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Self-assembled multifunctional nanotheranostics against circulating tumor clusters in metastatic breast cancer

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1711-1725页

作者： Ramya Dhandapani Swaminathan Sethuraman Uma Maheswari Krishnan Anuradha Subramanian centre for nanotechnology&Advanced Biomaterials School of Chemical&BiotechnologySASTRA Deemed UniversityThanjavur 613401India

Circulating tumor clusters(CTC)disseminating from the primary tumor are responsible for secondary tumor formation where the conventional treatments such as chemotherapy and radiotherapy does not prevent the metastasis at locally advanced stage of breast *** this study,a smart nanotheranostic system has been developed to track and eliminate the CTCs before it can colonize at a new site,which would reduce metastatic progression and increase the five-year survival rate of the breast cancer *** multiresponsive(magnetic hyperthermia and pH)nanomicelles incorporated with NIR fluorescent superparamagnetic iron oxide nanoparticles were developed based on self-assembly for dual modal imaging and dual toxicity for spontaneous killing of CTCs in blood stream.A heterogenous tumor clusters model was developed to mimic the CTCs isolated from breast cancer *** nanotheranostic system was further evaluated for the targeting property,drug release kinetics,hyperthermia and cytotoxicity against developed CTC model in *** vivo model in BALB/c mice equivalent to stageⅢandⅣhuman metastatic breast cancer was developed to evaluate the biodistribution and therapeutic efficacy of micellar nanotheranostic *** CTCs in blood stream and low distant organ metastasis after treatment with the nanotheranostic system demonstrates its potential to capture and kill the CTCs that minimize the secondary tumor formation at distant sites.

关键词： Self-assembly Hybrid nanotheranostic system Circulating tumor clusters Advanced breast cancer Cancer stem cells Heterogenous clusters SPIONs NIR Metastasis CD44

Mixed iridium-nickel oxides supported on antimony-doped tin oxide as highly efficient and stable acidic oxygen evolution catalysts

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Materials Futures 2024年第1期3卷 165-180页

作者： Jonathan Ruiz Esquius Alec P LaGrow Haiyan Jin Zhipeng Yu Ana Araujo Rita Marques Adélio Mendes Lifeng Liu Clean Energy Cluster International Iberian Nanotechnology LaboratoryAv.Mestre JoséVeigaBraga 4715-330Portugal Carbon Science and Technology Institute INCAR-CSICFrancisco Pintado Fe 26Oviedo 33011Spain Scientific Imaging Section Okinawa Institute of Science and Technology Graduate UniversityKunigami-gunOkinawa 904-0412Japan Songshan Lake Materials Laboratory Dongguan 523808People’s Republic of China Laboratory for Process Engineering EnvironmentBiotechnology and EnergyFaculty of EngineeringUniversity of PortoRua Dr Roberto FriasPorto 4200-465Portugal Associate Laboratory in Chemical Engineering Faculty of EngineeringUniversity of PortoRua Dr Roberto FriasPorto 4200-465Portugal.

Proton exchange membrane(PEM)water electrolysis represents a promising technology for green hydrogen production,but its widespread deployment is greatly hindered by the indispensable usage of platinum group metal catalysts,especially iridium(Ir)based materials for the energy-demanding oxygen evolution reaction(OER).Herein,we report a new sequential precipitation approach to the synthesis of mixed Ir-nickel(Ni)oxy-hydroxide supported on antimony-doped tin oxide(ATO)nanoparticles(IrNiyO_(x)/ATO,20 wt.%(Ir+Ni),y=0,1,2,and 3),aiming to reduce the utilisation of scarce and precious Ir while maintaining its good acidic OER *** tested in strongly acidic electrolyte(0.1 M HClO_(4)),the optimised IrNi1Ox/ATO shows a mass activity of 1.0 mAµgIr^(−1) and a large turnover frequency of 123 s^(−1) at an overpotential of 350 mV,as well as a comparatively small Tafel slope of 50 mV dec^(−1),better than the IrOx/ATO control,particularly with a markedly reduced Ir loading of only 19.7µgIr cm^(−2).Importantly,IrNi1O_(x)/ATO also exhibits substantially better catalytic stability than other reference catalysts,able to continuously catalyse acidic OER at 10 mA cm^(−2) for 15 h without obvious *** in-situ synchrotron-based x-ray absorption spectroscopy confirmed that the Ir^(3+)/Ir^(4+)species are the active sites for the acidic ***,the performance of IrNi1Ox/ATO was also preliminarily evaluated in a membrane electrode assembly,which shows better activity and stability than other reference *** IrNi1Ox/ATO reported in this work is a promising alternative to commercial IrO_(2) based catalysts for PEM electrolysis.

