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Facile synthesis of a tumor microenvironment-responsive nanomaterial with metallic polyphenol-encapsulated for enhanced synergistic therapy

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Journal of Rare Earths 2024年第10期42卷 1895-1902页

作者： Kaige Yu Nuo Kou Shouqiang Zhang Tianqi Cao Hanqing Wu Jing Zhou Department of Chemistry Capital Normal UniversityBejing100048China College of Teacher Education Capital Normal University Beijing100048China

The tumor microenvironment(TME)differs from normal tissue cells in its physiological and biochemical *** construction of TME-responsive nanoplatforms requires a tedious preparation process and complex multicomponent *** this work,Er@EGCG-Cu,a TME-responsive nanoplatform,was simply and rapidly synthesized by combining rare earth-doped nanomaterials(NaLuF_(4):Yb,Er)with EGCG-Cu which is based on the ability of metal ions to coordinate with polyphenols to form a metal-phenolic network(MPN)*** MPN structure is then destroyed under an acidic TME,releasing the chemotherapy(CT)drug EGCG,which can cause apoptosis,Cu_(x)S_(y)is generated by combining Cu^(2+)with H_2S overexpressed in human colorectal cancer cells and can be used for photothermal therapy(PTT).Cell experiments show that laser irradiation improves the CT/PTT synergistic effect of Er@*** study has significance for the construction of TME-responsive nanomedicines with simple and rapid preparation for synergistic therapy.

关键词： Tumor microenvironment Metal-polyphenol networks Synergistic therapy Rare earths Nanomaterials

Synthesis of ordered hierarchically mesoporous/microporous carbon materials via compressed CO_(2) for fructose-to-HMF transformation

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Green Energy & Environment 2022年第5期7卷 1033-1044页

作者： Sen Luan Wei Li Zanwu Guo Wenxiu Li Xiaojian Hou Yi Song Ran Wang Qian Wang Department of Chemistry Capital Normal UniversityBeijing100048China

Well-ordered hierarchically mesoporous/microporous carbon materials have been successfully fabricated by using dual soft-templating approach through compressed CO_(2).Pluronic F127 and different type of surfactants,including nonionic,cationic,and anionic surfactants,were used as dual templates to investigate the influence on the morphology and nanostructure of the as-prepared carbon ***,SEM,N2 sorption,wide-angle and small-angle XRD analysis were employed to reveal the well-ordered hierarchically micro-mesoporous structure with2 D hexagonal symmetry by using compressed CO_(2).The prepared HPC samples with different pressures as the catalyst carriers have been functioned by chlorosulfonic acid for the fructose conversion into *** acid concentration,catalyst dosage and reaction temperature have been optimized for fructose-to-HMF transformation with the obtained *** performances of as-made HPC-SO_(3) H samples in HMF yield and reaction rate of fructose-to-HMF transformation have been *** stability of the samples was also conducted in the dehydration of fructose to HMF for five *** possible catalytic mechanism by using hierarchically porous carbon materials as catalyst support for fructose-to-HMF transformation was proposed.

关键词： ordered catalyst carbon

Enhanced hyperthermia performance in hard-soft magnetic mixed Zn0.5CoxFe2.5−xO4/SiO2 composite magnetic nanoparticles

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Chinese Physics B 2021年第3期30卷 409-415页

作者： Xiang Yu Li-Chen Wang Zheng-Rui Li Yan Mi Di-An Wu Shu-Li He Department of Physics Capital Normal UniversityBeijing 100048China

High quality Zn0.5CoxFe2.5−xO4(x=0,0.05,0.1,0.15)serial magnetic nanoparticles with single cubic structures were prepared by the modified thermal decomposition method,and Zn0.5CoxFe2.5−xO4/SiO2 composite magnetic nanoparticles were prepared by surface modification of *** magnetic anisotropy of the sample increases with the increase of the doping amount of Co2+.When the doping amount is 0.1,the sample shows the transition from superparamagnetism to ferrimagnetism at room *** the Zn0.5CoxFe2.5−xO4/SiO2 serial samples,the maximum value of specific loss power(SLP)with 1974 W/gmetal can also be found at doping amount of x=*** composite nanoparticles are expected to be an excellent candidate for clinical magnetic hyperthermia.

