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Immunophenotypic characteristics of multipotent mesenchymal stromal cells that affect the efficacy of their use in the prevention of acute graft vs host disease

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World Journal of Stem Cells 2020年第11期12卷 1377-1395页

作者： Nataliya Petinati Nikolay Kapranov Yulia Davydova Alexey Bigildeev Olesya Pshenichnikova Dmitriy Karpenko Nina Drize Larisa Kuzmina Elena Parovichnikova Valeriy Savchenko Laboratory for Physiology of Hematopoiesis National Research Center for HematologyMoscow 125167Russia Laboratory for Immunophenotyping of Blood and Bone Marrow Cells National Research Center for HematologyMoscow 125167Russia Laboratory for Genetic Engineering National Research Center for HematologyMoscow 125167Russia Hematopoiesis depression and Bone Marrow Transplantation Department National Research Center for HematologyMoscow 125167Russia

BACKGROUND Multipotent mesenchymal stromal cells(MSCs)are widely used in the clinic due to their unique properties,namely,their ability to differentiate in all mesenchymal directions and their immunomodulatory *** donor MSCs were used to prevent the development of acute graft vs host disease(GVHD)after allogeneic bone marrow transplantation(allo-BMT).The administration of MSCs to patients was not always *** MSCs obtained from different donors have individual *** differences between MSC samples may affect their clinical *** To study the differences between effective and ineffective *** MSCs derived from the bone marrow of a hematopoietic stem cells donor were injected intravenously into allo-BMT recipients for GVHD prophylaxis at the moment of blood cell *** of 52 MSC samples that were administered to patients were examined,and the same cells were cultured in the presence of peripheral blood mononuclear cells(PBMCs)from a third-party donor or treated with the pro-inflammatory cytokines IL-1β,IFN and *** cytometry revealed the immunophenotype of the nontreated MSCs,the MSCs cocultured with PBMCs for 4 d and the MSCs exposed to *** proportions of CD25-,CD146-,CD69-,HLA-DR-and PD-1-positive CD4+and CD8+cells and the distribution of various effector and memory cell subpopulations in the PBMCs cocultured with the MSCs were also *** Differences in the immunophenotypes of effective and ineffective MSCs were *** the effective samples,the mean fluorescence intensity(MFI)of HLAABC,HLA-DR,CD105,and CD146 was significantly *** MSCs were treated with IFN or cocultured with PBMCs,the HLA-ABC,HLA-DR,CD90 and CD54 MFI showed a stronger increase in the effective MSCs,which indicated an increase in the immunomodulatory activity of these *** PBMCs were cocultured with effective MSCs,the proportions of CD4+and CD8+central memory cells significantly decreased

关键词： Multipotent mesenchymal stromal cells Acute graft vs host disease Immunophenotype Lymphocytes Immunomodulation Pro-inflammatory cytokines

A Multi-center Cross-Sectional Study on Visual Impairment and depression Among Students—Jiangsu Province,China,2017–2022

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China CDC weekly 2023年第51期5卷 1145-1149页

作者： Xiyan Zhang Wei Du Yan Wang Wenyi Yang Xin Wang Jie Yang Jiangsu Provincial center for Disease Control and Prevention Nanjing CityJiangsu ProvinceChina School of Public Health Nanjing Medical UniversityNanjing CityJiangsu ProvinceChina School of Public Health Southeast UniversityNanjing CityJiangsu ProvinceChina.

What is already known about this topic?China exhibits a significantly high prevalence ofmyopia compared to other countries globally. Childrenwith vision impairment have been found to engage lessin physical activities, achieve lower academicperformance, and have increased vulnerability *** is added by this report?During a six-year observational study, a populationlevelcorrelation was identified between varying degreesof visual impairment and the presence of depressivesymptoms among students. Specifically, individualswith a visual acuity below 4.0 had a significantly higherodds ratio of 1.90 (95% confidence interval:1.53–2.37) compared to individuals with normal vision(visual acuity ≥5.0).What are the implications for public healthpractice?This study highlights the importance of holistic healthinterventions that address both visual and psychologicalaspects. Understanding common mechanisms andinfluential factors can guide the development of moreimpactful public health strategies.

