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Layer by layer surface engineering of poly (lactide-co-glycolide) nanoparticles:A versatile tool for nanoparticle engineering for targeted drug delivery

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Science China Chemistry 2013年第8期56卷 1029-1039页

作者： ROMERO Gabriela MURRAY Richard A. QIU Yuan SANZ David MOYA Sergio E. Biosurfaces Department CIC biomaGUNE Department of Polymer Science and Engineering Zhejiang University

Recent work regarding the Layer by Layer （LbL） engineering of poly（lactide-co-glycolide） nanoparticles （PLGA NPs） is reviewed here. The LbL engineering of PLGA NPs is applied as a means of generating advanced drug delivery devices with tailored recognition, protection, cargo and release properties. LbL in combination with covalent chemistry is used to attach PEG and folic acid to control cell uptake and direct it towards cancer cells. LbL coatings composed of chitosan and alginate show low protein interactions and can be used as an alternative to Pegylation. The assembly on top of LbL coatings of lipid layers composed of variable percentages of 1,2-dioleoyl-sn-glycero-3-choline （DOPC） and 1,2-dioleoyl-sn-glycero-3-phospho- L-serine （DOPS） increases NP uptake and directs the NPs towards the endoplasmic reticulum. The antibody anti-TNF-ct is encapsulated forming a complex with alginate that is assembled LbL on top of PLGA NPs. The antibody is released in cell culture following first order kinetics. The release kinetics of encapsulated molecules inside PLGA NPs are studied when the PLGA NPs are coated via LbL with different polyelectrolytes. The intracellular release of encapsulated Doxorubicin is studied in the HepG2 cell line by means of Fluorescence Lifetime Imaging.

关键词： layer by layer PLGA NPs cell uptake antibody delivery lipid layers intracellular release

Modulating the growth of cysteine-capped cadmium sulfide quantum dots with enzymatically produced hydrogen peroxide

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Nano Research 2017年第6期10卷 1932-1941页

作者： Ruta Grinyte Javier Barroso Laura Saa Valeri Pavlov Biosensing Unit CIC BiomaGUNE Parque Tecnologico de San Sebastian Paseo Miramon 182 Donostia-San Sebastian 20014 Spain

Cysteine （CSH） readily stabilizes cadmium sulfide quantum dots （CdS QDs） that grow in aqueous buffered solutions. The oxidation of CSH by hydrogen peroxide （H202） at room temperature yields cystine （CSSC）, which is less efficient in stabilizing CdS QDs compared to CSH. Herein, we demonstrate that such oxidation causes a decrease in the formation rate of CSH-capped CdS QDs from Cd^2＋ and S^2- ions. For the first time, we combined the oxidation of CSH with the glucose oxidase （GOx）-assisted biocatalytic oxidation of D-glucose, which leads to a buildup of H2O2 in the reaction mixture. The enzymatically modulated in situ growth of CdS QDs was monitored using two techniques： fluorescence spectroscopy and photoelectrochemical （PEC） analysis. This system enables quantification of GOx and glucose in human serum.

关键词： quantum dots photoelectrochemistry enzyme fluorescence hydrogen peroxide

Evaluation of glial cell proliferation with non-invasive molecular imaging methods after stroke

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Neural Regeneration Research 2021年第11期16卷 2209-2210页

作者： Ana Joya Abraham Martín Achucarro Basque Center for Neuroscience LeioaSpain cic biomagune Basque Research and Technology Alliance(BRTA)PaseoSpain Ikerbasque Basque Foundation for Science BilbaoSpain

Glial proliferation:For the last decades,glial cells have been wrongly believed to have a mere passive supporting role for ***,this notion has clearly changed and it is now admitted that these cells are essential for the correct development and regulation of the nervous *** cell population are commonly subdivided in astrocytes,oligodendrocytes and *** the development,neural stem cells(NSCs)(called neuroepithelial progenitor cells or NPCs)transform into radial glia,the primary progenitor cells for neurons,astrocytes and oligodendrocytes(Zuchero and Barres,2015).Microglial cells,however,derive from a mesenchymal precursor infiltration,meaning that during brain development,precursors generated in the bone narrow invade the nervous parenchyma and differentiate into microglial cells(Zuchero and Barres,2015).This proliferative capacity is preserved in the adult mammalian brain,and neurogenic NSCs are stored in two restricted regions of the central nervous system(CNS),the forebrain subventricular zone(SVZ)and the hippocampal dentate gyrus(subgranular zone).These cells continue to produce neurons and glial cells during the adulthood,being activated after certain signals and leaving the quiescent state(Urbán et al.,2019).This process,in which glial progenitor cells differentiate into mature glia during development and in the adult brain to maintain and regulate brain function,is called gliogenesis(Ardaya et al.,2020).

