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Evodiamine inhibits high-fat diet-induced colitis-associated cancer in mice through regulating the gut microbiota

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Journal of Integrative Medicine 2021年第1期19卷 56-65页

作者： Li-qing Zhu Li Zhang Jia Zhang Guo-lin Chang Gang Liu Dan-dan Yu Xiao-min Yu Mi-sheng Zhao Bin Ye Department of Pathogenic Biology Chongqing Medical UniversityChongqing 400016China Research Center for Molecular Medicine and TumorChongqing Medical UniversityChongqing 400016China Department of Clinical LaboratoryThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325023Zhejiang ProvinceChina Department of PathophysiologyChongqing Medical UniversityChongqing 400016China Department of Clinical LaboratoryWenzhou People’s HospitalWenzhou 325023Zhejiang ProvinceChina Department of EmergencyUniversity-Town Hospital of Chongqing Medical UniversityChongqing 401331China

Objective:High-fat diet is one of the main risk factors that disrupt the balance of gut microbiota,which eventually will induce colorectal cancer(CRC).Evodiamine(EVO)is a wildly used multifunctional traditional Chinese medicine *** this study,we investigated the role of gut microbiota in high-fat dietpropelled CRC and the potential of EVO for CRC ***:Gut microbiota,serum D-lactic acid and endotoxin from 38 patients with colon cancer and 18 healthy subjects were detected by quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assay(ELISA).In addition,body mass index,phospho-signal transducer and activator of transcription 3(p-STAT3)expression in cancer tissues and paracancerous tissues were detected by immunohistochemistry.A mouse intestinal inflammatory tumor model was established by azomethane/sodium dextran sulfate,followed by treatment with EVO and 5-aminosalicylic acid(ASA).Gut microbiota and inflammatory factors were detected by quantitative polymerase chain reaction,while serum D-lactic acid and endotoxin were detected by ***,cell proliferation,cell apoptosis,and interleukin(IL)-6/STAT3/P65 pathway were evaluated by 5-ethynyl-20-deoxyuridine,terminal-deoxynucleotidyl transferase-mediated nick-end labeling,and Western blot ***:In patients with colon cancer,the numbers of Enterococcus faecalis and Escherichia coli were increased,while those of Bifidobacterium,Campylobacter and Lactobacillus were *** endotoxin and D-lactic acid levels and p-STAT3 levels were significantly *** the mouse model,both EVO and ASA inhibited tumor formation,decreased the proliferation of tumor cells,and induced apoptosis of tumor *** with the control group,the numbers of *** and *** were decreased,while Bifidobacterium,Campylobacter and Lactobacillus numbers were *** the EVO group,serum endotoxin and D-lactic acid levels and inflammatory factors were signifi

关键词： Evodiamine Gut microbiota Colitis-associated cancer Signal transducer and activator of transcription 3

Human immunodeficiency virus patients with low CD4 counts are more likely to have precancerous polyps identified during index colonoscopy

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World Journal of Gastrointestinal Endoscopy 2023年第9期15卷 545-552页

作者： Michelle Likhtshteyn Evan Marzouk Fray M Arroyo-Mercado Gurasees Chawla Sabrina Rosengarten Renata Lerer Hector Ojeda-Martinez Savanna Thor Department of Gastroenterology SUNY Downstate Health Sciences UniversityBrooklynNY 11203United States Department of Internal Medicine and Pediatrics Baystate Medical CenterSpringfieldIL 01199United States Department of Gastroenterology University of New MexicoAlbuquerqueNM 87106United States Department of Emergency Medicine New York-Presbyterian Queens HospitalQueensNY 11355United States Department of Gastroenterology University of PennsylvaniaPhiladelphiaPA 19104United States Department of Infectious Disease Nuvance Health-Vassar Brothers Medical CenterPoughkeepsieNY 12601United States

