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Laser polarization-variable autofluorescence of the network of optically anisotropic biological tissues:Diagnostics and differentiation of early stages of cancer of cervia uteri

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Journal of Innovative Optical Health Sciences 2014年第3期7卷 98-107页

作者： Yu.A.Ushenko M.I.Sidor N.Pashkovskaia G.D.Koval Yu.F.Marchuk D.Andreichuk Correlation Optics Department Chernivtsi National University 2 Kotsyubinsky StreetChernivtsi 58012Ukraine Clinical Immanology Allergology and Endocrinology Dep artmentBucovinian State Medical University2 Theatral Sq.Chernivtsi 58002Ukraine

This research presents the results of investigation of laser_polarization fluorescence ofbiological layers(histological sections,cy tological smears)in the task of diagnostics and differ-en tiation of early stages of cancer:Dysplasia-cervical microinvasive carcinoma of cervic *** analytical conditions of polarization-optimal probing of biological layers were determinedbasing on the model of linear birefringence and dichroism of birefringent(fibrllar,porphyrin)*** technique of polarization-variable laser autofluorescence was developed andexperimentally *** objective criteria(statistical moments)of differentiation of histo-logical sections autofluorescent images of endometrium biopsy and cytological smears of itmucous coat were *** operational characteristics(sensitivity,speifity,accuracy)ofthis technique were determined concerning the positions of probative medicine,and clinical efficiency.

关键词： Autofluorescence polarization birefringence statistical optics diagnostics medical and autofluorescence imaging.

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Biomedical applications of Jones-matrix tomography to polycrystalline films of biological fuids

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Journal of Innovative Optical Health Sciences 2019年第6期12卷 72-84页

作者： V.A.Ushenko A.Yu.Sdobnov W.D.Mishalov A.V.Dubolazov O.V.Olar V.T.Bachinskyi A.G.Ushenko Yu.A.Ushenko O.Ya.Wanchuliak I.Meglinsk Chernivtsi National university 2 Kotsiubynskyi St. Chernivtsi58012 Ukraine Faculty of Information Technology and Electrical Engineering university of Oulu Oulu 90570Finland Shupyk National medical Academy of Postgraduate Education 9 Dorogozhytska St.Kyiv04112 Ukraine bukovinian state medical university 3 theatral sq. Chernivtsi58000 Ukraine Interdisciplinary Laboratory of Biophotonics National Research Tomsk state university Tomsk 634050 Russia Institute of Engineering Physics for Biomedicine(PhysBio)National Research Nuclear university"MEPhI"Moscow 15409 Russia Aston Institute of Materials Research School of Engineering and Applied Science Aston university BirminghamB47ETUK School of Life and Health Sciences Aston University BirminghamB47ETUK

Algorithms for reconstruction of linear and circular birefringence-dichroism of optically thin anisotropic biological layers are *** technique of Jones matrix tomography of poly-crystalline films of biological fuids of various human organs has been developed and experimentally *** coordinate distributions of phase and amplitude anisotropy of bile films and synovial fuid taken from the knee joint are determined and statistically ***(statistical moments of 3rd and 4th orders)of differential diagnostics of early stages of cholelithiasis and septic arthritis of the knee joint with excellent balanced accuracy were *** on the diagnostic fficiency of the Jones matrix tomography method for polyerystalline plasma(liver disease),urine(albuminuria)and cytological smears(cervical cancer)are presented.

关键词： Polarization Fourier optics and signal processing imaging systems medical and biological imnaging

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NEW PARAMETER FOR DESCRIBING AND ANALYZING THE OPTICAL-ANISOTROPIC PROPERTIES OF BIOLOGICAL TISSUES

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Journal of Innovative Optical Health Sciences 2011年第4期4卷 463-475页

作者： Yu.A.USHENKO O.I.TELENGA A.P.PERESUNKO O.K.NUMAN Correlation Optics Department Chernivtsi National University 2 Kotsyubinsky StreetChernivtsi 58012Ukraine Optics and Spectroscopy Department Chernivtsi National university 2 Kotsyubinsky Street Chernivtsi 58012Ukraine Chernivtsi medical university 2 theatral sq Chernivtsi 58002Ukraine

To characterize the degree of similarity inherent to parameters of the optically uniaxial birefringent protein-fibril networks of biological tissues,a new parameter-complex degree of mutual anisotropy-has been *** technique of polarization measuring the coordinate distributions of the complex degree of mutual anisotropy of biological tissues has been *** has been shown that statistical approach to the analysis of complex degree of mutual anisotropy distributions for biological tissues in various morphological and physiological states and for different optical thicknesses appears to be more sensitive and efficient in differentiation of physiological state,as compared to investigations of complex degree of mutual polarization in the corresponding laser images.

关键词： Polarization birefringence correlation statistics biological tissue skin derma

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