关键词： admitted maintain supporting

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很高兴认识你

科学新闻 2017年第1期 88-89页

作者： MalouHenriksen-Lacey Juan J.Giner-Casares 姜天海 cic biomagune

初次见面时,我们听起来并不像是一对自然走到一起的合作伙伴:一个是刚从英国药学小组来的生物学家,一个是来自于德国纳米材料小组的材料科学家。但是,我们有几个共同点:我们都在西班牙巴斯克地区的一家生物材料研究所——cic biomagune... 详细信息

初次见面时,我们听起来并不像是一对自然走到一起的合作伙伴:一个是刚从英国药学小组来的生物学家,一个是来自于德国纳米材料小组的材料科学家。但是,我们有几个共同点:我们都在西班牙巴斯克地区的一家生物材料研究所——cic biomagune的纳米粒子实验室做博士后;而且我们都有意于拓展自己的视野,并想要在自身学科培养之外继续成长。因此,尽管最初我们在一起能做出任何有成效的成果的可能性似乎比较低,但最终我们克服困难并形成了愉快的合作关系,进行了真正的跨学科研究。

关键词：生物学家巴斯克

Templated Colloidal Self-Assembly for Lattice Plasmon Engineering

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Accounts of Materials Research 2021年第9期2卷 816-827页

作者： Leonardo Scarabelli David Vila-Liarte Agustín Mihi Luis M.Liz-Marzán Institute of Materials Science of Barcelona ICMAB-CSIC08193 BellaterraSpain cic biomagune Basque Research and Technology Alliance(BRTA)20014 Donostia-San SebastiánSpain Centro de Investigación Biomédica en Red BioingenieríaBiomateriales y Nanomedicina(CIBER-BBN)20014 Donostia-San SebastiánSpain Ikerbasque Basque Foundation for Science48013 BilbaoSpain

CONSPECTUS:Over the past 30 years,the engineering of plasmonic resonances at the nanoscale has progressed dramatically,with important contributions in a variety of different fields,including chemistry,physics,biology,engineering,and ***,heavy optical losses related to the use of noble metals for the fabrication of plasmonic structures hindered their application in various ***,an answer to these long-lasting issues emerged in the use of lattice plasmon resonances(LPRs,also called surface lattice resonances),bringing new excitement in the field of ***,the organization of plasmonic nanoparticles into ordered arrays enables far-field coupling of the scattered light exploiting the diffraction modes of the array,generating plasmonic resonances with bandwidths as narrow as a few nanometers,corresponding to an increase of over 10-fold in the quality factors compared to localized plasmon *** such,LPRs offer new opportunities to harness light−matter interactions at the nanoscale,while generating renewed interest in the self-assembly of colloidal metal nanoparticles,as a scalable approach to the preparation of such plasmonic *** self-assembly emerged as one of the most versatile approaches,being compatible with soft-lithographic techniques such as nanoimprint lithography and amenable to a variety of materials,colloids,and *** self-assembly additionally allows the preparation of arrays where the repeating units are composed of multiple self-assembled nanoparticles(i.e.,plasmonic clusters).In this system,near-field coupling can be finely tuned,thereby showing promising results in biosensing,catalysis,or plasmonic *** this Account,we review the preparation of ordered arrays of clusters of plasmonic *** present various aspects involved in the templated self-assembly of colloidal nanoparticles,with the aim of achieving at the same time close-packed structures within each cavity

关键词： coupling enable versatile

Influence of ZnO/graphene nanolaminate periodicity on their structural and mechanical properties

