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Asian Journal of Andrology 2023年第1期25卷 98-102页

作者： Xin Lv Yu-Ting Jiang Xin-Yue Zhang Lei-Lei Li Hong-Guo Zhang Rui-Zhi Liu center of Reproductive Medicine and center of prenatal diagnosis The First Hospital of Jilin UniversityChangchun 130021China

Body mass index(BMI)has been increasing globally in recent *** studies reported that BMI was associated with sex hormone levels,but the results were generated via linear regression or logistic regression,which would lose part of *** regression analysis can maximize the use of variable *** study compared the associations among different regression *** participants were recruited from the center of Reproductive Medicine,The First Hospital of Jilin University(Changchun,China)between June 2018 and June *** used linear,logistic,and quantile regression models to calculate the associations between sex hormone levels and *** total,448 men were included in this *** average BMI was 25.7(standard deviation[s.d.]:3.7)kg m^(-2);29.7%(n=133)of the participants were normal weight,45.3%(n=203)of the participants were overweight,and 23.4%(n=105)of the participants were *** levels of testosterone and estradiol significantly differed among BMI groups(all P<0.05).In linear regression and logistic regression,BMI was associated with testosterone and estradiol levels(both P<0.05).In quantile regression,BMI was negatively associated with testosterone levels in all quantiles after adjustment for age(all P<0.05).BMI was positively associated with estradiol levels in most quantiles(≤80^(th))after adjustment for age(all P<0.05).Our study suggested that BMI was one of the influencing factors of testosterone and *** note,the quantile regression showed that BMI was associated with estradiol only up to the 80^(th) percentile of estradiol.

关键词： body mass index estradiol obesity overweight testosterone

Application of fetal cell-free DNA enrichment in non-invasive prenatal screening: experience from a single center in Eastern China

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Chinese Medical Journal 2021年第1期134卷 104-106页

作者： Ying Lin Dong Liang Ping Hu Hang Li Chun-Yu Luo Zheng-Feng Xu Department of prenatal diagnosis Women's Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China

Sequencing cell-free DNA(cfDNA)from the peripheral blood of pregnant women has been successfully applied in prenatal screening for fetal chromosomal aneuploidies,known as non-invasive prenatal screening(NIPS).[1,2]With large-scale clinical practices,it is recognized that the accuracy and reliability of this method largely relies on the proportion of fetal cfDNA presenting in total cfDNA from maternal plasma,known as the fetal fraction.

关键词： fetal clinical Eastern

Confusing finding of quantitative fluorescent polymerase chain reaction analysis in invasive prenatal genetic diagnosis:A case report

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World Journal of Clinical Cases 2023年第28期11卷 6895-6901页

作者： Cui Chen Tao Tang Qi-Ling Song Yong-Jun He Yan Cai Genetic and prenatal diagnosis center Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Quantitative fluorescent polymerase chain reaction(QF-PCR)is a rapid prenatal diagnostic method for abnormalities on chromosomes 21,18,and 13 and sex chromosomal ***,the value of QF-PCR in diagnosing chromosomal structural abnormalities is *** this article,we report a confusing QF-PCR finding in a pregnant woman who underwent *** SUMMARY The short tandem repeat marker AMXY(Xp22.2/Yp11.2)located on the sex chromosome exhibited a trisomic biallelic pattern,indicating that the karyotype of the fetus might be 47,*** analysis performed on cultured amniocytes showed a normal male karyotype of the *** number variation sequencing confirmed a 500 kb duplication at Yp11.2-Yp11.2(chrY:6610001_7110000)and a 250 kb duplication at Yp11.2-Yp11.2(chrY:7110001_7360000).CONCLUSION In conclusion,the comprehensive application of different methods could achieve a higher detection rate and accuracy for the prenatal diagnosis of chromosomal disorders through chromosomal testing.

