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A nitroreductase-responsive nanoprobe with homogeneous composition and high loading for preoperative non-invasive tumor imaging and intraoperative guidance

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Chinese Chemical Letters 2024年第7期35卷 313-318页

作者： Jingqi Xin Shupeng Han Meichen Zheng Chenfeng Xu Zhongxi Huang Bin Wang Changmin Yu Feifei An Yu Ren Institute of Medical Engineering Department of BiophysicsSchool of Basic Medical ScienceHealth Science CenterXi'an Jiaotong UniversityXi'an 710061China School of Public Health Health Science CenterXi'an Jiaotong UniversityXi'an 710061China Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech UniversityNanjing 211816China department of breast surgery the First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061China

Tumor microenvironment(TME)-activatable probes have been proven to effectively increase signal-tobackground ratios(SBRs)and improve the success rate of complete tumor ***,many fluorescence probes have to be loaded into a nanocarrier for tumor targeted delivery,which consequently encounters poor drug loading,heterogeneous composition and non-encapsulated drug aggregates occurred during nanoformulation ***,a nitroreductase(NTR)-activated“OFF-ON”near-infrared fluorescence nanoprobe,named Nano Bodipy,was synthesized by the spontaneous self-assembling of NTRresponsive dye-polyethylene glycol(PEG)amphiphilic polymer in *** NTR-responsive dye acted as the hydrophobic segment in the amphiphilic polymer,yielding a homogeneous composition and a high loading of 12.2 wt%(according to calculation)in the synthesized Nano *** synthesized Nano Bodipy can efficiently accumulate in tumors via the enhanced permeability and retention(EPR)effect,enabling non-invasive tumor-targeted fluorescence imaging and guiding complete tumor *** the synthesized Nano Bodipy entered the tumor cells,they dissociated and were activated by overexpressed *** the real-time fluorescence guide of Nano Bodipy,complete tumor resection surgery was performed successfully.

关键词： Nitroreductase Tumor diagnosis Intraoperative guidance Self-assembly Nanoprobe

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Design,synthesis,and biological evaluation of novel chrysin derivatives as poly(ADP-ribose)polymerase 1(PARP1)inhibitors for the treatment of breast cancer

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Chinese Journal of Natural Medicines 2024年第5期22卷 455-465页

作者： YANG Yao TONG Jing XIE Xianshun CAO Hong FU Yong LUO Yong LIU Shan CHEN Wen YANG Ning Hengyang Medical School University of South ChinaHengyang 421200China Emergency department Hengyang Medical SchoolThe Second Affiliated HospitalUniversity of South ChinaHengyang 421200China Hengyang Medical School The Second Affiliated HospitalUniversity of South ChinaHengyang 421200China Hemato-oncology department Hengyang Medical SchoolThe Second Affiliated HospitalUniversity of South ChinaHengyang 421200China department of breast and Thyroid surgery Hengyang Medical SchoolThe Second Affiliated HospitalUniversity of South ChinaHengyang 421200China

In this study,we reported the discovery and structure-activity relationship analysis of chrysin derivatives as a new class of inhibitors targeting poly(ADP-ribose)polymerase 1(PARP1).Among these derivatives,compound 5d emerged as the most effective chrysin-based inhibitor of PARP1,with an IC50 value of 108 nmol·L^(-1).This compound significantly inhibited the proliferation and migration of breast cancer cell lines HCC-1937 and MDA-MB-436 by inducing DNA ***,5d induced apoptosis and caused an extended G1/S-phase in these cell *** docking studies revealed that 5d possesses a strong binding affinity toward *** vivo,in a xenograft model,5d effectively reduced tumor growth by downregulating PARP1 ***,compound 5d shows promise as a potential therapeutic agent for the treatment of BRCA wild-type breast cancer.

关键词： Chrysin derivatives PARP1 Antitumor DNA damage Small molecules

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Correlation and predictive value of pathological complete response and ultrasound characteristic parameters in neoadjuvant chemotherapy for breast

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World Journal of Clinical Cases 2024年第23期12卷 5320-5328页

作者： Lei Zheng Li-Xian Yang Jing-Yi Liu Zhe Jiang Xiao-Wei Li Peng-Peng Pu department of breast surgery Xingtai People's HospitalXingtai 054001Hebei ProvinceChina department of Medical Imaging Xingtai People´s HospitalXingtai 054001Hebei ProvinceChina