关键词： globally Visual Jiangsu

Analysis of the Effect of Midwives’ Psychological Care Intervention on the Progress of Labor and Cesarean Rate of Elderly Women in Labor

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Journal of Clinical and Nursing Research 2024年第5期8卷 271-276页

作者： Chan Yan Lianyungang Maternal and Child Health center Lianyungang 222000Jiangsu ProvinceChina

Objective:To analyze the effect of midwife psychological nursing intervention in the clinical care of elderly women in ***:According to the order of admission,74 elderly women were divided into the control group and the observation *** addition to the routine perinatal nursing interventions,the observation group strengthened the implementation of midwives’psychological nursing *** duration of labor,mode of delivery,psychological state,and stress response indexes of the two groups were analyzed and ***:The observation group had a shorter duration of all labor stages and total duration of labor than the control group,a lower cesarean section rate than the control group,and a higher degree of improvement in anxiety,depression,and stress response indexes in the 3-day postpartum period as compared to the control group(P<0.05).Conclusion:The implementation of midwife psychological care intervention in perinatal care of elderly women can further shorten the duration of labor,reduce the cesarean section rate,and improve the psychological state and stress indicators,which is worth promoting.

关键词： Midwife Psychological care Elderly women Labor Cesarean section rate

Engagement of N^(6)-methyladenisine methylation of Gng4 mRNA in astrocyte dysfunction regulated by CircHECW2

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1644-1660页

作者： Ying Bai Di Chang Hui Ren Minzi Ju Yu Wang Biling Chen Han Li Xue Liu Daxing Li Xinchen Huo Xiaofei Guo Mengze Tong Ying Tan Honghong Yao Bing Han Department of Pharmacology Jiangsu Provincial Key Laboratory of Critical Care MedicineSchool of MedicineSoutheast UniversityNanjing 210009China Department of Radiology Zhongda HospitalJiangsu Key Laboratory of Molecular and Functional ImagingMedical School of Southeast UniversityNanjing 210009China Co-Innovation center of Neuroregeneration Nantong UniversityNantong 226001China Institute of Life Sciences Key Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjing 210096China center for Global Health School of Public HealthNanjing Medical UniversityNanjing 211166China

The N^(6)-methyladenosine(m^(6)A)modification is the most prevalent modification of eukaryotic mRNAs and plays a crucial role in various physiological processes by regulating the stability or function of target *** evidence has suggested that m6A methylation may be involved in the pathological process of major depressive disorder(MDD),a common neuropsychiatric disorder with an unclear ***,we found that the levels of the circular RNA HECW2(circHECW2)were significantly increased in the plasma of both MDD patients and the chronic unpredictable stress(CUS)mouse ***,the downregulation of circHECW2 attenuated astrocyte dysfunction and depression-like behaviors induced by ***,we demonstrated that the downregulation of circHECW2 increased the expression of the methylase WTAP,leading to an increase in Gng4 expression via m^(6)A *** findings provide functional insight into the correlation between circHECW2 and m^(6)A methylation,suggesting that circHECW2 may represent a potential target for MDD treatment.

关键词： N^(6)-Methyladenosine depression circHECW2 Astrocyte WTAP Ubiquitination GNG4 Dysfunction

Ultra-brief crisis interpersonal psychotherapy based intervention for suicidal children and adolescents

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World Journal of Psychiatry 2021年第8期11卷 403-411页

作者： Anat Brunstein Klomek Liat Haruvi Catalan Alan Apter Baruch Ivcher School of Psychology Interdisciplinary CenterHerzliya 4610101Israel depression and Suicide Clinic Schneider Children’s Medical CenterPetach Tikva 49202Israel Sackler Faculty of Medicine Tel Aviv UniversityTel Aviv 69978Israel

Suicidal behaviors in adolescence are a major public health *** dramatic rise in self-injurious behaviors among adolescents has led to an overwhelming increase in the number of those presenting to the emergency *** intervention described below was constructed on the basis of brief and focused interventions that were found to be effective among suicidal adults using an adaptation of interpersonal psychotherapy for *** intervention has four main objectives:first,a focused treatment for reducing suicide risk;second,a short and immediate response;third,building a treatment plan based on understanding the emotional distress and interpersonal aspects underlying suicidal behavior;and lastly,to generate hope among adolescents and their *** intervention includes intensive five weekly sessions,followed by 3 mo of email follow-up.