关键词： magnetic nanoparticles magnetic anisotropy Zn0.5CoxFe2.5−xO4/SiO2 magnetic hyperthermia

Bimetallic ZIFs-derived electrospun carbon nanofiber membrane as bifunctional oxygen electrocatalyst for rechargeable zinc-air battery

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Journal of Energy Chemistry 2023年第8期83卷 138-149,I0006页

作者： Yanan Ma Shaoru Tang Haimeng Wang Yuxuan Liang Dingyu Zhang Xiaoyang Xu Qian Wang Wei Li Department of Chemistry Capital Normal UniversityBeijing 100048China

The recharged zinc-air battery(ZAB) has drawn significant attention owing to increasing requirement for energy conversion and storage *** the efficient bifunctional oxygen catalyst using a convenient strategy is vitally important for the rechargeable *** this study,the bimetallic ZIFs-containing electrospun(ES) carbon nanofibers membrane with hierarchically porous structure was prepared by coaxial electrospinning and carbonization process,which was expected to be a bifunctional electrocatalyst for *** to the formed dual single-atomic sites of Co-N_(4) and Zn-N_(4),the obtained ES-Co/ZnCNZIFexhibited the preferable performance toward oxygen reduction reaction(ORR) with E1/2of 0.857 V and JLof 5.52 mA cm^(-2),which were more than Pt/***,it exhibited a marked oxygen evolution reaction(OER) property with overpotential of 462 mV due to the agglomerated metallic Co ***,the ZAB based on the ES-Co/Zn-CNZIFcarbon nanofibers membranes delivered peak power density of 215 mW cm^(-2),specific capacity of 802.6 mA h g^(-1),and exceptional cycling stability,far larger than Pt/C+RuO_(2)-based ZABs.A solid-state ZAB based on ES-Co/Zn-CNZIFshowed better flexibility and stability with different bending angles.

关键词： Electrospun nanofibers membranes Zeolite imidazole framework Zinc-air battery ORR/OER bifunction Dual single-atomic sites catalysts

Polaron and molecular states of a spin-orbit coupled impurity in a spinless Fermi sea

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Chinese Physics B 2021年第10期30卷 447-456页

作者： Hong-Hao Yin Tian-Yang Xie An-Chun Ji Qing Sun Department of Physics Capital Normal UniversityBeijing 100048China

We investigate the polaron and molecular states of a fermionic atom with one-dimensional spin-orbit coupling(SOC)coupled to a three-dimensional spinless Fermi *** of the interplay among the SOC,Raman coupling and spinselected interatomic interactions,the polaron state induced by the spin-orbit coupled impurity exhibits quite unique *** find that the energy dispersion of the polaron generally has a double-minimum structure,which results in a finite center-of-mass(c.m.)momentum in the ground state,different from the zero-momentum polarons where SOC are introduced into the majority *** further tuning the parameters such as the atomic interaction strength,a discontinuous transition between the polarons with different *** may occur,signaled by the singular behavior of the quasiparticle residue and effective mass of the ***,the molecular state as well as the polaron-to-molecule transition is also strongly affected by the Raman coupling and the effective Zeeman field,which are introduced by the lasers generating SOC on the impurity *** also discuss the effects of a more general spin-dependent interaction and mass *** results would be beneficial for the study of impurity physics brought by SOC.

关键词： spin-orbit coupling polaron Fermi gas

Effective Hamiltonian of the Jaynes–Cummings model beyond rotating-wave approximation

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Chinese Physics B 2021年第6期30卷 300-305页

作者： Yi-Fan Wang Hong-Hao Yin Ming-Yue Yang An-Chun Ji Qing Sun Department of Physics Capital Normal UniversityBeijing 100048China

The Jaynes–Cummings model with or without rotating-wave approximation plays a major role to study the interaction between atom and light. We investigate the Jaynes–Cummings model beyond the rotating-wave approximation. Treating the counter-rotating terms as periodic drivings, we solve the model in the extended Floquet space. It is found that the full energy spectrum folded in the quasi-energy bands can be described by an effective Hamiltonian derived in the highfrequency regime. In contrast to the Z_(2) symmetry of the original model, the effective Hamiltonian bears an enlarged U(1)symmetry with a unique photon-dependent atom-light detuning and coupling strength. We further analyze the energy spectrum, eigenstate fidelity and mean photon number of the resultant polaritons, which are shown to be in accordance with the numerical simulations in the extended Floquet space up to an ultra-strong coupling regime and are not altered significantly for a finite atom-light detuning. Our results suggest that the effective model provides a good starting point to investigate the rich physics brought by counter-rotating terms in the frame of Floquet theory.