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Journal of Materials Science & Technology 2018年第9期34卷 1487-1493页

作者： Igor Iatsunskyi Margarita Baitimirova Emerson Coy Luis Yate Roman Viter Arunas Ramanavicius Stefan Jurga Mikhael Bechelany Donats Erts NanoBioMedical Centre. Adam Mickiewicz University 85 Urnultowska str. 61-614. Poznan Poland Institute of Chemical Physics and Institute of Atomic Physics and Spectroscopy University of Latvia 19 Raina Boulevard LV 1586 Riga Latvia Surface Analysis and Fabrication Platform CIC biomaGUNE Paseo Miramoin 182 20009 Donostia-San Sebastian Spain Department of Physical Chemistry Institute of Chemistry Faculty of Chemistry and Geosciences Vilnius UniversityNaugarduko str. 24 LT-03225 VilniusLithuania Institut Européen des Membranes IEM - UMR 5635 ENSCM CNRS Univ Montpellier Montpellier France

Structural, electronic and mechanical properties of ZnO/Graphene（ZnO/G） nanolaminates fabricated by low temperature atomic layer deposition（ALD） and chemical vapor deposition（CVD） were *** performed scanning and transmission electron microscopy（SEM/TEM）, X-ray diffraction（XRD）, electron energy loss spectroscopy（EELS）, Raman spectroscopy, X-Ray photoelectron spectroscopy（XPS） and nanoindentation to characterize the ZnO/G nanolaminates. The main structural and mechanical parameters of ZnO/G nanolaminates were calculated. The obtained results were analyzed and interpreted taking into account mechanical interaction and charge effects occurring at the G-ZnO interface. The influence of graphene sublayers number on the mechanical behavior of the ZnO/G nanolaminates was studied. By reducing the bilayer thickness, the mechanical parameters of the films can be tuned（Young＇s modulus100-200 GPa, hardness 3-9 GPa）. The softer response of the multilayers as compared to the single layers of ZnO and graphene was attributed to the structural changes in the ZnO layer and the interfaces. This study shows the mechanical behavior of ZnO/G nanolaminates and their influence on the development of novel electro-optical devices based on these structures.

关键词： Nanolaminate Graphene ZnO XPS Nanointendation Multilayers Atomic layer deposition Chemical vapor deposition

Plasmonic metal‐organic frameworks

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SmartMat 2021年第4期2卷 446-465页

作者： Guangchao Zheng Isabel Pastoriza‐Santos Jorge Pérez‐Juste Luis M.Liz‐Marzán School of Physics and Microelectronics Key Laboratory of Material PhysicsMinistry of EducationZhengzhou UniversityZhengzhouChina CINBIO Universidade de VigoDepartamento de Química FísicaVigoSpain Galicia Sur Health Research Institute(IIS Galicia Sur) SERGAS‐UVIGOVigoSpain cic biomagune Basque Research and Technology Alliance(BRTA)Donostia‐San SebastianSpain Ikerbasque Basque Foundation for ScienceBilbaoSpain Centro de Investigación Biomédica en Red BioingenieríaBiomateriales y NanomedicinaCIBER‐BBNDonostia‐San SebastiánSpain

Plasmonic metal‐organic frameworks are composite nanoparticles comprising plasmonic metal nanoparticles(NPs)embedded within a metalorganic framework(MOF)*** a result,not only the functionalities of the individual components are retained,but synergistic effects additionally provide improved chemical and physical *** progress in plasmonic MOFs has demonstrated the potential for nanofabrication and various nanotechnology *** challenges toward plasmonic MOFs have been recently addressed,resulting in new opportunities toward practical applications,such as surface‐enhanced Raman scattering,therapy,and *** impact of key parameters(thermodynamic ***)on the synthetic pathways of plasmonic MOFs is reviewed,while providing insight into related progress toward structure‐derived applications.

关键词： catalysis drug delivery metal‐organic frameworks nanocomposites plasmonic metal nanoparticles plasmonic MOFs surface‐enhanced Raman scattering

Plasmonic metal-organic frameworks for surface-enhanced Raman scattering

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Plasmonic metal-organic frameworks for surface-enhanced Rama...

