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世界核心医学期刊文摘（皮肤病学分册） 2006年第12期2卷 5-页

作者： Kleinpenning M.M. Smits T. Ewalds E. 党倩丽 Department of Dermatology Radboud University Nijmegen Medical Center Rene Descartesdreef 1 6525 GL Nijmegen Netherlands

Background: Psoriasis has been shown to highly accumulate protoporphyrin IX (PpIX), but a variable distribution within plaques after fluorescence diagnosis is seen. It is unknown what causes this heterogeneity of fluorescence in psoriatic skin, despite adequate keratolytic treatment. Variations in fluorescence might explain the variable and the mostly partial clinical response of psoriasis seen after photodynamic therapy (PDT).Objectives: This study examines morphological and immunohistochemical differences in inhomogeneous PpIX-induced fluorescence in stable plaque psoriasis. Materials and methods: Fourteen patients with stable plaque psoriasis were included in this study. In each patient one psoriatic plaque was incubated with 20%5-aminolaevulinic acid (ALA) ointment for 3 h after keratolytic treatment. Fluorescence diagnosis with ALA induced porphyrins (FDAP) was performed and subsequently high-and low-fluorescent psoriatic skin samples were biopsied. Biopsies were investigated with respect to histologicalhyperkeratosis (thickness of stratum corneum), proliferation (Ki-67 antigen), keratinization (K10, filaggrin) and inflammation (CD3). Digital images acquired with FDAP were analysed using image analysis software. Results: Inhomogeneous fluorescence was seen in 12 of the 14 plaques. A significantly thicker stratum corneum was found in low-fluorescent psoriatic skin compared with highly fluorescent skin. Fluorescence intensity and thickness of the stratum corneum proved to be negatively correlated. The variable-fluorescent parts of the lesional psoriatic skin showed no differences in epidermal proliferation, keratinization or inflammation. Conclusions: Heterogeneous ALA-induced fluorescence in psoriasis plaques related to inhomogeneous distribution of PpIX in the epidermis may result from differences in penetration of ALA and/or light within a plaque caused by differences in stratum corneum thickness. The variable clinical response seen after PDT in psoriasis coul

关键词：银屑病皮损白疮免疫组化荧光量异质性患者氨基乙酰丙酸

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Principles of diagnosis and treatment of Patients with diagnosis of Covid-19 and Developing Viral Pneumonia

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Journal of Pharmacy and Pharmacology 2021年第7期9卷 239-244页

作者： Kamala Namazova Hasanov Hafiz Hasanov Fuad Muradov Nizami Guliev Rashad Abasova Machruch Karimov Qeys Asgerov Gunel Mamedova Gunel Shirinova Lala Scientific Surgery center named after Acad.M.A.Topchubashov Baku AZ1000Azerbaijan Mediclub Hospital Baku AZ1000Azerbaijan Baku State University Faculty of BiologyBaku AZ1000Azerbaijan

The article provides information on our achievements in the application of modern diagnostic methods and modern methods of treating patients with viral pneumonia,confirmed by *** this,statistical data of 2,000 patients were *** the 2,000 patients treated,920 were men,1,070 were women and 10 were *** pneumonia-glaucoma syndrome in 1650 out of 2,000 patients with 10-20%damage;In 350,the diagnosis of viral pneumonia-frostbite syndrome with 50-85%damage,CRDS,respiratory failure was ***,50 out of 350 patients treated at the intensive care unit(ICU)out of 2,000 were intubated and connected to artificial *** research was carried out in 3 stages:I stage-admission to the intensive care unit;II stage-from the day of intubation to spontaneous breathing(7-14 days);and III stage-covers the period of extubation and *** results of clinical,functional,hemodynamic and echocardiographic studies of the patients participating in the examination were ***,the patients underwent bacteriological research studied the sensitivity to *** addition,the composition of blood gases and the oxygenation index-Carrico were studied.

