Beyond natural targets: chemical synthesis reprograms the target specificity of rapamycin

作     者：Ziyang Zhang Ziyang Zhang

作者机构：Department of Cellular and Molecular PharmacologyUniversity of California 

出 版 物：《National Science Review》 (国家科学评论(英文版))

年 卷 期：2022年第9卷第11期

页      面：8-9页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

主　　题：PRODUCTS 

摘      要：Natural products have served as a rich source of new drugs, either directly or as inspirations for pharmacophores [1].Under the constant pressure of evolution,natural products have exploited numerous biosynthetic machineries to achieve their extraordinary chemical diversity as well as unique mechanisms of action.