检索结果-南通市图书馆

Dual-functional extracellular vesicles enable synergistic treatment via m^(6)A reader YTHDF1-targeting epigenetic regulation and chemotherapy

引用

Nano Research 2023年第12期16卷 13309-13321页

作者： Rong Du Qing You Jingyi Liu Chen Wang Ling Zhu Yanlian Yang CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory of Biological Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Chemotherapy remains one of the most prevailing strategies for cancer treatment.However,its treatment effect is hampered by drug resistance,nonspecific tumor targeting,and severe toxic side effects.Combination chemotherapy with synergistic effect has become an attractive tumor therapy.N6-methyladenosine(m6A)regulators determine the fate of m6A-modified transcripts and play vital roles in cancer development and drug resistance.Gene therapy such as small interfering RNA(siRNA)is a promising strategy to reduce the abnormal gene expression of m6A regulators.However,its poor selectivity and high systemic toxicity necessitate the use of delivery vectors to target specific cells and tissues.Here,we constructed a dual-functional targeted nanodrug platform for the synergetic m6A-associated epigenetic regulation and chemotherapy of ovarian cancer.We encapsulated siRNA targeting the m6A reader YT521-B homology(YTH)N6-methyladenosine RNA-binding protein 1(YTHDF1)and docetaxel(DTX),the first-line chemotherapeutic agent of ovarian cancer,into mesenchymal stem cell-derived small extracellular vesicles(MsEVs).This nanosystem exhibits significant tumor targeting and endo/lysosomal escape of siYTHDF1.It effectively depletes YTHDF1 and suppresses the protein translation of eukaryotic translation initiation factor 3 subunit C(EIF3C)in an m6A-dependent manner.The combination of YTHDF1-targeting epigenetic regulation significantly enhances the anti-tumor effect of DTX and effectively inhibits ovarian cancer progression without causing significant systemic toxicity.This co-delivery nanoplatform offers a promising approach for combinational cancer treatment,showing improved anti-tumor efficacy through the synergistic effects of epigenetic regulation and chemotherapeutic inhibition.

关键词： extracellular vesicles N6-methyladenosine(m6A)modulators docetaxel small interfering RNA(siRNA)delivery ovarian cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Temperature-modulated inversion and switching of chiroptical responses in dynamic side-by-side oligomers of gold nanorods

引用

Nano Research 2023年第12期16卷 13392-13399页

作者： Hanbo Li Dejing Meng Chenqi Zhang Yinglu Ji Xinshuang Gao Zhijian Hu Xiaochun Wu CAS Key Laboratory of Standardization and Measurement for Nanotechnology National Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Herein,a new strategy is proposed for achieving dynamic chiral controls in self-assembly systems of plasmonic nanorods based on temperature-modulation.Via enlarging Au{100}side facets of Au nanorod(AuNR)building block and changing surface ligand from often-used cetyltrimethylammonium bromide(CTAB)to cetylpyridinium chloride(CPC),inversion of chiroptical signal in side-by-side(SS)oligomers is realized.Under the guide of chiral cysteine(Cys),Au{100}side facet-linked SS rods twist in the opposite direction compared with Au{110}side facet-linked counterparts.At high CPC concentration,by controlling the incubation temperature of chiral Cys,the dominant twist mode can be regulated.Finite-difference time-domain(FDTD)simulations indicate the key role of the twisting dihedral angle of the oligomers in driving chiral signal inversion.At low CPC concentration,a temperature-sensitive chiral switching is observed owing to the conformation change of the CPC ligand layer.The temperature-modulated chiral responses are based on the interactions of chiral molecules,achiral surface ligands,and exposed facets of the building block.The rich dynamic tunability of chiroptical responses of plasmonic assemblies may find applications in stimulus-responsive nanodevices.

关键词： plasmonic circular dichroism gold nanorods chiral oligomers cetylpyridinium chloride temperature stimulus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Spectroscopy and carrier dynamics of one-dimensional nanostructures

引用

Journal of Semiconductors 2022年第12期43卷 12-21页

作者： Yutong Zhang Zhuoya Zhu Shuai Zhang Xianxin Wu Wenna Du Xinfeng Liu CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

In recent years,one-dimensional(1D)nanomaterials have raised researcher's interest because of their unique structur-al characteristic to generate and confine the optical signal and their promising prospects in photonic applications.In this re-view,we summarized the recent research advances on the spectroscopy and carrier dynamics of 1D nanostructures.First,the condensation and propagation of exciton-polaritons in nanowires(NWs)are introduced.Second,we discussed the properties of 1D photonic crystal(PC)and applications in photonic-plasmonic structures.Third,the observation of topological edge states in 1D topological structures is introduced.Finally,the perspective on the potential opportunities and remaining chal-lenges of 1D nanomaterials is proposed.