关键词： Covid-19 acute respiratory distress syndrome total pnevmonia acute respiratory failure oxygenation index.

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diagnosis and treatment of iron-deficiency anemia in gastrointestinal bleeding:A systematic review

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World Journal of Gastroenterology 2020年第45期26卷 7242-7257页

作者： Jose Cotter Cilenia Baldaia Manuela Ferreira Guilherme Macedo Isabel Pedroto Department of Gastroenterology Hospital da Senhora da Oliveira-GuimarãesGuimarães 4835-044Portugal Department of Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoBraga 4710-057Portugal Department of Life and Health Sciences Research Institute(ICVS)/3B’s PT Government Associate LaboratoryBraga 4710-057Portugal Department of Gastroenterology Hospital de Santa MariaCentro Hospitalar Lisboa NorteLisbon 1649-035Portugal Department of University Clinic of Medicine II Faculty of MedicineUniversity of LisbonLisbon 1649-028Portugal Department of Gastroenterology Centro Hospitalar e Universitário de CoimbraCoimbra 3000-075Portugal Department of Faculty of Medicine University of CoimbraCoimbra 3004-504Portugal Department of Gastroenterology Centro Hospitalar de São JoãoPorto 4200-319Portugal Department of Gastroenterology Faculty of MedicineUniversity of PortoPorto 4200-319Portugal Department of Gastroenterology and Hepatology Training center World Gastroenterology OrganizationPorto 4200-319Portugal Department of Gastroenterology Centro Hospitalar do PortoPorto 4099-001Portugal Department of Institute of Biomedical Sciences Abel Salazar University of PortoPorto 4050-313Portugal

BACKGROUND Anemia is considered a public health issue and is often caused by iron ***-deficiency anemia(IDA)often originates from blood loss from lesions in the gastrointestinal tract in men and postmenopausal women,and its prevalence among patients with gastrointestinal bleeding has been estimated to be 61%.However,few guidelines regarding the appropriate investigation of patients with IDA due to gastrointestinal bleeding have been *** To review current evidence and guidelines concerning IDA management in gastrointestinal bleeding patients to develop recommendations for its diagnosis and *** Five gastroenterology experts formed the Digestive Bleeding and Anemia Workgroup and conducted a systematic literature search in PubMed and professional association ***(via PubMed)searches combined medical subject headings(MeSH)terms and the keywords“gastrointestinal bleeding”with“iron-deficiency anemia”and“diagnosis”or“treatment”or“management”or“prognosis”or“prevalence”or“safety”or“iron”or“transfusion”or“quality of life”,or other terms to identify relevant articles reporting the management of IDA in patients over the age of 18 years with gastrointestinal bleeding;retrieved studies were published in English between January 2003 and April *** professional association websites were searched for clinical practice *** lists from guidelines were reviewed to identify additional relevant *** recommendations were developed by consensus during two meetings and were supported by the published literature identified during the systematic *** From 494 Literature citations found during the initial literature search,17 original articles,one meta-analysis,and 13 clinical practice guidelines were *** on the published evidence and clinical experience,the workgroup developed the following ten recommendations for the management of IDA in patients with gastrointestinal bleeding:(1)Evaluation of

关键词： Anemia iron-deficiency Erythrocyte transfusion Ferric carboxymaltose Gastrointestinal hemorrhage Iron Practice guidelines as topic

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因急性心肌梗死住院的年轻患者中糖尿病患病率的长期趋势

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世界核心医学期刊文摘(心脏病学分册) 2006年第2期 61-61页

作者： Kamalesh M. Subramanian U. Ariana A. 张宪伟 Roudebush VA Medical center 1481 W 10th Street Indianapolis IN 46202 United States

