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Acta Pharmaceutica Sinica B 2024年第3期14卷 1077-1097页

作者： Lindokuhle Cindy Nene Heidi Abrahamse laser Research centre Faculty of Health SciencesUniversity of JohannesburgDoornfontein 2028South Africa

Cancer remains one of the diseases with the highest incidence and mortality *** treatment modalities have demonstrated threatening drawbacks including invasiveness,noncontrollability,and development of resistance for some,including chemotherapy,radiation,and ***-photodynamic combinatorial therapy(SPDT)has been developed as an alternative treatment modality which offers a non-invasive and controllable therapeutic *** combines the mechanism of action of sonodynamic therapy(SDT),which uses ultrasound,and photodynamic therapy(PDT),which uses light,to activate a sensitizer and initiate cancer *** use of phthalocyanines(Pcs)as sensitizers for SPDT is gaining interest owing to their ability to induce intracellular oxidative stress and initiate toxicity under SDT and *** review discusses some of the structural prerequisites of Pcs which may influence their overall SPDT activities in cancer therapy.

关键词： Sonodynamic therapy Photodynamic therapy Combinatorial therapy Phthalocyanines Sensitizer Cancer

Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

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Neural Regeneration Research 2025年第2期20卷 598-608页

作者： Daniella Da Silva Madeleen Jansen van Rensburg Anine Crous Heidi Abrahamse laser Research centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

Kinetics of dense plasma in the field of short laser pulses:A generalized approach

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Matter and Radiation at Extremes 2024年第5期9卷 87-92页

作者： V.A.Astapenko V.S.Lisitsa Moscow Institute of Physics and Technology(national Research University) Institutskii per.9141701 DolgoprudnyiRussia national Research centre“Kurchatov Institute ”123182 MoscowRussia national Research Nuclear University MEPhI 115409 MoscowRussia

A generalized kinetic model of atomic level populations in an optically dense plasma excited by laser pulses of arbitrary duration is formulated and *** model is based on a nonstationary expression for the probability of excitation of an atomic transition and takes into account the effects of laser pulse penetration into an optically dense medium.A universal formula for the excitation probability as a function of time and propagation length is derived and applied to the case of a Lorentzian spectral profile of an atomic transition excited by a laser pulse with a Gaussian *** features of nonstationary excitation probabilities are presented for different optical depths of the plasma,laser pulse durations,and carrier *** formulas derived here will be useful for the description of atomic populations excited by laser pulses under realistic conditions of dense plasmas.

关键词： laser excitation excited

Towards a new avenue for rapid synthesis of electrocatalytic electrodes via laser-induced hydrothermal reaction for water splitting

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International Journal of Extreme Manufacturing 2024年第1期6卷 340-351页

作者： Yang Sha Menghui Zhu Kun Huang Yang Zhang Francis Moissinac Zhizhou Zhang Dongxu Cheng Paul Mativenga Zhu Liu Department of Materials School of Natural SciencesThe University of ManchesterOxford RoadManchester M139PLUnited Kingdom laser Processing Research centre Department of MechanicalAerospace and Civil EngineeringSchool of EngineeringThe University of ManchesterOxford RoadManchester M139PLUnited Kingdom national Graphene Institute The University of ManchesterOxford RoadManchester M139PLUnited Kingdom Department of Chemical Engineering and Analytical Science School of EngineeringThe University of ManchesterOxford RoadManchester M139PLUnited Kingdom Research centre for laser Extreme Manufacturing Ningbo Institute of Materials Engineering and TechnologyChinese Academy of SciencesNingboPeople’s Republic of China

