabolic products of toxigenic fungi, bacteria and actinomycetes;and inflammagens, can lead to a persistent innate immune inflammatory illness. This illness, termed a chronic inflammatory response syndrome (CIRS-WDB), is systemic with symptoms acquired from multiple organ systems. Treatment of CIRS-WDB has progressed rapidly as a better understanding of the inflammatory pathophysiology has led to targeted, sequential therapies. The fundamental basis of uncontrolled innate immune responses, the humoral deficiency of regulatory neuropeptides melanocyte stimulating hormone (MSH) or vasoactive intestinal polypeptide (VIP), seen in over 98% of pa tients, has not consistently responded to any treatment modality. Use of replacement VIP has been attempted anecdotally;VIP replacement therapies show promise in short term studies but longer therapies have not been attempted. Here we report an open label trial of 20 patients with refractory CIRS-WDB illness who took replacement VIP in a nasal spray for at least 18 months with confirmation of durable efficacy and absence of significant side effects. These 20 patients were similar in symptoms and lab find- ings to three previously published cohorts in- volving 1829 patients and 169 controls. Dosage of VIP was titrated downwards from four to zero doses a day to determine minimum effective dose, and retitrated upwards for maximum improvement over time. The trial showed that VIP therapy safely 1) reduced refractory symptoms to equal controls;2) corrected inflammatory parameters C4a, TGF beta-1, VEGF, MMP9;3) corrected estradiol, testosterone and 25-OH Vitamin D;4) returned pulmonary artery systolic pressure (PASP) during exercise to normal;and 5) enhanced quality of life in 100% of trial patients. Subsequent identification of correction of T-regulatory cell levels supports the potential role of VIP in both innate and adaptive immune function.

关键词： Vasoactive Intestinal Polypeptide (VIP) Chronic Inflammatory Response Syndrome (CIRS) TGF Beta-1 C4a MSH T Regulatory Cells Water-Damaged Buildings

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive materials from berberine-treated human bone marrow mesenchymal stem cells accelerate tooth extraction socket healing through the jaw vascular unit

引用

Science China Life Sciences 2025年

作者： Ruyu Wang Tianxiao Wang Ziyu Chen Jiandong Jiang Yifei Du Hua Yuan Yongchu Pan Yuli Wang Department of Oral and Maxillofacial Surgery The Affiliated Stomatological Hospital of Nanjing Medical University State Key Laboratory Cultivation Base of Research Prevention and Treatment for Oral Diseases Jiangsu Province Engineering Research Centre of Stomatological Translational Medicine Nanjing Medical University Department of Stomatology Chongzhou People's Hospital Medical Basic research Innovation Centre for Cardiovascular and Cerebrovascular Diseases Ministry of Education International Joint Laboratory for Drug Target of Critical Illnesses School of PharmacyNanjing Medical University Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences & Peking Union Medical College Department of Orthodontic The Affiliated Stomatological Hospital of Nanjing Medical University State Key Laboratory Cultivation Base of Research Prevention and Treatment for Oral Diseases Jiangsu Province Engineering Research Centre of Stomatological Translational Medicine Nanjing Medical University

Delayed tooth extraction socket(TES) healing can cause failure of subsequent oral implantation and increase socioeconomic burden on patients. Excessive amounts of M1 macrophages, apoptotic neutrophils(ANs), and neutrophil extracellular traps(NETs) impair alveolar bone regeneration during TES healing. In the present study, we first discovered that conditioned medium(CM) collected from berberine-treated human bone marrow mesenchymal stem cells(BBR-HB-CM) accelerated TES healing. BBR-HB-CM contained bioactive materials that promoted the polarization of macrophages from M1 to M2, impeded the formation of ANs and NETs, and modulated M2 macrophage efferocytosis in vivo and in vitro. Mechanistically, BBR-HB-CM promoted bone formation by inhibiting macrophage-myofibroblast transition and reprogrammed macrophage polarization through p85/AKT/mTOR pathway-dependent autophagy. The 3-methyladenine abolished the therapeutic effects of BBR-HB-CM. Further studies revealed that BBR-HB-CM accelerated TES healing in rats with type 2 diabetes mellitus. Overall, our results demonstrated that BBR-HB-CM had high potential to promote rapid TES healing.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Evidence of neurodegeneration in autism spectrum disorder