关键词： Suicide depression Adolescents Crisis intervention Interpersonal psychotherapy

Factor Structure and Longitudinal Invariance of the CES-D across Diverse Residential Backgrounds in Chinese Adolescents

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International Journal of Mental Health Promotion 2024年第4期26卷 261-269页

作者： Yanjing Cao Chenchen Xu Qi Li Shan Lu Jing Xiao Beijing Key Laboratory of Learning and Cognition and Department of Psychology Capital Normal UniversityBeijing100048China center for Child Development Capital Normal UniversityBeijing100048China

Background:Valid and reliable measures of depressive symptoms are crucial for understanding risk factors,outcomes,and interventions across rural and urban *** this need,the longitudinal invariance of these measures over time remains *** research explores the structural components of the center for Epidemiological Studies depression Scale(CES-D)and examines its consistency across various living environments and temporal stability in a cohort of Chinese ***:In the initial phase,1,042 adolescents furnished demographic details and undertook the CES-D *** a three-month interval,967 of these participants repeated the CES-D *** study employed Confirmatory factor analysis(CFA)to scrutinize the scale’s structural *** investigated factorial invariance by conducting a twopronged CFA:one comparing urban *** backgrounds,and another contrasting the results from the initial assessment with those from the ***:The CES-D demonstrated adequate reliability in both rural and urban high school student *** preliminary four-factor model applied to the CES-D demonstrated a good fit with the collected *** tests,including multigroup analyses comparing rural and urban samples and longitudinal assessments,confirmed the scale’s ***:The results suggest that the CES-D serves as a reliable instrument for evaluating depressive symptoms among Chinese *** applicability is consistent across different living environments and remains stable over time.

关键词： depression factor structure measurement invariance Chinese adolescent longitudinal invariance

Presurgical structural imaging and clinical outcome in combined bed nucleus of the stria terminalis-nucleus accumbens deep brain stimulation for treatment-resistant depression

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General Psychiatry 2024年第3期37卷 412-421页

作者： Fengting Wang Lulin Dai Tao Wang Yingying Zhang Yuhan Wang Yijie Zhao Yixin Pan Liuguan Bian Dianyou Li Shikun Zhan Yijie Lai Valerie Voon Bomin Sun Department of Neurosurgery Shanghai Jiao Tong University Medical School Affiliated Ruijin HospitalShanghaiChina Department of Psychiatry Zhejiang University School of Medicine Sir Run Run Shaw HospitalHangzhouChina Fudan University Institute of Science and Technology for Brain-inspired Intelligence ShanghaiChina Clinical Research center for Mental Disorders Shanghai Pudong New Area Mental Health CenterShanghaiChina Department of Psychiatry University of CambridgeCambridgeUK

Background Structural imaging holds great potential for precise targeting and stimulation for deep brain stimulation(DBS).The anatomical information it provides may serve as potential biomarkers for predicting the efficacy of DBS in treatment-resistant depression(TRD).Aims The primary aim is to identify preoperative imaging biomarkers that correlate with the efficacy of DBS in patients with *** Preoperative imaging parameters were estimated and correlated with the 6-month clinical outcome of patients with TRD receiving combined bed nucleus of the stria terminalis(BNST)-nucleus accumbens(NAc)*** matter(WM)properties were extracted and compared between the response/non-response and remission/non-remission *** connectome was constructed and analysed using graph *** of the volume of activated tissue(VAT)to the main modulating tracts were also estimated to evaluate the *** Differences in fibre bundle properties of tracts,including superior thalamic radiation and reticulospinal tract,were observed between the remission and nonremission *** of the centre of the VAT to tracts connecting the ventral tegmental area and the anterior limb of internal capsule on the left side varied between the remission and non-remission groups(p=0.010,t=3.07).The normalised clustering coefficient(γ)and the small-world property(σ)in graph analysis correlated with the symptom improvement after the correction of *** Presurgical structural alterations in WM tracts connecting the frontal area with subcortical regions,as well as the distance of the VAT to the modulating tracts,may influence the clinical outcome of BNST-NAc *** findings provide potential imaging biomarkers for the DBS treatment for patients with TRD.

