Topical Calendula officinalis *** inflammatory pain through antioxidant,anti-inflammatory and peripheral opioid mechanisms

作     者：Bárbara B.Garrido-Suárez Gabino Garrido Addis Bellma Menéndez Nelson Merino Odalys Valdés Nilia de la Paz Aylema Romero Livan Delgado Miguel D.Fernández Octavio Piñeros RenéDelgado-Hernández Bárbara B.Garrido-Suárez;Gabino Garrido;Addis Bellma Menéndez;Nelson Merino;Odalys Valdés;Nilia de la Paz;Aylema Romero;Livan Delgado;Miguel D.Fernández;Octavio Pi?eros;René Delgado-Hernández

作者机构：Pharmacology and ToxicologyChemical Analytic and Pharmaceutical Technology LaboratoriesCenter for Pharmaceutical Research and Development(CIDEM)Havana 10600Cuba Department of PharmacologyInstitute of Marine Science(ICIMAR)Havana 10300Cuba Department of Pharmaceutical SciencesFaculty of SciencesCatholic University of the NorthAntofagasta 1240000Chile Research DepartmentUniversity of Santiago de CaliCali 760032Colombia Center for Research and Biological EvaluationsInstitute of Pharmacy and FoodUniversity of HavanaHavana 17100Cuba 

出 版 物：《Journal of Integrative Medicine》 (结合医学学报（英文版）)

年 卷 期：2023年第21卷第1期

页      面：34-46页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：This research was financed by the projects of Ministerio de Salud Pública(MINSAP)Cuba(No.0808001) Agencia Presidencial de Cooperación Internacional de Colombia(APC),Bilateral Program Cuba-Colombia,and Fondo Nacional de Desarrollo Científico y Tecnológico(FONDECYT)Chile(No.1130601) 

主　　题：Calendulaofficinalis L. Formalintest Pain Hyperalgesia Inflammation 

摘      要：Objective The present study evaluated the antinociceptive activity of Calendula officinalis L.(Ca)cream on inflammatory *** Creams with different Ca concentrations were tested for their ability to ameliorate pain-related behavior and edema in rats using formalin test,carrageenan(Cg)-induced acute inflammation model,bradykinin(BK)-induced acute inflammation model,and complete Freund’s adjuvant(CFA)-induced chronic inflammation *** the formalin test,we also examined the implication of peripheral opioid receptors in the antinociceptive mechanisms of Ca cream,by means of Q-naloxone,a peripherally acting nonselective opioid ***,the effects of Ca cream compared with diclofenac on BK-induced edema were examined when the kininase II in tissue was preserved or inhibited by *** local production of redox biomarkers in formalin model,tumor necrosis factor-α(TNF-α)in Cg model and histopathological changes in CFA model were also *** A single application of Ca cream at a dose of 10%or 30%(w/w)decreased the formalin-induced licking/biting behavior during both phases of this test in a Q-naloxone-sensitive *** effect was associated with the reduction of oxidative stress in the injured paw and the edema associated with the later phase of formalin-induced pain.A single application of Ca cream(10%or 30%)reduced paw edema and thermal hypernociception in Cg-induced acute inflammation,corresponding with a local decrease in TNF-α.Ca cream also inhibited BK-induced spontaneous nociceptive behavior and paw inflammation in both paradigms *** applications of Ca cream also decreased CFA-induced chronic inflammation,mechanical hypernociception and histopathological changes in the *** These results reveal the topical antinociceptive and antiedematogenic effects of Ca cream.A modulatory action on peripheral opioid receptors associated with its antioxidant mechanism may be involved,at least in par