引用

Translational Neurodegeneration 2013年第1期2卷 113-118页

作者： Janet K Kern David A Geier Lisa K Sykes Mark R Geier Institute of Chronic illnesses IncorporationSilver SpringMDUSA University of Texas Southwestern Medical center at Dallas DallasTXUSA CoMeD IncorporationSilver SpringMDUSA

Autism spectrum disorder(ASD)is a neurological disorder in which a significant number of children experience a developmental regression characterized by a loss of previously-acquired skills and *** of neurological function in ASD,as observed in affected children who have regressed,can be explained as *** there is research evidence of neurodegeneration or progressive encephalopathy in ASD,the issue of neurodegeneration in ASD is still under *** of neurodegeneration in the brain in ASD includes:(1)neuronal cell loss,(2)activated microglia and astrocytes,(3)proinflammatory cytokines,(4)oxidative stress,and(5)elevated 8-oxo-guanosine *** evidence from this review suggests that neurodegeneration underlies the loss of neurological function in children with ASD who have experienced regression and loss of previously acquired skills and abilities,and that research into treatments to address the issue of neurodegeneration in ASD are warranted.

关键词： Autism spectrum disorder(ASD) Autism Neurodegeneration Regression Neuronal cell loss Microglia Oxidative stress Cytokines

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particulate matter(PM(2.5)) exposure season-dependently induces neuronal apoptosis and synaptic injuries

引用

Journal of Environmental Sciences 2017年第4期29卷 336-345页

作者： Minjun Chen Ben Li Nan Sang College of Environment and Resource Research Center of Environment and HealthShanxi University

Epidemiological studies have shown that particulate matter 2.5（PM（2.5）） not only increases the incidence of cardiopulmonary illnesses but also relates to the development of neurodegenerative diseases. Considering that PM（2.5）is highly heterogeneous with regional disparity and seasonal variation, we investigated whether PM（2.5）exposure induced neuronal apoptosis and synaptic injuries in a season-dependent manner. The results indicated that PM（2.5）altered the expression of apoptosis-related proteins（mainly bax and bcl-2）, activated caspase-3 and caused neuronal apoptosis. Additionally, PM（2.5）decreased the levels of synaptic structural protein postsynaptic density（PSD-95） and synaptic functional protein N-methyl-D-aspartate（NMDA） receptor subunit（NR2B） expression. These effects occurred in a season-dependent manner, and PM（2.5）collected from the winter showed the strongest changes. Furthermore, the effect was coupled with the inhibition of phosphorylated extracellular signal-regulated kinase 1/2（p-ERK1/2） and phosphorylated c AMP-response element binding protein（p-CREB）. Based on the findings, we analyzed the correlations between the chemical composition of PM（2.5）samples and the biological effects, and confirmed that winter PM（2.5）played a major role in causing neuronal apoptosis and synaptic injuries among different season samples.

关键词： Particulate matter(PM(2.5)) Season-dependent effect Neuronal apoptosis Synaptic injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A cross-sectional study of complementary and alternative medicine use in patients with coagulation disorders in Southern Iran

引用

Journal of Integrative Medicine 2017年第5期15卷 359-364页

作者： Mohammadreza Bordbar Mehdi Pasalar Rezvan Aresehiri Sezaneh Haghpanah Soheila Zareifar Fatemeh Amirmoezi Hematology research center Shiraz University of Medical SciencesShiraz ***Iran research center for Traditional Persian Medicine and History of Medicine Shiraz University of Medical SciencesShiraz ***Iran

