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Combined cell-based therapy strategies for the treatment of Parkinson's disease:focus on mesenchymal stromal cells

Neural Regeneration research 2023年第3期18卷 478-484页

作者： Jannette Rodríguez-Pallares María García-Garrote Juan A.Parga JoséLuis Labandeira-García Laboratory of cellular and molecular Neurobiology of Parkinson´s Disease Research Center for Molecular Medicine and Chronic Diseases(CiMUS)IDISDepartment of Morphological SciencesUniversity of Santiago de CompostelaSantiago de CompostelaSpain Networking research center on Neurodegenerative Diseases(CIBERNED) MadridSpain

Parkinson’s disease is a neurodegenerative condition characterized by motor impairments caused by the selective loss of dopaminergic neurons in the substantia *** is an effective and well-tolerated dopamine replacement ***,levodopa provides only symptomatic improvements,without affecting the underlying pathology,and is associated with side effects after long-term ***-based replacement is a promising strategy that offers the possibility to replace lost neurons in Parkinson’s disease *** studies of transplantation of human fetal ventral mesencephalic tissue have provided evidence that the grafted dopaminergic neurons can reinnervate the striatum,release dopamine,integrate into the host neural circuits,and improve motor *** of the limiting factors for cell therapy in Parkinson’s disease is the low survival rate of grafted dopaminergic *** factors could cause cell death of dopaminergic neurons after grafting such as mechanical trauma,growth factor deprivation,hypoxia,and *** factors play an essential role in the survival of grafted ***,direct,timely,and controllable delivery of neurotrophic factors into the brain faces important *** types of cells secrete neurotrophic factors constitutively and co-transplantation of these cells with dopaminergic neurons represents a feasible strategy to increase neuronal *** this review,we provide a general overview of the pioneering studies on cell transplantation developed in patients and animal models of Parkinson’s disease,with a focus on neurotrophic factor-secreting cells,with a particular interest in mesenchymal stromal cells;that co-implanted with dopaminergic neurons would serve as a strategy to increase cell survival and improve graft outcomes.

关键词： brain repair cell replacement co-grafts dopaminergic neurons fetal ventral mesencephalic tissue mesenchymal stem cells neural grafting neural transplantation neuroblasts neurotrophic factors

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Axon regeneration:membrane expansion and lipidomics

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Neural Regeneration research 2022年第5期17卷 989-990页

作者： Sean Meehan Sanjoy K.Bhattacharya Graduate Program in molecular and cellular Pharmacology Miami Integrative Metabolomics Research CenterBascom Palmer Eye InstituteUniversity of MiamiMiamiFLUSA

Axon regeneration requires protein synthesis and membrane *** presence of granular material was discovered in the perikaryon of neurons but not axons using Nissl staining(Gomes,2019).This is one of the characteristic ... 详细信息

关键词： expansion. expansion regeneration

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The potential of miR-183 family expression in inner ear for regeneration,treatment,diagnosis and prognosis of hearing loss

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Journal of Otology 2017年第2期12卷 55-61页

作者： Mohammad-Reza Mahmoodian-sani Ameneh Mehri-Ghahfarrokhi research center for molecular Medicine Hamadan University of Medical SciencesHamadanIran Dept.of Genetics and molecular Medicine Hamadan University of Medical SciencesHamadanIran cellular and molecular research center Shahrekord University of Medical SciencesSharekordIran

miRNA-183 family, in normal biology, is expressed in a harmonious and stable manner in the neurosensory organs and cells. Studies have also shown that miRNA-183 family, in different pathways, affects the neurosensory development, maintenance, survival and function. In addition, it has potential neuroprotective effects in response to neurosensory destructive stimulations. miRNA-96 mutation causes hereditary deafness in humans and mice, and therefore affects the inner ear activity and its maintenance. Certain roles have been identified for mi R-96 in the maintenance and function of the inner ear. The comparison of the target genes of family-183 in transcriptomes of newborn and adult hair cells shows that hundreds of target genes in this family may affect development and maintenance of the ears. Identifying the genes that are regulated by miRNA-183 family provides researchers with important information about the complex development and environmental regulation of the inner ear, and can offer new approaches to the maintenance and regeneration of hair cells and auditory nerve.