Uptake and Intracellular Fate of Fluorophore Labeled Metal−Organic-Framework(MOF)Nanoparticles

第二十届全国光散射学术会议（CNCLS20）

作者：郑广超 Jorge Perez-Juste 洪梅 Sara Bals Luis M.Liz-marzan 郑州大学物理工程学院 CINBIO Campus Universitario Lagoas-Marcosende 化学生物学与生物技术学院北京大学深圳研究生院 EMAT-University of Antwerp cic biomagune Bionanoplasmonics Laboratory

金属-有机骨架化合物（metal–organic frameworks,MOFs）由于其比表面积大、孔径均一等优点,在催化、光学、电学等领域引起了广泛的关注。最近,基于MOFs的形貌控制研究其性能的形貌依赖性是一个热点。众所周知,表面活性剂能够很好的控... 详细信息

金属-有机骨架化合物（metal–organic frameworks,MOFs）由于其比表面积大、孔径均一等优点,在催化、光学、电学等领域引起了广泛的关注。最近,基于MOFs的形貌控制研究其性能的形貌依赖性是一个热点。众所周知,表面活性剂能够很好的控制晶体纳米颗粒的形貌。在这里,我们设计了一种利用双表面活性剂,十六烷基三甲基溴化铵（cetyltrimethylammonium bromide,CTAB）和三羟甲基氨基甲烷（tris（hydroxymethyl）aminomethane,TRIS）,来有效的控制MOFs的形貌[1]。另外,单一的金属纳米颗粒包覆在MOFs当中形成的核-壳结构能够有效的提高该等离激元MOFs在催化过程中的稳定性和选择性。我们发展了一种不依赖与金属纳米颗粒形貌、组分、尺寸的等离激元MOFs的制备方法。同时,由于等离激元纳米颗粒的局域表面等离子体共振效应,等离激元MOFs还可以通过利用表面增强拉曼散射（surface-enhanced Raman scattering,SERS）研究了MOFs孔径的灵活性[2]。

关键词：等离激元MOFs 孔径灵活性表面增强拉曼散射

来源： cnki会议评论

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Environment & Health 2023年第4期1卷 270-277页

作者： Ziyao Liu Andreas Zimpel Ulrich Lächelt Maria Pozzi Marta Gallego Gonzalez Indranath Chakraborty Stefan Wuttke Neus Feliu Wolfgang J.Parak Center for Hybrid Nanostructures Universität Hamburg22761 HamburgGermany Key Laboratory of Biological Nanotechnology of National Health Commission Xiangya HospitalCentral South UniversityChangsha 410008China Department of Chemistry and Center for NanoScience(CeNS) LMU Munich81377 MunichGermany Department of Pharmacy and Center for NanoScience(CeNS) LMU Munich81377 MunichGermany Department of Pharmaceutical Sciences University of Vienna1090 ViennaAustria Center for Cooperative Research in Biomaterials(cic biomagune) Basque Research and Technology Alliance(BRTA)20014 Donostia-San SebastiánSpain School of Nano Science and Technology Indian Institute of Technology KharagpurKharagpur 721302India BCMaterials Basque Center for MaterialsApplications and Nanostructures48950 LeioaSpain IKERBASQUE Basque Foundation for Science48009 BilbaoSpain

The uptake and the fate of Zr-based metal−organic-framework nanoparticles labeled with organic fluorophores in HeLa cells has been monitored with fluorescence detection and elemental *** nanoparticles have been selected as a model system of carrier nanoparticles(here Zr-based metal−organic-framework nanoparticles)with integrated cargo molecules(here organic fluorophores),with aze that does not allow for efficient exocytosis,a material which only partly degrades under acidic conditions as present in endosomes/lysosomes,and with limited colloidal *** show that,for Zr-based metal−organic-framework nanoparticles of 40 nm size as investigated here,the number of nanoparticles per cells decreases faster due to particle redistribution upon proliferation than due to nanoparticle exocytosis and that,thus,also for this system,exocytosis is not an efficient pathway for clearance of the nanoparticles from the cells.

关键词： nanoparticle endocytosis exocytosis proliferation fate of nanoparticles intracellular degradation metal organic framework nanoparticles