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Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural Regeneration research 2025年第1期20卷 67-81页

作者： Yubo Wang Tingli Yuan Tianjie Lyu Ling Zhang Meng Wang Zhiying He Yongjun Wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical research center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering research center of Stem Cells Translational Medicine ShanghaiChina National center for healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain research BeijingChina research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering research center of Digital healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

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A Comprehensive Survey on Federated Learning Applications in Computational Mental healthcare

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 49-90页

作者： Vajratiya Vajrobol Geetika Jain Saxena Amit Pundir Sanjeev Singh Akshat Gaurav Savi Bansal Razaz Waheeb Attar Mosiur Rahman Brij B.Gupta Institute of Informatics and Communication University of DelhiDelhi110021India Maharaja Agrasen College University of DelhiDelhi110096India Computer Engineering Ronin InstituteMontclairNJ 07043USA Department of research and innovation Insights2TechinfoJaipur302001India University Centre for research and Development(UCRD) Chandigarh UniversityChandigarh140413India Management Department College of Business AdministrationPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia CCRI&Department of Computer Science and Information Engineering Asia UniversityTaichung413Taiwan Symbiosis Centre for Information Technology(SCIT) Symbiosis International UniversityPune411057India center for Interdisciplinary research University of Petroleum and Energy Studies(UPES)Dehradun248007India

Mental health is a significant issue worldwide,and the utilization of technology to assist mental health has seen a growing *** aims to alleviate the workload on healthcare professionals and aid *** applications have been developed to support the challenges in intelligent healthcare ***,because mental health data is sensitive,privacy concerns have *** learning has gotten some *** research reviews the studies on federated learning and mental health related to solving the issue of intelligent healthcare *** explores various dimensions of federated learning in mental health,such as datasets(their types and sources),applications categorized based on mental health symptoms,federated mental health frameworks,federated machine learning,federated deep learning,and the benefits of federated learning in mental health *** research conducts surveys to evaluate the current state of mental health applications,mainly focusing on the role of Federated Learning(FL)and related privacy and data security *** survey provides valuable insights into how these applications are emerging and evolving,specifically emphasizing FL’s impact.

关键词： Depression emotional recognition intelligent healthcare systems mental health federated learning stress detection sleep behaviour

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Regional rural transformation and its association with household income and poverty incidence in Indonesia in the last two decades

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Journal of Integrative Agriculture 2023年第12期22卷 3596-3609页

作者： Tahlim SUDARYANTO ERWIDODO Saktyanu Kristyantoadi DERMOREDJO Helena Juliani PURBA Rika Reviza RACHMAWATI Aldho Riski IRAWAN research center for Behavioral and Circular Economics National Research and Innovation Agency(BRIN)Jakarta 12710Indonesia research center for Economics of Industry Services and TradeNational Research and Innovation Agency(BRIN)Jakarta 12710Indonesia Indonesian center for Agriculture Socio-Economic and policy Studies Bogor 16111Indonesia

Increasing rural household income and reducing poverty rank among Indonesia’s top development *** rural transformation is one strategic policy framework to achieve these *** the last three decades,agricultural production has shifted from low-value food crops to high-value commodities,such as horticulture,estate crops,and *** studies have analyzed rural transformation in Indonesia at the national level,but information on the magnitudes of impact across regions remains *** study aims to analyze the changes in rural transformation at a regional level in the past two *** research utilizes secondary data from Statistics Indonesia(BPS),covering 34 provinces from 2000 to 2020,analyzed using descriptive and panel data regression *** results show an increasing trend in the share of high-value agriculture(RT_(1))and rural non-farm employment(RT_(2)).Both RT_(1)and RT_(2)are positively associated with the growth of rural household income and a lower poverty ***,the speed of structural transformation(ST),RT_(1),RT_(2),rural income growth,and poverty reduction vary across *** research implies that improving rural income and reducing poverty should be done by integrating policies,i.e.,promoting highvalue agriculture and expanding rural non-farm *** attention should also be given to provinces with slow growth in ST,RT_(1),RT_(2),and rural household income.

关键词： rural transformation high-value agriculture rural non-farm employment

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Constitutionally adaptive crown ether-based macrocyclic bolaamphiphile with redox-responsive switching of lower critical solution temperature behaviors

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Chinese Chemical Letters 2021年第12期32卷 4024-4028页

作者： Qiangqiang Xu Zhiliyu Cui Jizhen Yao Bo Li Ping Lv Xin Shen Zhuo Yu Yan Ge Zhenhui Qi Sino-German Joint research Lab for Space Biomaterials and Translational Technology Synergetic Innovation Center of Biological Optoelectronics and Healthcare Engineering(BOHE)Xi'an 710072China

Constitutionally adaptive chemistry of selenium-containing crown ethers(CEs) offers a new platform for controlling/switching the hydration of bolaamphiphile skeletons in water in an effective and simple manner by the virtue of covalent bonding. The adaptive behaviour of the macrocyclic bolaamphiphiles(transformations between C7SeBola and C7SeOBola) in response to redox environment was found to be a decisive factor.