Background: Diabetes prevalence is increasing in the population, both in the young and the elderly. We assessed the impact of increasing prevalence of diabetes on admissions for acute myocardial infarctions(MI) from 1990 through 1997. Methods and results: We retrospectively identified all patients discharged with the primary diagnosis of MI from any Veteran' s Affairs Medical center(VAMC) in the country between October 1990 and September 1997. Patients were classified as having diabetes from the ICD-9-CM codes and stratified by age. Demographic data were extracted from the patient treatment files. Prevalence of diabetes among MI patients for the years 1990 through 1997 was compared to that in the general population obtained from the center for Disease Control. We identified 67,889 patients with MI of whom 17,756(26% ) had diabetes. In the age group ≤ 44 years, the prevalence of diabetes remained at approximately 11.5% from 1991 to 1998. In the age group 45-64 years, the increase was from 23% to 28% -a 23% increase(p< 0.001), while in the older age group over 65 years, it increased from 25% to 33.5% -a 34% increase(p< 0.001). In the general population, prevalence of diabetes increased by 50% , 63% and 44% in the three age groups. Conclusions: Despite substantial increase in prevalence of diabetes among the younger population, it does not appear to be predisposing them to increased risk for MI. The prevalence of diabetes among older patients with MI paralleled the increase seen in the general population with the steepest increase seen in the group ≥ 65 years. These data are important in focusing our resources for preventive measures.

关键词：糖尿病患病率心肌梗死心肌梗死患者

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Combining PD1 inhibitor,PARP inhibitor and antiangiogenic medication for lung squamous cell carcinoma with liver metastasis:a case report

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Precision Medicine Research 2022年第4期4卷 1-5页

作者： Ruo-Qi Wang Shan-Qi Guo Jun Chen Wen-Yan Fang Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Oncology The First Teaching Hospital of Tianjin University of Traditional Chinese MedicineNational Clinical Research Center for Chinese Medicine Acupuncture and MoxibustionTianjin 300381China

A 68-year-old man with left chest pain accompanied by chest tightness was *** computed tomography revealed a massive liver *** and pathological tests confirmed advanced squamous cell lung carcinoma with the mutation of breast cancer susceptibility gene 1 and liver *** primary lung lesions and local liver metastases were well controlled through combined immunotherapy,antiangiogenic medications and Poly ADP-ribose polymerase *** the high tumor load and the generally poor condition of the patient,transarterial chemoembolization,in place of the conventional chemotherapy treatment mode was chosed for liver metastasis in the current *** discussed selecting a tailored program and outlined the patient’s diagnosis and treatment *** mentioned multiple drug combination strategies for squamous lung cancer.

关键词： immunotherapy Programmed cell death protein 1 squamous cell carcinoma Poly ADP-ribose polymerase inhibitors

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Trends in medication use and treatment patterns in Chinese patients with inflammatory bowel disease

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World Journal of Gastroenterology 2022年第30期28卷 4102-4119页

作者： Ling-Ya Yao Bu-Le Shao Feng Tian Mei Ye Yu-Qin Li Xiao-Lei Wang Lin Wang Shao-Qi Yang Xiao-Ping Lv Yan Jia Xue-Hong Wang Xiao-Qi Zhang Yan-Ling Wei Qian Cao Department of Gastroenterology Sir Run Run Shaw HospitalCollege of Medicine Zhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhan 430000Hubei ProvinceChina Department of Gastroenterology Bethune First Affiliated Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Gastroenterology Shanghai 10th People's HospitalTongji UniversityShanghai 200072China Department of Gastroenterology Zhongshan Hospital Affiliated to Xiamen UniversityXiamen 361000Fujian ProvinceChina Department of Gastroenterology General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530000Guangxi Zhuang Autonomous RegionChina Department of Gastroenterology The 7th Medical Center of Chinese PLA General HospitalBeijing 100000China Department of Gastroenterology Second Xiangya HospitalChangsha 410011Hunan ProvinceChina Department of Gastroenterology Nanjing Drum Tower HospitalNanjing 210000Jiangsu ProvinceChina Department of Gastroenterology Daping HospitalArmy Medical UniversityChongqing 400000China