OBJECTIVE：Complementary and alternative medicine（CAM）use has an increasing trend around the *** the wild application of CAM in patients with coagulation disorders,its efficacy is still questioned by many *** aim of this study was to determine the frequency and types of CAM usage,and the factors affecting CAM use among patients with bleeding ***：This cross-sectional study investigated the usage of CAM with a standard validated questionnaire in coagulopathic patients who were referred to Dastgheib Hospital,an educational therapeutic center affiliated to the Shiraz University of Medical Sciences in Shiraz,Southern ***：Between December 2015 and May 2016,75 patients were included in this *** hemophilia A and rare bleeding disorders were the most frequent among our ***,nearly half of the studied population（49.3%）used at least one CAM product or *** most common products were multivitamin（29.3%）,followed by folic acid（21.3%）and chamomile（12%）.32%of the patients resorted to faith *** main reasons of using CAM were reported to be increased general health,correction of anemia and thrombocytopenia and control of bleeding ***：CAM is being used frequently in patients with coagulation disorders like many other chronic illnesses all around the *** to emerging concern regarding the safety and possible interaction with the conventional medicine,it is necessary to develop basic data about the hematologic effects of these methods in order to use them more safely.

关键词： medicine, traditional complementary medicine alternative therapies coagulation disorder hemophilia Iran

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The interaction between the nervous system and the stomatognathic system: from development to diseases

引用

International Journal of Oral Science 2023年第3期15卷 355-370页

作者： Yuzhu Wu Yanhua Lan Jiajie Mao Jiahui Shen Ting Kang Zhijian Xie Stomatology Hospital School of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zhejiang UniversityEngineering Research Center of Oral Biomaterials and Devices of Zhejiang ProvinceHangzhouChina

The crosstalk between the nerve and stomatognathic systems plays a more important role in organismal health than previously appreciated with the presence of emerging concept of the“brain-oral axis”.A deeper understanding of the intricate interaction between the nervous system and the stomatognathic system is warranted,considering their significant developmental homology and anatomical proximity,and the more complex innervation of the jawbone compared to other *** this review,we provide an in-depth look at studies concerning neurodevelopment,craniofacial development,and congenital anomalies that occur when the two systems develop *** summarizes the cross-regulation between nerves and jawbones and the effects of various states of the jawbone on intrabony nerve *** closely related to both the nervous system and the stomatognathic system are divided into craniofacial diseases caused by neurological illnesses,and neurological diseases caused by an aberrant stomatognathic *** two-way relationships between common diseases,such as periodontitis and neurodegenerative disorders,and depression and oral diseases were also *** review provides valuable insights into novel strategies for neuro-skeletal tissue engineering and early prevention and treatment of orofacial and neurological diseases.

关键词： diseases prevention system

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Neurovascular Unit Dysfunction in the Molecular Mechanisms of Epileptogenesis and Targeted Therapy

引用

Neuroscience Bulletin 2024年第5期40卷 621-634页

作者： Xiuxiu Liu Ying Zhang Yanming Zhao Qian Zhang Feng Han Medical Basic research Innovation center for Cardiovascular and Cerebrovascular Diseases Ministry of EducationNanjing211166China International Joint Laboratory for Drug Target of Critical illnesses School of PharmacyNanjing Medical UniversityNanjing211166China Institute of Brain Science The Affiliated Brain Hospital of Nanjing Medical UniversityNanjing211166China Gusu School Nanjing Medical UniversitySuzhou Municipal HospitalThe Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou210019China

Epilepsy is a multifaceted neurological syndrome characterized by recurrent,spontaneous,and synchronous *** pathogenesis of epilepsy,known as epileptogenesis,involves intricate changes in neurons,neuroglia,and endothelium,leading to structural and functional disorders within neurovascular units and culminating in the development of spontaneous *** current research on epilepsy treatments primarily centers around anti-seizure drugs,it is imperative to seek effective interventions capable of disrupting *** this end,a comprehensive exploration of the changes and the molecular mechanisms underlying epileptogenesis holds the promise of identifying vital biomarkers for accurate diagnosis and potential therapeutic *** early diagnosis and timely intervention is paramount,as it stands to significantly improve patient prognosis and alleviate the socioeconomic *** this review,we highlight the changes and molecular mechanisms of the neurovascular unit in epileptogenesis and provide a theoretical basis for identifying biomarkers and drug targets.

关键词： Epileptogenesis Neurovascular unit Molecular mechanisms Drug targets

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mental Health Disorders of the Indonesian People in the Early Stages of the COVID-19 Pandemic:Who is Vulnerable to Experiencing it?

