检索结果-南通市图书馆

Diverse Roles of ERECTA Family Genes in Plant Development

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2013年第12期55卷 1238-1250页

作者： Elena D.Shpak Department of Biochemistry Cellular and Molecular BiologyUniversity of Tennessee

Multiple receptor-like kinases （RLKs） enable intercellular communication that coordinates growth and development of plant tissues. ERECTA family receptors （ERfs） are an ancient family of leucine-rich repeat RLKs that in Arabidopsis consists of three genes： ERECTA, ERL1, and ERL2. ERfs sense secreted cysteine-rich peptides from the EPF/EPFL family and transmit the signal through a MAP kinase cascade. This review discusses the functions of ERfs in stomata development, in regulation of longitudinal growth of aboveground organs, during reproductive development, and in the shoot apical meristem. In addition the role of ERECTA in plant responses to biotic and abiotic factors is examined.

关键词： Arabidopsis ERECTA leaf primordium initiation receptor-like kinase stomata vasculature.

Glucose-regulated protein precursor （GRP78） and tumor rejection antigen （GP96） are unique to hamster caput epididymal spermatozoa

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2010年第3期12卷 344-355,I0009页

作者： Duvvuri Butchi Kameshwari Satish Bhande Curam Sreenivasacharlu Sundaram Venkatesh Kota Archana B. Siva Sisinthy Shivaji Centre for cellular and molecular Biology Hyderabad 500007 India

The immotile testicular mammalian spermatozoon gets transformed into a motile spermatozoon during ＇epididymal maturation＇. During this process, the spermatozoa transit from the caput to the cauda epididymis and undergo a number of distinct morphological, biophysical and biochemical changes, including changes in protein composition and protein modifications, which may be relevant to the acquisition of motility potential. The present proteome-based study of the hamster epididymal spermatozoa of caput and cauda led to the identification of 113 proteins spots using Matrix- assisted laser desorption/ionization tandem mass spectrometry （MALDI-MS/MS） analysis. Comparison of these 113 protein spots indicated that 30 protein spots （corresponding to 20 proteins） were significantly changed in intensity. Five proteins were increased and eleven were decreased in intensity in the cauda epididymal spermatozoa. In addition, two proteins, glucose-regulated protein precursor （GRP78） and tumor rejection antigen （GP96）, were unique to the caput epididymal spermatozoa, while one protein, fibrinogen-like protein 1, was unique to cauda epididymal spermatozoa. A few of the five proteins, which increased in intensity, were related to sperm metabolism and ATP production during epididymal maturation. The changes in intensity of a few proteins such as ERp57, GRP78, GP96, Hsp60, Hsp70, and dihydrolipoamide S-acetyltransferase were validated by immunoblotting. The present study provides a global picture of the changes in protein composition occurring during hamster sperm epididymal maturation, besides being the first ever report on the proteome of hamster spermatozoa.

关键词： epididymis hamster motility proteome spermatozoa

Heat Shock Factor A1s are required for phytochrome-interacting factor 4-mediated thermomorphogenesis in Arabidopsis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2024年第1期66卷 20-35页

作者： Bingjie Li Shimeng Jiang Liang Gao Wenhui Wang Haozheng Luo Yining Dong Zhihua Gao Shuzhi Zheng Xinye Liu Wenqiang Tang Key Laboratory of molecular and cellular Biology of Ministry of Education Hebei Research Center of the Basic Discipline of Cell BiologyHebei Collaboration Innovation Center for Cell SignalingHebei Key Laboratory of Molecular and Cellular BiologyCollege of Life SciencesHebei Normal UniversityShijiazhuang 050024China School of Information Technology Hebei University of Economics and BusinessShijiazhuang 050061China

Thermomorphogenesis and the heat shock(HS)response are distinct thermal responses in plants that are regulated by PHYTOCHROME-INTERACTING FACTOR 4(PIF4)and HEAT SHOCK FACTOR A1s(HSFA1s),*** is known about whether these responses are interconnected and whether they are activated by similar *** analysis of transcriptome dynamics in response to warm temperature(28℃)treatment revealed that 30 min of exposure activated the expression of a subset of HSFA1 target genes in Arabidopsis ***,a loss-of-function HSFA1 quadruple mutant(hsfa1-cq)was insensitive to warm temperature-induced hypocotyl *** hsfa1-cq plants grown at 28℃,the protein and transcript levels of PIF4 were greatly reduced,and the circadian rhythm of many thermomorphogenesis-related genes(including PIF4)was ***,the nuclear localization of HSFA1s and the binding of HSFA1d to the PIF4 promoter increased following warm temperature exposure,whereas PIF4 overexpression in hsfa1-cq partially rescued the altered warm temperature-induced hypocotyl growth of the *** together,these results suggest that HSFA1s are required for PIF4 accumulation at a warm temperature,and they establish a central role for HSFA1s in regulating both thermomorphogenesis and HS responses in Arabidopsis.

