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Highly conformable chip-in-foil implants for neural applications

Microsystems & Nanoengineering 2023年第3期9卷 245-257页

作者： Thomas Stieglitz Calogero Gueli Julien Martens Niklas Floto Max Eickenscheidt Markus Sporer Maurits Ortmanns Laboratory for Biomedical Microtechnology Department of Microsystems Engineering-IMTEKUniversity of FreiburgD-79110 FreiburgGermany brainlinks-braintools//IMBIT University of FreiburgD-79110 FreiburgGermany Institute of Microelectronics University of UlmD-89081 UlmGermany

Demands for neural interfaces around functionality,high spatial resolution,and longevity have recently *** requirements can be met with sophisticated silicon-based integrated *** miniaturized dice in flexible polymer substrates significantly improves their adaptation to the mechanical environment in the body,thus improving the systems’structural biocompatibility and ability to cover larger areas of the *** work addresses the main challenges in developing a hybrid chip-in-foil neural *** considered(1)the mechanical compliance to the recipient tissue that allows a long-term application and(2)the suitable design that allows the implant’s scaling and modular adaptation of chip *** element model studies were performed to identify design rules regarding die geometry,interconnect routing,and positions for contact pads on *** edge fillets in the die base shape proved an effective measure to improve die-substrate integrity and increase the area available for contact ***,routing of interconnects in the immediate vicinity of die corners should be avoided,as the substrate in these areas is prone to mechanical stress *** pads on dice should be placed with a clearance from the die rim to avoid delamination when the implant conforms to a curvilinear body.A microfabrication process was developed to transfer,align,and electrically interconnect multiple dice into conformable polyimide-based *** process enabled arbitrary die shape and size over independent target positions on the conformable substrate based on the die position on the fabrication wafer.

关键词： neural positions shape

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A flexible protruding microelectrode array for neural interfacing in bioelectronic medicine

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Microsystems & Nanoengineering 2022年第6期8卷 165-179页

作者： Helen Steins Michael Mierzejewski Lisa Brauns Angelika Stumpf Alina Kohler Gerhard Heusel Andrea Corna Thoralf Herrmann Peter D.Jones Günther Zeck Rene von Metzen Thomas Stieglitz NMI Natural and Medical Sciences Institute at the University of Tübingen ReutlingenGermany Laboratory for Biomedical Microtechnology Department of Microsystems EngineeringUniversity of FreiburgFreiburgGermany Institute of Biomedical Electronics TU WienViennaAustria Bernstein Center Freiburg University of FreiburgFreiburgGermany brainlinks-braintools University of FreiburgFreiburgGermany

Recording neural signals from delicate autonomic nerves is a challenging task that requires the development of a lowinvasive neural interface with highly selective,micrometer-sized *** paper reports on the development of a three-dimensional(3D)protruding thin-film microelectrode array(MEA),which is intended to be used for recording low-amplitude neural signals from pelvic nervous structures by penetrating the nerves transversely to reduce the distance to the *** gold pillars(O 20 or 50μm,~60μm height)were fabricated on a micromachined polyimide substrate in an electroplating *** sidewalls were insulated with parylene C,and their tips were optionally modified by wet etching and/or the application of a titanium nitride(TiN)*** microelectrodes modified by these combined techniques exhibited low impedances(~7 kΩ at 1 kHz for ∅ 50μm microelectrode with the exposed surface area of~5000μm^(2))and low intrinsic noise *** functionalities were evaluated in an ex vivo pilot study with mouse retinae,in which spontaneous neuronal spikes were recorded with amplitudes of up to 66μ*** novel process strategy for fabricating flexible,3D neural interfaces with low-impedance microelectrodes has the potential to selectively record neural signals from not only delicate structures such as retinal cells but also autonomic nerves with improved signal quality to study neural circuits and develop stimulation strategies in bioelectronic medicine,e.g.,for the control of vital digestive functions.