关键词： Macrocycle Crown ether Bola Amphiphiles Selenium

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Climate pledges versus commitment: Are policy actions of Middle-East and North African countries consistent with their emissions targets?

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Advances in Climate Change research 2022年第4期13卷 612-621页

作者： Hermas ABUDU Presley K.WESSEH Jr Boqiang LIN School of Management China Institute for Studies in Energy PolicyCollaborative Innovation Center for Energy Economics and Energy PolicyXiamen UniversityFujian361005China Belt and Road research Institute Xiamen UniversityFujian361005China

Carbon emission is inevitable,and changes with energy consumption and economic development,presents policy options toward sustainable development ***,there is little assurance from policymakers in committing to climate change pledges:taking the Middle-East and North African(MENA)region as a specific case with using 2019 as a cut-off *** conducted an interim assessment of the Paris Agreement to ascertain whether climate actions are in tandem with emissions reduction *** use of difference-in-difference technique as a quasiexperiment supported by fixed-effects and placebo treatment models,the results point to evidence of less than 1%effective CO_(2) emissions reduction as of 2019 compared to the 2015 *** current carbon emissions reduction commitment level is far-reaching contrary to the Nationally Determined Contributions(NDCs)pledged(16.43%on average by 2030 compared to the 2015 level).The analysis suggests that achieving NDCs commitments are currently major burden on policymakers since the economic development is highly linked with nonrenewable energy ***,a more comprehensive framework when accounting for all available renewable and clean energy projects shows reduction levels in the range of 30%-40%from 2020 to *** results suggest that the Paris Agreement in MENA countries may be more effective from 2020,thus underscore the importance of capturing ongoing projects(involving renewable and clean energy technologies)into interim policy *** shared implication is that greater efforts are demanded from the region and at country levels to further decrease emissions through the use of negative emissions technologies particularly in the electricity generation sector.

关键词： Paris Agreement Carbon emissions reduction potential Carbon effciency:Climate change policy quasi-experiment MENA climate change performance

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Oral manifestation in inflammatory bowel disease:A review

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World Journal of Gastroenterology 2013年第46期19卷 8571-8579页

作者： Kamran B Lankarani Gholam Reza Sivandzadeh Shima Hassanpour Department of Internal Medicine Healthcare Policy Research Center Shiraz University of Medical Sciences Department of Internal Medicine Gastroenterohepatology Research Center Namazi Hospital Shiraz University of Medical Sciences Gastroenterohepatology research center Namazi Hospital Shiraz University of Medical Sciences

Inflammatory bowel diseases (IBDs), including Crohn’s disease (CD) and ulcerative colitis, not only affect the intestinal tract but also have an extraintestinal involvement within the oral cavity. These oral manifestations may assist in the diagnosis and the monitoring of disease activity, whilst ignoring them may lead to an inaccurate diagnosis and useless and expensive workups. Indurated tag-like lesions, cobblestoning, and mucogingivitis are the most common specific oral findings encountered in CD cases. Aphthous stomatitis and pyostomatitis vegetans are among non-specific oral manifestations of IBD. In differential diagnosis, side effects of drugs, infections, nutritional deficiencies, and other inflammatory conditions should also be considered. Treatment usually involves managing the underlying intestinal disease. In severe cases with local symptoms, topical and/or systemic steroids and immunosuppressive drugs might be used.

关键词： Inflammatory bowel disease, Crohn’ s disease, Ulcerative colitis, Extra-intestinal manifestations, Pyostomatitis vegetans, Aphthous stomatitis, Cobblestoning, Mucogingivitis, Oral manifestation

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The Pattern of policy Change on Disaster Management in China:A Bibliometric Analysis of policy Documents, 1949–2016

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International Journal of Disaster Risk Science 2018年第1期9卷 55-73页

作者： Qiang Zhang Qibin Lu Deping Zhong Xuanting Ye School of Social Development and Public policy Beijing Normal University innovation center for Risk Resilience Beijing Normal University center for Crisis Management research Tsinghua University School of Management and Economics Beijing Institute of Technology

This article presents a comprehensive review of China's policy system for the management of natural hazard-induced disasters from 1949 to 2016 through a quantitative bibliometric analysis of 5472 policy documents on such disasters. It identifies four phases of China's evolving disaster management system, which focused on agriculture, economic development, government and professional capacity building, and disaster governance,respectively. Characteristics of policies and contributing factors of policy change in each of the four phases are discussed in depth. This article provides a quantitative foundation for understanding the dynamic policy change of the disaster management system in China with a particular emphasis on the governance capacity and may serve as a basis for exploring the potential pathways of transformation according to the Sendai Framework for Disaster Risk Reduction 2015–2030 and the Sustainable Development Goals.