关键词： HSFA1 PIF4 thermomorphogenesis

PARP inhibitors as precision medicine for cancer treatment

在线全文

学校读者我要写书评

暂无评论

National Science Review 2017年第4期4卷 576-592页

作者： Yi Du Hirohito Yamaguchi Jennifer L.Hsu Mien-Chie Hung Department of molecular and cellular Oncology The University of Texas MD Anderson Cancer Center Graduate Institute of Biomedical Sciences and center for molecular Medicine China Medical University Department of Biotechnology Asia University Graduate Institute of Biomedical Sciences and center for molecular Medicine China Medical UniversityTaichung

Personalized or precision medicine is an emerging treatment approach tailored to individuals or certain groups of patients based on their unique characteristics. These types of therapies guided by biomarkers tend to be more effective than traditional approaches, especially in cancer. The inhibitor against poly(ADP-ribose) polymerase(PARP), olaparib(Lynparza, Astra Zeneca), which was approved by the US Food and Drug Administration(FDA) in 2014, demonstrated efficacy specifically for ovarian cancer patients harboring mutations in BRCA genes, which encode proteins in DNA double-strand break ***, the response to PARP inhibitors has been less encouraging in other cancer types that also carry defects in the BRCA genes. Thus, furthering our understanding of the underlying mechanism of PARP inhibitors and resistance is critical to improve their efficacy. In this review, we summarize the results of preclinical studies and the clinical application of PARP inhibitors, and discuss the future direction of PARP inhibitors as a potential marker-guided personalized medicine for cancer treatment.

关键词： PARP inhibitor kinase DNA damage precision medicine combination therapy

An Overview of the Role of Peroxisome Proliferator-activated Receptors in Liver Diseases

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2023年第7期11卷 1542-1552页

作者： Zahra Changizi Forough Kajbaf Azam Moslehi cellular and molecular research center Qom University of Medical SciencesQomIran Veterinary Department Faculty of AgricultureIslamic Azad UniversityShoushtar BranchShoushtarIran

Peroxisome proliferator-activated receptors(PPARs)are a superfamily of nuclear transcription receptors,consisting of PPARa,PPARy,and PPARβ/δ,which are highly expressed in the *** control and modulate the expression of a large number of genes involved in metabolism and energy homeostasis,oxidative stress,inflammation,and even apo-ptosis in the ***,they have critical roles in the pathophysiology of hepatic *** review provides a general insight into the role of PPARS in liver diseases and some of their agonists in the clinic.

关键词： Liver Endoplasmic reticulum stress Nonalcoholic fatty liver dis-ease PPARa PPAR PPARβ/δ

Metabolic programming determines the lineage-differentiation fate of murine bone marrow stromal progenitor cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bone research 2019年第4期7卷 410-423页

作者： Michaela Tencerova Elizabeth Rendina-Ruedy Ditte Neess Nils Faergeman Florence Figeac Dalia Ali Morten Danielsen Anders Haakonsson Clifford J.Rosen Moustapha Kassem Department of molecular Endocrinology University of Southern Denmark and Odense University Hospital5000 OdenseDenmark center for molecular Medicine Maine Medical Center Research InstituteScarboroughME 04074USA Villum center for Analytical Biosciences Department of Biochemistry and Molecular BiologyUniversity of Southern Denmark5230 OdenseDenmark MSOmics 2950 CopenhagenDenmark Department of cellular and molecular Medicine Novo Nordisk Foundation Center for Stem Cell Biology(DanStem)University of Copenhagen2200 CopenhagenDenmark

Enhanced bone marrow adipogenesis and impaired osteoblastogenesis have been observed in obesity,suggesting that the metabolic microenvironment regulates bone marrow adipocyte and osteoblast progenitor differentiation *** determine the molecular mechanisms,we studied two immortalized murine cell lines of adipocyte or osteoblast progenitors(BMSCs^adipo and BMSC^sosteo,respectively)under basal and adipogenic culture *** baseline,BMSCs^adipo,and BMSCs^osteo exhibit a distinct metabolic program evidenced by the presence of specific global gene expression,cellular bioenergetics,and metabolomic signatures that are dependent on insulin signaling and glycolysis in BMSCs^osteo versus oxidative phosphorylation in BMSCs^*** test the flexibility of the metabolic program,we treated BMSCsadipo with parathyroid hormone,S961(an inhibitor of insulin signaling)and oligomycin(an inhibitor of oxidative phosphorylation).The treatment induced significant changes in cellular bioenergetics that were associated with decreased adipocytic ***,12 weeks of a high-fat diet in mice led to the expansion of adipocyte progenitors,enhanced adipocyte differentiation and insulin signaling in cultured *** data demonstrate that BMSC progenitors possess a distinct metabolic program and are poised to respond to exogenous metabolic cues that regulate their differentiation fate.

