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Science China Chemistry 2024年第9期67卷 2989-2997页

作者： Pengxin Wang Xiaoyong Zhang Lingqing Wang Rui Wang Dongxu Yang Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences&Research Unit of Peptide ScienceChinese Academy of Medical SciencesLanzhou UniversityLanzhou 730000China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China School of Sciences Great Bay UniversityDongguan 523000China institute of Systems and Physical Biology Shenzhen Bay LaboratoryShenzhen 518055China

Chirality transformation is a basic,attractive,and important strategy for obtaining enantioenriched products with desired chiral *** reported chirality conversion reaction often involves the process from one type of chirality to another *** better utilize the chirality transformation strategy for obtaining two or more products with different chiral elements in a single reaction,a new method of kinetic resolution accompanied by a chirality transformation protocol is proposed and successfully realized in this *** process is used for the asymmetric oxidation of phenol compounds along with the kinetic resolution of oxaziridines.A wide scope of products,including axially chiral phenols,oxaziridines,andα-hydroxyl cyclic ketones were smoothly obtained in high levels of yields and enantioselectivities in the developed *** products can be readily used for the synthesis of various types of chiral ligands,which are potential choices for other catalytic asymmetric reactions.

关键词： chirality transformation kinetic resolution accompanied axially chiral phenols chiral oxaziridines

Inhibition of the NF-κB Signaling Pathway Improves Cigarette Mainstream Smoke-Induced Lung Injury and Gut Microbiota Disturbance

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Biomedical and Environmental Sciences 2024年第6期37卷 676-681页

作者： Hong Huang Shengjie Li Lifang Zeng Yan Zhang Ying Chen Yanbing Ma Jing Wei Changwei Zou Tingtao Chen School of Resources and Environment Nanchang UniversityNanchang 330031JiangxiChina National Engineering research Center for Bioengineering Drugs and the Technologies Institute of Translational MedicineJiangxi Medical CollegeNanchang UniversityNanchang 330031JiangxiChina School of Pharmacy Jiangxi Medical CollegeNanchang UniversityNanchang 330006JiangxiChina

Currently,cigarette smoke(CS)remains a major contributor to disease morbidity and *** can be divided into cigarette mainstream smoke(CMS)and side-stream smoke,depending on where it is produced by burning tobacco^([1]).CMS is inhaled by smokers from the filter end during cigarette combustion and is strongly associated with the development of several diseases^([2-4]).

关键词： smoke CMS cigarette

Analysis and Key Parameter Optimization Design of Leningrader Seal Performance

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Wuhan University Journal of Natural Sciences 2024年第2期29卷 177-192页

作者： YANG Dongya WANG Xuelin WANG Feng ZHANG Hailong GAO Gui College of Mechanical and Electrical Engineering Lanzhou University of TechnologyLanzhou 730050Gansu China Wenzhou Pump and Valve Engineering research institute Lanzhou University of TechnologyWenzhou 325000ZhejiangChina State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000GansuChina

In order to improve the performance and service life of the Leningrader seal of the Stirling engine piston rod,interference,pre-load and friction coefficient were taken as influencing factors,and the curved surface response method was adopted to reduce the contact stress of sealing surface and von Mises stress of the sealing sleeve as the response index,with the optimization goal of reducing wear and extending *** above three key parameters are analyzed and optimized,the influence of each parameter on the sealing performance and service life is obtained,and the best combination scheme of the three is *** results show that the interaction between pre-tightening force and interference fit has the greatest impact on contact *** interaction between interference fit and friction coeffi-cient has the most significant effect on von Mises *** optimized parameters can reduce the maximum contact stress and maximum von Mises stress of the sealing sleeve by 26.3%and 20.6%,respectively,under a media pressure of 5-9 *** bench verification shows that the leakage of the optimized sealing device in 12 h is reduced by 0.44 cc·min^(-1)(1 cc=1 cm^(3)).The wear rate of the sealing sleeve is 1.08%before optimization and 0.45%after optimization,indicating that the optimized parameters in this paper are effective.

关键词： Leningrader seal Stirling engine performance analysis optimized design parameter configuration

Application of Earthquake-Proof Design in Highway Bridge Design

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Journal of World Architecture 2024年第4期8卷 1-6页

作者： Meng Wan China Merchants Chongqing Communications Technology research&Design institute Co. LTD.Chongqing 400067China

Highway bridges are an important part of transportation *** the rapid development of transportation,the design of bridge construction has received significant *** complex environment of some regions necessitates the selection of seismic design to improve the stability of the structure during the design phase of highway bridge *** article briefly discusses bridge structures that may be subject to seismic hazards and analyzes seismic design standards to explore their application in the design process of highway bridges,with the aim of providing support for bridge construction.

