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Neural Regeneration Research 2025年第6期20卷 1703-1704页

作者： Paolo Abondio Francesco Bruno IRCCS Istituto delle Scienze Neurologiche di bologna BolognaItaly Association for Neurogenetic Research(ARN) Lamezia TermeCatanzaroItaly

The brain,with its trillions of neural connections,different cellular types,and molecular complexities,presents a formidable challenge for researchers aiming to comprehend the multifaceted nature of neural *** traditional methods have provided valuable insights,emerging technologies offer unprecedented opportunities to delve deeper into the underpinnings of brain *** the everevolving landscape of neuroscience,the quest to unravel the mysteries of the human brain is bound to take a leap forward thanks to new technological improvements and bold interpretative frameworks.

关键词： function artificial landscape

A novel solution treatment and aging for powder bed fusion-laser beam Ti-6Al-2Sn-4Zr-6Mo alloy:Microstructural and mechanical characterization

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 414-424页

作者： Gianluca Pirro Alessandra Martucci Alessandro Morri Mariangela Lombardi Lorella Ceschini Department of Industrial Engineering(DIN) Alma Mater Studiorum-University of BolognaBologna 40136Italy Department of Applied Science and Technology(DISAT) Politecnico di TorinoTorino TO 10129Italy

Ti-6Al-4Zr-2Sn-6Mo alloy is one of the most recent titanium alloys processed using powder bed fusion-laser beam(PBF-LB)*** alloy has the potential to replace Ti-6Al-4V in automotive and aerospace applications,given its superior mechanical properties,which are approximately 10%higher in terms of ultimate tensile strength(UTS)and yield strength after appropriate heat *** as-built conditions,the alloy is characterized by the presence of soft orthorhombicα″martensite,necessitating a postprocessing heat treatment to decompose this phase and enhance the mechanical properties of the ***,PBFed Ti6246 components undergo an annealing process that transforms theα″martensite into anα-βlamellar *** primary objective of this research was to develop a solution treatment and aging(STA)heat treatment tailored to the unique microstructure produced by the additive manufacturing process to achieve an ultrafine bilamellar microstructure reinforced by precipitation *** study investigated the effects of various solution temperatures in theα-βfield(ranging from 800 to 875℃),cooling media(air and water),and aging time to determine the optimal heat treatment parameters for achieving the desired bilamellar *** each heat treatment condition,differentα-βmicrostructures were found,varying in terms of theα/βratio and the size of the primaryα-phase *** attention was given to how these factors were influenced by increases in solution temperature and how microhardness correlated with the percentage of the metastableβphase present after *** tests were performed on samples subjected to the most promising heat treatment parameters.A comparison with literature data revealed that the optimized STA treatment enhanced hardness and UTS by13%and 23%,respectively,compared with those of the annealed *** surface analyses were conducted to investigate fracture mechanisms.

关键词： powder bed fusion-laser beam titanium alloys heat treatments mechanical properties fractographic analysis

SPECTROSCOPY OF MESONS CONTAINING TWO HEAVY QUARKS

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Chinese Physics C 2016年第10期40卷 785-793页

作者： S. Eidelman C. Hanhart B.K. Heltsley J.J. Hernandez-Rey R.E. Mitchell S. Navas C. Patrignani Budker Inst. and Novosibirsk State univ. Forschungszentrum Jiilich Cornell univ. univ. Valencia-CSIC Indiana univ. univ. Granada bologna univ. INFN

A golden age for heavy quarkonium physics dawned at the turn of this century, initiated by the confluence of exciting advances in quantum chromodynamics （QCD） and an explosion of related experimental activity. The subsequent broad spectrum of breakthroughs, surprises, and continuing puzzles had not been anticipated. In that period, the BESII program concluded only to give birth to BESIII; the B-factories and CLEO-c flourished; quarkonium production and polarization measurements at HERA and the Tevatron matured; and heavyion collisions at RHIC opened a window on the deconfinement regime. Recently also ATLAS, CMS and LHCb started to contribute to the field. For an extensive presentation of the status of heavy quarkonium physics, the reader is referred to several reviews [1-8]. This note focuses on experimental developments in heavy quarkonium spectroscopy with very few theoretical comments. Some other comments on possible theoretical interpretations of the states not predicted by the quark model are presented in the mini-review on non qq-states.

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BRANCHING RATIOS OF φ（2S） AND xc0,1,2

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Chinese Physics C 2016年第10期40卷 794-795页

作者： J.J. Herngndez-Rey S. Navas C. Patrignani IFIC Valencia univ.rsity of Granada bologna univ. INFN

Since 2002, the treatment of the branching ratios of the φ（2S） and Xc0,1,2 has undergone an important restructuring. When measuring a branching ratio experimentally, it is not always possible to normalize the number of events observed in the corresponding decay mode to the total number of particles produced. Therefore, the experimenters sometimes report the number of observed decays with respect to another decay mode of the same or another particle in the relevant decay chain. This is actually equivalent to measuring combinations of branching fractions of several decay modes.