BACKGROUND breast cancer ranks as one of the most prevalent malignant tumors among women,significantly endangering their health and *** radical surgery has been a pivotal method for halting disease progression,it alone is insufficient for enhancing the quality of life for *** To investigate the correlation between ultrasound characteristic parameters of breast cancer lesions and clinical efficacy in patients undergoing neoadjuvant chemotherapy(NAC).METHODS Employing a case-control study design,this research involved 178 breast cancer patients treated with NAC at our hospital from July 2019 to June *** to the Miller-Payne grading system,the pathological response,***,of the NAC in the initial breast lesion after NAC was *** these,59 patients achieved a pathological complete response(PCR),while 119 did not(non-PCR group).Ultrasound characteristics prior to NAC were compared between these groups,and the association of various factors with NAC efficacy was analyzed using univariate and multivariate *** In the PCR group,the incidence of posterior echo attenuation,lesion diameter≥2.0 cm,and Alder blood flow grade≥II were significantly lower compared to the non-PCR group(Pbreast cancer patients(P<0.05).CONCLUSION While ultrasound characteristics such as posterior echo attenuation,lesion diameter≥2.0 cm,and Alder blood flow grade≥II exhibit limited predictiv

关键词： breast cancer Ultrasound Neoadjuvant chemotherapy Efficacy Pathological complete response

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Predictive modeling for postoperative delirium in elderly patients with abdominal malignancies using synthetic minority oversampling technique

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1227-1235页

作者： Wen-Jing Hu Gang Bai Yan Wang Dong-Mei Hong Jin-Hua Jiang Jia-Xun Li Yin Hua Xin-Yu Wang Ying Chen Intensive Care Unit Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China department of Anesthesia and Perioperative Medicine Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China department of Nursing Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China department of Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

BACKGROUND Postoperative delirium,particularly prevalent in elderly patients after abdominal cancer surgery,presents significant challenges in clinical *** To develop a synthetic minority oversampling technique(SMOTE)-based model for predicting postoperative delirium in elderly abdominal cancer *** In this retrospective cohort study,we analyzed data from 611 elderly patients who underwent abdominal malignant tumor surgery at our hospital between September 2020 and October *** incidence of postoperative delirium was recorded for 7 d *** were divided into delirium and non-delirium groups based on the occurrence of postoperative delirium or not.A multivariate logistic regression model was used to identify risk factors and develop a predictive model for postoperative *** SMOTE technique was applied to enhance the model by oversampling the delirium *** model’s predictive accuracy was then *** In our study involving 611 elderly patients with abdominal malignant tumors,multivariate logistic regression analysis identified significant risk factors for postoperative *** included the Charlson comorbidity index,American Society of Anesthesiologists classification,history of cerebrovascular disease,surgical duration,perioperative blood transfusion,and postoperative pain *** incidence rate of postoperative delirium in our study was 22.91%.The original predictive model(P1)exhibited an area under the receiver operating characteristic curve of *** comparison,the SMOTE-based logistic early warning model(P2),which utilized the SMOTE oversampling algorithm,showed a slightly lower but comparable area under the curve of 0.856,suggesting no significant difference in performance between the two predictive *** This study confirms that the SMOTE-enhanced predictive model for postoperative delirium in elderly abdominal tumor patients shows performance equivalent to that of tradi

关键词： Elderly patients Abdominal cancer Postoperative delirium Synthetic minority oversampling technique Predictive modeling Surgical outcomes

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Risk of interstitial lung disease with the use of programmed cell death 1 (PD-1) inhibitor compared with programmed cell death ligand 1 (PD-L1) inhibitor in patients with breast cancer: A systematic review and meta-analysis

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Cancer Pathogenesis and Therapy 2024年第2期2卷 91-102页

作者： Lijuan Guo Xiaoyi Lin Xin Lin Yulei Wang Jiali Lin Yi Zhang Xiangqing Chen Miao Chen Guochun Zhang Yifang Zhang department of breast surgery Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong 510000China Schol of Medicine South China University of TechnologyGuangzhouGuangdong 510000China Medical College Shantou UniversityShantouGuangdong 515000China The Second School of Clinical Medicine Southerm Medical UniversityGuangzhouGuangdong 510000China department of breast Cancer Guangdong Provincial People's Hospital's Nanhai HospitalFoshanGuangdong 528000China department of Emergency Medicine Guangdong Provincial People's Hospitals Nanhai HospitalFoshanGuangdong 528000China

