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Nanoparticles for the treatment of spinal cord injury

Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di Lu Jiuping Wu Fuming Liang Huayi Wang Junjie Yang Ganggang Zhang Chen Wang Yanlian Yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina cas key laboratory of standardization and measurement for nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

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Dependence of the surface-assisted fullerene-based complex structure on the template molecule design

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Nano Research 2019年第7期12卷 1509-1537页

作者： Yanfang Geng Qingdao Zeng Chen Wang cas key laboratory of standardization and measurement for nanotechnology CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China

Fullerene derivatives as a kind of star carbon materials have received intense investigation because of their three-dimensional shape,anisotropic electron mobility,and high electron ***,the cutting-edge developments of fullerene nanomaterials have had a tremendous impact on a wide range of applications,such as organic solar cells,field effect transistors,and *** explore their full potential applications,research into fullerene-based multilevel nanostructures relying on hierarchical interactions from bottom to top is rapidly *** is of great theoretical and practical significance to prepare multilevel fullerene nanostructures with structural and properties controlled by optimizing the influencing *** review would offer several aspects including the chemical structures of organic molecules and the nanostructures of the organic molecules and fullerene-organic *** monolayers or multilayers,fullerene molecules tend to fall into a space of suitable size,in which the located positions are affected by the intermolecular *** the covered surfaces,fullerenes are more likely to approach the electron-withdrawing units through the donor-acceptor and charge transfer *** the implementation of this review,an exhaustive analysis on the chemical modification,including the molecular backbone and substituents,preformed network synergies,and adsorption sites is *** addition,the relationship between the molecules and structures that illustrates the importance of the molecular design for the controlled fullerenes hybrid nanostructures can be further understood based on the results of the joined experimental and computational investigations.

关键词： fullerene organic molecule nanostructure property molecular design

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Tcn and Tcn@C70 Endohedral Metalofullerenes: ab initio Spin-density-functional Calculations

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Chinese Journal of Chemical Physics 2015年第4期28卷 -页

作者： Li-jing Zeng Ke Deng cas key laboratory of standardization and measurement for nanotechnology National Center for Nanoscience and Technology (NCNST) Beijing 100190 China

Ab initio spin-density-functional calculations have been performed to study the equilibrium structural, electronic, and magnetic properties of Tcn and Tcn@C70 endohedral metalofullerenes. Our results indicate that C70 can encapsulate Tcn clusters with up to n=9 atoms. Except n=2, the formation of Tcn@C70 endohedral metalofullerenes is predicted to be exothermic when n≤5, while the encapsulation process becomes increasingly endothermic beyond n=5. When encapsulating into the C70 cage, the geometries as well as electronic structures of the Tc cluster undergo comparative changes. Especially, compared to the isolated Tcn clusters, the total magnetic moments of Tcn@C70 reduce significantly. The analyses of the orbital population, Hirshfeld population and density of states show that electrons transfer from the Tc cluster to the carbon cage through the Tc–C efficient hybridization, which is responsible for such reduction of the whole magnetism.

关键词： Density functional theory Endohedral metalofullerenes Tcn@C70 Vienna ab initio simulation package

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Minimizing the effect of near-distance dielectric sensitivity on retrieving average aspect ratio of gold nanorod by optical extinction spectroscopy:in the case of CTAB adsorption

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Chinese Science Bulletin 2014年第16期59卷 1822-1831页

作者： Zhijian Hu Yinglu Ji Shuai Hou Xiaochun Wu cas key laboratory of standardization and measurement for nanotechnology National Center for Nanoscience and Technology

The aspect ratio(AR)is one of the most intriguing parameters of gold nanorods(GNRs),which plays an important role in determining localized surface plasmon(LSPR)*** of conventional imaging techniques,the optical extinction spectroscopy(OES)method has been developed for allowing fast statistically measuring the average AR under static *** this work,combining with the previous achievements in spectroscopic technique,we further analyze the effects of gold dielectric function and near distance dielectric *** former may reflect possible dielectric loss of real Au samples from ideal single *** latter reflects the cetyltrimethylammonium bromide(CTAB)adsorption on the surface of GNR induces different LSPR shifts below and above critical micelle concentration(CMC).However,their effect on the determination of AR has not been evaluated in OES *** average AR measurements as a function of absorbance of CTAB-GNRs and LSPR maximum below the CMC were *** results indicate that after considering these factors,the mean ARs obtained from spectroscopic techniques are closer to those obtained from imaging techniques.