关键词： progenitor impaired programming

Boosting corticospinal system synaptic plasticity to recover motor functions

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration research 2023年第10期18卷 2182-2183页

作者： Weiguo Song John H.Martin Feinstein Institutes for Medical research ManhassetNYUSA Department of molecular Cellularand Biomedical SciencesCenter for Discovery and Innovation Neuroscience Program Graduate Center of the City University of New YorkNew YorkNYUSA

An importa nt strategy to promote voluntary movements after motor system injury is to strengthen the connections between the motor cortex and muscles by taking advantage of the plasticity of the corticospinal motor *** neuromodulation approaches are directed to activate the spinal cord and peripheral axons to strengthen muscle *** discuss in this perspective that,the cortex and spinal cord should be ta rgeted together to enhance cortex-to-musclefunction(Amer and Martin,2022).

关键词： plasticity system activation

The effects of advanced paternal age on fertility

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2013年第6期15卷 723-728,I0005页

作者： Jason R Kovac Josephine Addai Ryan P Smith Robert M Coward Dolores J Lamb Larry I Lipshultz Scott Department of Urology Department of Molecular and Cellular Biology The Center for Reproductive Medicine Baylor College of Medicine Houston TX 77030 USA

Modern societal pressures and expectations over the past several decades have resulted in the tendency for couples to delay conception. While women experience a notable decrease in oocyte production in their late thirties, the effect of age on spermatogenesis is less well described. While there are no known limits to the age at which men can father children, the effects of advanced paternal age are incompletely understood. This review summarizes the current state of knowledge regarding advanced paternal age and its implications on semen quality, reproductive success and offspring health. This review will serve as a guide to physicians in counseling men about the decision to delay paternity and the risks involved with conception later in life.

关键词： aging male fertility outcomes male infertility paternal age

cellular and molecular basis of chronic constipation: Taking the functional/idiopathic label out

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第26期19卷 4099-4105页

作者： Gabrio Bassotti Vincenzo Villanacci Dragos Cretoiu Sanda Maria Cretoiu Gabriel Becheanu Gastroenterology and Hepatology Section Department of Clinical and Experimental Medicine University of Perugia Second Pathology Section Spedali Civili Division of cellular and molecular Medicine Department of Morphological Sciences "Carol Davila" University of Medicine and Pharmacy Department of molecular Medicine "Victor Babes" National Institute of Pathology Department of Ultrastructural Pathology "Victor Babes" National Institute of Pathology Department of Gastroenterology and Hepatology Fundeni Clinical Institute

In recent years, the improvement of technology and the increase in knowledge have shifted several strongly held paradigms. This is particularly true in gastroenterology, and specifically in the field of the so-called "functional" or "idiopathic" disease, where conditions thought for decades to be based mainly on alterations of visceral perception or aberrant psychosomatic mechanisms have, in fact, be reconducted to an organic basis (or, at the very least, have shown one or more demonstrable abnormalities). This is particularly true, for instance, for irritable bowel syndrome, the prototype entity of "functional" gastrointestinal disorders, where low-grade inflammation of both mucosa and myenteric plexus has been repeatedly demonstrated. Thus, researchers have also investigated other functional/idiopathic gastrointestinal disorders, and found that some organic ground is present, such as abnormal neurotransmission and myenteric plexitis in esophageal achalasia and mucosal immune activation and mild eosinophilia in functional dyspepsia. Here we show evidence, based on our own and other authors' work, that chronic constipation has several abnormalities reconductable to alterations in the enteric nervous system, abnormalities mainly characterized by a constant decrease of enteric glial cells and interstitial cells of Cajal (and, sometimes, of enteric neurons). Thus, we feel that (at least some forms of) chronic constipation should no more be considered as a functional/idiopathic gastrointestinal disorder, but instead as a true enteric neuropathic abnormality.

关键词： Constipation Enteric glia Enteric nervous system Enteric neurons Interstitial cells of Cajap Neurogastroenterology