BACKGROUND Medications for inflammatory bowel disease(IBD)have changed dramatically over ***,no study on long-term medication profiles has been conducted in the Chinese *** To evaluate temporal changes in medication use and treatment patterns for Chinese patients with *** A multicenter retrospective cohort study was conducted among Chinese patients newly diagnosed with Crohn’s disease(CD)and ulcerative colitis(UC)between January 1999 and December *** characteristics and drug prescriptions were *** in medication use and therapeutic patterns were *** In total,3610 patients were *** follow-up,5-aminosalicylates(5-ASA)and corticosteroids(CS)prescriptions gradually decreased,accompanied by a notable increase in immunosuppressants(IMS)and infliximab(IFX)prescriptions in patients with *** rates of 5-ASA and CS were stable,whereas IMS and IFX slightly increased since 2007 in patients with ***(n=957)analyses showed a switch from conventional medications to IFX in patients with CD,while 5-ASA and CS were still steadily prescribed in patients with *** regression analyses revealed that surgical history,disease behavior,and disease location were associated with initial therapeutic strategies in patients with ***,medications before diagnosis,disease location,and diagnostic year might affect initial strategies in patients with *** Long-term treatment strategies analyses has provided unique insight into the switch from conventional drugs to IFX in Chinese patients with CD.

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Medication trends treatment pattern Infliximab

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Adult female syphilis prevalence,congenital syphilis case incidence and adverse birth outcomes,Mongolia 2000e2016:Estimates using the Spectrum STI tool

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Infectious Disease Modelling 2018年第1期3卷 13-22页

作者： Erdenetungalag Enkhbat Eline L.Korenromp Jugderjav Badrakh Setsen Zayasaikhan Purevsuren Baya Enkhjargal Orgiokhuu Narantuya Jadambaa Sergelen Munkhbaatar Delgermaa Khishigjargal Narantuya Khad Guy Mahiane Naoko Ishikawa Davaalkham Jagdagsuren Melanie M.Taylor Mongolia National Centre for Communicable Disease AIDS/STI Surveillance and Research DepartmentUlaanbaatar210648Bayanzurkh DistrictNam-Yan-Ju StreetMongolia Avenir Health GenevaSwitzerland1 route de Morillons/150 Route de Ferney(WCCOffice 164)PO Box 2100CH-1211 Geneva 2Switzerland World Health Organization Post Box 663Ulaanbaatar-13Mongolia Mongolia Global Fund Supported Project on AIDS and TB Peace Avenue 13/3Sukhbaatar DistrictUlaanbaatarMongolia Mongolia center for Health Development Enkhtaivan Street-13bSukhbaatar DistrictUlaanbaatarMongolia Avenir Health 655 Winding Brook DriveGlastonburyCTCT-06033USA World Health Organization Western Pacific Regional OfficePO Box 2932(United Nations Avenue)1000 ManilaPhilippines World Health Organization Department of Reproductive Health and Research8 Avenue Appia(L152)1211 GenevaSwitzerland centers for Disease Control and Prevention Atlanta GAUSA

Introduction:Mongolia's health ministry prioritizes control of Sexually Transmitted Infections,including syphilis screening and treatment in antenatal care(ANC).Methods:Adult syphilis prevalence trends were fitted using the Spectrum-STI estimation tool,using data from ANC surveys and routine screening over *** were combined with programmatic data to estimate numbers of treated and untreated pregnant women with syphilis and associated incidence congenital syphilis(CS)and CS-attributable adverse birth outcomes(ABO),which we compared with CS case ***:Syphilis prevalence in pregnant women was estimated at 1.7%in 2000 and 3.0%in *** estimated 652 CS cases,of which 410 ABO,in *** larger,annually increasing numbers of CS cases and ABO were estimated to have been prevented:1654 cases,of which 789 ABO in 2016thanks to increasing coverages of ANC(99%in 2016),ANC-based screening(97%in 2016)and treatment of women diagnosed(81%in 2016).The 42 CS cases reported nationally over 2016(liveborn infants only)represented 27%of liveborn infants with clinical CS,but only 7%of estimated CS cases among women found syphilis-infected in ANC,and 6%of all estimated CS cases including those born to women with undiagnosed ***/Conclusion:Mongolia's ANC-based syphilis screening program is reducing CS,but maternal prevalence remains *** eliminate CS(target:treatment,and under-diagnosis of CS including still-births and neonatal deaths,and expand syphilis screening and prevention programs.