关键词： Quantitative fluorescent polymerase chain reaction Copy number variation sequencing prenatal diagnosis Partial duplication Karyotyping Case report

Two factors affecting the success rate of the second non-invasive prenatal screening after initial no-call result: experience from a single tertiary center in China

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Chinese Medical Journal 2021年第12期134卷 1416-1421页

作者： Ying Lin Dong Liang Hang Li Chun-Yu Luo Ping Hu Zheng-Feng Xu Department of prenatal diagnosis Women's Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China center of Genetic Medicine Women's Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China

Background:One inevitable shortcoming of non-invasive prenatal screening(NIPS)/cell-free DNA(cfDNA)sequencing is the uninterpretable(“no-call”)result,which is mainly caused by an insufficient fetal *** study was performed to investigate the factors associated with a successful second NIPS in these cases and determine the optimal management for women with initial no-call ***:We retrospectively analyzed the data of women who underwent NIPS with initial no-call results due to an insufficient fetal fraction from 2017 to 2019 in our *** compared these women's maternal and pregnancy information with the data of women who had attained a successful second NIPS result and women who had received no-call results for a second ***:Among the 33,684 women who underwent NIPS,137 with a no-call result underwent a *** between the 87(63.50%)women with a successful retest and the other 50(36.50%)women showed a significant difference in both the initial fetal fraction and maternal body mass index(BMI),whereas the other factors showed no significant *** addition,with an initial fetal fraction of<2.00%,the retest success rate was very ***:We identified two major factors associated with a successful NIPS retest:the initial fetal fraction and the maternal *** findings suggest the need for specialized management for this subset of women and would be instructional for the counseling for these women.

关键词： Non-invasive prenatal screening Cell-free DNA No-call results Maternal body mass index Initial fetal fraction

Application of intelligent algorithms in Down syndrome screening during second trimester pregnancy

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World Journal of Clinical Cases 2021年第18期9卷 4573-4584页

作者： Hong-Guo Zhang Yu-Ting Jiang Si-Da Dai Ling Li Xiao-Nan Hu Rui-Zhi Liu center for Reproductive Medicine and center for prenatal diagnosis First HospitalJilin UniversityChangchun 130021Jilin ProvinceChina College of Communication Engineering Jilin UniversityChangchun 130012Jilin ProvinceChina

BACKGROUND Down syndrome(DS)is one of the most common chromosomal aneuploidy *** screening and diagnostic tests can aid the early diagnosis,appropriate management of these fetuses,and give parents an informed choice about whether or not to terminate a *** recent years,investigations have been conducted to achieve a high detection rate(DR)and reduce the false positive rate(FPR).Hospitals have accumulated large numbers of screened ***,artificial intelligence methods are rarely used in the risk assessment of prenatal screening for *** To use a support vector machine algorithm,classification and regression tree algorithm,and AdaBoost algorithm in machine learning for modeling and analysis of prenatal DS *** The dataset was from the center for prenatal diagnosis at the First Hospital of Jilin *** designed and developed intelligent algorithms based on the synthetic minority over-sampling technique(SMOTE)-Tomek and adaptive synthetic sampling over-sampling techniques to preprocess the dataset of prenatal screening *** machine learning model was then ***,the feasibility of artificial intelligence algorithms in DS screening evaluation is *** The database contained 31 DS diagnosed cases,accounting for 0.03%of all *** dataset showed a large difference between the numbers of DS affected and non-affected cases.A combination of over-sampling and undersampling techniques can greatly increase the performance of the algorithm at processing non-balanced *** the number of iterations increases,the combination of the classification and regression tree algorithm and the SMOTETomek over-sampling technique can obtain a high DR while keeping the FPR to a *** The support vector machine algorithm and the classification and regression tree algorithm achieved good results on the DS screening *** the T21 risk cutoff value was set to 270,machine learning m

关键词： Down syndrome prenatal screening Algorithms Classification and regression tree Support vector machine Risk cutoff value

Bioinspired flexible piezoresistive sensor for high-sensitivity detection of broad pressure range

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Bio-Design and Manufacturing 2023年第3期6卷 243-254页

作者： Meng Wang Hao Zhang Han Wu Suqian Ma Lei Ren Yunhong Liang Chunbao Liu Zhiwu Han center of Reproductive Medicine Center of Prenatal DiagnosisThe First Hospital of Jilin UniversityChangchun 130021China The Key Laboratory of Bionic Engineering Ministry of EducationJilin UniversityChangchun 130025China School of Mechanical and Aerospace Engineering Jilin UniversityChangchun 130025China

