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Proceedings of Anticancer Research 2024年第2期8卷 46-52页

作者： Yalan Chen Ruiyao Wang Na Zhao Jie Liang department of gastroenterology The Affiliated Hospital of Hebei UniversityBaoding 071000China department of Thoracic Surgery The Affiliated Hospital of Hebei UniversityBaoding 071000China Endoscopy center Department of GastroenterologyThe Affiliated Hospital of Hebei UniversityBaoding 071000China

Objective:To investigate the therapeutic effect of Biling Weitong Granules combined with oryz-aspergillus enzyme and pancreatin tablets on patients with reflux esophagitis with functional ***:Sixty patients diagnosed with reflux esophagitis with functional dyspepsia who were admitted to the Affiliated Hospital of Hebei University between June 2020 and June 2023 were selected and divided into two groups:the control group and the observation group,each consisting of 30 *** control group received oryz-aspergillus enzyme and pancreatin tablets only,while the observation group received Biling Weitong Granules in addition to the *** clinical efficacy,Chinese medicine syndrome points,esophageal kinetic indexes,gastrointestinal hormone levels,and therapeutic safety of both groups were ***:The total efficiency of the observation group reached 93.33%,significantly higher than the 73.33%of the control group(Ppain,and loss of appetite compared to the control group(P0.05).Conclusion:The combination of Biling Weitong Granules with oryz-aspergillus enzyme and pancreatin tablets demonstrates significant efficacy in the treatment of reflux esophagitis with functional dyspepsia,wi

关键词： Biling Weitong Granules Oryz-aspergillus enzyme and pancreatin tablets Reflux esophagitis Functional dyspepsia

Do inflammatory bowel disease patient preferences from treatment outcomes differ by ethnicity and gender?A cross-sectional observational study

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World Journal of Clinical Cases 2022年第35期10卷 12899-12908页

作者： Timna Naftali Vered Richter Amir Mari Tawfik Khoury Haim Shirin Efrat Broide Institute of gastroenterology Meir Medical CenterKfar-saba 4428164Israel department of gastroenterology Shamir Medical CenterZerifin 70300Israel department of gastroenterology Nazareth HospitalNazareth 16100Israel Shamir(Assaf Harofeh)Medical center Affiliated to Sackler School of MedicineThe Gonczarowski Family Institute of Gastroenterology and Liver DiseasesTel Aviv UniversityZerifin 70300Israel Pediatric gastroenterology Unit Asaf Harofeh Medical CenterZrifin 70300Israel

BACKGROUND Inflammatory bowel disease(IBD)patients’expectations of treatment outcomes may differ by *** To investigate treatment preferences of Jewish and Arabs *** This prospective survey ranked outcomes treatment preferences among Arab IBD patients,based on the 10 IBD-disk items compared to historical data of *** anonymous questionnaire in either Arabic or Hebrew was distributed among IBD *** were required to rank 10 statements describing different aspects of IBD according to their importance to the patients as treatment *** were compared to the answers of a historical group of Jewish *** IBD-disk items of 121 Arabs were compared to 240 Jewish *** Jewish patients included more females,[151(62.9%)vs 52(43.3%);Ppain,energy,and regular defecation ranked highest for both *** gave significantly lower rankings(range 4.29-6.69)than Jewish patients(range 6.25-9.03)regarding all items,except for body *** to Arab women,Jewish women attached higher priority to abdominal pain,energy,education/work,sleep,and joint *** regression analysis revealed that higher patient preferences were associated with Jewish ethnicity(OR 4.77;95%CI 2.36-9.61,P<0.001)and disease *** more active the disease,the greater the odds ratio for higher ranking of the questionnaire items(1-2 attacks per year:OR 2.13;95%CI 1.02-4.45,P=0.043;and primarily active disease:OR 5.29;95%CI 2.30-12.18,P<0.001).Factors inversely associated with higher patient preference were male gender(OR 0.5;95%CI 0.271-0.935,P=0.030),UC(OR 0.444;95%CI 0.241-0.819,P=0.009),and above average income level(OR 0.267;95%CI:0.124-0.577,P=0.001).CONCL

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Patients’preferences Ethnicity IBD-disk Patients reported outcomes

Risk factors and outcomes of peptic ulcer bleed in a Pakistani population:A single-center observational study

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第3期15卷 1-9页

作者： Nazish Butt Muhammad Tayyab Usmani Nimrah Mehak Saba Mughal Fakhar Ali Qazi-Arisar Ghulam Mohiuddin Gulzar Khan department of gastroenterology Jinnah Postgraduate Medical CentreKarachi 75505SindhPakistan National Institute of Liver&GI Diseases Dow University of Health SciencesKarachi 75330SindhPakistan School of Public Health Dow University of Health SciencesKarachi 75330SindhPakistan