BACKGROUND Antiretroviral treatment(ART)has improved the life expectancy of patients living with human immunodeficiency virus(HIV).As these patients age,they are at increased risk for developing non-acquired immunodeficiency syndrome defining malignancies(NADMs)such as colon *** To determine which factors are associated with the development of precancerous polyps on screening colonoscopy in patients with HIV and to investigate whether HIV disease status,measured by viral load and CD4 count,might influence precancerous polyp *** A retrospective review of records at two urban academic medical centers was performed for HIV patients who had a screening colonoscopy between *** with a history of colorectal cancer or polyps,poor bowel preparation,or inflammatory bowel disease were *** data such as sex,age,race,and body mass index(BMI)as well as information regarding the HIV disease status such as CD4 count,viral load,and medication regimen were ***-controlled patients were defined as those that had viral load500(P=0.0276).In patients with CD4>500,53.85%of patients were female,and 70.87%of patients with CD

关键词： Colonoscopy Non-acquired immunodeficiency syndromes defining malignancies Human immunodeficiency virus Adenoma detection rate Antiretroviral treatment Advanced adenoma

Lactobacillus bulgaricus inhibits colitis-associated cancer via a negative regulation of intestinal inflammation in azoxymethane/dextran sodium sulfate model

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World Journal of Gastroenterology 2020年第43期26卷 6782-6794页

作者： Denise Sayuri Calheiros Silveira Luciana Chain Veronez Luis Carlos Lopes-Junior Elen Anatriello Mariangela Ottoboni Brunaldi Gabriela Pereira-da-Silva Department of Biochemistry and Immunology University of São Paulo at Ribeirão Preto Medical SchoolRibeirão Preto 14049-900SPBrazil Health Sciences center Federal University of Espírito Santo-UFESVitória 29043-900ESBrazil Institute of Science and Technology Federal University of São PauloUNIFESPSão Josédos Campos 12231-280SPBrazil Department of Pathology and Forensic Medicine University of São PauloRibeirao Preto 14040-902SPBrazil Department of Maternal-Infant Nursing and Public Health University of São Paulo at Ribeirão Preto College of NursingRibeirão Preto 14040-902SPBrazil

BACKGROUND Colitis-associated cancer(CAC)accounts for 2%-3%of colorectal cancer(CRC)cases preceded by inflammatory bowel diseases(IBD)such as Crohn's disease and ulcerative *** microbiota has been reported to play a central role in the pathogenesis of IBD and ***,numerous prebiotics and probiotics have being investigated as antitumor agents due to their capacity to modulate inflammatory *** studies have indicated that lactic acid bacteria could be successfully used in managing sporadic CRC,however little is known about their role in *** To investigate the effect of the probiotic Lactobacillus bulgaricus(***)during the development of an experimental model of colitis associated colon cancer(CAC).METHODS C57BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg),followed by three cycles of sodium dextran sulphate diluted in water(5%w/v).Probiotic group received daily *** inflammation was determined by scoring clinical *** levels were determined from colon and/or tumor samples by ELISA BD OptEIATM *** level of significance was set at Ptreatment inhibited of total tumor volume and mean size of *** addition,the probiotic also attenuated the clinical signs of intestinal inflammation inducing a decrease in intestinal and tumor levels of IL-6,TNF-α,IL-17,IL-23 and IL-1β.CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on *** regulates the inflammatory response and preventing CAC.

关键词： Lactobacillus bulgaricus Colitis-associated cancer colorectal cancer Carcinogenesis Probiotics Inflammation

CYP24A1 Involvement in inflammatory Factor Regulation Occurs via the Wnt Signaling Pathway

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Current Medical Science 2022年第5期42卷 1022-1032页

作者： Xue-qi CHEN Jia-yu MAO Chun-saier WANG Wen-bin LI Tao-tao HAN Ke LV Jing-nan LI Department of Medical Ultrasound Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical ScienceBeijing100730China Department of Critical Care Medicine Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical ScienceBeijing100730China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing100050China Department of Gastroenterology Beijing HospitalNational Center of GerontologyInstitute of Geriatrics MedicineChinese Academy of Medical SciencesBeijing100730China Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical Science Key Laboratory of Gut Microbiota Translational Medicine Research Chinese Academy of Medical ScienceBeijing100730China