关键词： miRNA-183 family Hearing loss miRNA Inner ear Hair cell

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Gut microbiota derived metabolites in cardiovascular health and disease

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Protein & Cell 2018年第5期9卷 416-431页

作者： Zeneng Wang Yongzhong Zhao Department of cellular and molecular Medicine Lerner Research Institute Cleveland Clinic Cleveland OH 44195 USA

Trillions of microbes inhabit the human gut, not only providing nutrients and energy to the host from the ingested food, but also producing metabolic bioactive signaling molecules to maintain health and elicit dis- ease, such as cardiovascular disease （CVD）. CVD is the leading cause of mortality worldwide. In this review, we presented gut microbiota derived metabolites involved in cardiovascular health and disease, including trimethylamine-N-oxide （TMAO）, uremic toxins, short chain fatty acids （SCFAs）, phytoestrogens, antho- cyanins, bile acids and lipopolysaccharide. These gut microbiota derived metabolites play critical roles in maintaining a healthy cardiovascular function, and if dysregulated, potentially causally linked to CVD. A bet- ter understanding of the function and dynamics of gut microbiota derived metabolites holds great promise toward mechanistic predicative CVD biomarker discoveries and precise interventions.

关键词： gut microbiota metabolites cardiovascularhealth cardiovascular disease

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Hyaluronic acid algorithm-based models for assessment of liver fibrosis： translation from basic science to clinical application

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Hepatobiliary & Pancreatic Diseases International 2016年第2期15卷 131-140页

作者： Zeinab Babaei Hadi Parsian Student research Committee&Department of Biochemistry and Biophysics Babol University of Medical SciencesBabolIran cellular and molecular Biology research center Health Research InstituteBabol University of Medical SciencesBabolIran

BACKGROUND： The estimation of liver fibrosis is usually dependent on liver biopsy evaluation. Because of its disadvantages and side effects, researchers try to find non-invasive methods for the assessment of liver injuries. Hyaluronic acid has been proposed as an index for scoring the severity of fibrosis, alone or in algorithm models. The algorithm model in which hyaluronic acid was used as a major constituent was more reliable and accurate in diagnosis than hyaluronic acid alone. This review described various hyaluronic acid algorithm-based models for assessing liver *** SOURCE： A Pub Med database search was performed to identify the articles relevant to hyaluronic acid algorithmbased models for estimating liver ***： The use of hyaluronic acid in an algorithm model is an extra and valuable tool for assessing liver ***： Although hyaluronic acid algorithm-based models have good diagnostic power in liver fibrosis assessment, they cannot render the need for liver biopsy obsolete and it is better to use them in parallel with liver biopsy. They can be used when frequent liver biopsy is not possible in situations such as highlighting the efficacy of treatment protocol for liver fibrosis.

关键词： algorithm hyaluronic acid liver disease liver fibrosis

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Beyond functional MRI signals:molecular and cellular modifiers of the functional connectome and cognition

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Neural Regeneration research 2024年第5期19卷 937-938页

作者： Lorenzo Pini Alessandro Salvalaggio Maurizio Corbetta Padova Neuroscience center University of PadovaItaly Veneto Institute of molecular Medicine VIMMPadovaItaly Department of Neuroscience University of PadovaItaly

Our brain is constantly *** at rest,the brain carries out essential functions such as maintenance of resting potentials,subthreshold synaptic activity,and spiking activity related to information *** resting activity can be assessed with several in vivo tools,such as resting-state functional magnetic resonance *** technique measures subtle changes in blood flow,volume,and oxygenation that occur over *** vascular in nature,resting-state functional magnetic resonance imaging is considered a reliable proxy of neural activity and several studies have shown that the brain is functionally divided into interacting neural networks called the“functional connectome”.

关键词： functional neural measures

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Exosomes as mediators of neuron-glia communication in neuroinflammation

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Neural Regeneration research 2020年第5期15卷 796-801页

作者： María Pascual Francesc Ibánez Consuelo Guerri Department of molecular and cellular Pathology of Alcohol Príncipe Felipe Research CenterValenciaSpain Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain

In recent years,a type of extracellular vesicles named exosomes has emerged that play an important role in intercellular communication under physiological and pathological *** nanovesicles (30–150 nm) contain proteins,RNAs and lipids,and their internalization by bystander cells could alter their normal *** review focuses on recent knowledge about exosomes as messengers of neuron-glia communication and their participation in the physiological and pathological functions in the central nervous *** emphasis is placed on the role of exosomes under toxic or pathological stimuli within the brain,in which the glial exosomes containing inflammatory molecules are able to communicate with neurons and contribute to the pathogenesis of neuroinflammation and neurodegenerative *** the small size and characteristics of exosomes,they can cross the blood-brain barrier and be used as biomarkers and diagnosis for brain disorders and ***,although the application potential of exosome is still limited,current studies indicate that exosomes represent a promising strategy to gain pathogenic information to identify therapeutically targets and biomarkers for neurological disorders and neuroinflammation.