BACKGROUND Peptic ulcer disease(PUD)remains a significant healthcare burden,contributing to morbidity and mortality *** advancements in therapies,its prevalence persists,particularly in regions with widespread nonsteroidal antiinflammatory drugs(NSAIDs)use and Helicobacter pylori *** To comprehensively analyse the risk factors and outcomes of PUD-related upper gastrointestinal(GI)bleeding in Pakistani *** This retrospective cohort study included 142 patients with peptic ulcer bleeding who underwent upper GI endoscopy from January to December *** on demographics,symptoms,length of stay,mortality,re-bleed,and Forrest classification was *** The mean age of patients was 53 years,and the majority was men(68.3%).Hematemesis(82.4%)and epigastric pain(75.4%)were the most common presenting *** patients(73.2%)were discharged within five *** mortality rates at one week and one month were 10.6%and 14.8%,***-bleed within 24 h and seven days occurred in 14.1%and 18.3%of patients,*** ulcers were Forrest class(FC)Ⅲ(72.5%).Antiplatelet use was associated with higher mortality at 7 and 30 d,while alternative medications were linked to higher 24-hour re-bleed *** use was associated with more FCⅢ***-bleed at 24 h and 7 d was strongly associated with one-week or one-month *** Antiplatelet use and rebleeding increase the risk of early mortality in PUD-related upper GI bleeding,while alternative medicines are associated with early rebleeding.

关键词： Non variceal bleed Mortality Re-bleed Forrest classification Antiplatelets Alternative medicines

Update on Sphincter of Oddi Dysfunction: A Review

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Journal of Clinical and Translational Hepatology 2022年第3期10卷 515-521页

作者： Jaimy Villavicencio Kim George Y.Wu department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Sphincter of Oddi dysfunction(SOD)encompasses a spectrum of clinical syndromes that are not fully understood,and various diagnostic and therapeutic methods have had varying results depending on the type of *** review explored various mechanisms that might play a role in SOD and methods of diagnosis and *** is important to rule out other causes of abdominal pain with laboratory testing,imaging studies,and endoscopic *** that affect sphincter motility should be identified as *** is the gold standard for diagnosis but it is not always *** example,patients with type I SOD may have symptomatic improvement with sphincterotomy without need for a diagnostic *** scintigraphy and fatty meal sonography may also have diagnostic *** is not always effective for symptomatic improvement in type II and III *** therapies with calcium channel blockers and botulinum toxin have been studied and might be considered as options after discussing the risks and benefits with the patients.

关键词： Sphincter of Oddi Sphincter of Oddi dysfunction Common bile duct Manometry Sphincterotomy

Natural history,clinical characteristics,outcomes,and long-term follow-up of pain-free chronic pancreatitis

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gastroenterology Report 2023年第1期11卷 309-315页

作者： Awais Ahmed Ishani Shah Rachel Bocchino Steven D.Freedman Darshan J.Kothari Sunil G.Sheth department of Medicine Division of GastroenterologyBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA department of Medicine Division of Internal MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA department of Medicine Division of GastroenterologyDuke UniversityDurhamNCUSA

Background:Chronic pancreatitis(CP)is characterized by chronic abdominal pain and functional ***,a small subset of patients with prior acute pancreatitis(AP)and/or underlying risk factors for developing CP may be pain-free at diagnosis and may have a different clinical *** aimed to compare the clinical characteristics,outcomes,and healthcare utilization between CP patients with and without ***:Reviewed patients with established CP were followed in our Pancreas center between January 2016 and April *** without risk factors for developing CP and/or without AP prior to their diagnosis and only with incidental radiologic features of CP were excluded,so as tominimize confounding factors of pancreatopathy unrelated to *** were divided into painful and pain-free groups to analyze differences in demographics,outcomes,and healthcare ***:Of 368 CP patients,49(13.3%)were pain-free at diagnosis and had remained so for>9 *** were no significant differences in body mass index,race,sex,or co-morbidities between the two ***-free patients were older at diagnosis(53.9 vs 45.7,P=0.004)and had less recurrent AP(RAP)(43.8%vs 72.5%,Ppain-free patients had less disability(2.2%vs 22.0%,P=0.003),mental illness(20.4%vs 61.0%,Ppainfree at *** were older at diagnosis,had less EPI and RAP,and overall favorable outcomes with minimal resource utilization.