关键词： Seismic design Highway bridges Design

From Historical Landscapes to the Contemporary City: Interview with Professor Tim Bunnell

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全球城市研究（中英文） 2024年第2期5卷 136-148页

作者： Tim Bunnell Chong Xu Asia research institute National University of Singapore Geography at National University of Singapore History at Soochow University History at Soochow University

*** Xu:It is my great honour to have this opportunity to interview *** were trained as a geographer at the University of Nottingham in the *** you talk to us about why you have chosen urban studies as your main resear... 详细信息

关键词： interview Chong opportunity

Effects of Volcanic Activity on Organic Matter Sources and the Paleoenvironment:Geochemical Evidence from Upper Carboniferous Source Rocks(Batamayineishan Formation)in Eastern Junggar,NW China

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Journal of Earth Science 2024年第5期35卷 1482-1498页

作者： Ming Shao Tianzhu Lei Shuncun Zhang Shengyin Zhang Yu Pei Sen Song Northwest institute of Eco-Environment and Resources Chinese Academy of SciencesLanzhou 730000China Key Laboratory of Petroleum Resources Exploration and Evaluation Gansu ProvinceLanzhou 730000China State Key Laboratory of Baiyunobo Rare Earth Resource researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014060China

The mudstone,gray tuffite and carbonaceous shale in the Upper Carboniferous Batamayineishan Formation(Bashan Formation)are essential source rocks for the volcanic reservoir in eastern Junggar,northwestern *** kerogen components,vitrinite reflectance,Rock-Eval pyrolysis,lipid biomarkers and isotope compositions were measured to understand the provenance and depositional environment of Bashan Formation under the background of volcanic *** were 10 and 4 periods of volcanic eruptions identified in the wells CS and DZ,*** source rocks developed in the late or intermittent phase of volcanic *** original island arcs of the Early Carboniferous evolved into the Wucaiwan sag and the Dishuiquan sag in the Bashan *** Wucaiwan sag inherited the restricted,closed residual sea,which had a slightly anoxic and hypersaline *** Dishuiquan sag was generally an oxidizing lacustrine environment,influenced by a marine transgression that may have occurred at the end of the DZ_(Ⅲ)period during the Late *** the total organic matter decreased due to the volcanic eruption,ash could cause an increase of aquatic organisms,coinciding with increases in salinity and reducibility in the Dishuiquan sag.

关键词： organic geochemistry volcanic activity paleoenvironment upper carboniferous east-ern Junggar petroleumgeology

Refinement of α′Martensite by Oxygen in Selective Laser Melted Ti-6Al-4V

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Acta Metallurgica Sinica(English Letters) 2024年第5期37卷 777-792页

作者： Hasfi FNurly Jinhu Zhang Dechun Ren Yusheng Cai Haibin Ji Dongsheng Xu Zhicheng Dong Hao Wang Qingmiao Hu Jiafeng Lei Rui Yang School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials and Chemistry/Interdisciplinary Centre for Additive Manufacturing University of Shanghai for Science and TechnologyShanghai 200093China Centre for Adaptive System Engineering ShanghaiTech UniversityShanghai 201210China

Oxygen is crucial in influencing the microstructure evolution of selective laser melted(SLMed)Ti–6Al–4V,significantly impacting its applicability in various ***,this study investigates the influnce of oxygen on microstructure evolution,particularlyα′martensite transformation and refinement *** alloys,Ti–6Al–4V–xO(x=0.11,0.16,0.21,and 0.25 wt%),were fabricated by the SLM *** martensite start temperature(M_(s))of Ti–6Al–4V,as evaluated by computation,is 656.8°C,and oxygen was found to increase the M_(s) by about 10°C per 0.1 wt%.The SLMed alloy samples exhibit[001]_(β)growth texture along the build *** analysis of martensite morphology suggests internal twinning on{1011}planes as the lattice invariant strain,which becomes more predominant with increasing oxygen *** of α′martensite plates by oxygen is due to increased lattice distortion,reduced prior β grain size,and oxygen segregation toβgrain *** findings contribute to improving the understanding of the effect of oxygen on the transformation mechanism ofα′martensite during SLM of Ti–6Al–4V.

关键词： Selective laser melting α′Martensite Martensite start temperature Oxygen Ti-6Al-4V

The Effects of Thickness and Location of PCMon the Building’s Passive Temperature-Control–A Numerical Study

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Energy Engineering 2024年第3期121卷 681-702页

作者： Zhengrong Shi JieRen Tao Zhang Yanming Shen College of Energy and Mechanical Engineering Shanghai University of Electric PowerShanghai201306China research and Development Center Heatmate New Energy Technology Co.Ltd.Shanghai200090China Shanghai Non-Carbon Energy Conversion and Utilization institute Shanghai Jiao Tong UniversityShanghai200240China