关键词： CTAB 消光光谱吸附作用平均值纵横比纳米棒灵敏度近距离

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Nanoscale structural and electronic evolution for increased efficiency in polymer solar cells monitored by electric scanning probe microscopy

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Chinese Science Bulletin 2014年第4期59卷 360-368页

作者： Denghua Li Han Yan Chao Li Yanlian Yang Zhixiang Wei Chen Wang cas key laboratory of standardization and measurement for nanotechnology National Center for Nanoscience and Technology

Control of blend morphology at multi-scale is critical for optimizing the power conversion efficiency(PCE)of plastic solar *** better understand the physics of photoactive layer in the organic photovoltaic devices,it is necessary to gain understanding of morphology and the corresponding electronic *** we report the correlation between nanoscale structural,electric properties of bulk heterojunction(BHJ)solar cells and the annealing-induced PCE *** demonstrate that the PCE of BHJ solar cells are dramatically improved(from1.3%to 4.6%)by thermal annealing,which results from P3HT crystalline stacking and the PCBM aggregation for interpenetrated *** similar trend for annealinginduced photovoltage and PCE evolution present as an initial increase followed by a decrease with the annealing time and *** surface roughness increase slowly and then abruptly after the same inflection points observed for photovoltage and *** phase images in electric force microscopy indicate the optimized P3HT and PCBM crystallization for interpenetrating network formation considering the spectroscopic results as *** the correlation between surface photovoltage,blend morphology,and PCE,we propose a model to illustrate the film structure and its evolution under different annealing *** work would benefit the better design and optimization of the morphology and local electric properties of solar cell active layers for improved PCE.

关键词：塑料太阳能电池扫描探针显微镜纳米结构进化电子聚合物表面光电压监测

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A simple spectroscopic method for the quantification of gold nanoparticle number concentration in water and fetal bovine serum solutions

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Chinese Science Bulletin 2014年第16期59卷 1816-1821页

作者： Ruimin Wang Kuan Chen Guanglu Ge cas key laboratory of standardization and measurement for nanotechnology National Center for Nanoscience and Technology

In this work,we developed a facile and low-cost method with sufficient sensitivity for the quantitative determination of gold nanoparticles(GNPs)number concentration in water and fetal bovine serum *** Au(III)digested from GNPs was reduced to Au(I)presumably by the thiol group of 2-mercaptobenzimidazole,then the Au(I)–thiolate complex was formed,the concentration of which is determined by absorbance at 300 *** number concentration of GNPs can be converted using microscopic images and simple *** interference of serum can be avoided in this *** limit of detection(LOD)of GNPs was calculated as 2.1 910-12mol/L in water solution and 1.3 9 10-11mol/L in fetal bovine serum(FBS)*** method provides a simple and fast way to determine the concentration of GNPs,which can be in carried out in the routine laboratory practice.

关键词：金纳米粒子粒子数浓度胎牛血清水溶液谱方法定量化国民生产总值定量测定

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Photoinduced phase transitions in two-dimensional charge-density-wave 1T-TaS_2

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Chinese Physics B 2019年第5期28卷 1-10页

作者： Wen Wen Chunhe Dang Liming Xie cas key laboratory of standardization and measurement for nanotechnology CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology University of Chinese Academy of Sciences

Charge-density-wave(CDW) materials with strongly correlated electrons have broadband light absorption and ultrafast response to light irradiation, and hence hold great potential in photodetection. 1 T-TaS2 is a typical CDW material with various thermodynamically CDW ground states at different temperatures and fertile out-of-equilibrium intermediate/hidden states. In particular, the light pulses can trigger melting of CDW ordering and also forms hidden states, which exhibits strikingly different electrical conductivity compared to the ground phase. Here, we review the recent research on phase transitions in 1 T-TaS2 and their potential applications in photodetection. We also discuss the ultrafast melting of CDW ordering by ultrafast laser irradiation and the out-of-equilibrium intermediate/hidden states by optical/electrical pulse. For photodetection, demonstrations of photoconductors and bolometers are introduced. Finally, we discuss some of the challenges that remain.