关键词： Bibliometric analysis China Disaster governance Disaster management policy change policy document

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Atom-economic macrocyclic amphiphile based on guanidinium-functionalized selenacrown ether acting as redox-responsive nanozyme

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Chinese Chemical Letters 2023年第4期34卷 266-270页

作者： Bo Li Qiangqiang Xu Xin Shen Tiezheng Pan Jie Shang Yan Ge Zhenhui Qi Sino-German Joint research Lab for Space Biomaterials and Translational Technology Synergetic Innovation Center of Biological Optoelectronics and Healthcare Engineering(BOHE)Shaanxi Provincial Synergistic Innovation Center for Flexible Electronics&Health Sciences(FEHS)School of Life SciencesNorthwestern Polytechnical UniversityXi’an 710072China

Control of self-assembly is significant to the preparation of supramolecular materials, but the control of hydration, responsiveness, dimension, catalysis of macrocyclic amphiphiles in an atom-economic manner is still a great challenge. The herein presented 527 Da low-molecular-weight macrocyclic amphiphile was fabricated by utilizing the selenium-containing crown ether as a hydrophobic motif together with guanidinium group as the hydrophilic moiety. The resulting benzo[21]crown-7 based macrocyclic amphiphile readily forms a redox-responsive solid nanoparticles in water, which can further interconnect into wrinkled pattern on-surface, as well as exhibits as a nanozyme for catalyzing disulfid bond formation. The present work highlights the great potential of guanidinium-and selenium-containing crown ethers for the control of functional assemblies.

关键词： Selenium Guanidinium Macrocycle amphiphile Crown ether Molecular assembly Winkled surface Nanozyme

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Social network structures among the livestock farmers vis a vis calcium supplement technology

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Information Processing in Agriculture 2019年第1期6卷 170-182页

作者： Sreeram Vishnu Jancy Gupta S.P.Subash center for research on innovation and Science policy(CRISP) Road number 10Banjara HillsHyderabadTelengana PIN:500034India Division of Dairy Extension ICAR-National Dairy Research InstituteKarnalHaryanaIndia ICAR-National Institute of Agricultural Economics and policy research New DelhiIndia

This study aims to delineate and analyze the configuration of social networks of farmers with respect to the acquisition of information on vital livestock *** stage sampling was carried out by interviewing 320 technology-adopter farmers from four districts of Kerala State in *** mapping the network,social network analysis(SNA)was used,which revealed the important sources as well as patterns of information access by *** established the predominance of a formal communication source(veterinary doctor)in the study locales followed by small-sized peer groups of livestock farmers for crucial information support on technology *** trend is observed irrespective of their gender in various study *** the study thus,underscored the role of homogenous peer groups of farmers in facilitating meaningful interactions as well as information sharing on the *** the low level of adoption of most livestock technologies along with the weak livestock extension machinery in the country,these findings could be used by extension agencies to strategize future technological interventions.

关键词： Social network analysis Communication Joint liability group Knowledge Extension Dairying

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The dynamic covalent reaction based on diselenide-containing crown ether irradiated by visible light

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Chinese Chemical Letters 2021年第6期32卷 2005-2008页

作者： Jie Shang Hanlin Gong Qian Zhang Zhiliyu Cui Shuangran Li Ping Lv Tiezheng Pan Yan Ge Zhenhui Qi Sino-German Joint research Lab for Space Biomaterials and Translational Technology Synergetic Innovation Center of Biological Optoelectronics and Healthcare Engineering(BOHE)Shaanxi Provincial Synergistic Innovation Center for Flexible Electronics&Health Sciences(FEHS)School of Life SciencesNorthwestern Polytechnical UniversityXi'an 710072China

A novel diselenide-containing crown ether(BC7Se_(2))was fabricated,which can polymerize to form cyclic oligomers through intermolecular dynamic covalent reaction by irradiation of visible *** size and distribution of oligomers are related to the monomer *** decomposition reaction of oligomers is controlled by topology and ***,potassium cation can inhibit the polymerization of BC7Se_(2)and accelerate the decomposition of oligomers.

关键词： Dynamic covalent Crown ether Metathesis reaction Visible light Diselenide bond

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