关键词： neural microelectrode electronic

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Bringing sensation to prosthetic hands-chronic assessment of implanted thin-film electrodes in humans

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npj Flexible Electronics 2023年第1期7卷 32-45页

作者： PaulČvančara Giacomo Valle Matthias Müller Inga Bartels Thomas Guiho Arthur Hiairrassary Francesco Petrini Stanisa Raspopovic Ivo Strauss Giuseppe Granata Eduardo Fernandez Paolo M.Rossini Massimo Barbaro Ken Yoshida Winnie Jensen Jean-Louis Divoux David Guiraud Silvestro Micera Thomas Stieglitz Laboratory for Biomedical Microtechnology Department of Microsystems Engineering-IMTEKAlbert-Ludwig-University FreiburgFreiburgGermany Center for Neuroprosthetics and Institute of Bioengineering School of EngineeringÉcole Polytechnique Fédérale de Lausanne(EPFL)LausanneSwitzerland The Biorobotics Institute Scuola Superiore Sant’AnnaPisaItaly Camin Team INRIAUniversity of MontpellierMontpellierFrance Institute of Neurology Catholic University of the Sacred HeartRomaItaly Institute of Neurosurgery Catholic University of the Sacred HeartRomaItaly Department of Neuroscience&Neurorehabilitation IRCCS San Raffaele Roma00166 RomeItaly Department of Electrical and Electronic Engineering University of CagliariCagliariItaly Biomedical Engineering Department Indiana University-Purdue UniversityIndianapolisINUSA SMI Dept.Health Science and TechnologyAalborg UniversityAalborgDenmark AXONIC/Groupe MXM VallaurisFrance brainlinks-braintools Albert-Ludwig-University FreiburgFreiburgGermany Bernstein Center Freiburg Albert-Ludwig-University FreiburgFreiburgGermany Present address:Laboratory for Neuroengineering Department of Health Sciences and TechnologyInstitute for Robotics and Intelligent SystemsETH ZürichZürichSwitzerland

Direct stimulation of peripheral nerves with implantable electrodes successfully provided sensory feedback to amputees while using hand *** of the electrodes is key to success,which we have improved for the polyimide-based transverse intrafascicular multichannel electrode(TIME).The TIMEs were implanted in the median and ulnar nerves of three trans-radial amputees for up to six *** present a comprehensive assessment of the electrical properties of the thin-film metallization as well as material status post *** TIMEs stayed within the electrochemical safe limits while enabling consistent and precise amplitude *** lead to a reliable performance in terms of eliciting *** signs of corrosion or morphological change to the thin-film metallization of the probes was observed by means of electrochemical and optical *** presented longevity demonstrates that thin-film electrodes are applicable in permanent implant systems.

关键词： film electrodes sensation

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Author Correction: Bringing sensation to prosthetic hands— chronic assessment of implanted thin-film electrodes in humans

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npj Flexible Electronics 2024年第1期8卷 918-918页

作者： PaulČvančara Giacomo Valle Matthias Müller Inga Bartels Thomas Guiho Arthur Hiairrassary Francesco Petrini Stanisa Raspopovic Ivo Strauss Giuseppe Granata Eduardo Fernandez Paolo MRossini Massimo Barbaro Ken Yoshida Winnie Jensen Jean-Louis Divoux David Guiraud Silvestro Micera Thomas Stieglitz Laboratory for Biomedical Microtechnology Department of Microsystems Engineering – IMTEK Albert-Ludwig-University Freiburg Freiburg Germany brainlinks-braintools Albert-Ludwig-University Freiburg Freiburg Germany Bernstein Center Freiburg Albert-Ludwig-University Freiburg Freiburg Germany Center for Neuroprosthetics and Institute of Bioengineering School of Engineering École Polytechnique Fédérale de Lausanne (EPFL) Lausanne Switzerland The Biorobotics Institute Scuola Superiore Sant’Anna Pisa Italy Camin Team INRIA University of Montpellier Montpellier France Institute of Neurology Catholic University of the Sacred Heart Roma Italy Institute of Neurosurgery Catholic University of the Sacred Heart Roma Italy Department of Neuroscience & Neurorehabilitation IRCCS San Raffaele Roma 00166 Rome Italy Department of Electrical and Electronic Engineering University of Cagliari Cagliari Italy Biomedical Engineering Department Indiana University-Purdue University Indianapolis IN USA SMI Dept. Health Science and Technology Aalborg University Aalborg Denmark AXONIC/Groupe MXM Vallauris France

In this article,the affiliation details for Paolo Maria Rossini were Institute of Neurology,Catholic University of the Sacred Heart,Roma,Italy,and Polyclinic *** Foundation-IRCCS,Roma,Italy but should have been Department of Neuroscience&Neurorehabilitation,IRCCS San Raffaele Roma,00166 Rome,*** original article has been corrected.

关键词： sensation details film

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