关键词： one-dimensional nanostructures carrier dynamics nanowires exciton-polaritons photonic crystals topological struc-tures

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Minimizing the effect of near-distance dielectric sensitivity on retrieving average aspect ratio of gold nanorod by optical extinction spectroscopy:in the case of CTAB adsorption

引用

Chinese Science Bulletin 2014年第16期59卷 1822-1831页

作者： Zhijian Hu Yinglu Ji Shuai Hou Xiaochun Wu CAS Key Laboratory of Standardization and Measurement for Nanotechnology National Center for Nanoscience and Technology

The aspect ratio(AR)is one of the most intriguing parameters of gold nanorods(GNRs),which plays an important role in determining localized surface plasmon(LSPR)properties.Instead of conventional imaging techniques,the optical extinction spectroscopy(OES)method has been developed for allowing fast statistically measuring the average AR under static approximation.In this work,combining with the previous achievements in spectroscopic technique,we further analyze the effects of gold dielectric function and near distance dielectric sensitivity.The former may reflect possible dielectric loss of real Au samples from ideal single crystalline.The latter reflects the cetyltrimethylammonium bromide(CTAB)adsorption on the surface of GNR induces different LSPR shifts below and above critical micelle concentration(CMC).However,their effect on the determination of AR has not been evaluated in OES method.The average AR measurements as a function of absorbance of CTAB-GNRs and LSPR maximum below the CMC were studied.Our results indicate that after considering these factors,the mean ARs obtained from spectroscopic techniques are closer to those obtained from imaging techniques.

关键词： CTAB 消光光谱吸附作用平均值纵横比纳米棒灵敏度近距离

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nanoscale structural and electronic evolution for increased efficiency in polymer solar cells monitored by electric scanning probe microscopy

引用

Chinese Science Bulletin 2014年第4期59卷 360-368页

作者： Denghua Li Han Yan Chao Li Yanlian Yang Zhixiang Wei Chen Wang CAS Key Laboratory of Standardization and Measurement for Nanotechnology National Center for Nanoscience and Technology

Control of blend morphology at multi-scale is critical for optimizing the power conversion efficiency(PCE)of plastic solar cells.To better understand the physics of photoactive layer in the organic photovoltaic devices,it is necessary to gain understanding of morphology and the corresponding electronic property.Herein we report the correlation between nanoscale structural,electric properties of bulk heterojunction(BHJ)solar cells and the annealing-induced PCE change.We demonstrate that the PCE of BHJ solar cells are dramatically improved(from1.3%to 4.6%)by thermal annealing,which results from P3HT crystalline stacking and the PCBM aggregation for interpenetrated network.The similar trend for annealinginduced photovoltage and PCE evolution present as an initial increase followed by a decrease with the annealing time and temperature.The surface roughness increase slowly and then abruptly after the same inflection points observed for photovoltage and PCE.The phase images in electric force microscopy indicate the optimized P3HT and PCBM crystallization for interpenetrating network formation considering the spectroscopic results as well.From the correlation between surface photovoltage,blend morphology,and PCE,we propose a model to illustrate the film structure and its evolution under different annealing conditions.This work would benefit the better design and optimization of the morphology and local electric properties of solar cell active layers for improved PCE.

关键词：塑料太阳能电池扫描探针显微镜纳米结构进化电子聚合物表面光电压监测

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A simple spectroscopic method for the quantification of gold nanoparticle number concentration in water and fetal bovine serum solutions

引用

Chinese Science Bulletin 2014年第16期59卷 1816-1821页

作者： Ruimin Wang Kuan Chen Guanglu Ge CAS Key Laboratory of Standardization and Measurement for Nanotechnology National Center for Nanoscience and Technology

In this work,we developed a facile and low-cost method with sufficient sensitivity for the quantitative determination of gold nanoparticles(GNPs)number concentration in water and fetal bovine serum solutions.The Au(III)digested from GNPs was reduced to Au(I)presumably by the thiol group of 2-mercaptobenzimidazole,then the Au(I)–thiolate complex was formed,the concentration of which is determined by absorbance at 300 nm.The number concentration of GNPs can be converted using microscopic images and simple calculations.The interference of serum can be avoided in this method.The limit of detection(LOD)of GNPs was calculated as 2.1 910-12mol/L in water solution and 1.3 9 10-11mol/L in fetal bovine serum(FBS)solution.This method provides a simple and fast way to determine the concentration of GNPs,which can be in carried out in the routine laboratory practice.

关键词：金纳米粒子粒子数浓度胎牛血清水溶液谱方法定量化国民生产总值定量测定

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Principles of amino-acid–ribonucleotide interaction revealed by binding affinities between homogeneous oligopeptides and singlestranded RNA molecules

引用

Nano Research 2023年第12期16卷 13294-13300页

作者： Pengyu Wang Xiaocui Fang Ping Li Minxian Li Yanlian Yang Chen Wang key laboratory for Biological Effects of Nanomaterials and Nanosafety(Chinese Academy of Sciences(cas)) Key Laboratory of Standardization and Measurement for Nanotechnology(CAS)CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