The human skin has the ability to sense tactile touch and a great range of ***,in prosthetic or robotic systems,it is necessary to prepare pressure sensors with high sensitivity in a wide measurement range to provide human-like tactile ***,we developed a flexible piezoresistive pressure sensor that is highly sensitive in a broad pressure range by using lotus leaf micropatterned polydimethylsiloxane and multilayer *** superposing four layers of micropatterned constructive substrates,the multilayer piezoresistive pressure sensor achieves a broad pressure range of 312 kPa,a high sensitivity of 2.525 kPa^(−1),a low limit of detection(LOD)of<12 Pa,and a fast response time of 45 *** with the traditional flexible pressure sensor,the pressure range of this sensor can be increased by at least an order of *** flexible piezoresistive pressure sensor also shows high robustness:after testing for at least 1000 cycles,it shows no sign of *** importantly,these sensors can be potentially applied in various human motion detection scenarios,including tiny pulse monitoring,throat vibration detection,and large under-feet pressure *** proposed fabrication strategy may guide the design of other kinds of multifunctional sensors to improve the detection performance.

关键词： Bionic Piezoresistive pressure sensor Microstructure Multilayer Wide pressure range

prenatal cytogenetic diagnosis study of 2782 cases of high-risk pregnant women

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Chinese Medical Journal 2010年第4期123卷 423-430页

作者： ZHANG Lin ZHANG Xiao-hong LIANG Mei-ying REN Mei-hong prenatal diagnosis center Peking University People's Hospital Beijing 100044 China

Background prenatal diagnoses are extremely advantageous for pregnant women with high-risk indicators and can help prevent the birth of malformed infants. However, no large-scale statistical study analyzing the correlation between fetal chromosome disorders and abnormal indicators during pregnancy has been done in China. The objectives of this study were to diagnose and analyze fetal chromosome abnormalities, determine the feasibility of the various prenatal test methods and establish diagnostic guidelines for the early, middle, and late trimesters. Methods From January 2004 to May 2009, 2782 pregnant women at high-risk underwent prenatal diagnoses. Categorized data expressed as either actual counts or percentages were analyzed by the chi-square or Fisher＇s exact test. Chorionic villus sampling was performed in the early-trimester （10-12 weeks of gestation）, amniocentesis in mid-trimester （16-28 weeks of gestation）, and umbilical cord blood collection in mid- or late-trimester （16-37 weeks of gestation）. In 51 cases either autopsy samples from intrauterine fetal deaths or placental tissues from aborted fetuses were tested. Results Chromosomal abnormalities were observed in 3.99% （111/2782） of the samples. Overall, the success rate of cytogenetic analysis for high-risk pregnancy groups was 98.17% （2731/2782）. It was significantly less successful when used to analyze data from the chorionic villus sampling compared with that from amniocentesis and umbilical cord blood （P=-0.000）. Abnormal chromosome carriers had the highest percentage of abnormal chromosomes （67.86%） when compared with chromosomal abnormalities in patients with ultra-sonographic ＂soft markers＂（11.81%）, advanced maternal age （4.51%） and those who had positive serum screening results （P=-0.000）. Conclusions Invasive prenatal diagnostic techniques are feasible tools for confirming fetal chromosomal abnormalities. Abnormal chromosomes detected in one of the parents carrying abnormal chromosome, ultrasoun

关键词： chorionic villus sampling amniocentesis umbilical cord blood collection chromosomal karyotype prenatal diagnosis

Targeting CXCR4 and EDN1 for the treatment of recurrent miscarriage using stearic acid from traditional Chinese medicine

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Traditional Medicine Research 2024年第11期9卷 65-75页

作者： Fang Liu Dong-Mei Shi Wen-Ye Ma Da-Wei Tang Gang Bai Xin-You Yu Reproductive center of Yinchuan Maternal and Child Health Hospital Yinchuan 750001China prenatal diagnosis center of Ningxia Medical University General Hospital Yinchuan 750004China

