Gut microbiota derived metabolites in cardiovascular health and disease

作     者：Zeneng Wang Yongzhong Zhao 

作者机构：Department of Cellular and Molecular Medicine Lerner Research Institute Cleveland Clinic Cleveland OH 44195 USA 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2018年第9卷第5期

页      面：416-431页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 090403[农学-农药学(可授农学、理学学位）] 08[工学] 09[农学] 0904[农学-植物保护] 083203[工学-农产品加工及贮藏工程] 

基　　金：supported by grants from the National Institutes of Health and the Office of Dietary Supplements 

主　　题：gut microbiota metabolites cardiovascularhealth cardiovascular disease 

摘      要：Trillions of microbes inhabit the human gut, not only providing nutrients and energy to the host from the ingested food, but also producing metabolic bioactive signaling molecules to maintain health and elicit dis- ease, such as cardiovascular disease （CVD）. CVD is the leading cause of mortality worldwide. In this review, we presented gut microbiota derived metabolites involved in cardiovascular health and disease, including trimethylamine-N-oxide （TMAO）, uremic toxins, short chain fatty acids （SCFAs）, phytoestrogens, antho- cyanins, bile acids and lipopolysaccharide. These gut microbiota derived metabolites play critical roles in maintaining a healthy cardiovascular function, and if dysregulated, potentially causally linked to CVD. A bet- ter understanding of the function and dynamics of gut microbiota derived metabolites holds great promise toward mechanistic predicative CVD biomarker discoveries and precise interventions.