Objective While the upregulation of cytochrome P450 family 24 subfamily A member 1(CYP24A1)gene expression has been reported in colon cancer,its role in tumorigenesis remains largely *** this study,we aimed to investigate the involvement of CYP24A1 in Wnt pathway regulation via the nuclear factor kappa B(NF-κB)*** The human colon cancer cell lines HCT-116 and Caco-2 were subjected to stimulation with interleukin-6(IL-6)as well as tumor necrosis factor alpha(TNF-α),with subsequent treatment using the NF-κB pathway-specific inhibitor ammonium pyrrolidinedithiocarbamate(PDTC).Furthermore,CYP24A1 expression was subjected to knockdown via the use of small interfering RNA(siRNA).Subsequently,NF-κB pathway activation was determined by an electrophoretic mobility shift assay,and the transcriptional activity ofβ-catenin was determined by a dual-luciferase reporter assay.A mouse ulcerative colitis(UC)-associated carcinogenesis model was established,wherein TNF-αand the NF-κB pathway were blocked by anti-TNF-αmonoclonal antibody and NF-κB antisense oligonucleotides,*** the tumor size and protein level of CYP24A1 were *** IL-6 and TNF-αupregulated CYP24A1 expression and activated the NF-κB pathway in colon cancer *** significantly inhibited this increase in CYP24A1 ***,knockdown of CYP24A1 expression by siRNA could partially antagonize Wnt pathway *** CYP24A1 expression was observed in the colonic epithelial cells of UC-associated carcinoma mouse ***-TNF-αmonoclonal antibody and NF-κB antisense oligonucleotides decreased the tumor size and suppressed CYP24A1 *** Taken together,this study suggests that inflammatory factors may increase CYP24A1 expression via NF-κB pathway activation,which in turn stimulates Wnt signaling.

关键词： CYP24A1 Wnt/β-catenin signaling pathway colorectal neoplasms

Inhibitory activity of medicinal mushroom Ganoderma lucidum on colorectal cancer by attenuating inflammation

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precision Clinical Medicine 2021年第4期4卷 231-245页

作者： Mandy M.Liu Tiantian Liu Steven Yeung Zhijun Wang Bradley Andresen Cyrus Parsa Robert Orlando Bingsen Zhou Wei Wu Xia Li Yilong Zhang Charles Wang Ying Huang Department of Pharmaceutical Sciences College of PharmacyWestern University of Health SciencesPomonaCA 91766USA center for Genomics&Department of Basic Sciences School of MedicineLoma Linda UniversityLoma LindaCA 92350USA Department of Pharmaceutical Sciences College of PharmacyMarshall B.Ketchum UniversityFullertonCA 92831USA College of Osteopathic Medicine of the Pacific Western University of Health SciencesPomonaCA 91766USA Department of Pathology Beverly HospitalMontebelloCaliforniaCA 90640USA Beijing Tong Ren Tang Chinese Medicine Co. Ltd.New TerritoriesHong Kong 999077China

The medicinal mushroom Ganoderma lucidum(GL,Reishi or Lingzhi)exhibits an inhibitory effect on ***,the underlying mechanism of the antitumor activity of GL is not fully *** this study,we characterized the gene networks regulated by a commercial product of GL containing a mixture of spores and fruiting bodies namely“GLSF”,in colorectal *** found that in vitro co-administration of GLSF extract at non-toxic concentrations significantly potentiated growth inhibition and apoptosis induced by paclitaxel in CT26 and HCT-15 *** inhibited NF-κB promoter activity in HEK-293 cells but did not affect the function of P-glycoprotein in K562/DOX ***,we found that when mice were fed a modified diet containing GLSF for 1 month prior to the CT26 tumor cell inoculation,GLSF alone or combined with Nab-paclitaxel markedly suppressed tumor growth and induced ***-seq analysis of tumor tissues derived from GLSF-treated mice identified 53 differentially expressed genes compared to normal *** of the GLSFdown-regulated geneswere involved in NF-κB-regulated inflammation pathways,such as IL-1β,IL-11 and *** enrichment analysis suggested that several inflammatory pathways involving leukocytemigration and adhesion were most affected by the *** analysis predicted activation of multiple tumor suppressors such asα-catenin and TP53 and inhibition of critical inflammatory mediators.“cancer”was the major significantly inhibited biological effect of GLSF *** results demonstrate that GLSF can improve the therapeutic outcome for colorectal cancer through a mechanism involving suppression of NF-κB-regulated inflammation and carcinogenesis.