关键词： Syphilis Congenital syphilis Surveillance Screening Antenatal care Epidemiological modelling

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Enzyme-free photothermally amplified fluorescent immunosorbent assay(PAFISA)for sensitive cytokine quantification

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Aggregate 2023年第6期4卷 137-145页

作者： Dian Li Wei He Xuyan Lin Xiaodong Cui Stefan Nagl Angela Ruohao Wu Ryan T.K.Kwok Renhua Wu Ben Zhong Tang Department of Medical Imaging The 2nd Affiliated HospitalMedical CollegeShantou UniversityShantouP.R.China Department of Physics Shantou UniversityShantouP.R.China Department of Physics University of Hong KongHong Kong SARP.R.China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University of Science and TechnologyKowloonP.R.China Division of Life Science The Hong Kong University of Science and TechnologyKowloonP.R.China HKUST Fok Ying Tung Research Institute GuangzhouP.R.China Department of Chemistry The Hong Kong University of Science and TechnologyKowloonP.R.China Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyKowloonP.R.China School of Science and Engineering Shenzhen Key Laboratory of Functional Aggregate MaterialsThe Chinese University of Hong KongShenzhenP.R.China

Cytokine monitoring has attracted great attention due to its significance in the diagnosis and treatment of many diseases,such as tumors,microbial infections,and immunological ***-linked immunosorbent assay(ELISA)is one of the most popular methods in cytokine detection,ascribing to the lavish signal amplification methods in the ELISA *** addition to classical enzymes,other signal amplifiers such as fluorescent probes,artificial nano-enzymes,and photothermal reagents have been applied to reduce the detection limit and produce more sensitive ELISA *** to the accumulative effect of heat,photothermal reagents are promising materials in the signal amplification of ***,the lack of efficient photothermal generation material at an aggregate scale may delay the further development of this *** this contribution,based on an efficient organic photothermal aggregate material,an enzyme-free photothermally amplified fluorescent immunosorbent assay system consisting of an assay microfluidic chip and detecting platform was *** photothermal nanoparticles with highly efficient photothermal conversion by harvesting energy via excited-state intramolecular motions and enlarging molar absorptivity were successfully *** detection concentration at 50 pg/mL of interleukin-2 was achieved,realizing a signal improvement of detection limits by 20-fold compared to that of previously reported photothermal *** microscopic imaging integrated with plane sweeping technology provided high spatial resolution and precision,indicating the potential of achieving high throughput profiling at the ***,as an alternative excitation source,light-emitting diode not only provided a more affordable and miniaturized detection system but also revealed the great feasibility of intramolecular motion-induced photothermy nanoparticles for biological analyses.

关键词： cytokine quantitation enzyme free fluorescence intensity ratio metric interleukin-2 microchip microscopic mapping photothermally amplified fluorescent immunosorbent assay

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Patients direct costs to undergo TB diagnosis

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Infectious Diseases of Poverty 2016年第1期5卷 221-229页

