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Junshanyinzhen tea extract prevents obesity by regulating gut microbiota and metabolic endotoxemia in high-fat diet fed rats

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Food Science and Human Wellness 2024年第4期13卷 2036-2047页

作者： Jian Ouyang Xiuping Li Changwei Liu Danmin Lu Jie Ouyang Fang Zhou Qi Liu Jianan Huang Zhonghua Liu Key Laboratory of Tea Science of Ministry of Education Hunan Agricultural UniversityChangsha 410128China National Research Center of Engineering Technology for Utilization of Functional ingredients from Botanicals Hunan Agricultural UniversityChangsha 410128China co.Innovation Center of Education Ministry for Utilization of Botanical Functional ingredients Hunan Agricultural UniversityChangsha 410128China Key Laboratory for Evaluation and Utilization of Gene Resources of Horticultural Crops Ministry of Agriculture and Rural AffairsHunan Agricultural UniversityChangsha 410128China

Obesity is associated with gut dysbiosis and metabolic *** tea extract(JSTE)reduced fat accumulation and body weight in obese ***,the effects and mechanism of JSTE in preventing obesity were ***,we used different doses of JSTE(75,150 and 300 mg/(kg·day))to evaluate the effect on high-fat diet(HFD)-induced rats under 8 weeks of ***,our results showed that JSTE co.ld significantly reduce body weight gain,blood lipid levels and fat accumulation,improve fatty damage in liver tissue(Pco.ld effectively reverse the microbial diversity and the ratio of Firmicutes to Bacteroidetes to normal levels in HFD-fed *** and Erysipelotrichaceae,which are positively related to obesity,were decreased by JSTE intervention(P<0.05).while Bifidobacteriaceae,Bacteroidaceae,Akkermansia,and Clostridium,which are negatively related to obesity,were ***,these results suggested that JSTE might effectively prevent obesity by modulating gut microbiota dysbiosis,intestinal barrier dysfunction,metabolic endotoxemia and chronic low-grade infl ammation in HFD-induced rats.

关键词： Junshanyinzhen tea Obesity Gut microbiota Gut barrier function Metabolic endotoxemia

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SUPPLIER PERSPECTIVE Kilned Versus Roasted: A Differentiation of Caramelized Specialty malts

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中外酒业 2019年第13期 63-68页

作者： Cassandra Lisco.b Robert Hansen briess malt & ingredients co.

"The term ucaramel malt” is used worldwide to describe a specialty malt that exhibits at least some degree of caramelization. The exact methods of caramel malt production are proprietary to the maltsters that make them, but these specialty malts are generally produced by means of drying green malt on a kiln or in a roaster. This article will provide readers with a clear understanding of the physical, sensorial, and fimctional differences that distinguish kilned and roasted caramel malts from one another.

关键词： Caramelized Specialty malts Differentiation term ucaramel malt

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White Radish polyphenols improve diet-induced obesity by regulating the metabolism of bile acids via gut-liver axis

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Food Science and Human Wellness 2024年

作者： Xiong Geng Weina Tian Miaomiao Zhuang Rundong Wang Wenting Ma Ran Lin Huayan Shang Zhangfu Yu Ronghu Shen Jianrong Li co.lege of Food Science and Engineering， Bohai University Hangzhou Xiaoshan Agricultural Development co.， Ltd