关键词： Ganoderma lucidum colorectal carcinoma RNA-seq NF-κB inflammation

Protective effect of notoginsenoside and tanshinone IIA on inflammation-related colorectal cancer mice and the inhibition effect on COX-2 expression

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Digital Chinese Medicine 2021年第1期4卷 54-63页

作者： CAO Wen ZHOU Xiaoqing Graduate School Hunan University of Chinese MedicineChangshaHunan 410208China The Second Hospital of Hunan University of Chinese Medicine ChangshaHunan 410005China Hunan Traditional Chinese Medicine Key Diagnostic Laboratory Hunan University of Chinese MedicineChangshaHunan 410208China Digital Chinese Medicine Collaborative Innovation center Hunan University of Chinese MedicineChangshaHunan 410208China

Objective To explore the preventive effects and possible mechanisms of action of notoginsenoside(NGS)and tanshinone IIA(TSN)in inflammation-related colorectal cancer(IRCC)in *** Eighty-eight male C57BL/6 mice were randomly assigned to 11 groups(n=8 each group).Azomethane oxide+dextran sulfate(AOM+DSS)model control(model),NGS lowdose(l-NGS),NGS medium-dose(m-NGS),NGS high-dose(h-NGS),TSN low-dose(l-TSN),TSN medium-dose(m-TSN),TSN high-dose(h-TSN),(NGS+TSN)low-dose[l-(NGS+TSN)],(NGS+TSN)medium-dose[m-(NGS+TSN)],(NGS+TSN)high-dose[h-(NGS+TSN)],and blank groups were *** first 10 groups were intraperitoneally injected with AOM to induce inflammatory colon cancer,whereas the blank group was intraperitoneally injected with 0.9%NaCl *** first 10 groups drank a 2.5%sodium DSS aqueous solution continuously from day 5 for three cycles(one cycle:five days,every three weeks),and the blank group was allowed free access to *** groups were administered NGS(low,medium,or high dose),TSN(low,medium,or high dose),or NGS+TSN(low,medium,or high dose),and the model and blank groups were administered saline by lavage until the end of the *** general activity,body weight,and survival rate of and incidence of adenocarcinoma in mice were detected and the expression of cyclooxygenase 2(COX-2)was detected by ***(1)The survival rate of mice with IRCC in the h-NGS,m-TSN,h-TSN,m-(NGS+TSN),and h-(NGS+TSN)groups was significantly increased than that in other groups(Ptreatments in mice with IRCC,and h-(NGS+TSN)treatment inhibited the COX-2 pathway.

关键词： colorectal cancer Cyclooxygenase-2 (COX-2) Inflammation Notoginsenoside Tanshinone ⅡA

Combinatorial cell surface display system in Escherichia coli for noninvasive colorectal cancer detection

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Journal of Bio-X Research 2019年第4期2卷 185-196页

作者： Hsiao Chiayi Fang Qingwei Zheng Shuyu He Peixiang Zhang Kairan Hong Yirui Ran Yuncong Sun Shiyu Liu Zhixiang Liang Zhihan Zhong Bozitao Wu Weiwen Xia Ruoyu Bai Shihao Yao Kuan Wang Yushu He Lin Ma Gang Bio-X-Renji Hospital Research center Renji HospitalSchool of MedicineShanghaiChina Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education)ShanghaiChina 2018 SJTU-BioX-Shanghai Team for The International Genetically Engineered Machine Competition(iGEM) Shanghai Jiao Tong UniversityShanghaiChina Shanghai Jiao Tong University School of MedicineShanghaiChina