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Cluster-Based Nearest-Neighbour Classifier and Its Application on the Lightning Classification

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Journal of Computer Science & Technology 2008年第4期23卷 573-581页

作者： Loris Nanni Alessandra Lumini DEIS IEIIT-CNRUniversità di BolognaViale Risorgimento 240136 Bologna

The problem addressed in this paper concerns the prototype generation for a cluster-based nearest-neighbour classifier. It considers, to classify a test pattern, the lines that link the patterns of the training set and a set of prototypes. An efficient method based on clustering is here used for finding subgroups of similar patterns with centroid being used as prototype. A learning method is used for iteratively adjusting both position and local-metric of the prototypes. Finally, we show that a simple adaptive distance measure improves the performance of our nearest-neighbour-based classifier. The performance improvement with respect to other nearest-neighbour-based classifiers is validated by testing our method on a lightning classification task using data acquired from the Fast On-orbit Recording of Transient Events （FORTE） satellite, moreover the performance improvement is validated through experiments with several benchmark datasets. The performance of the proposed methods are also validated using the Wilcoxon Signed-Rank test.

关键词： nearest-neighbour classifier clustering adaptive distance

Growth associated protein 43 and neurofilament immunolabeling in the transected lumbar spinal cord of lizard indicates limited axonal regeneration

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Neural Regeneration Research 2022年第5期17卷 1034-1041页

作者： Lorenzo Alibardi Comparative Histolab Padova and Department of Biology University of BolognaBolognaItaly

Previous cytological studies on the transected lumbar spinal cord of lizards have shown the presence of differentiating glial cells,few neurons and axons in the bridge region between the proximal and distal stumps of the spinal cord in some cases.A limited number of axons(20-50)can cross the bridge and re-connect the caudal stump of the spinal cord with small neurons located in the rostral stump of the spinal *** axonal regeneration appears to be related to the recovery of hind-limb movements after initial *** present study extends previous studies and shows that after transection of the lumbar spinal cord in lizards,a glial-connective tissue bridge that reconnects the rostral and caudal stumps of the interrupted spinal cord is formed at 11-34 days *** an initial paralysis some recovery of hindlimb movements occurs within 1-3 months *** and ultrastructural analysis for a growth associated protein 43(GAP-43)of 48-50 k Da shows that sparse GAP-43 positive axons are present in the proximal stump of the spinal cord but their number decreased in the bridge at 11-34 days *** immunolabeled axons with a neurofilament protein of 200-220 k Da were seen in the bridge at 11-22 days post-transection but their number increased at 34 days and 3 months post-amputation in lizards that have recovered some hindlimb *** neurons in the rostral and caudal stumps of the spinal cord were also labeled for GAP43,a cytoplasmic protein that is trans-located into their axonal growth *** indicates that GAP-43 biosynthesis is related to axonal regeneration and sprouting from neurons that were damaged by the *** together,previous studies that utilized tract-tracing technique to label the present observations confirm that a limited axonal re-connection of the transected spinal cord occurs 1-3 months post-injury in *** few regenerating-sprouting axons within the bridge reconnect

关键词： GAP-43 immunocytochemistry lizard neurofilaments regeneration spinal cord

High voltage direct current transmission cables to help decarbonisation in Europe:Recent achievements and issues

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High Voltage 2022年第4期7卷 633-644页

作者： Giovanni Mazzanti Department of Electrical Electronic and Information EngineeringUniversity of BolognaBolognaItaly

High Voltage Direct Current(HVDC)underground and submarine cables constitute an essential technology for the long-distance transmission of renewable electrical power with low losses,thereby fostering *** the past 2 decades,all this yielded a quasi-exponential rise of HVDC cable systems installed worldwide,but has also made the working conditions of HVDC cables *** this paper,the contribution of HVDC cables to decarbonisation is tackled,with particular reference to the situation in Europe,and a few simple calculations showing in general terms the quantitative contribution provided by HVDC cable systems to decarbonisation are ***,the major issues towards long-lasting and reliable HVDC cable systems are summarised briefly,focussing-for the sake of brevity-on the influence of the main HVDC cable technologies,of cable laying environment and of duty *** hints are also provided at the chances given by multiterminal HVDC systems.

关键词： cable submarine thereby

Ex vivo effect of vascular wall stromal cells secretome on enteric ganglia

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World Journal of Gastroenterology 2019年第33期25卷 4892-4903页

作者： Giovanni Dothel Chiara Bernardini Augusta Zannoni Maria Rosaria Spirito Roberta Salaroli Maria Laura Bacci Monica Forni Fabrizio De Ponti Department of Medical and Surgical Sciences University of BolognaBologna 40126Italy Department of Veterinary Medical Sciences University of BolognaBologna 40064Italy