Electrochemical production of hydrogen from water requires the development ofelectrocatalysts that are active,stable,and low-cost for water *** address these challenges,researchers are increasingly exploring binder-free electrocatalytic integratedelectrodes (IEs) as an alternative to conventional powder-based electrode preparation methods,for the former is highly desirable to improve the catalytic activity and long-term stability for large-scale applications of ***,we demonstrate a laser-inducedhydrothermal reaction (LIHR) technique to grow NiMoO4nanosheets on nickel foam,which is then calcined under H2/Ar mixed gases to prepare the IE *** electrode exhibits superior hydrogen evolution reaction performance,requiring overpotentials of 59,116 and143 mV to achieve current densities of 100,500 and 1000 mA·*** the 350 h chronopotentiometry test at current densities of 100 and 500 m A·cm-2,the overpotentialremains essentially *** addition,NiFe-layered double hydroxide grown on Ni foam is also fabricated with the same LIHR method and coupled with IE-NiMo-IR to achieve water *** combination exhibits excellent durability under industrial current *** energy consumption and production efficiency of the LIHR method are systematicallycompared with the conventional hydrothermal *** LIHR method significantly improves the production rate by over 19 times,while consuming only 27.78%of the total energy required by conventional hydrothermal methods to achieve the same production.

关键词： electrocatalytic electrode laser-induced hydrothermal reaction NiFe layered double hydroxides hydrogen evolution reaction water splitting energy consumption production rate

Hydro-uvarovite from Mantle Peridotites of Naga Hills Ophiolite: A Mineral Tracer for Neo-Tethyan Mantle Wedge Metasomatism

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Acta Geologica Sinica(English Edition) 2024年第4期98卷 867-877页

作者： Anisha VERENCAR Abhishek SAHA Nilanjana SORCAR Sohini GANGULY Pankaj KUMAR Atul Kumar SINGH csir-national Institute of Oceanography Dona PaulaGoa 403004India School of Earth Ocean and Atmospheric SciencesGoa UniversityTaleigao PlateauGoa 403206India national centre for Earth Science Studies ThiruvananthapuramKeralaIndia Inter University Accelerator centre(IUAC) New Delhi 110067India North-Eastern Hill University ShillongMeghalaya 793022India

Hydrous Cr-bearing uvarovite garnets are rare in natural occurrences and belong to the ugrandite series and exist in binary solid solutions with grossular and andradite garnets. Here, we report the occurrence of hydrous uvarovite garnet having Cr_(2)O_(3) upto 19.66 wt% and CaO of 32.12–35.14 wt% in the serpentinized mantle peridotites of Naga Hills Ophiolite(NHO), India. They occur in association with low-Cr diopsides. They are enriched in LILE(Ba, Sr), LREEs, with fractionating LREE-MREE [avg.(La/Sm)_(N) = 2.16] with flat MREE/HREE patterns [avg.(Sm/Yb)_(N) = 0.95]. Raman spectra indicate the presence of hydroxyl(OH^(–)) peaks from 3500 to 3700 cm^(-1). Relative abundances in fluid mobile elements and their close association with clinopyroxenes are suggestive of the formation of uvarovite garnets through low temperature metasomatic alteration of low-Cr diopsides by hydrothermal slab fluids. The high LREE concentration and absence of Eu anomaly in the garnet further attest to alkaline nature of the transporting slab dehydrated fluid rather the involvement of low-p H solution. The chemical characteristics of the hydroxyl bearing uvarovite hosted by the mantle peridotite of NHO deviate from the classical features of uvarovite garnet, and their origin is attributed to the fluid-induced metasomatism of the sub arc mantle wedge in a suprasubduction zone regime.

关键词： uvarovite hydroxyl metasomatic alteration low-Cr diopsides serpentinization mantle peridotite

The importance of Righi-Leduc heat flux to the ablative Rayleigh-Taylor instability during a laser irradiating targets

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High Power laser Science and Engineering 2024年第3期 14-24页

作者： Ye Cui Xiao-Hu Yang Yan-Yun Ma Guo-Bo Zhang Bi-Hao Xu Ze-Hao Chen Ze Li Fu-Qiu Shao Jie Zhang Department of Nuclear Science and Technology National University of Defense Technology Collaborative Innovation centre of IFSA Shanghai Jiao Tong University College of Advanced Interdisciplinary Studies National University of Defense Technology Department of Physics National University of Defense Technology Key Laboratory for laser Plasmas (Ministry of Education) School of Physics and Astronomy Shanghai Jiao Tong University