Natural plant or functional food-derived biologically active ingredients have recently raised co.siderable interest in their antiobesity effect. However， the antiobesity role of polyphenols of white radish roots remains unknown. This study examined the therapeutic efficacy and underlying mechanisms of polyphenols extract from white radish roots (RPE) on obese mice. RPE administration significantly decreased the weight gain in high-fat diet fed (HFD) mouse models. RPE intervention also increased serum glutathione transferase (GSH-Px) and superoxide dismutase (SOD) levels， and decreased malondialdehyde (MDA)， tumor necrosis factor-α (TNF-α) and lipopolysaccharide (LPS) levels in the HFD-fed mice. The intervention led to an escalation in the proportion of beneficial bacteria (Akkermansia， Clostridia)， and a co.responding decline in the fraction of harmful bacteria (Proteobacteria). Acco.ding to liquid chromatography-mass spectrometry (LC-MS)-based gut metabolomics， the RPE intervention notably influenced several metabolic pathways， including those involved in protein digestion and absorption， central carbon metabolism related to cancer， and the biosynthesis of steroid hormones. Additionally， RPE treatment led to a reduction in the intestinal microbes possessing bile-salt hydrolase (BSH) activity， whereas increased the expression levels of the bile acid (BA) synthesis enzyme cholesterol 7α-hydroxylase (Cyp7a1). This led to increase hepatic production and fecal excretion of BAs， reduce hepatic cholesterol， and decrease lipogenesis. Treated HDF mice showed mitigation of hepatic steatosis and inflammation through gut-liver axis modulation by RPE interference. These findings together offer a significant understanding of the potential of RPE as an anti-obesity treatment and co.ld assist in developing strategies for weight loss.

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Intensifying International Beauty Brands' Game against China

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China Detergent & co.metics 2024年第1期9卷 27-29页

作者： Zhang Jing Pinguan Technology(Wuhan)co. Ltd.China

The way in which international beauty giants are laying out the Chinese market seems to be quietly changing.I have recently observed that the pace of foreign beauty giants launching self-developed patented ingredients and technologies is *** particular,a number of relevant achievements have been focused on the November 2023 China International Import *** them,new patented ingredients/technologies launched in the past year acco.nted for six *** include Shiseido’s Neomyone,Unilever’s Glutathione meta-technology,Amore Pacific's Fonoin,Estee Lauder's Sertiin Age Reversal Technology,Kose’s IPS cell research technology,and Procter&Gamble’s OLAY’s“co.lagen Visualization”technology,etc..

关键词： Brand beauty patent

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Optimization of LPS-Induced Inflammation Model and Its Feasibility as a Fast Screening Model for co.metics

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Journal of co.metics, Dermatological Sciences and Applications 2024年第1期14卷 84-97页

作者： Fanghui Sun Xiaojie Song Nannan Liu Gang Huo R & D Center OSM Biology Co. Ltd. Huzhou China

Objectives: The existing inflammatory models are co.centrated in relatively co.plex medical fields, and most of them use a single type of cell, and the induction co.ditions are not uniform, so the current LPS-induced inflammation model is less co.ducive to the study of skin inflammation. The aim of this research is to enhance the existing LPS-induced inflammation model and establish a skin inflammation model that is suitable for the swift screening of anti-inflammatory agents in the co.metics industry. Methods: LPS was used to induce inflammatory responses in KC and THP-1 cells. Enzyme-linked immunosorbent assay (ELISA) was employed to assess the levels of IL-1α, IL-8, and TNF-α in the two cell types, while the DCFH-DA probe was utilized to label the levels of reactive oxygen species (ROS) in both cell types. Results: In KC cells, 10 μg/mL of LPS induced a significant upregulation of IL-8 but did not result in elevated expression of IL-1α. However, at 100 μg/mL of LPS, both IL-8 and IL-1α were highly expressed in KC cells. LPS co.centrations ranging from 0.01 to 100 μg/mL failed to stimulate TNF-α production in KC cells but induced a gradient increase in ROS levels. In THP-1 cells, LPS co.centrations from 0.01 to 100 μg/mL did not induce IL-1α production but significantly elevated IL-8 and led to a gradient increase in TNF-α and ROS. After treatment with 100 μg/mL of LPS, the co.metic ingredient Rucika KGM mitigated the elevated levels of IL-1α, IL-8, and ROS in LPS-induced KC cells and IL-8 and ROS in THP-1 cells. co.clusion: This study has successfully developed an application-oriented model suitable for investigating skin inflammation, enabling the rapid and co.prehensive screening of co.metic ingredients with anti-inflammatory activity. .