Background:Programmed cell death 1(PD-1)and programmed cell death ligand 1(PD-L1)inhibitors have become integral elements within the current landscape of breast cancer treatment modalities;however,they are associ-ated with interstitial lung disease(ILD),which is rare but potentially ***,only a few studies have compared the difference in ILD incidence between PD-1 and PD-L1 ***,this study aimed to assess the discrepancies regarding ILD risk between the two immune checkpoint *** also reported three cases of ILD after PD-1 inhibitor ***:We comprehensively searched PubMed,EMBASE,and the Cochrane Library to identify clinical trials that investigated PD-1/PD-L1 inhibitor treatment for patients with breast *** overall estimates of incidence and risk ratio(RR)were calculated with a 95%confidence interval(CI),and a mirror group analysis was per-formed using eligible ***:This meta-analysis included 29 studies with 4639 patients who received PD-1/PD-L1 inhibitor treatment.A higher ILD incidence was observed among 2508 patients treated with PD-1 inhibitors than among 2131 patients treated with PD-L1 inhibitors(0.05 vs.0.02).The mirror group analysis further revealed a higher ILD event risk in patients treated with PD-1 inhibitors than in those treated with PD-L1 inhibitors(RR=2.34,95%CI,1.13-4.82,P=0.02).Conclusion:Our findings suggest a greater risk of ILD with PD-1 inhibitors than with PD-L1 *** findings are instrumental for clinicians in treatment deliberations,and the adoption of more structured diagnostic approaches and management protocols is necessary to mitigate the risk of ILD.

关键词： Programmed cell death 1 inhibitor Programmed cell death ligand 1 inhibitor Interstitial lung disease breast cancer Immune-related adverse events

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Pregnancy Complicated With a Giant Pancreatic Tumor and Decompensation of Liver Cirrhosis:A Case Report and Literature Review

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Maternal-Fetal Medicine 2024年第1期6卷 50-53页

作者： Yi Yu Lirong Teng Juntao Liu Xinyan Liu Ping Peng Qian Zhou Congcong Liu department of Obstetrics and Gynecology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China National Clinical Research Center for Obstetric and gynecologic Diseases Beijing 100730China

Pregnancy with solid pseudopapillary tumor of the pancreas(SPTP)is *** pregnancy hormones may cause tumor progression,the management and treatment of SPTP need to balance the safety of pregnant women and fetuses with surgical *** reported a case of a giant pancreatic tumor diagnosed during pregnancy that was considered to be *** also showed hepatitis B virus infection and severe decompensation of liver *** termination of pregnancy was *** patient has lived with the tumor until now without *** retrieved the published case reports,summarized the clinical characteristics of pregnancy with SPTP,and explored its management during the perinatal *** patients with SPTP have a good prognosis with good maternal and fetal outcomes,and it is important to choose an appropriate treatment method and ***,pregnancy combined with decompensated liver cirrhosis needs to be terminated in a timely manner because of its high-risk status.

关键词： Pregnancy complications Pancreatic tumor Solid pseudopapillary tumor of the pancreas Liver cirrhosis decompensation Abnormal coagulation function

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Diagnostic challenges and individualized treatment of cervical adenocarcinoma metastases to the breast:A case report

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World Journal of Clinical Cases 2024年第2期12卷 412-417页

作者： Allison Akers Susan Read John Feldman Casey Gooden Diana P English department of Obstetrics and Gynecology University of South FloridaTampaFL 33606United States department of gynecologic Oncology Sky Ridge Medical CenterLone TreeCO 80124United States department of Radiology University of South FloridaTampaFL 33606United States department of Pathology University of South FloridaTampaFL 33606United States

BACKGROUND Cervical cancer is a rare primary tumor resulting in metastases to the breast with few cases reported in *** metastases are associated with poor *** following case highlights the diagnostic challenges associated with metastatic cervical cancer to the breast along with individualized *** SUMMARY A 44-year-old G7P5025 with no significant past medical or surgical history presented with heavy vaginal to an outside emergency department where an exam and a pelvic magnetic resonance imaging showed a 4.5 cm heterogenous lobulated cervical mass involving upper two thirds of vagina,parametria and lymph node *** biopsies confirmed high grade adenocarcinoma with mucinous features.A positron emission tomography/computed tomography(PET/CT)did not show evidence of metastatic *** received concurrent cisplatin with external beam radiation *** up PET/CT scan three months later showed no suspicious fluorodeoxyglucose uptake in the cervix and no evidence of metastatic *** was lost to follow up for six *** was re-imaged on re-presentation and found to have widely metastatic disease including breast *** biopsy confirmed programmed death-ligand 1 positive metastatic cervical *** patient received six cycles of carboplatin and paclitaxel with *** imaging demonstrated *** continued on pembrolizumab with disease *** Metastatic cervical cancer to the breast is uncommon with nonspecific clinical findings that can make diagnosis *** history and immunohistochemical evaluation of breast lesion,and comparison to primary tumor can support diagnosis of metastatic cervical cancer to the ***,the prognosis is poor,but immunotherapy can be considered in select patients and may result in good disease response.