The Righi±Leduc heat flux generated by the self-generated magnetic field in the ablative Rayleigh±Taylor instability driven by a laser irradiating thin targets is studied through two-dimensional extended-magnetohydrodynamic simulations. The perturbation structure gets into a low magnetization state though the peak strength of the self-generated magnetic field could reach hundreds of teslas. The Righi±Leduc effect plays an essential impact both in the linear and nonlinear stages, and it deflects the total heat flux towards the spike base. Compared to the case without the self-generated magnetic field included, less heat flux is concentrated at the spike tip, finally mitigating the ablative stabilization and leading to an increase in the velocity of the spike tip. It is shown that the linear growth rate is increased by about 10%and the amplitude during the nonlinear stage is increased by even more than 10%due to the feedback of the magnetic field,respectively. Our results reveal the importance of Righi±Leduc heat flux to the growth of the instability and promote deep understanding of the instability evolution together with the self-generated magnetic field, especially during the acceleration stage in inertial confinement fusion.

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Equation of state for boron nitride along the principal Hugoniot to 16 Mbar

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Matter and Radiation at Extremes 2024年第5期9卷 77-86页

作者： Huan Zhang Yutong Yang Weimin Yang Zanyang Guan Xiaoxi Duan Mengsheng Yang Yonggang Liu Jingxiang Shen Katarzyna Batani Diluka Singappuli Ke Lan Yongsheng Li Wenyi Huo Hao Liu Yulong Li Dong Yang Sanwei Li Zhebin Wang Jiamin Yang Zongqing Zhao Weiyan Zhang Liang Sun Wei Kang Dimitri Batani national Key Laboratory of Plasma Physics Laser Fusion Research CenterChina Academy of Engineering PhysicsMianyang 621900China HEDPS Center for Applied Physics and Technologyand College of PhysicsPeking UniversityBeijing 100871China HEDPS Center for Applied Physics and Technologyand School of EngineeringPeking UniversityBeijing 100871China Institute of Plasma Physics and laser Microfusion Hery 2301-497 WarszawaPoland Universitéde Bordeaux CNRSCEACELIA(Centre Lasers Intenses et Applications)UMR 5107F-33405 TalenceFrance Institute of Applied Physics and Computational Mathematics Beijing 100094China

The thermodynamic properties of boron nitride under extreme pressures and temperatures are of great interest and importance for materials science and inertial confinement fusion physics,but they are poorly understood owing to the challenges of performing experiments and realizing ab initio ***,we report the first shock Hugoniot data on hexagonal boron nitride at pressures of 5–16 Mbar,using hohlraum-driven shock waves at the SGIII-p laser facility in *** density functional theory molecular dynamics calculations closely match experimental data,validating the equations of state for modeling the shock response of boron nitride and filling a crucial gap in the knowledge of boron nitride properties in the region of multi-Mbar pressures and eV *** results presented here provide fundamental insights into boron nitride under the extreme conditions relevant to inertial confinement fusion,hydrogen–boron fusion,and high-energy-density physics.

关键词： boron Hugoniot extreme

Compact ultrafast neutron sources via bulk acceleration of deuteron ions in an optical trap

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Matter and Radiation at Extremes 2024年第5期9卷 22-31页

作者： Zhiyu Lei Hanghang Ma Xiaobo Zhang Lin Yu Yihang Zhang Yutong Li Suming Weng Min Chen Jie Zhang Zhengming Sheng Key Laboratory for laser Plasmas and School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation centre of IFSA Shanghai Jiao Tong UniversityShanghai 200240China Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 201210China College of Physics and Electronics Engineering Northwest Normal UniversityLanzhou 730070China Beijing national Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