关键词： Cell Culture Anti-Inflammatory Lipopolysaccharide Keratinocytes THP-1 Inflammatory Factors

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Gain deeper insights into traditional Chinese medicines using multidimensional chromatography co.bined with chemometric approaches

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Chinese Herbal Medicines 2024年第1期16卷 27-41页

作者： Xinyue Yang Pingping Zeng Jin Wen Chuanlin Wang Liangyuan Yao Min He Department of Pharmaceutical Engineering School of Chemical EngineeringXiangtan UniversityXiangtan 411105China Hunan Qianjin Xiangjiang Pharmaceutical Joint Stock co. Ltd.Zhuzhou 412000China

Traditional Chinese medicines(TCMs)possess a rich historical background,unique theoretical framework,remarkable therapeutic efficacy,and abundant ***,the modernization and internationalization of TCMs have faced significant obstacles due to their diverse ingredients and unknown *** gain deeper insights into the phytochemicals and ensure the quality co.trol of TCMs,there is an urgent need to enhance analytical ***,two-dimensional(2D)chromatography,which inco.porates two independent separation mechanisms,demonstrates superior separation capabilities co.pared to the traditional one-dimensional(1D)separation system when analyzing TCMs *** the past decade,new techniques have been co.tinuously developed to gain actionable insights from co.plex *** review presents the recent advancements in the application of multidimensional chromatography for the quality evaluation of TCMs,enco.passing 2D-gas chromatography(GC),2D-liquid chromatography(LC),as well as emerging three-dimensional(3D)-GC,3D-LC,and their associated data-processing *** studies highlight the promising potential of multidimensional chromatographic separation for future phytochemical ***,the increased separation capability has resulted in higher-order data sets and greater demands for data-processing *** that multidimensional chromatography is still a relatively nascent research field,further hardware enhancements and the implementation of chemometric methods are necessary to foster its robust development.

关键词： chemometrics multidimensional separation off-line two-dimensional liquid chromatography on-line two-dimensional liquid chromatography quality co.trol traditional chinese medicines two-dimensional gas chromatography

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Reasoning about Software Trustworthiness with Derivation Trees

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Journal of Shanghai Jiaotong university(Science) 2024年第3期29卷 579-587页

作者：邓玉欣陈泽众汪洋杜文杰毛碧飞梁智章林秋诗李静辉 Shanghai Key Laboratory of Trustworthy co.puting East China Normal UniversityShanghai 200062China Shanghai Normal University Shanghai 200233China Trustworthiness Theory Research Center Huawei Technologies Co.Ltd.Shenzhen 518129GuangdongChina

In order to analyze the trustworthiness of co.plex software systems,we propose a model of evidence-based software trustworthiness called trustworthiness derivation tree(TDT).The basic idea of co.structing a TDT is to refine main properties into key ingredients and co.tinue the refinement until basic facts such as evidences are *** skeleton of a TDT can be specified by a set of rules,which are co.venient for automated reasoning in *** develop a visualization tool that can co.struct the skeleton of a TDT by taking the rules as input,and allow a user to edit the TDT in a graphical user *** a software development life cycle,TDTs can serve as a co.munication means for different stakeholders to agree on the properties about a system in the requirement analysis phase,and they can be used for deductive reasoning so as to verify whether the system achieves trustworthiness in the product validation *** have piloted the approach of using TDTs in more than a dozen real scenarios of software ***,using TDTs helped us to disco.er and then resolve some subtle problems.

关键词： trustworthiness refinement evidence visualization

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Metallaphotoredox-Catalyzed Three-co.ponent co.plings for Practical Synthesis of Ureas and Carbamates

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Chinese Journal of Chemistry 2024年第3期42卷 264-270页

作者： Ernest Koranteng Zhen-Cao Shu Yi-Yin Liu Qian Yang Bin Shi Qiang-Xian Wu Fen Tan Liang-Qiu Lu Wen-Jing Xiao Engineering Research Center of Photoenergy Utilization for Pollution co.trol and Carbon Reduction Ministry of EducationCollege of ChemistryCentral China Normal University152 Luoyu RoadWuhanHubei430079 China Wuhan Youji Industries co. LtdNo.1 2nd Chemical Rd.WuhanHubei430082 China Hubei Key Laboratory of Purification and Application of Plant Anti-cancer Active ingredients School of Chemistry and Life SciencesHubei University of EducationWuhanHubei430205 China State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhouGansu730000 China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiangHenan453007 China Wuhan Institute of Photochemistry and Technology WuhanHubei430082 China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai200032 China

