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Nano-multilayered ZrN‒Ag/Mo‒S‒N film design for stable anti-frictional performance at a wide range of temperatures

Friction 2024年第12期12卷 2826-2837页

作者： Hongbo JU Jing LUAN Junhua XU Albano CAVALEIRO Manuel EVARISTO Filipe FERNANDES School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China Department of Mechanical Engineering CEMMPREARISEUniversity of CoimbraRua Luís Reis SantosCoimbra 3030-788Portugal TINT-Laboratory for Tribology and Interface Nanotechnology Faculty of Mechanical EngineeringUniversity of LjubljanaAškerčeva 6Ljubljana 1000Slovenia cidem ISEP-Polytechnic of PortoRua Dr.António Bernardino de AlmeidaPorto 4249-015Portugal

A multilayer film,composed by ZrN‒Ag(20 nm)and Mo‒S‒N(10 nm)layers,combining the intrinsic lubricant characteristics of each layer was deposited using DC magnetron sputtering system,to promote lubrication in a wide-range of *** results showed that the ZrN‒Ag/Mo‒S‒N multilayer film exhibited a sharp interface between the different layers.A face-centered cubic(fcc)dual-phases of ZrN and Ag co-existed in the ZrN‒Ag layers,whilst the Mo‒S‒N layers displayed a mixture of hexagonal close-packed MoS_(2)(hcp-MoS_(2))nano-particles and an amorphous *** multilayer film exhibited excellent room temperature(RT)triblogical behavior,as compared to the individual monolayer film,due to the combination of a relative high hardness with the low friction properties of both *** reorientation of MoS_(2)parallel to the sliding direction also contributed to the enhanced anti-frictional performance at *** 400℃,the reorientation of MoS_(2)as well as the formation of MoO_(3)phase were responsible for the lubrication,whilst the hard t-ZrO_(2)phase promoted abrasion and,consequently,led to increasing wear *** 600℃,the Ag_(2)MoO_(4)double-metal oxide was the responsible for the low friction and wear-resistance;furthermore,the observed transformation from t-ZrO_(2)to m-ZrO_(2),could also have contributed to the better tribological performance.

关键词： DC magnetron sputtering ZrN‒Ag/Mo‒S‒N multilayer film tribological properties tribo-phases

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Topical Calendula officinalis *** inflammatory pain through antioxidant,anti-inflammatory and peripheral opioid mechanisms

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Journal of Integrative Medicine 2023年第1期21卷 34-46页

作者： Bárbara B.Garrido-Suárez Gabino Garrido Addis Bellma Menéndez Nelson Merino Odalys Valdés Nilia de la Paz Aylema Romero Livan Delgado Miguel D.Fernández Octavio Piñeros RenéDelgado-Hernández Pharmacology and Toxicology Chemical Analytic and Pharmaceutical Technology LaboratoriesCenter for Pharmaceutical Research and Development(CIDEM)Havana 10600Cuba Department of Pharmacology Institute of Marine Science(ICIMAR)Havana 10300Cuba Department of Pharmaceutical Sciences Faculty of SciencesCatholic University of the NorthAntofagasta 1240000Chile Research Department University of Santiago de CaliCali 760032Colombia Center for Research and Biological Evaluations Institute of Pharmacy and FoodUniversity of HavanaHavana 17100Cuba

Objective The present study evaluated the antinociceptive activity of Calendula officinalis L.(Ca)cream on inflammatory *** Creams with different Ca concentrations were tested for their ability to ameliorate pain-related behavior and edema in rats using formalin test,carrageenan(Cg)-induced acute inflammation model,bradykinin(BK)-induced acute inflammation model,and complete Freund’s adjuvant(CFA)-induced chronic inflammation *** the formalin test,we also examined the implication of peripheral opioid receptors in the antinociceptive mechanisms of Ca cream,by means of Q-naloxone,a peripherally acting nonselective opioid ***,the effects of Ca cream compared with diclofenac on BK-induced edema were examined when the kininase II in tissue was preserved or inhibited by *** local production of redox biomarkers in formalin model,tumor necrosis factor-α(TNF-α)in Cg model and histopathological changes in CFA model were also *** A single application of Ca cream at a dose of 10%or 30%(w/w)decreased the formalin-induced licking/biting behavior during both phases of this test in a Q-naloxone-sensitive *** effect was associated with the reduction of oxidative stress in the injured paw and the edema associated with the later phase of formalin-induced pain.A single application of Ca cream(10%or 30%)reduced paw edema and thermal hypernociception in Cg-induced acute inflammation,corresponding with a local decrease in TNF-α.Ca cream also inhibited BK-induced spontaneous nociceptive behavior and paw inflammation in both paradigms *** applications of Ca cream also decreased CFA-induced chronic inflammation,mechanical hypernociception and histopathological changes in the *** These results reveal the topical antinociceptive and antiedematogenic effects of Ca cream.A modulatory action on peripheral opioid receptors associated with its antioxidant mechanism may be involved,at least in par

关键词： Calendulaofficinalis L. Formalintest Pain Hyperalgesia Inflammation

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Ca^(2+)-亚氨二醋酸金属离子亲和色谱法吸附内毒素(英文)

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色谱 2012年第11期30卷 1194-1202页

作者： André Moreni LOPES Jorge Sánchez ROMEU Rolando Páez MEIRELES Gabriel Marquez PERERA Rolando Perdomo MORALES Adalberto PESSOA Lourdes Zumalacárregui CáRDENAS Department of Biochemical and Pharmaceutical Technology School of Pharmaceutical SciencesUniversity of So Paulo(FCF/USP) Purification Development Department Center for Genetic Engineering and Biotechnology(CIGB) Center for Pharmaceuticals Research and Development(cidem) Higher Polytechnic Institute José Antonio Echeverría(CUJAE)

Endotoxins(also known as lipopolysaccharides(LPS)) are undesirable by-products of recombinant proteins,purified from Escherichia *** can be considered stable under a wide range of temperature and pH,making their removal one of the most difficult tasks in downstream processes during protein *** inherent toxicity of LPS makes their removal an important step for the application of these proteins in several biological assays and for a safe parenteral *** metal affinity chromatography(IMAC) enables the affinity interactions between the metal ions(immobilized on the support through the chelating compound) and the target molecules,thus enabling high-efficiency separation of the target molecules from other components present in a *** chromatography is applied with Ca2+-iminodiacetic acid(IDA) to remove most of the LPS contaminants from the end product(more than90%).In this study,the adsorption of LPS on an IDA-Ca2+ was *** adsorption Freundlich isotherm of LPS-IDA-Ca2+ provides a theoretical basis for LPS *** was found that LPS is bound mainly by interactions between the phosphate group in LPS and Ca2+ ligands on the *** factors such as pH(4.0 or 5.5) and ionic strength(1.0 mol/L) are essential to obtain effective removal of LPS for contaminant levels between endotoxin' concentration values less than100 EU/mL and 100 000 EU/*** new protocol represents a substantial advantage in time,effort,and production costs.

关键词： immobilized metal affinity chromatography(IMAC) lipopolysaccharides(LPS) endotoxin removal recombinant proteins isotherms protein purification

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