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Commentary:Mammokine directs beige adipocytes to reserve energy for milk production in breast

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1472-1476页

作者： Lina Tang Jianping Ye metabolic disease Research center Zhengzhou University Affiliated Zhengzhou Central HospitalZhengzhou 450007China Research center for Basic Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhou 450052China

Beige/brown adipocytes play a crucial role in regulating the body’s overall energy *** thermogenic function is under the influence of various tissues,including the brain,muscles,and ***,the breast tissue is not in th... 详细信息

关键词： Beige Breast Epitheliail cells scRNA-seq Thermogenesis

β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture

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bone Research 2024年第2期12卷 302-313页

作者： Jie Huang Tong Wu Yi-Rong Jiang Xuan-Qi Zheng Huan Wang Hao Liu Hong Wang Hui-Jie Leng Dong-Wei Fan Wan-Qiong Yuan Chun-Li Song Department of Orthopedics Peking University Third Hospital100191 BeijingChina Beijing Key Laboratory of Spinal disease 100191 BeijingChina Engineering Research center of bone and Joint Precision Medicine 100191 BeijingChina

The autonomic nervous system plays a crucial role in regulating bone metabolism,with sympathetic activation stimulating bone resorption and inhibiting bone *** found that fractures lead to increased sympathetic tone,enhanced osteoclast resorption,decreased osteoblast formation,and thus hastened systemic bone loss in ovariectomized(OVX)***,the combined administration of parathyroid hormone(PTH)and theβ-receptor blocker propranolol dramatically promoted systemic bone formation and osteoporotic fracture healing in OVX *** effect of this treatment is superior to that of treatment with PTH or propranolol *** vitro,the sympathetic neurotransmitter norepinephrine(NE)suppressed PTH-induced osteoblast differentiation and mineralization,which was rescued by ***,NE decreased the PTH-induced expression of Runx2 but enhanced the expression of Rankl and the effect of PTH-stimulated osteoblasts on osteoclastic differentiation,whereas these effects were reversed by ***,PTH increased the expression of the circadian clock gene Bmal1,which was inhibited by NE-βAR ***1 knockdown blocked the rescue effect of propranolol on the NE-induced decrease in PTHstimulated osteoblast *** together,these results suggest that propranolol enhances the anabolic effect of PTH in preventing systemic bone loss following osteoporotic fracture by blocking the negative effects of sympathetic signaling on PTH anabolism.

关键词： blocker metabolism inhibited

A comprehensive index to evaluate cognitive health at the population scale

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中华医学杂志(英文版) 2024年第18期137卷 2024 Aug 9页

作者： Lu Yuanyuan Mao Fan Yin Peng Chang Jie Zhao Zhenping Yang Kun Qin Qi Zhou Maigeng Tang Yi Department of Neurology and Innovation center for Neurological Disorders Xuanwu Hospital Capital Medical University National Center for Neurological Disorders Beijing China Department on Obesity and metabolic diseases Control and Prevention National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China Department on Vital Registry and Mortality Surveillance National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China National center for Neurological Disorders Xuanwu Hospital Capital Medical University Beijing China Department on Risk Factors Surveillance National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China National center for Chronic and Non-communicable disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China

Commentary:The central lymphatic drainage in pharmacological,surgical and physical therapies of Alzheimer’s disease

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3291-3293页

作者： Lixuan Ren Jianping Ye metabolic disease Research center Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhou 450000China Tianjian Laboratory of Advanced Biomedical Sciences Academy of Medical SciencesZhengzhou UniversityZhengzhou 450001China

Alzheimer’s disease(AD)is a prevalent neurodegenerative disease in the aged *** of AD remains largely unknown and no effective drugs are available in clinical settings to reverse or delay the disease *** recent years,the brain’s lymphatic systems,including glymphatic3 that exists in the brain interstitial space and meningeal lymphatic vessels4 that presents within the dural sinuses,have been found to play an important role in the AD pathogenesis.

关键词： Ab Central lymphatic drainage Surgery NPLP AD

Hepatocellular carcinoma and musculoskeletal system: A narrative literature review

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World Journal of Gastroenterology 2024年第15期30卷 2109-2117页

作者： Jelena Jadzic Danijela Djonic center of bone Biology Faculty of MedicineUniversity of BelgradeBelgrade 11000Serbia

Musculoskeletal alterations in hepatocellular carcinoma(HCC)are less common than liver-related ***,they can significantly impact the quality of life and overall prognosis of patients with *** main obstacle in the clinical assessment of HCC-induced musculoskeletal alterations is related to effective and timely diagnosis because these complications are often asym-ptomatic and unapparent during routine clinical *** narrative literature review aimed to provide a comprehensive overview of the contem-porary literature related to the changes in the musculoskeletal system in patients with HCC,focusing on its clinical implications and underlying etiopathogenetic *** bone metastases are the most common skeletal alterations associated with HCC,which could be associated with an increased risk of low-trauma bone ***,previous studies reported that osteopenia,sarcopenia,and myosteatosis are associated with poor clinical outcomes in patients with *** though low bone mineral density and sarcopenia are consistently reported as reliable predictors of pretransplantation and post-transplantation mortality in HCC patients,these complications are frequently overlooked in the clinical management of patients with *** together,contemporary literature suggests that a multidisciplinary approach is essential for early recognition and clinical management of HCC-associated musculoskeletal alterations to improve patient *** research into the mechanisms and treatment options for musculoskeletal complications is warranted to enhance our understanding and clinical management of this aspect of HCC.