Background:Recurrent miscarriage(RM)affects an estimated 1-3%of couples attempting to conceive,and its molecular components stay ineffectively caught *** study aims to explore potential therapeutic targets for RM by examining gene expression patterns and biological pathways in both mouse and human RM ***,explore relevant traditional Chinese medicine(TCM)components targeting potential therapeutic ***:We utilized the GSE211251 mouse and the GSE26787 human datasets,employing gene set enrichment analysis and gene metaphysics analysis to examine differentially expressed genes and enriched ***-cell RNA analysis uncovered cellular heterogeneity and arranged pharmacology-mapped potential drug-target *** employed molecular docking strategies to assess the affinity of TCM components for key ***:In the mouse model,genes such as Ly6f1 and Gpr26 were upregulated,while Stc5a and Galca exhibited *** set enrichment analysis identified key pathways,including the tumor necrosis factor-mediated signaling *** human samples,Gene Ontology analysis highlighted processes such as apoptosis and cell ***-cell RNA analysis revealed distinct cellular populations between normal and RM *** pharmacology identified C-X-C motif chemokine receptor 4(CXCR4)and endothelin 1(EDN1)as potential key targets,and molecular docking confirmed that stearic acid from TCM appears to regulate these ***:This study presents a comprehensive analysis of the genetic and cellular underpinnings of RM,identifying CXCR4 and EDN1 as promising therapeutic *** acid from TCM could provide targeted treatment by modulating these key proteins,paving the way for new RM treatment strategies.

关键词： RM gene expression single-cell RNA analysis CXCR4 EDN1 stearic acid

Recent progress in 4D printing of stimuli-responsive polymeric materials

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Science China(Technological Sciences) 2020年第4期63卷 532-544页

作者： MA SuQian ZHANG YunPeng WANG Meng LIANG YunHong REN Lei REN LuQuan Key Laboratory of Bionic Engineering Ministry of EducationJilin UniversityChangchun 130025China School of Mechanical Aerospace and Civil EngineeringUniversity of ManchesterManchester M139PLUK center of Reproductive Medicine Center of Prenatal DiagnosisThe First Hospital of Jilin UniversityChangchun 130021China

4D printing is proposed based on the additive manufacturing of stimuli-responsive materials and structures,which can realize shape changing upon external *** article reviews the 4D printing methods and actuating performances of 4D printing structures based on shape memory polymers,hydrogels,liquid crystal elastomers,and electroactive *** article shows that the shape morphing properties of single materials are limited,while 4D printing of composites can integrate the various driving modes of different smart *** the end,challenges facing 4D printing such as broadening the scope of smart materials,improving printing processes,the compatibility of printing different materials have been discussed.

关键词： 4D printing additive manufacturing smart materials driving mode shape memory polymer hydrogel liquid crystal elastomer electroactive polymer

High-performance Multilayer Flexible Piezoresistive Pressure Sensor with Bionic Hierarchical and Anisotropic Structure

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Journal of Bionic Engineering 2022年第5期19卷 1439-1448页

作者： Meng Wang Yue Yu Yunhong Liang Zhiwu Han Chunbao Liu Suqian Ma Zhaohua Lin Lei Ren The Key Laboratory of Bionic Engineering Ministry of EducationJilin UniversityChangchun 130025China center of Reproductive Medicine Center of Prenatal DiagnosisThe First Hospital of Jilin UniversityChangchun 130021China Department of Endocrinology and Metabolism China-Japan Union Hospital of Jilin UniversityChangchun 130033China School of Mechanical and Aerospace Engineering Jilin UniversityChangchun 130025China

Flexible pressure sensor that enables detection of multimodal signals has greater advantages in human–computer interaction,medical/health care,and other *** make a versatile flexible pressure sensor,hierarchical and anisotropy structure are key features to improve sensing performance and realize multi-signal ***,traditional flexible sensors usually have narrow linear range and single signal detection ***,a highly sensitive flexible piezoresistive pressure sensor which has broad linear range of pressure is developed by replicating one dimensional microstructures from reed leaf and using multilayer superposition of micropatterned polydimethylsiloxane(m-PDMS).Through superposing 4 layers of parallel micropatterned constructive substrates,the multilayer piezoresistive pressure sensor exhibits a high sensitivity of 2.54 kPa?1,a fast response time of 30 ms,and a broad linear range of 107 *** flexible piezoresistive pressure sensor is also highly robust:there is no fatigue after testing for at least 1000 *** to the specific anisotropy of the micro-structure,the sensor can measure the tangential force in different *** permits multimode signal detection,including pressure,tangential force,and *** versatile flexible pressure sensor enables effective monitoring of multisignals,it reveals great potential for medical and health care,flexible human–computer interaction,and intelligent robot.

关键词： Piezoresistive pressure sensor Multilayer Anisotropy Micro-structure Bionic