关键词： charge density wave phase transition 1T-TaS2 photodetection

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Quantitative study of protein coronas on gold nano- particles with different surface modifications

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Nano Research 2014年第3期7卷 345-352页

作者： Menghua Cui Renxiao Liu Zhaoyi Deng Guanglu Ge Ying Liu Liming Xie cas key laboratory of standardization and measurement for nanotechnology National Center for Nanoscience and TechnologyBeijing 100190 China

Protein coronas provide the biological identity of nanomaterials in vivo. Here we have used dynamic light scattering （DLS） and transmission electron microscopy （TEM） to investigate the adsorption of serum proteins, including bovine serum albumin （BSA）, transferrin （TRF） and fibrinogen （FIB）, on gold nanoparticles （AuNPs） with different surface modifications （citrate, thioglycolic acid, cysteine, polyethylene glycol （PEG, Mw = 2 k and 5 k））. AuNPs with PEG（5 k） surface modification showed no protein adsorption. AuNPs with non-PEG surface modifications showed aggregation with FIB. AuNPs with citrate and thioglycolic acid surface modifications showed 6-8 nm thick BSA and TRF coronas （corres- ponding to monolayer or bilayer proteins）, in which the microscopic dissociation constants of BSA and TRF protein coronas are in the range of 104 to 104 M.

关键词： protein corona gold nanoparticle dynamic light scattering transmission electronmicroscopy surface modification

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Two-dimensional (2D) Supramolecular Coordination at Liquid/ Solid Interfaces Studied by Scanning Tunneling Microscopy

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Chinese Journal of Chemistry 2015年第1期33卷 53-58页

作者： Jing Xu Qingdao Zeng cas key laboratory of standardization and measurement for nanotechnology National Center for Nanoscience and Technology(NCNST)Beijing 100190China

In this review, supramolecular coordination processes on two-dimensional (2D) surfaces or interfaces observed by scanning tunneling microscopy (STM) are discussed. Four parts are mainly involved, which include (1) recognition of Fe^(3+) through functional molecular networks, (2) K^(+)-induced switching of valinomycin, (3) supramolecular coordination happened in a nano-reactor, (4) reversible 2D supramolecular spring driven by coordination. The direct insight of the coordination phenomena provided by STM supplements our knowledge of its mechanism. Since different building blocks can be connected into a whole part through coordination, the understanding of its mechanism will be beneficial to the future design of molecular devices.

关键词： metal-ligand coordination scanning tunneling microscopy(STM) self-assembly

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Phase behaviors of binary mixtures composed of electron-rich and electron-poor triphenylene discotic liquid crystals

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Chinese Physics B 2016年第9期25卷 143-148页

作者：安玲玲景敏肖波白小燕曾庆祷赵可清 College of Chemistry and Materials Science Sichuan Normal University cas key laboratory of standardization and measurement for nanotechnology National Center for Nanoscience and Technology (NCNST)

Disk-like liquid crystals（DLCs） can self-assemble to ordered columnar mesophases and are intriguing onedimensional organic semiconductors with high charge carrier *** improve their applicable property of mesomorphic temperature ranges,we exploit the binary mixtures of electronic donor-acceptor DLC *** electron-rich2,3,6,7,10,11-hexakis（alkoxy）triphenylenes（C4,C6,C8,C10,C12） and an electron-deficient tetrapentyl triphenylene-2,3,6,10-tetracarboxylate have been prepared and their binary mixtures have been *** mesomorphism of the1：1（molar ratio） mixtures has been characterized by polarizing optical microscopy（POM）,differential scanning calorimetry（DSC）,and small angel x-ray scattering（SAXS）.The self-assembled monolayer structure of a discogen on a solid-liquid interface has been imaged by the high resolution scanning tunneling microscopy（STM）.The match of peripheral chain length has important influence on the mesomorphism of the binary mixtures.

关键词： binary mixtures discotic liquid crystals triphenylene mesomorphism

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