关键词： Hepatocellular carcinoma Osteopenia Osteoporosis Sarcopenia bone metastases bone fragility

Early-life famine exposure,adulthood obesity patterns,and risk of low-energy fracture

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Frontiers of Medicine 2024年第1期18卷 192-203页

作者： Hongyan Qi Chunyan Hu Jie Zhang Lin Lin Shuangyuan Wang Hong Lin Xiaojing Jia Yuanyue Zhu Yi Zhang Xueyan Wu Mian Li Min Xu Yu Xu Tiange Wang Zhiyun Zhao Weiqing Wang Yufang Bi Meng Dai Yuhong Chen Jieli Lu Department of Endocrine and metabolic diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai National Clinical Research center for Endocrine and metabolic diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the People’s Republic of ChinaShanghai National Center for Translational MedicineRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China

Malnutrition in early life increases the risk of osteoporosis,but the association of early-life undernutrition combined with adulthood obesity patterns with low-energy fracture remains *** study included 5323 community-dwelling subjects aged⩾40 years from ***-life famine exposure was identified based on the participants’birth *** obesity was assessed using the body mass index(BMI),and abdominal obesity was evaluated with the waist-to-hip ratio(WHR).Low-energy fracture was defined as fracture occurring after the age of⩾40 typically caused by falls from standing height or *** to the nonexposed group,the group with fetal,childhood,and adolescence famine exposure was associated with an increased risk of fracture in women with odds ratios(ORs)and 95%confidence intervals(CIs)of 3.55(1.57–8.05),3.90(1.57–9.71),and 3.53(1.05–11.88),respectively,but not in *** interactions were observed between fetal famine exposure and general obesity with fracture among women(P for interaction=0.0008).Furthermore,compared with the groups with normal BMI and WHR,the group of women who underwent fetal famine exposure and had both general and abdominal obesity had the highest risk of fracture(OR,95%CI:3.32,1.17–9.40).These results indicate that early-life famine exposure interacts with adulthood general obesity and significantly increases the risk of low-energy fracture later in life in women.

关键词： famine obesity body mass index waist-to-hip ratio low-energy fracture

Gut microbial-host-isozymes are new targets for diseases

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Science China(Life Sciences) 2024年第7期67卷 1525-1527页

作者： Zhiwei Zhang Kai Wang Changtao Jiang Department of Physiology and Pathophysiology School of Basic Medical SciencesState Key Laboratory of Female Fertility PromotionCenter for Reproductive MedicinePeking UniversityBeijing 100191China center for Obesity and metabolic disease Research School of Basic Medical SciencesState Key Laboratory of Vascular Homeostasis and RemodelingPeking UniversityBeijing 100191China

Gut microbiota can interact with the host through lots of media including small molecular metabolites and proteins(Cani,2019;Fan and Pedersen,2021;Krautkramer et al.,2021).Recently,a new interaction pattern was identified,i.e.,gut microbiota can mimic the function of the host by producing a variety of enzymes with functions homologous to host enzymes.

关键词： diseases pattern

Mechanism of action of the bile acid receptor TGR5 in obesity

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Acta Pharmaceutica Sinica B 2024年第2期14卷 468-491页

作者： Weijun Lun Qihao Yan Xinghua Guo Minchuan Zhou Yan Bai Jincan He Hua Cao Qishi Che Jiao Guo Zhengquan Su Guangdong Engineering Research center of Natural Products and New Drugs Guangdong Provincial University Engineering Technology Research Center of Natural Products and DrugsGuangdong Pharmaceutical UniversityGuangzhou 510006China Guangdong metabolic disease Research center of Integrated Chinese and Western Medicine Key Laboratory of Glucolipid Metabolic DisorderMinistry of Education of ChinaGuangdong TCM Key Laboratory for Metabolic DiseasesGuangdong Pharmaceutical UniversityGuangzhou 510006China School of Public Health Guangdong Pharmaceutical UniversityGuangzhou 510310China School of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityZhongshan 528458China Guangzhou Rainhome Pharm&Tech Co. Ltd.Science CityGuangzhou 510663China

G protein-coupled receptors(GPCRs)are a large family of membrane protein receptors,and Takeda G protein-coupled receptor 5(TGR5)is a member of this *** a membrane receptor,TGR5 is widely distributed in different parts of the human body and plays a vital role in regulating metabolism,including the processes of energy consumption,weight loss and blood glucose *** studies have shown that TGR5 plays an important role in glucose and lipid metabolism disorders such as fatty liver,obesity and *** the global obesity situation becoming more and more serious,a comprehensive explanation of the mechanism of TGR5 and filling the gaps in knowledge concerning clinical ligand drugs are urgently *** this review,we mainly explain the anti-obesity mechanism of TGR5 to promote the further study of this target,and show the electron microscope structure of TGR5 and review recent studies on TGR5 ligands to illustrate the specific binding between TGR5 receptor binding sites and ligands,which can effectively provide new ideas for ligand research and promote drug research.

关键词： Obesity TGR5 Bile acids Ligand Appetite Metabolism GLP-1 Inflammation

Insufficient Physical Activity among Students Aged 6-17 Years in China,2016-2017

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Biomedical and Environmental Sciences 2024年第5期37卷 531-536页

作者： XUE Tao Tao GAO Xing Xing WANG Li Min ZHANG Xiao ZHAO Zhen Ping LI Chun NYASHA Grace Mudoti LIU Chen Yi ZHANG Mei Division of Chronic disease and Risk Factor Surveillance National Center for Chronic and Non-communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 100050China International Education School China Medical UniversityShenyang 110122LiaoningChina

Regular physical activity of sufficient duration and intensity can provide health benefits such as improved physical fitness,which promotes bone health,prevents hypertension,improves mental health,and reduces adiposit... 详细信息

关键词： hypertension Regular benefits