关键词： Jaynes–Cummings model Floquet theory high-frequency approximation

Pharmacophore Screening on Piperidinecarboxamides Derivatives Based on GALAHAD and CoMFA Models

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Chinese Journal of Chemistry 2011年第6期29卷 1075-1083页

作者： Liu, Ming Wu, Qiangsan Hu, Wenxiang College of Life Science Capital Normal University Beijing 100048 China Department of Chemistry Capital Normal University Beijing 100048 China

In order to discover the novel anticonvulsant drugs, pharmacophore screening of the anticonvulsant inhibitors was enforced. Genetic Algorithm with Linear Assignment for Hypermolecular Alignment of Datasets （GALAHAD） and Comparative Molecular Field Analysis （CoMFA） studies were combined to implement our research. Firstly, multiple models were generated using GALAHAG based on high active molecules. Secondly, several of them were validated using the CoMFA study. Finally, a good values of q2 from training set and promising predictive power from test set were obtained based on one model simutaneously. One model had been selected as the most reasonable pharmacophore model. The results of the CoMFA study based on the model 1 suggested that both steric and electrostatic interactions played important roles.

关键词： pharmacophore comparative molecular field analysis (CoMFA) genetic algorithm with linear assignment for hypermolecular alignment of datasets (GALAHAD) piperidinecarboxamide

Rare earth fluorescent nanoprobes with minimal side effects enable tumor microenvironment activation for chemotherapy

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Journal of Rare Earths 2024年第2期42卷 256-262,I0001页

作者： Tianqi Cao Yuxin Liu Qi Jia Xiaolu Wang Shouqiang Zhang Jing Zhou Department of Chemistry Capital Normal UniversityBeijing100048China

Chemotherapy,the use of antitumor drugs to kill cancer cells,is currently one of the most effective treatments for ***,serious toxic side effects caused by long-term drug accumulation can cause significant damage to the body,which limits the clinical application of antitumor *** this study,a novel RENPs@DOX-Fe nanoprobe(NP) was constructed by coating the surface of rare earth nanomaterials(NaLuF_(4):Yb,Er) with a complex formed by doxorubicin(DOX) and iron ion(Ⅲ).Due to the low toxicity of anthracycline-metal complexes,the damage to normal cells is *** unique acidic microenvironment in tumor cells facilitates the decomposition and gradual release of DOX from the DOX-Fe *** addition,the DOX-Fe complex can convert near-infrared(NIR) light into heat energy,which promotes the decomposition of the complex,further enhancing the release of DOX in the tumor *** change of ratio fluorescence of rare earth nanomaterials at 660 and 1550 nm after DOX release enables visual monitoring of drug release,which can potentially improve the chemotherapeutic *** vitro experiments established that RENPs@DOX-Fe NPs with NIR illumination had good therapeutic efficacy in *** work provides new insights into designing tumor microenvironment-responsive nanoprobes for chemotherapy with minimal side effects.

关键词： Rare earth nanoprobes Fluorescence Ratiometric imaging DOX Chemotherapy

Deterministic nondestructive state analysis for polarization-spatial-time-bin hyperentanglement with cross-Kerr nonlinearity

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Chinese Physics B 2021年第3期30卷 176-182页

作者： Hui-Rong Zhang Peng Wang Chang-Qi Yu Bao-Cang Ren Department of Physics Capital Normal UniversityBeijing 100048China

We present a deterministic nondestructive hyperentangled Bell state analysis protocol for photons entangled in three degrees of freedom(DOFs),including polarization,spatial-mode,and time-bin *** polarization Bell state analyzer and spatial-mode Bell state analyzer are constructed by polarization parity-check quantum nondemolition detector(P-QND)and spatial-mode parity-check quantum nondemolition detector(S-QND)using cross-Kerr nonlinearity,*** time-bin Bell state analyzer is constructed by the swap gate for polarization state and time-bin state of a photon(P-T swap gate)and *** Bell states analyzer for one DOF will not destruct the Bell states of other two DOFs,so the polarization-spatial-time-bin hyperentangled Bell states can be determinately distinguished without *** deterministic nondestructive state analysis method has useful applications in quantum information protocols.

关键词： quantum communication deterministic nondestructive state analysis polarization-spatial-time-bin hyperentanglement