作者： Rachel M.Anderson de Cuevas Lovett Lawson Najla Al-Sonboli Nasher Al-Aghbari Isabel Arbide Jeevan B.Sherchand Emenyonu E.Nnamdi Abraham Aseffa Mohammed A.Yassin Saddiq T.Abdurrahman Joshua Obasanya Oladimeji Olanrewaju Daniel Datiko Sally J.Theobald Andrew Ramsay S.Bertel Squire Luis E.Cuevas Liverpool School of Tropical Medicine Pembroke PlaceLiverpool L35QAUK Zankli Medical center AbujaNigeria Bingham University Nassarawa StateAbujaNigeria Medical Faculty Sana’a UniversitySana’aYemen National Tuberculosis Institute Sana’aYemen Bushullo Major Health Centre AwassaEthiopia Tribhuvan University Institute of Medicine KathmanduNepal Armauer Hansen Research Institute Addis AbabaEthiopia The Global Fund to Fight AIDS Tuberculosis and MalariaGenevaSwitzerland Federal Capital Territory Tuberculosis and Leprosy Control Programme AbujaNigeria Nigeria Tuberculosis and Leprosy Control Programme AbujaNigeria REACH Ethiopia HawassaEthiopia UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases World Health OrganizationGenevaSwitzerland

Background:A major impediment to the treatment of TB is a diagnostic process that requires multiple *** of patient costs associated with diagnosis use different protocols and are not ***:We aimed to describe the direct costs incurred by adults attending TB diagnostic centres in four countries and factors associated with expenditure for *** of 2225 adults attending smear-microscopy centres in Nigeria,Nepal,Ethiopia and ***>18 years with cough>2 weeks were enrolled *** costs were quantified using structured *** with costs>75^(th) quartile were considered to have high expenditure(cases)and compared with patients with costs<75^(th) quartile to identify factors associated with high ***:The most significant expenses were due to clinic fees and *** participants attended the centres with *** expenditure was associated with attending with company,residing in rural areas/other towns and ***:The costs incurred by patients are substantial and share common patterns across *** user fees,transparent charging policies and reimbursing clinic expenses would reduce the poverty-inducing effects of direct diagnostic *** locations with limited resources,support could be prioritised for those most at risk of high expenditure;those who are illiterate,attend the service with company and rural residents.

关键词： Tuberculosis Costs Access to healthcare Ethiopia Nepal Nigeria Yemen

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Guidelines for management of pediatric acute hyperextension spinal cord injury

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Chinese Journal of Traumatology 2023年第1期26卷 2-7页

作者： Lian Zeng Yu-Long Wang Xian-Tao Shen Zhi-Cheng Zhang Gui-Xiong Huang Jamal Alshorman Tracy Boakye Serebour Charles H.Tator Tian-Sheng Sun Ying-Ze Zhang Xiao-Dong Guo on behalf of Chinese Orthopaedic Association,Spinal Cord Injury and Rehabilitation Group,Chinese Association of Rehabilitation Medicine,Group of Spinal Injury and Functional Reconstruction,Neuroregeneration&Neurorestoration Professional Committee,Association of Chinese Research Hospital,Sino-Canada Spinal and Spinal Cord Injury center Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Orthopedics Wuhan No.1 HospitalWuhan Integrated TCM&Western Medicine HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Pediatric Orthopaedic Surgery Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430016China Toronto Western Research Institute Toronto Western Hospital and University of TorontoTorontoOntarioCanada Department of Orthopedics The Seventh Medical Center of Chinese PLA General HospitalBeijing100700China Department of Orthopedic Surgery The Third Hospital of Hebei Medical UniversityShijiazhuang 050051China

Pediatric acute hyperextension spinal cord injury(SCI)named as PAHSCI by us,is a special type of thoracolumbar SCI without radiographic abnormality and highly related to back-bend in dance training,which has been increasingly *** present,it has become the leading cause of SCI in children,and brings a heavy social and economic *** domestic and foreign academic institutions and dance education organizations lack a correct understanding of PAHSCI and relevant standards,specifications or *** order to provide standardized guidance,the expert team formulated this guideline based on the principles of science and practicability,starting from the diagnosis,differential diagnosis,etiology,admission evaluation,treatment,complications and *** guideline puts forward 23 recommendations for 14 related issues.

关键词： Spinal cord injury Pediatric acute hyperextension spinal cord injury SCIWORA Pediatric back bend paralysis diagnosis and treatment Guidelines

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