关键词： chronic pancreatitis pain-free pancreatic insufficiency diabetes

The efficacy and safety of endoscopic ultrasound-guided fine-needle biopsy in gallbladder masses

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Hepatobiliary & Pancreatic Diseases International 2023年第6期22卷 632-638页

作者： Ting Tong Li Tian Min-Zi Deng Xue-Jie Chen Tian Fu Ke-Jia Ma Jia-Hao Xu Xiao-Yan Wang Endoscopic center Department of Gastroenterologythe Third Xiangya HospitalCentral South UniversityNo.138 Tongzipo Road Yuelu DistrictChangsha 410013China

Background: Endoscopic ultrasound-guided fine-needle biopsy(EUS-FNB) is a widely used modality for acquiring various target samples, but its efficacy in gallbladder masses is unknown. The aim of this retrospective study was to evaluate the efficacy and safety of EUS-FNB in patients with gallbladder masses. Methods: The study samples were composed of patients from March 2015 to July 2019 who needed to identify the nature of gallbladder masses through EUS-FNB. The outcomes of this study were the adequacy of specimens, diagnostic yields, technical feasibility, and adverse events of the EUS-FNB in gallbladder masses. Results: A total of 27 consecutive patients with a median age of 58 years were included in this study. The 22-gauge FNB needle was feasible in all lesions. The median follow-up period of the patients was 294 days. The specimens sufficient for diagnosis account for 89%(24/27) and 93%(25/27) in cytology and histology, respectively. The overall diagnostic yields for malignancy showed the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 95.45% [95% confidence interval(CI): 75.12%-99.76%], 100%(95% CI: 46.29%-10 0%), 10 0%(95% CI: 80.76%-100%), 83.33%(95% CI: 36.48%-99.12%), and 96.30%(95% CI: 80.20%-99.99%), respectively. The subgroup analysis revealed that FNB could obtain sufficient specimens and high diagnostic yields in both gallbladder mass pain after the procedure and recovered within one day. Conclusions: EUS-FNB is a reasonable diagnostic tool for the pretreatment diagnosis of patients with gallbladder masses, especially for patients who may miss the opportunity of surgery and need sufficient specimens to identify the pathological type so as to determine chemotherapy regimens. Further largescale studies are needed to confirm our conclusion.

关键词： Adverse events Diagnostic yields Endoscopic ultrasound-guided fine-needle biopsy Gallbladder masses Specimen adequacy

Should gastroenterologists prescribe cannabis? The highs, the lows and the unknowns

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World Journal of Clinical Cases 2023年第18期11卷 4210-4230页

作者： Sonia Samuel Mark Michael Micheal Tadros department of Internal Medicine Albany Medical CenterAlbanyNY 12208United States department of gastroenterology and Hepatology Albany Medical CenterAlbanyNY 12208United States

Cannabis,commonly known as marijuana,is a drug extracted from the Cannabis plant known for its psychotropic and medicinal *** has been used for healing purposes during ancient times,although its psychoactive components led to its restricted use in ***,cannabis is found to have modulatory effects on the endocannabinoid system exhibiting its medicinal role in the gastrointestinal(GI)*** animal and human studies demonstrate the influential effects of cannabis on a variety of GI diseases including inflammatory bowel disease,motility disorders and GI *** also has a regulatory role in GI symptoms including nausea and vomiting,anorexia,weight gain,abdominal pain,among ***,both its acute and chronic use can lead to undesirable side effects such as dependency and addiction,cognitive impairment and cannabinoid hyperemesis *** will discuss the role of cannabis in the GI system as well as dosing strategies to help guide gastroenterologists to assess its efficacy and provide patient counseling before prescription of medical marijuana.

关键词： Marijuana cannabis Endocannabinoid system Side effects Gastrointestinal disorders

Multimodal pain stimulation of the gastrointestinal tract

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World Journal of gastroenterology 2006年第16期12卷 2477-2486页

作者： Asbjφrn Mohr Drewes Hans Gregersen center for biomechanics and pain Department of GastroenterologyAalborg Hospital & Center for Sensory-Motor Interactions (SMI)Department of Health Science and TechnologyAalborg UniversityAalborgDenmark center for biomechanics and pain Department of GastroenterologyAalborg Hospital

疼痛和另外的感觉症状的理解和描述在在有胃肠的混乱的病人的诊断和评价的最重要的问题之中。唤起并且估计试验性的疼痛的方法最近为多模式的刺激与可能性发展成一个新区域(例如，电、机械、热、化学的刺激) 不同神经和疼痛，在人的小... 详细信息