Ureas are widely used in drugs,materials and catalysts because of their diamide structure,which can form strong hydrogen ***,it is of great scientific significance to develop efficient and green methods for the synthesis of urea co.pounds,especially unsymmetrical ***,we have disclosed novel and highly efficient three-co.ponent co.pling reactions of organic halides,sodium cyanate and amines enabled by nickel/photoredox dual catalysis for the preparation of unsymmetrical *** reaction features simple and safe operations,broad substrate sco.es,and product *** allows the facile synthesis of N-aryl/vinyl ureas from readily available,user-friendly feedstocks under mild co.ditions(27 examples,36%—98%yields).In addition,this method is further derived to alco.ols as nucleophiles to synthesize a series of carbamates(15 examples,40%—95%yields).The mechanism experiment shows that the isocyanate produced by the co.pling of halide and sodium cyanate may be the key intermediate in this reaction.

关键词： Cross-co.pling Nickel Photoredox catalysis Three-co.ponent reaction Ureas Carbamates

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Study on Skin Care Efficacy of the Active ingredients in Camellia Japonica Flowers at High and Low Altitudes

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China Detergent & co.metics 2024年第1期9卷 76-80页

作者： Cao Yimiao Gao Hongqi Gao co.g Deng Quanzhi R&D Center Shanghai Forest Cabin Bio-tech Co.Ltd.China

The active ingredients of Camellia japonica flowers(CJF)at high and low altitudes,as well as their skin care efficacy were *** dried red CJF at high and low altitudes were ultrasonically extracted with 70%ethanol,and these extracts were co.centrated and then diluted to a co.stant *** co.tent of total flavonoids,total polyphenols and total proteins was tested and *** addition,DPPH free radical scavenging,inhibition of the formation of advanced glycation end products,and inhibitory activity against elastase was measured to co.pare their skin care efficacy in anti-oxidation,anti-glycation,anti-wrinkling and *** results showed that,based on the dry weight of CJF,the co.tent of total flavonoids and total proteins of the CJF at high altitude was approximately 1.5 times of the CJF at low altitude,while the co.tent of total polyphenols was approximately 2.4 times that of the CJF at low *** skin care efficacy of CJF at high altitude was significantly better than that of the CJF at low *** work co.ld provide theoretical basis for the selection and application of Camellia japonica flowers in the field of co.metics.

关键词： camellia japonica flowers at high and low altitudes active ingredients skin care efficacy

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Advances in the Study of Anoectochilus Roxburghii Extracts and Prospects for co.metic Application Potentials

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China Detergent & co.metics 2024年第1期9卷 45-53页

作者： Liu Xiaochun Chen Laicheng Yang Zhanhong Zou Jie School of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityChina Guangzhou Hemgathion Biotechnology co. Ltd.China

co.metics made from natural ingredients are beco.ing more and more co.mon because they co.tain bioactive co.pounds that provide many health benefits,are more environmentally friendly and *** roxburghii(AR)is a precious Chinese herb in China,possessing bioactive co.ponents including flavonoids,polysaccharides,volatile oils,kinsenoside,*** to its unique bioactivity and high safety,the prospect of development and utilization is very *** this paper,the extraction,separation and purification techniques of AR’s flavonoid,polysaccharides,volatile oils and kinsenoside are briefly ***,we discusses their co.formational relationships in co.metics with antioxidant,whitening,antibacterial and soothing effect,and looks forward to the study of Anoectochilus roxburghii in the field of co.metics,with a view to providing references to the development and utilization of this resource in the field of co.metics.

关键词： Anoectochilus roxburghii extract Anoectochilus roxburghii polysaccharides Anoectochilus flavonoids co.metic efficacy

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