Building energy consumption and building carbon emissions both account for more than 20%of their total national values in *** employing phase change material(PCM)for passive temperature control shows a promising prospect in meeting the comfort demand and reducing energy consumption ***,there is a lack of more detailed research on the interaction between the location and thickness of PCM and indoor natural convection,as well as indoor temperature *** this study,the numerical model of a passive temperature-controlled building integrating the developed PCM module is established with the help of *** which,the actual weather condition of Beijing city is set as the boundary conditions and the indoor natural convection is simulated with the consideration of radiation *** effects of PCM’s thickness and location on the internal temperature field are analyzed and *** results show that the room could maintain within the human comfort temperature range with the longest ratio of 94.10%and the shortest ratio of 51.04%as integrating *** comparison,the value is only 26.70%without *** room’s maximum temperature fluctuation can also be improved;it could be lowered by 64.4%compared to the normal *** the quantity of PCM is sufficient,further increasing the PCM amount results in a temperature fluctuation reduction of less than 0.1°C and does not increase the comfort *** PCM on the wall induces an apparent variation in indoor temperature along the vertical ***,placing PCM on the roof can lead to a heat transfer rate difference of up to seven *** optimal placement of PCM depends on the difference between the environmental and phase change *** the difference is positive,placing PCM on the roof is more effective;conversely,the opposite *** to the results over the entire cycle,PCM application on vertical walls yields better *** significant diffe

关键词： Phase change materials passive temperature regulation numerical simulation temperature field

The anodic dissolution kinetics of Mg alloys in water based on ab initio molecular dynamics simulations

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Materials Genome Engineering Advances 2024年第2期2卷 83-91页

作者： Jieqiong Yan Xinchen Xu Gaoning Shi Yaowei Wang Chaohong Guan Yuyang Chen Yao Yang Tao Ying Hong Zhu Qingli Tang Xiaoqin Zeng University of Michigan-Shanghai Jiao Tong University Joint institute Shanghai Jiao Tong UniversityShanghaiChina State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghaiChina Shenyang Aircraft Industry Co. Ltd.Technology Research InstituteShenyangChina Shanghai Advanced research institute Chinese Academy of SciencesShanghaiChina

The corrosion susceptibility of magnesium(Mg)alloys presents a significant challenge for their broad *** there have been extensive experimental and theoretical investigations,the corrosion mechanisms of Mg alloys are still unclear,especially the anodic dissolution ***,a thorough theoretical investigation based on ab initio molecular dynamics and metadynamics simulations has been conducted to clarify the underlying corrosion mechanism of Mg anode and propose effective strategies for enhancing corrosion *** comprehensive analyses of interfacial structures and equilibrium potentials for Mg(0001)/H_(2)O interface models with different water thicknesses,the Mg(0001)/72 H_(2)O model is identified to be reasonable with−2.17 V *** hydrogen electrode equi-librium *** addition,utilizing metadynamics,the free energy barrier for Mg dissolution is calculated to be 0.835 eV,enabling the theoretical determination of anodic polarization curves for pure Mg that aligns well with experimental *** on the Mg(0001)/72 H_(2)O model,we further explore the effects of various alloying elements on anodic corrosion resistance,among which Al and Mn alloying elements are found to enhance corrosion resistance of *** study provides valuable atomic-scale insights into the corrosion mechanism of magnesium alloys,offering theoretical guidance for developing novel corrosion-resistant Mg alloys.

关键词： AIMD corrosion equilibrium potential Mg atom dissolution polarization curve

Surgical Repair of Ventricular Septal Defect in Neonates: Indications and Outcomes

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Congenital Heart Disease 2024年第1期19卷 69-83页

作者： Jae Hong Lee Sungkyu Cho Jae Gun Kwak Hye Won Kwon Woong-Han Kim Mi Kyoung Song Sang-Yun Lee Gi Beom Kim Eun Jung Bae Department of Thoracic and Cardiovascular Surgery Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsanKorea Department of Thoracic and Cardiovascular Surgery Seoul National University Children’s HospitalSeoulKorea Department of Pediatrics Seoul National University Children’s HospitalSeoulKorea

Background:The optimal surgical timing and clinical outcomes of ventricular septal defect(VSD)closure in neo-nates remain *** aimed to evaluate the clinical outcomes of VSD closure in neonates(age≤30 days).Methods:We retrospectively reviewed 50 consecutive neonates who underwent VSD closure for isolated VSDs between August 2003 and June *** for the procedure included congestive heart failure/failure to thrive and pulmonary *** adverse events(MAEs)were deﬁned as the composite of all-cause mortality,reoperation,persistent atrioventricular block,and signiﬁcant(≥grade 2)valvular ***:The median age and body weight at operation were 26.0 days(interquartile range[IQR],18.8–28.3)and 3.7 kg(IQR,3.3–4.2),*** median follow-up duration was 110.4 months(IQR,56.8–165.0).Seven patients required preoperative respiratory support,andﬁve had signiﬁcant(≥grade 2)preoperative valvular *** early mortality occurred due to irreversible cardiogenic shock;no late mortality was *** reopera-tion was due to hemodynamically signiﬁcant residual VSD at 103.8 months *** overall survival,freedom from reoperation,and freedom from MAE at 15-years were 98.0%,96.3%,and 94.4%,***-operative mechanical ventilation was associated with a longer duration of postoperative mechanical ventilation(p<0.001)and a longer length of intensive care unit stay(p<0.001).Conclusions:VSD closure with favorable outcomes without morbidities is feasible even in ***,neonates requiring preoperative respiratory support may require careful postoperative management considering the long-term postoperative ***,surgical VSD closure might be indicated earlier in neonates with respiratory compromise.

关键词： Ventricular septal defect neonate early surgery neonatal surgery