关键词： biomarkers exosomes glial cells neuroinflammation neuron-glia commuication neurons neuropathology therapy

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Sustained small and intermediate size proteins expression in phorbol 12-myristate 13-acetate/ionomycine prolonged stimulated human fibroblasts

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Asian Pacific Journal of Tropical Biomedicine 2017年第5期7卷 432-436页

作者： Zeinab Abedian Sadegh Fattahi Roghayeh Pourbagher Sahar Edrisi Amrollah Mostafazadeh cellular and molecular Biology research center Health Research InstituteBabol University of Medical SciencesBabolIran Dental Material research center Faculty of DentistryBabol University of Medical SciencesBabolIran

Objective:To compare the protein profile of culture supernatants in stimulated and unstimulated human fibroblasts to find some proteins indicating the presence of fibroblasts and their activation ***:Dermal fibroblasts were stimulated with phorbol 12-myristate 13-acetate(PMA)/ionomycine for 72 *** assay was done to determine cell viability and A/E fluorescent staining was used to evaluate the cell death *** analysis was performed by gradient SDS polyacrylamide gel electrophoresis 8%–16%.Results:The supernatant of 24 h cultured both stimulated and unstimulated fibroblasts showed two bands in SDS-PAGE analysis with relative molecular weights of 8.59 and78.8 k *** bands density was decreased during the next 48 h in unstimulated cells while their expression was continued in PMA or PMA/ionomycine stimulated cells and a new 85.3 k Da band was appeared in unstimulated and 72 h PMA stimulated ***,we found another seven small size(10–19.5 k Da) proteins in supernatants of48 h and 72 h unstimulated but not in PMA or PMA/Ionomycine stimulated *** of these proteins expression were down regulated following fibroblast *** down-regulation is consistent with our finding that PMA or PMA/ionomycine stimulated cells exhibited a significant level of apoptosis cell ***:Human fibroblasts produce some small to intermediate sized proteins with specific SDS-PAGE profile upon cell *** of these proteins can be excreted in urine and can be immunogen theoretically so this data provided a reliable clue for fibrosis biomarker screening based on designation of an appropriated immunoassay.

关键词： Fibroblast activation Apoptosis Protein electrophoresis phorbol 12-myristate 13-acetate Ionomycine Fibrosis Biomarker

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Wood of trees:cellular structure,molecular formation,and genetic engineering

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Journal of Integrative Plant Biology 2024年第3期66卷 443-467页

作者： Yingying Zhu Laigeng Li State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems and College of Ecology Lanzhou UniversityLanzhou 730000China National Key Laboratory of Plant molecular Genetics CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 200032China

Wood is an invaluable asset to human society due to its renewable nature,making it suitable for both sustainable energy production and material ***,wood derived from forest trees plays a crucial role in sequestering a significant portion of the carbon dioxide fixed during photosynthesis by terrestrial ***,with the expansion of the global population and ongoing industrialization,forest coverage has been substantially decreased,resulting in significant challenges for wood production and *** production practices have changed away from natural forests toward plantation ***,understanding the underlying genetic mechanisms of wood formation is the foundation for developing high-quality,fast-growing plantation *** ideal forest trees for wood production using genetic technologies has attracted the interest of *** studies have been carried out in recent years on the molecular,genetic,and cell-biological mechanisms of wood formation,and considerable progress and findings have been *** studies and findings indicate enormous possibilities and prospects for tree *** review will outline and assess the cellular and molecular mechanisms of wood formation,as well as studies on genetically improving forest trees,and address future development prospects.

关键词： cambium cell wall Populus wood formation xylem

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Novel roles of Skp2 E3 ligase in cellular senescence,cancer progression,and metastasis

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癌症 2012年第4期31卷 169-177页

作者： Chia-Hsin Chan Department of molecular and cellular Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

S-phase kinase-associated protein 2 (Skp2) belongs to the F-box protein *** is a component of the SCF E3 ubiquitin ligase ***2 has been shown to regulate cellular proliferation by targeting several cell cycle-regulated proteins for ubiquitination and degradation,including cyclin-dependent kinase inhibitor ***2 has also been demonstrated to display an oncogenic function since its overexpression has been observed in many human *** review discusses the recent discoveries on the novel roles of Skp2 in regulating cellular senescence,cancer progression,and metastasis,as well as the therapeutic potential of targeting Skp2 for human cancer treatment.

关键词： Skp2 p53 RhoA cellular senescence metastasis cancer therapy

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