关键词： mixed oxides oxygen evolution reaction polymer electrolyte membrane antimony doped tin oxide membrane electrode assembly

Biosynthesis of Silver Nanoparticles with Clerodendron phlomoides Leave Extract:Particle Morphology,Antimicrobial Potential and Application

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Journal of Clinical and Nursing research 2024年第1期8卷 51-64页

作者： Kirubanandan Shanmugam Subha Veeramani Renganathan Sahadevan Saveetha School of Engineering SIMATSChennai 602105India National centre for Nanoscience and nanotechnology University of MadrasGuindy CampusChennai 600025India centre for biotechnology A.C.TechAnna UniversityChennai 600025India

Silver nanoparticles are versatile nanomaterials that have found numerous applications in various *** use of plant extract for the synthesis of silver is a green and sustainable *** phlomoides leaves extract has been found to contain various phytochemicals,such as phenols,flavonoids,tannins,and alkaloids,which possess reducing and stabilizing properties that can aid the production of silver *** this paper,morphological and topographical analyses were performed on silver *** biosynthesized silver nanoparticles showed antimicrobial potential against wound *** and TEM micrographs revealed that the particles were sphere and nanosized,which makes them suitable for various biomedical applications.

关键词： Silver nanoparticles Clerodendron phlomoides Biosynthesis Morphology SEM TEM FTIR Antimicrobial activity and wound pathogens

Recent updates on nano-phyto-formulations based therapeutic intervention for cancer treatment

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Oncology research 2024年第1期32卷 19-47页

作者： ABHISHEK WAHI MAMTA BISHNOI NEHA RAINA MEGHNA AMRITA SINGH PIYUSH VERMA PIYUSH KUMAR GUPTA GINPREET KAUR HARDEEP SINGH TULI MADHU GUPTA Department of Pharmaceutics School of Pharmaceutical SciencesDelhi Pharmaceutical Sciences and Research University(DPSRU)Pushp ViharNew Delhi110017India Department of Pharmaceutical Sciences Gurugram UniversityHaryana122003India Department of Life Sciences Sharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh201310India Department of biotechnology Graphic Era(Deemed to be University)DehradunUttarakhand248002India Department of Pharmacology Shobhaben Pratapbhai Patel School of Pharmacy&Technology ManagementSVKM’s NMIMSVile Parle(West)Mumbai400056India Department of Bio-Sciences and Technology Maharishi Markandeshwar Engineering CollegeMaharishi Markandeshwar(Deemed to be University)MullanaAmbala133207India

Cancer is a leading cause of death globally,with limited treatment options and several *** agents often result in toxicity which long-term conventional *** are natural constituents that are more effective in treating various diseases with less toxicity than the chemotherapeutic agents providing alternative therapeutic approaches to minimize the *** phytoconstituents act in several ways and deliver optimum effectiveness against ***,the effectiveness of phyto-formulations in the management of cancers may be constrained due to challenges related to inadequate solubility,bioavailability,and *** presents a promising avenue for transforming current cancer treatment methods through the incorporation of phytochemicals into nanosystems,which possess a range of advantageous characteristics such as biocompatibility,targeted and sustained release capabilities,and enhanced protective *** holds significant potential for future advancements in cancer ***,this review aims to provide intensive literature on diverse nanocarriers,highlighting their applications as cargos for phytocompounds in ***,it offers an overview of the current advancements in the respective field,emphasizing the characteristics that contribute to favourable outcomes in both in vitro and in vivo ***,clinical development and regulatory concerns are also discussed to check on the transformation of the concept as a promising strategy for combination therapy of phytochemicals and chemotherapeutics that could lead to cancer management in the future.

