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Brain-derived neurotrophic factor plays with TRiC:focus on synaptic dysfunction in Huntington’s disease

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Neural Regeneration Research 2025年第10期20卷 2919-2920页

作者： Yingli Gu Kijung Sung Chengbiao Wu Department of Neurosciences University of California San DiegoLa JollaCAUSA

Brain-derived neurotrophic factor(BDNF)exerts pleiotropic effects on brain processes including psychiatric disorders,aging,neurodegeneration,and metabolic homeostasis.A simple PubMed search using the key word“BDNF,”to date,yields over 33,000 *** fundamental biology to potential therapeutic applications,BDNF has clearly garnered extensive and significant attention in the field of neurobiology research.

关键词： Huntington homeostasis therapeutic

Immunoassay development guidelines for neurodegenerative disorders:lessons from a failed pS129-α-synuclein electrochemiluminescence immunoassay

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Neural Regeneration Research 2025年第10期20卷 2906-2908页

作者： Hash Brown Taha Alanna Morris Leonard Davis School of Gerontology University of Southern CaliforniaLos AngelesCAUSA Deparmtent of Neurobiology David Geffen School of MedicineUniversity of California Los AngelesLos AngelesCAUSA

An aging population is a double-edged *** one hand,advancements in biotechnology and healthcare allow more people to enjoy longer *** the other hand,increases in the aging population accompany a surge in age-associated diseases,particularly neurodegenerative *** aging is the primary risk factor for many neurodegenerative disorders,living longer does not necessarily equate to maintaining a reasonable quality of life(Feigin et al.,2020).

关键词： aging degenerative necessarily

Biomarker bust:meta-analyses reveal unreliability of neuronal extracellular vesicles for diagnosing parkinsonian disorders

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Neural Regeneration Research 2025年第1期20卷 201-202页

作者： Hash Brown Taha Leonard Davis School of Gerontology University of Southern CaliforniaLos AngelesCAUSA

A range of neurodegenerative disorders,collectively termed parkinsonian disorders,present with a complex array of both motor and non-motor *** in this group are Parkinson’s disease(PD),dementia with Lewy bodies(DLB),multiple system atrophy(MSA),corticobasal syndr.me(CBS),and progressive supranuclear palsy(PSP).These disorders are differentiated neuropathologically by their dominant protein pathologies involvingα-synuclein(α-syn)and/or tau,the types of brain cells affected,such as neurons,oligodendr.glia,and astrocytes,and the specific brain regions involved(Tolosa et al.,2021).

关键词： disorders parkin

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna Jennifer Aguilar Emily Lee William J.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

Brain endothelial cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway in aging and neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 2005-2007页

作者： Bryan Sun Lulin Li Jian Luo Palo Alto Veterans Institute for Research VA Palo Alto Health Care SystemPalo AltoCAUSA Polytrauma System of care VA Palo Alto Health Care SystemPalo AltoCAUSA

The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway has emerged as a key mediator of *** current studies primarily attribute its effects to neurons and glial cells,emerging research suggests that cGAS-STING signaling may play a critical role in cerebral vasculature,particularly in brain endothelial ***,studying the role 7of inflammation caused by the cGAS-STING pathway in brain endothelial cells could provide a more comprehensive understanding of neuroinflammatory disease and new avenues for therapeutic ***,we review the multifaceted role of global cGAS-STING signaling in various neurological and neuroinflammatory diseases and the potential contribution of cGAS-STING in brain endothelial cells.

关键词： stimulator interferon inflammation

Characterizing dr.ught in california:new dr.ught indices and scenario-testing in support of resource management

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Ecological Processes 2018年第1期7卷 1-13页

作者： Lorraine E.Flint Alan L.Flint John Mendoza Julie Kalansky F.M.Ralph U.S.Geological Survey 6000 J.StSacramentoCA 95819USA Sonoma County Water Agency 404 Aviation Dr.Santa RosaCA 95403USA Scripps Institution of Oceanography 9500 Gilman Dr.La JollaCA 92093USA