BACKGROUND Mesenchymal stromal cell(MSC)-based therapy is currently under study to treat inflammatory bowel *** bioactive products could represent a valid alternative to overcome issues associated with systemic whole-cell ***,MSC anti-inflammatory mechanisms differ between rodents and humans,impairing the reliability of preclinical *** To evaluate the effect of conditioned medium(CM)derived from porcine vascular wall MSCs(pVW-MSCs)on survival and differentiation of porcine and guinea pig enteric ganglia exposed to lipopolysaccharide(LPS).METHODS Primary cultures of enteric ganglia were obtained by mechanic and enzymatic digestion of ileum resections from guinea pigs(Cavia porcellus)(GPEG)and pigs(Suus scrofa)(PEG).pVW-MSCs were derived by enzymatic digestion from vascular wall resections of porcine aorta and tested by immunoflowcytometry for MSC immune *** ganglia were treated with increasing concentrations of LPS,CM derived by pVW-MSCs or a combination of CM and LPS 1μg/*** count and morphometric analysis of HuD positive neurons and glial fibrillary acidic protein positive glial cells were performed by immunofluorecent staining of cultured *** PEG showed a higher number of neurons compared to ***,CM exerted a protective role on LPS-treated enteric *** in combination with LPS increased the number of glial cells per ganglion in both cultures evoking glial cells differentiation in porcine *** These findings suggest an immunomodulating activity of pVW-MSCs mediators on the enteric nervous system in inflammatory conditions.

关键词： Enteric nervous system Mesenchymal stromal cells Inflammatory bowel disease Ganglia Translational models

Prognostic factors for hepatocellular carcinoma recurrence

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World Journal of Gastroenterology 2014年第20期20卷 5935-5950页

作者： Antonio Colecchia Ramona Schiumerini Alessandro Cucchetti Matteo Cescon Martina Taddia Giovanni Marasco Davide Festi Department of Gastrointestinal Diseases and Internal Medicine University of Bologna 40138 Bologna Italy Department of General Surgery and Transplants University of Bologna 40138 Bologna Italy

The recurrence of hepatocellular carcinoma,the sixth most common neoplasm and the third leading cause of cancer-related mortality worldwide,represents an important clinical problem,since it may occur after both surgical and medical *** recurrence rate involves 2 phases:an early phase and a late *** early phase usually occurs within 2 years after resection;it is mainly related to local invasion and intrahepatic metastases and,therefore,to the intrinsic biology of the *** the other hand,the late phase occurs more than 2 years after surgery and is mainly related to de novo tumor formation as a consequence of the carcinogenic cirrhotic *** recent studies have reported that early and late recurrences may have different risk factors,it is clinically important to recognize these factors in the individual patient as soon as *** aim of this review was,therefore,to identify predicting factors for the recurrence of hepatocellularcarcinoma,by means of invasive and non-invasive methods,according to the different therapeutic strategies *** particular the role of emerging techniques(e.g.,transient elastography)and biological features of hepatocellular carcinoma in predicting recurrence have been *** particular,invasive methods were differentiated from non-invasive ones for research purposes,taking into consideration the emerging role of the genetic signature of hepatocellular carcinoma in order to better allocate treatment strategies and surveillance follow-up in patients with this type of tumor.

关键词： Percutaneous ethanol injection Percutaneous radiofrequency ablation Transarterial chemoembolization Hepatic resection Orthotopic liver transplant Liver biopsy Liver stiffness measurement Hepatocellular carcinoma

Correlation of molecular alterations with pathological features in hepatocellular carcinoma:Literature review and experience of an Italian center

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World Journal of Gastroenterology 2022年第25期28卷 2854-2866页

作者： Thais Maloberti Antonio De Leo Viviana Sanza Elisa Gruppioni Annalisa Altimari Mattia Riefolo MichelaVisani Deborah Malvi Antonia D’Errico Giovanni Tallini Francesco Vasuri Dario de Biase Department of Experimental Diagnostic and Specialty MedicineUniversity of BolognaBologna 40138Italy Solid Tumor Molecular Pathology Laboratory IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Department of Pathology IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Department of Pharmacy and biotechnology(FaBiT) University of BolognaBologna 40138Italy

Hepatocellular carcinoma(HCC)represents the primary carcinoma of the liver and the fourth leading cause of cancer-related *** World Health Organization estimates an increase in cases in the coming *** risk factors of HCC are multiple,and the incidence in different countries is closely related to the different risk factors to which the population is *** molecular mechanisms that drive HCC tumorigenesis are extremely complex,but understanding this multistep process is essential for the identification of diagnostic,prognostic,and therapeutic *** development of multigenic nextgeneration sequencing panels through the parallel analysis of multiple markers can provide a landscape of the genomic status of the *** the literature and our preliminary data based on 36 HCCs,the most frequently altered genes in HCCs are TERT,CTNNB1,and *** the years,many groups have attempted to classify HCCs on a molecular basis,but a univ.cal classification has never been ***,statistically significant correlations have been found in HCCs between the molecular signature and morphologic features,and this leads us to think that it would be desirable to integrate the approach between anatomic pathology and molecular laboratories.

关键词： Hepatocarcinoma Mutation Next-generation sequencing Review TP53 CTNNB1 TERT