关键词： Phyto-formulations Cancer Nanocarriers nanotechnology Clinical development

Microenvironment-responsive nanosystems for osteoarthritis therapy

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Engineered Regeneration 2024年第1期5卷 92-110页

作者： Song Li Yuan Xiong Hao Zhu Tian Ma Xuying Sun Jun Xiao Department of Orthopaedic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Chemical Engineering and biotechnology Nanyang Technological University21 Nanyang LinkSingapore 637371Republic of Singapore

Osteoarthritis(OA)represents an enduring and widespread global burden,causing significant morbidity and disability,whose pathology is characterized by persistent inflammation,progressive cartilage degeneration,ab-normal bone homeostasis,and excessive synovial hyperplasia,resulting from its complex ***,current therapeutic approaches for OA remain suboptimal,prompting increased interest in ad-vanced nanotechnology as a means to enhance therapeutic *** recent years,significant progress has been made in the development of versatile nanoplatforms designed to the specific microenvironment of OA,resulting in promising results and introducing the concept of“OA nanomedicine”.Compared to the conventional therapies like non-steroidal anti-inflammatory drugs(NSAIDs),OA nanomedicine offers precise targeted,controllable and personalized ways for OA therapy,contributing to better ***,a comprehensive review consoli-dating the“OA nanomedicine”is currently absent from ***,in this review,we aim to unravel the key pathological and microenvironmental characteristics of OA while summarizing the properties and advantages of nanosystems possessing microenvironment-reprogramming capabilities for OA ***,we make a retro-spection of the features of OA pathology and OA ***,we provide an overview of the advances in OA ***,we discuss the present challenges associated with OA nanomedicine and provide insights into its future prospects from a clinical-translational *** doing so,this review can foster and propel the successful development of OA nanomedicine,addressing the unmet needs in OA therapy.

关键词： Osteoarthritis Nanomedicine Therapy Microenvironment Cartilage Tissue regeneration

Platelet-based bioactive systems guided precision targeting and immune regulation for cancer therapy

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Nano research 2024年第9期17卷 8269-8284页

作者： Xinyi Cai Long Qiu Zhenying Diao Lintao Cai Ting Yin Hong Pan Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsCAS Key Laboratory of Biomedical Imaging Science and SystemInstitute of Biomedicine and BiotechnologyShenzhen Institute of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhen 518055China School of pharmacy Guangdong Medical UniversityDongguan 523808China Sino-Euro Center of Biomedicine and Health Shenzhen 518024China

The antitumor effects of conventional drug carriers are often attenuated and limited in application by biological barriers associated with tumor heterogeneity and resistance brought about by low tumor *** the rapid development of nanotechnology,naturally derived bioactive materials,and live cell carriers,a promising strategy emerges for targeting the tumor microenvironment(TME)for precision cancer *** unique injury-targeting properties of platelets can significantly extend functional activity,which cannot be achieved with conventional *** this review,three strategies based on platelet-engineered materials are systematically described,namely nanoparticles for platelet membrane camouflage,engineered activated platelets,and targeted-platelets ***-based nanomaterials can effectively coordinate local and distant tumor-host crosstalk with controlled active tumor site recognition and killing effects due to the presence of specific membrane proteins on the surface and the self-secretion of a large number of *** advances in platelets for effectively overcoming biological barriers and reducing immune resistance in cancer immunotherapy applications will be discussed in future clinical *** review provides an overview of recent research advances in platelet-based bioactive material-directed immunotherapy and chemotherapy to inform future antitumor combination therapies.