引用

International Journal of Mental Health Promotion 2022年第5期24卷 725-737页

作者： Rofingatul Mubasyiroh Indri Yunita Suryaputri Sri Idaiani Lely Indrawati Tri Wurisastuti Siti Isfandari Nikson Sitorus Enung Nurhotimah Felly Philipus Senewe research center for Public Health and Nutrition National Research and Innovation AgencyJakarta10340Indonesia research center for Pre Clinical and Clinical Medicine National Research and Innovation AgencyJakarta10340Indonesia Bandung Health Polytechnic Ministry of HealthBandung40173Indonesia

The extraordinary situation related to COVID-19 makes people worry about their health,family health,work,ﬁnances,and other daily *** condition can lead to social unrest,which has consequences for mental health *** study aims to determine the mental health consequences at the beginning of the COVID-19 pandemic in *** is a cross-sectional study involving a target population aged 18 years and over who had access to electronic communication *** online questionnaire was randomly distributed and snowballed throughout 34 provinces in *** study was conducted from 2 to 4 May ***-parametric and multi-variate linear regression analyses were performed to identify factors associated with anxiety and *** thousand seven hundred forty-three participants were involved in this study,with 69.16%*** sum,6.92%of participants had General Anxiety Disorder-7(GAD-7)scores≥10 for moderate-severe anxiety symptoms,and 8.57%had Patient Health Questionnaire-9(PHQ-9)scores≥10 for moderate-severe depressive *** multivariate linear regression analyses showed that the strongest factors inﬂuencing anxiety and depression were a history of mental illnesses,chronic illnesses,the group affected by layoffs or job seekers,unemployed,students,younger age group,living in a rented house,single,and *** contrast,the lower and secondary education level seems to reduce the risk of depression compared to those with higher education *** and depression occur during the periods of activity restriction during the COVID-19 pandemic and are inﬂuenced by several modiﬁable and non-modiﬁable *** is an urgent need to emphasize vulnerable groups such as those with a history of illness,those affected by layoffs/looking for work,and the younger age group.

关键词： General population mental health early-stage COVID-19 Indonesia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrating sequence and graph information for enhanced drug-target affinity prediction

引用

Science China(Information Sciences) 2024年第2期67卷 325-326页

作者： Haohuai HE Guanxing CHEN Calvin Yu-Chian CHEN Artificial Intelligence Medical research center School of Intelligent Systems EngineeringShenzhen Campus of Sun Yat-sen University

Drug discovery is a pivotal discipline involving the identification and development of innovative pharmaceuticals designed to combat a wide array of illnesses. It plays a crucial role in advancing global health outcomes and improving the standard of living for individuals worldwide. However,drug discovery often relies on laborious in vitro experiments,

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Therapeutic Perspectives of IL1 Family Members in Liver Diseases:An Update

引用

Journal of Clinical and Translational Hepatology 2022年第6期10卷 1186-1193页

作者： Ines Bilić Ćurčić Tomislav Kizivat Ana Petrović Robert Smolić Ashraf Tabll George Y.Wu Martina Smolić Faculty of Medicine Osijek University of OsijekOsijekCroatia University Hospital Osijek OsijekCroatia Faculty of Den-tal Medicine and Health Osijek University of OsijekOsijekCroatia National research center GizaEgypt Egypt center for research and Regenerative Medicine(ECRRM) CairoEgypt University of Connecticut Health center FarmingtonCTUSA

Interleukin(IL)1 superfamily members are a cornerstone of a variety of inflammatory processes occurring in various organs including the *** of acute and chronic liver diseases regardless of etiology depends on the stage of hepatocyte damage,the release of inflammatory cytokines and disturbances in gut ***1 cytokines and re-ceptors can have pro-or anti-inflammatory roles,even dual functionalities conditioned by the ***-oping novel therapeutic strategies to block the IL1/IL1R sign-aling pathways seems like a reasonable *** mode of action is now exploited by anakinra and canakinumab,which are used to treat different inflammatory illnesses,and studies in liver diseases are on the *** this mini review,we have focused on the IL1 superfamily members,given their cru-cial role in liver inflammation diseases,specifically discussing their potential role in developing new treatment strategies.

关键词： Interleukin 1 superfamily members Inflammation Acute liver dis-ease Chronic liver disease Therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：