疼痛和另外的感觉症状的理解和描述在在有胃肠的混乱的病人的诊断和评价的最重要的问题之中。唤起并且估计试验性的疼痛的方法最近为多模式的刺激与可能性发展成一个新区域(例如，电、机械、热、化学的刺激) 不同神经和疼痛，在人的小径毁坏。如此的方法模仿在诊所经验丰富的疼痛到高度。多模式的疼痛方法处于健康和疾病在内脏增加了我们不同外部受体的基本理解。和先进肌肉分析，方法增加了我们对敏感的受体的理解机械，在疾病的化学药品和温度刺激，例如全身的硬化和糖尿病。方法能也被用来解开中枢性痛机制例如涉及 allodynia 的那些，痛觉过敏和提交的疼痛。在中枢性痛机制的畸形经常依靠刺激可以帮助在这些病人理解症状的多模式的疼痛的长期的内脏疼痛和因此方法地在病人被看见。性差别在内脏的几疾病被观察了，并且在中枢性痛在男性和女性之间处理的差别用多模式的疼痛刺激被假设了。最后，多模式的方法最近被用来在官方补给的道对疼痛获得更多的卓见进药的效果。因此，多模式的方法无疑表示一个学生与内脏的各种各样的疾病在未来描述和病人的治疗向前走。

关键词：疼痛刺激实验胃肠道反应神经生理学

Update on endoscopic ultrasound-guided liver biopsy

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World Journal of gastroenterology 2022年第28期28卷 3586-3594页

作者： Shiva Rangwani Devarshi R Ardeshna Khalid Mumtaz Sean G Kelly Samuel Y Han Somashekar G Krishna Division of gastroenterology Hepatologyand NutritionDepartment of Internal MedicineOhio State University Wexner Medical CenterColumbusOH 43210United States

Endoscopic ultrasound guided liver biopsy(EUS-LB)has emerged as a minimally-invasive alternative to the traditional(percutaneous or transjugular)liver biopsy techniques for the diagnosis of liver parenchymal ***,EUS-LB combines the advantages of percutaneous and transjugular liver biopsy in addressing focused sampling in addition to measuring portal ***,EUS-LB facilitates access to both the lobes of the liver which is not considered with the traditional percutaneous liver *** studies have compared EUS-LB with conventional liver biopsy and reported comparable diagnostic yield,increased acquisition of complete portal tracts,and longer specimen length as compared to the traditional ***-LB is associated with lesser post-procedural pain and shorter recovery time,while providing lower risk of complications when compared to traditional liver *** in needle types,needle sizes and suction techniques have aimed at further optimizing the EUS-LB *** review article updates current literature with focus on the variations in the technique and equipment used for EUS-LB,and compares EUS-LB with traditional methods of liver biopsy.

关键词： Endoscopic ultrasound guided liver biopsy Liver biopsy Percutaneous liver biopsy Transjugular liver biopsy Liver parenchymal disease Portal pressure gradient

Bowel intussusception caused by a percutaneously placed endoscopic gastrojejunostomy catheter: A case report

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World Journal of Gastrointestinal Surgery 2022年第6期14卷 621-625页

作者： Maarten WJ Winters Sjoerd Kramer Albert HA Mazairac Ewoud H Jutte Paul G van Putten department of gastroenterology and Hepatology Medical Center LeeuwardenLeeuwarden 8934 ADNetherlands department of Radiology Medical Center LeeuwardenLeeuwarden 8934 ADNetherlands department of Surgery Medical Center LeeuwardenLeeuwarden 8934 ADNetherlands

BACKGROUND In adults,bowel intussusception is a rare diagnosis and is mostly due to an organic bowel *** rare cases,this is a complication of a percutaneously placed endoscopic gastro(jejunostomy)*** SUMMARY We describe a case of a 73-year-old patient with a history of myocardial infarction,chronic idiopathic constipation and Parkinson’s *** the admission of his Parkinson’s medication,a percutaneous endoscopic gastrostomy with jejunal extension(PEG-J)was *** patient presented three times at the emergency department of the hospital with intermittent abdominal pain with nausea and *** were no distinctive abnormalities from the physical and laboratory *** abdominal computed tomography scan showed a small bowel *** push endoscopy,a jejunal bezoar at the tip of the PEG-J catheter was found to be the cause of small bowel *** intussusception was resolved after removing the bezoar during push *** Endoscopic treatment of bowel intussusception caused by PEG-J catheter bezoar.

关键词： Bowel intussusception Percutaneous endoscopic gastrojejunostomy Bezoar Percutaneous endoscopic gastrostomy Case report