Introduction:california’s recent dr.ught(2012–2016)has implications throughout the state for natural resource management and adaptation planning and has generated many discussions about dr.ught characterization and *** study characterizes dr.ught conditions with two indices describing deficits in natural water supply and increases in landscape stress developed on the basis of water balance modeling,at a fine spatial scale to assess the variation in conditions across the entire state,and provides an in-depth evaluation for the Russian River basin in northern california to addr.ss local resource management by developing extreme dr.ught scenarios for consideration in planning and ***:We employed the USGS Basin Characterization Model to characterize dr.ught on the basis of water supply(a measure of recharge plus runoff)and landscape stress(climatic water deficit).These were applied to the state and to the Russian River basin where antecedent soil moisture conditions were evaluated and extreme dr.ught scenarios were developed and run through a water management and reservoir operations model to further explore impacts on water ***:dr.ught indices indicated that as of the end of water year 2016 when reservoirs were full,additional water supply and landscape replenishment of up to three average years of precipitation in some locations was needed to return to normal *** soil conditions in the Russian River were determined to contribute to very different water supply results for different years and were necessary to understand to anticipate proper watershed response to *** dr.ught scenarios manifested very different kinds of dr.ught and recovery and characterization helps to guide the management response to ***:These scenarios and indices illustrate how dr.ughts differ with regard to water supply and landscape stress and how long warm dr.ughts recover much more slowly than short very dr. dr.

关键词： california dr.ught Russian River Water supply Basin Characterization Model

Subnanometer imaging and controlled dynamical patterning of thermocapillary dr.ven deformation of thin liquid films

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Light(Science & Applications) 2019年第1期8卷 515-525页

作者： Shimon Rubin Brandon Hong Yeshaiahu Fainman Department of Electrical and Computer Engineering University of CaliforniaSan Diego9500 Gilman Dr.La JollaCA 92023USA

Exploring and controlling the physical factors that determine the topography of thin liquid dielectric films are of interest in manifold fields of research in physics,applied mathematics,and engineering and have been a key aspect of many technological *** of thin liquid dielectric film topography and local thickness measurements are essential tools for characterizing and interpreting the underlying ***,achieving high sensitivity with respect to subnanometric changes in thickness via standard optical methods is *** propose a combined imaging and optical patterning projection platform that is capable of optically inducing dynamical flows in thin liquid dielectric films and plasmonically resolving the resulting changes in topography and *** particular,we employ the thermocapillary effect in fluids as a novel heat-based method to tune plasmonic resonances and visualize dynamical processes in thin liquid dielectric *** presented results indicate that lightinduced thermocapillary flows can form and translate dr.plets and create indentation patterns on demand in thin liquid dielectric films of subwavelength thickness and that plasmonic microscopy can image these fluid dynamical processes with a subnanometer sensitivity along the vertical direction.

关键词： films dielectric liquid

Evidence supporting the relationship between maternal asthma and risk for autism spectrum disorders

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Neural Regeneration Research 2025年第4期20卷 1101-1102页

作者： Hadley Osman Paul Ashwood Department of Medical Microbiology and Immunology and the M.I.N.D.InstituteUniversity of California at DavisSacramentoCAUSA

During pregnancy,maternal immune activation(MIA),due to infection,chronic inflammatory disorders,or toxic exposures,can result in lasting health impacts on the developing *** has been associated with an increased risk of neurodevelopmental disorders,such as autism spectrum disorder(ASD)in the *** is characterized by increased repetitive and stereotyped behaviors and decreased *** of 2020,1 in 36 childr.n are diagnosed with ASD by the age of 8 years,with ASD rates continuing to increase in prevalence in usa(Tamayo et al.,2023).Post-mortem brain studies,biomarker and transcriptomic studies,and epidemiology studies have provided compelling evidence of immune dysregulation in the circulation and brain of individuals diagnosed with ***,the etiology of ASD is largely unknown,however,genetic components and environmental factors can contribute to increased *** allergic asthma(MAA),a form of MIA,has been identified as a potential risk factor for developing neurodevelopmental disorders(Patel et al.,2020).Asthma is a chronic inflammatory condition dr.ven by a T-helper type(TH)2 immune response.

关键词： disorders epidemiology fetus