Correlation and predictive value of pathological complete response and ultrasound characteristic parameters in neoadjuvant chemotherapy for breast

作     者：Lei Zheng Li-Xian Yang Jing-Yi Liu Zhe Jiang Xiao-Wei Li Peng-Peng Pu 

作者机构：Department of Breast SurgeryXingtai People's HospitalXingtai 054001Hebei ProvinceChina Department of Medical ImagingXingtai People´s HospitalXingtai 054001Hebei ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2024年第12卷第23期

页      面：5320-5328页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Breast cancer Ultrasound Neoadjuvant chemotherapy Efficacy Pathological complete response 

摘      要：BACKGROUND Breast cancer ranks as one of the most prevalent malignant tumors among women,significantly endangering their health and *** radical surgery has been a pivotal method for halting disease progression,it alone is insufficient for enhancing the quality of life for *** To investigate the correlation between ultrasound characteristic parameters of breast cancer lesions and clinical efficacy in patients undergoing neoadjuvant chemotherapy(NAC).METHODS Employing a case-control study design,this research involved 178 breast cancer patients treated with NAC at our hospital from July 2019 to June *** to the Miller-Payne grading system,the pathological response,***,of the NAC in the initial breast lesion after NAC was *** these,59 patients achieved a pathological complete response(PCR),while 119 did not(non-PCR group).Ultrasound characteristics prior to NAC were compared between these groups,and the association of various factors with NAC efficacy was analyzed using univariate and multivariate *** In the PCR group,the incidence of posterior echo attenuation,lesion diameter≥2.0 cm,and Alder blood flow grade≥II were significantly lower compared to the non-PCR group(P0.05).The area under the curve values for predicting NAC efficacy using posterior echo attenuation,lesion diameter,and Alder grade were 0.604,0.603,and 0.583,***,rates of pathological stage II,lymph node metastasis,vascular invasion,and positive Ki-67 expression were significantly lower in the PCR group(P0.05).Logistic regression analysis identified posterior echo attenuation,lesion diameter≥2.0 cm,Alder blood flow grade≥II,pathological stage III,vascular invasion,and positive Ki-67 expression as independent predictors of poor response to NAC in breast cancer patients(P0.05).CONCLUSION While ultrasound characteristics such as posterior echo attenuation,lesion diameter≥2.0 cm,and Alder blood flow grade≥II exhibit limited predictiv