Navigation and recognition of disease lesions remain challenging during colorectal cancer diagnosis and treatment,given that the precision and capacity of using specific surface antigens as recognition sites are relatively ***,the low penetration rate of noninvasive detection methods has delayed disease diagnosis in developing *** developed a bacterial device targeting the Thomsen-Friedenreich antigen,which is abundant on lesion tissue,and produced vesicles that serve as markers for ultrasonic *** device uses a bacterial cell surface display system and acoustic reporter gene to function as a screening device for colorectal cancer *** diagnostic efficiency of this device was determined by flow cytometry,immunohistochemistry,microfluidic chip-based assay,and ultrasonic examinations on both cellular and tissue *** all scales and experiments,our device showed great feasibility upon differentiating disease lesion and normal tissue,while foundation of the usage of vesicle reporter system as noninvasive method has also been *** application of this device provides insight into the practicability and prospect of bacterial detecting agents in the field of *** animal studies were approved by the Institutional Animal Care and Use Committee of Shanghai Jiao Tong University,China(approval No.201801015)on February 23,2018.

关键词： colorectal cancer cell-surface display ice nucleation protein ultrasonic detection

Complete response in anaplastic lymphoma kinase–rearranged oncocytic thyroid cancer:A case report and review of literature

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World Journal of Clinical Oncology 2020年第7期11卷 495-503页

作者： Victoire de Salins Gokoulakrichenane Loganadane Charlotte Joly Mukedaisi Abulizi Maya Nourieh Hélène Boussion Yazid Belkacemi Christophe Tournigand Emmanuelle Kempf Department of Medical Oncology Henri Mondor et Albert Chenevier Teaching HospitalAssistance Publique–Hôpitaux de ParisUniversity of Paris-Est CreteilCréteil 94010France Department of Radiation Oncology and Breast center Henri Mondor University HospitalAssistance Publique–Hôpitaux de ParisUniversity of Paris-Est Creteil and IMRB-INSERM 955 Team 21Creteil 94010France Department of Nuclear Medicine Henri Mondor et Albert Chenevier Teaching HospitalAssistance Publique–Hôpitaux de ParisUniversity of Paris-Est CreteilCréteil 94010France Department of Pathology Henri Mondor et Albert Chenevier Teaching HospitalAssistance Publique–Hôpitaux de ParisUniversity of Paris-Est CreteilCréteil 94010France

BACKGROUND Oncocytic carcinoma of the thyroid is a rare disease,characterized by a poor prognosis and low response rate to radioiodine *** is a specific anaplastic lymphoma kinase(ALK)inhibitor,which was initially developed in non-small cell lung *** solid tumors harboring a translocation in ALK have been described,such as renal carcinoma,thyroid,colorectal,ovarian cancers,and spitzoid *** research of ALK rearrangements in thyroid tumor is a promising therapeutic track,and treatments need to be *** SUMMARY We report the case of a 76-year-old woman with a history of multinodular goiter,who was hospitalized for impairment of her general *** was diagnosed with metastatic oncocytic thyroid *** metastases were found:Multiple mediastinal lymphadenopathies,lytic bone lesions and bilateral mammary *** in situ hybridization analysis revealed an ALK rearrangement in 61%of *** other mutation was found.A tumor board discussion based on molecular characteristics of the tumor suggested initiating a daily treatment by crizotinib,a specific ALK inhibitor.A positron emission tomography scan performed 4 mo after the initiation of crizotinib showed a complete metabolic *** This case highlights an unexpected efficacy of crizotinib in an ALK-rearranged thyroid tumor,and the need of further assessments.

关键词： Oncocytic tumors of the thyroid Hürthle cell tumors Crizotinib precision Medicine Case report