We have determined the binding strengths between ribonucleotides of adenine(A),guanine(G),uracil(U),and cytosine(C)in homogeneous single-stranded ribonucleic acids(ssRNAs)and homo-decapeptides consisting of 20 common amino acids.We use a bead-based fluorescence assay for these measurements in which decapeptides are immobilized on the bead surface and ssRNAs are in solutions.The results provide a molecular basis for analyzing selectivity,specificity,and polymorphisms of amino-acid–ribonucleotide interactions.Comparative analyses of the distribution of the binding energies reveal unique binding strength patterns assignable to each pair of amino acid and ribonucleotide originating from the chemical structures.Pronounced favorable(such as Arg–G)and unfavorable(such as Met–U)binding interactions can be identified in selected groups of amino acid and ribonucleotide pairs that could provide basis to elucidate energetics of amino-acid–ribonucleotide interactions.Such interaction selectivity,specificity,and polymorphism manifest the contributions from RNA backbone,RNA bases,as well as main chain and side chain of the amino acids.Such characteristics in peptide–RNA interactions might be helpful for understanding the mechanism of protein–RNA specific recognition and the design of RNA nano-delivery systems based on peptides and their derivatives.

关键词： peptides single-stranded ribonucleic acid(ssRNA) binding affinity flow cytometry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tcn and Tcn@C70 Endohedral Metalofullerenes: ab initio Spin-density-functional Calculations

引用

Chinese Journal of Chemical Physics 2015年第4期28卷 -页

作者： Li-jing Zeng Ke Deng CAS Key Laboratory of Standardization and Measurement for Nanotechnology National Center for Nanoscience and Technology (NCNST) Beijing 100190 China

Ab initio spin-density-functional calculations have been performed to study the equilibrium structural, electronic, and magnetic properties of Tcn and Tcn@C70 endohedral metalofullerenes. Our results indicate that C70 can encapsulate Tcn clusters with up to n=9 atoms. Except n=2, the formation of Tcn@C70 endohedral metalofullerenes is predicted to be exothermic when n≤5, while the encapsulation process becomes increasingly endothermic beyond n=5. When encapsulating into the C70 cage, the geometries as well as electronic structures of the Tc cluster undergo comparative changes. Especially, compared to the isolated Tcn clusters, the total magnetic moments of Tcn@C70 reduce significantly. The analyses of the orbital population, Hirshfeld population and density of states show that electrons transfer from the Tc cluster to the carbon cage through the Tc–C efficient hybridization, which is responsible for such reduction of the whole magnetism.

关键词： Density functional theory Endohedral metalofullerenes Tc_n@C_(70) Vienna ab initio simulation package

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Quantitative study of protein coronas on gold nano- particles with different surface modifications

引用

Nano Research 2014年第3期7卷 345-352页

作者： Menghua Cui Renxiao Liu Zhaoyi Deng Guanglu Ge Ying Liu Liming Xie CAS Key Laboratory of Standardization and Measurement for Nanotechnology National Center for Nanoscience and TechnologyBeijing 100190 China

Protein coronas provide the biological identity of nanomaterials in vivo. Here we have used dynamic light scattering (DLS) and transmission electron microscopy (TEM) to investigate the adsorption of serum proteins, including bovine serum albumin (BSA), transferrin (TRF) and fibrinogen (FIB), on gold nanoparticles (AuNPs) with different surface modifications (citrate, thioglycolic acid, cysteine, polyethylene glycol (PEG, M w = 2 k and 5 k)). AuNPs with PEG(5 k) surface modification showed no protein adsorption. AuNPs with non-PEG surface modifications showed aggregation with FIB. AuNPs with citrate and thioglycolic acid surface modifications showed 6–8 nm thick BSA and TRF coronas (corresponding to monolayer or bilayer proteins), in which the microscopic dissociation constants of BSA and TRF protein coronas are in the range of 10−8 to 10−6 M.

关键词：金纳米粒子表面修饰蛋白质电晕透射电子显微镜纤维蛋白原牛血清白蛋白柠檬酸盐

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phase-modulated quantum-sized TMDs for extreme saturable absorption

引用

Nano Research 2023年第4期16卷 5803-5808页

作者： Zhexue Chen Xinyu Sui Zhangqiang Li Yueqi Li Xinfeng Liu Yong Zhang cas key laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China

Two-dimensional semiconductors such as transition metal dichalcogenides(TMDs)have attracted much interest in the past decade.Herein,we present an all-physical top-down method for the scalable production of the intrinsic TMD quantum sheets(QSs).The phases of the TMDs(e.g.,2H-MoSe_(2),2H-WSe_(2),and Td-WTe2)remain stable during the transformation from bulk to QSs.However,phase transition(from Td to 2H)is detected in MoTe2.Such phase-modulation by size-reduction has never been reported before.The TMD QSs can be well dispersed in solvents,resulting in remarkable photoluminescence with excitation wavelength-,concentration-,and solvent-dependence.Meanwhile,the TMD QSs can be readily solution-processed into hybrid thin films,which demonstrate exceptional nonlinear saturation absorption(NSA).Notably,2H-MoTe2 QSs in poly(methyl methacrylate)show extremely high NSA performance with(absolute)modulation depth up to 46.6%and saturation intensity down to 0.81 MW·cm^(−2).Our work paves the way towards quantum-sized TMDs.

关键词： transition metal dichalcogenides(TMDs) intrinsic quantum sheets photoluminescence nonlinear saturation absorption

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：