关键词： Cervical adenocarcinoma breast metastases Immunotherapy Pembrolizumab Carboplatin Paclitaxel Case report

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年轻乳腺癌患者妻子角色期望的质性研究

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International Journal of Nursing Sciences 2024年第3期11卷 366-373,I0004页

作者：高文娟张倩王丹李晓旭张琳萍徐梦娇韩静 School of Nursing Xuzhou Medical UniversityJiangsuChina department of Oncology Center Affiliated Hospital of Xuzhou Medical UniversityJiangsuChina department of Nail and breast surgery Affiliated Hospital of Xuzhou Medical UniversityJiangsuChina

目的通过对自我和身份的反思,探索年轻乳腺癌患者为回归家庭需要履行的妻子角色期望,为医务工作者制订癌症家庭康复的相关干预措施提供参考依据。方法采用描述性现象学方法和目的取样法。于2023年3月-4月在江苏省徐州市某三级甲等医院... 详细信息

目的通过对自我和身份的反思,探索年轻乳腺癌患者为回归家庭需要履行的妻子角色期望,为医务工作者制订癌症家庭康复的相关干预措施提供参考依据。方法采用描述性现象学方法和目的取样法。于2023年3月-4月在江苏省徐州市某三级甲等医院的乳腺外科和肿瘤内科选取年轻乳腺癌患者及其配偶进行半结构化的面对面访谈。访谈内容被逐字转录,采用科莱兹现象学方法进行分析。结果16例乳腺癌患者和6名配偶参与了访谈,平均年龄分别为(35.95±3.36)岁和(37.67±5.28)岁。在治疗和康复期间,关于年轻乳腺癌患者妻子角色期望内容共提炼出3个主题,8个子主题:自尊自爱(保障自己的生命、坦然面对疾病、重拾女性角色的自信);夫妻关系的调适(和谐有效的夫妻沟通、为婚姻和爱情给予支持、共创美好的夫妻生活);协助家庭康复(减轻配偶的照护与经济负担、家庭日常的管理)。结论年轻乳腺癌患者及其配偶对妻子角色的期望主要包括自我、夫妻和家庭三个方面。自尊和自爱是最基本的期望,而调整夫妻关系和协助家庭康复则是更高的期望。

关键词：乳腺癌期望家庭定性研究角色妻子

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Deep learning automation of radiographic patterns for hallux valgus diagnosis

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World Journal of Orthopedics 2024年第2期15卷 105-109页

作者： Angela Hussain Cadence Lee Eric Hu Farid Amirouche department of Orthopaedic surgery University of Illinois College of MedicineChicagoIL 60612United States department of Orthopaedics surgery University of Illinois at ChicagoChicagoIL 60612United States department of Orthopaedic surgery Northshore University Health SystemSkokieIL 6007United States

Artificial intelligence(AI)and deep learning are becoming increasingly powerful tools in diagnostic and radiographic *** learning has already been utilized for automated detection of pneumonia from chest radiographs,diabetic retinopathy,breast cancer,skin carcinoma classification,and metastatic lymphadenopathy detection,with diagnostic reliability akin to medical *** the World Journal of Orthopedics article,the authors apply an automated and AIassisted technique to determine the hallux valgus angle(HVA)for assessing HV foot *** the U-net neural network,the authors constructed an algorithm for pattern recognition of HV foot deformity from anteroposterior highresolution *** performance of the deep learning algorithm was compared to expert clinician manual performance and assessed alongside clinician-clinician *** authors found that the AI tool was sufficient in assessing HVA and proposed the system as an instrument to augment clinical *** further sophistication is needed to establish automated algorithms for more complicated foot pathologies,this work adds to the growing evidence supporting AI as a powerful diagnostic tool.

关键词： Artificial intelligence Hallux valgus Deep learning Automated radiography

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DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis

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Genes & Diseases 2024年第1期11卷 91-94页

作者： Qiuxia Cui Jian Sun Jingping Yuan Juanjuan Li Chuanyu Yang Guangshi Du Chengang Zhou Pu Qiu Jidong Gao Yuanqi Zhang Dewei Jiang Ceshi Chen Affiliated Hospital of Guangdong Medical University Science&Technology of China ZhanjiangGuangdong 524000China department of breast Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhenGuangdong 518116China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China department of Pathology Renmin Hospital of Wuhan UniversityWuhanHubei 430060China department of breast and Thyroid surgery Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Translational Medicine Research Center of Guizhou Medical University GuiyangGuizhou 550025China department of breast Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Yunnan Cancer Hospital and the Third Affiliated Hospital of Kunming Medical University and Yunnan Cancer Center KunmingYunnan 650500China Academy of Biomedical Engineering Kunming Medical UniversityKunmingYunnan 650500China

Most basal-like breast cancers(BLBCs)have a poor prognosis and high crossover with triple-negative breast cancers(TNBCs).However,approximately 50%of TNBC patients develop chemoresistance.^(1) Dexamethasone reportedly induces Krüppel-like factor 5(KLF5)and can cause docetaxel and cisplatin resistance in TNBC.A super-enhancer can maintain the transcription of KLF5.

关键词： FOXO1 drugs damage

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