关键词： stimulation alterations treatment

The burden of depression,anxiety and schizophrenia among the older population in ageing and aged countries:an analysis of the Global Burden of Disease Study 2019

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General Psychiatry 2024年第1期37卷 83-93页

作者： Ying Cheng Yu Fang Jinxin Zheng shiyang Guan Meiti Wang Wu Hong Shanghai Mental Health center Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Nephrology Rujin HospitalInstitute of NephrologyInstitute of NephrologyShanghai Jiao Tong University School of MedicineShanghaiChina School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiChina Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefeiAnhuiChina

Background depression,anxiety and schizophrenia among older persons have become global public health ***,the burden of these disorders in ageing and aged countries has not been *** To investigate the burden of depression,anxiety and schizophrenia among older adults in ageing and aged *** Using data from the Global Burden of Disease Study 2019,we calculated the estimated annual percentage change(EAPC)in the age-standardised incidence rates(ASiR)and age-standardised disability-adjusted life years(DALYs)rates(ASDR)for depression,anxiety and schizophrenia of older people in ageing countries(China,India,Indonesia)and aged countries(Japan,Italy,Portugal)between 1990 and *** in incidence and DALYs were analysed by gender and *** In 2019,the highest incidence of depression,anxiety and schizophrenia in the older population in aged countries was in Japan(927271.3(752552.3-1125796.5),51498.2(37625.7-70487.3)and 126.0(61.0-223.2),respectively),while the highest incidence in ageing countries was in China(5797556.9(4599403.4-7133006.5),330256.1(246448.9-445987.4)and 1067.7(556.2-1775.9),respectively).DALYs for these disorders were similar,with the highest in Japan and *** 1990 to 2019,the ASIR for depressive disorders decreased in aged countries but increased in ageing countries;the ASIR for anxiety disorders and schizophrenia declined in both ageing and aged *** ASDR for depressive disorders was consistent with the ASIR but not for anxiety disorders and *** ASIR for depressive disorders was higher in older women,while the opposite was observed in anxiety disorders and ***,the conditions of burden of depressive disorders,anxiety disorders and schizophrenia in the 65-70-year-old age group were the most *** The incidence and DALYs of these three mental disorders increased while exhibiting differences between ageing and aged *** awareness about for

关键词： schizophrenia burden ageing

A Latent Class Analysis of Lifestyle Patterns in Relation to Depressive Symptoms Among Adolescents—Jiangsu Province,China,2022

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China CDC weekly 2024年第40期6卷 1028-1032,I0001页

作者： Linyuan Lai Xin Wang Ying Li Yan Wang Hui Xue Xiaoyan Ni Yifan Chen Lijun Fan Jie Yang Wei Du School of Public Health Southeast UniversityNanjing CityJiangsu ProvinceChina Department of Child and Adolescent Health Promotion Jiangsu Provincial Center for Disease Control and PreventionNanjing CityJiangsu ProvinceChina

What is already known about this topic?Interventions aimed at modifying lifestyle behaviors can effectively reduce the risk of depression among *** lifestyle behaviors tend to be interconnected;thus,changes to one behavior can often lead to changes in others,usually occurring *** is added by this report?Adolescents from Jiangsu Province displayed distinct lifestyle patterns,with those engaging in multiple specific behaviors,such as excessive consumption of sugar-sweetened beverages and prolonged screen time,showing increased odds of *** are the implications for public health practice?Early implementation of anti-depression interventions in adolescents should be advocated and prioritized,particularly targeting multiple high-risk lifestyles.

关键词： sugar Jiangsu lifestyle