A scheme for a quasi-monoenergetic high-flux neutron source with femtosecond duration and highly anisotropic angular distribution is *** scheme is based on bulk acceleration of deuteron ions in an optical trap or density grating formed by two counter-propagating laser pulses at an intensity of-10^(16)W~cm^(2)in a near-critical-density *** deuterons are first pre-accelerated to an energy of tens of keV in the ambipolar fields formed in the optical *** energy is boosted to the MeV level by another one or two laser pulses at an intensity of-10^(20)W~cm^(2),enabling fusion reactions to be triggered with high *** contrast to previously proposed pitcher–catcher configurations,our scheme can provide spatially periodic acceleration structures and effective collisions between deuterons inside the whole target ***,neutrons are generated directly inside the optical *** simulations show that neutron pulses with energy 2–8 MeV,yield 10^(18)–10^(19)n/s,and total number 106–107 in a duration-400 fs can be obtained with a 25μm ***,the neutron pulses exhibit unique angularly dependent energy spectra and flux distributions,predominantly along the axis of the energy-boosting *** microsize femtosecond neutron pulses may find many applications,such as high-resolution fast neutron imaging and nuclear physics research.

关键词： acceleration scheme angular

Effect of short-time low-temperature austenitizing on microstructure and mechanical properties of DT300 ultra-high strength steel fabricated by laser powder bed fusion

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Journal of Iron and Steel Research International 2024年第7期31卷 1763-1777页

作者： Chen-yang Jiang Xiao-qiang Li Jin-tao Wang Hao Luo Sheng-qing Gao Sheng-guan Qu Chao Yang national Engineering Research centre of Near-Net-Shape Forming for Metallic Materials South China University of TechnologyGuangzhou 510640GuangdongChina Institute of New Materials Guangdong Academy of ScienceGuangzhou 510650GuangdongChina

To address the inhomogeneous microstructure and improve the mechanical properties of DT300 ultra-high strength steel specimens fabricated by laser powder bed fusion,different post-heat treatment schedules are *** the increase in austenitizing temperature and time,the migration rate of austenite grain boundaries continuously increases with the dissolution of nano-carbides,and the formation of nano-oxides and twin martensite is also inhibited *** rapid growth in the size of prior austenite grains and martensite laths,as well as the decrease in the content of nano-oxides and twin martensite,led to a rapid decrease in the strength(yield strength and ultimate tensile strength)from HT2 to HTF *** HT1 specimens(austenitizing at 830℃for 30 min,then oil quenching and tempering at 300℃for 120 min and finally air cooling)display excellent mechanical properties of yield strength of 1572 MPa,ultimate tensile strength of 1847 MPa,elongation of 9.84%,and fracture toughness of 106 MPa m^(1/2),which are counterparts to those of conventional DT300 steel forgings after heat treatment.

关键词： DT300 ultra-high strength steel laser powder bed fusion-Short-time low-temperature austenitizing Microstructure Mechanical property

Harnessing the power of complex light propagation in multimode fibers for spatially resolved sensing

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Photonics Research 2024年第3期12卷 411-422页

作者： DARCY L.SMITH LINH V.NGUYEN MOHAMMAD I.REJA ERIK P.SCHARTNER HEIKE EBENDORFF-HEIDEPRIEM DAVID J.OTTAWAY STEPHEN C.WARREN-SMITH Institute for Photonics and Advanced Sensing and School of Physics Chemistry and Earth SciencesThe University of AdelaideAdelaideSA 5005Australia Australian Research Council centre of Excellence for Gravitational Wave Discovery(OzGrav) AdelaideSAAustralia Future Industries Institute University of South AustraliaMawson LakesSA 5095Australia laser Physics and Photonics Devices Laboratory University of South AustraliaMawson LakesSA 5095Australia

The propagation of coherent light in multimode optical fibers results in a speckled output that is both complex and sensitive to environmental *** properties can be a powerful tool for sensing,as small perturbations lead to significant changes in the output of the ***,the mechanism to encode spatially resolved sensing information into the speckle pattern and the ability to extract this information are thus far *** this paper,we demonstrate that spatially dependent mode coupling is crucial to achieving spatially resolved *** leverage machine learning to quantitatively extract the spatially resolved sensing information from three fiber types with dramatically different characteristics and demonstrate that the fiber with the highest degree of spatially dependent mode coupling provides the greatest accuracy.

关键词： fiber spatially resolved