关键词： platelets bionic targeting immune modulation precision therapy deep penetration

Characterization and optimization of EPSproducing and diesel oil-degrading Ochrobactrum anthropi MP3 isolated from refinery wastewater

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Petroleum Science 2014年第3期11卷 439-445页

作者： Sugumar Ramasamy Prabhakaran Mathiyalagan Preethy Chandran centre for nanotechnology and Advanced Biomaterials School of Chemical and Biotechnology SASTRA University

Petroleum refinery wastewater （PRW） containing hydrocarbon is highly toxic to the environment and the surrounding ecosystem. Proper treatment of the PRW effluent is necessary to remove the pollutants before discharge. Bioremediation is considered to be a promising approach as it is eco- friendly and efficient. The exopolysaccharide （EPS） produced by the O. anthropi acts as a bioemulsifier and showed the highest emulsification activity of 60% on diesel. An EPS yield of about 0.42 g/L was obtained under optimized conditions. The carbohydrate and protein content of the EPS was found to be 71.1% and 19.7% respectively, showing the glycoprotein nature. The structural properties of EPS were analyzed by FT-IR and 1H NMR. The batch degradation of oil in PRW by O. anthropi was studied gravimetrically, and showed about 53% degradation in 7 days, indicating the strong ability of the isolated strain to degrade the hydrocarbons in PRW.

关键词： Hydrocarbons Ochrobactrum anthropi MP3 EPS bioemulsifier degradation

In Vivo Studies and Flow Cytometric Investigation on Anticancer Potential of Selenium Nanoparticles Synthesized via Aqueous Extract of Clerodendron phlomidis

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Proceedings of Anticancer research 2024年第1期8卷 71-81页

作者： Veeramani Subha Kirubanandan Shanmugam Renganathan Sahadevan National centre for Nanoscience and nanotechnology University of MadrasGuindy CampusChennai 600025Tamil NaduIndia Saveetha School of Engineering SIMATSThandalamChennai 602107Tamil NaduIndia Department of biotechnology A.C.TechAnna UniversityChennai 600025Tamil NaduIndia

Nowadays,doctors and nutritionists recommend individuals incorporate selenium-rich foods such as nuts,cereals,and mushrooms into their regular diet to maintain fitness and overall *** nanoparticles(SeNPs)exhibit strong chemopreventive *** anticipations for SeNPs with enhanced and tunable bioactive activities have led to a keen interest in *** this study,the aqueous extract of Clerodendron phlomidis plant leaves was utilized for the synthesis of *** traditional Indian medicine,this plant extract is recognized as a significant anti-diabetic *** flavonoids tetrahydroxylflavone,7-hydroxyflavanone,and 6,4’-dimethyl-7-acetoxy-scutellarein present in this plant leaf extract demonstrate excellent anticancer *** secondary metabolites exhibit the ability to reduce sodium selenite into *** a concentration of 13μg/mL,the synthesized SeNPs effectively inhibited the proliferation of the HepG2 cell *** results suggest that the SeNPs possess promising anti-cancer potential against liver cancer and can be considered as a therapeutic agent for liver cancer ***,the cell cycle arrest induced by SeNPs was further confirmed by the fluorescence-activated cell sorting(FACS)method,indicating that SeNPs could efficiently differentiate cancer cells from normal ***,it showed a significant improvement in diethylnitrosamine(DEN)-induced Swiss Wistar rat *** scientific investigation highlights the high anti-cancer potential of SeNPs,positioning them as a promising therapeutic agent for liver cancer treatment.

关键词： Selenium nanoparticles Green synthesis Liver cancer Clerodendron phlomidis Flow cytometry In vivo studies

Thermoelectric coolers:Infinite potentials for finite localized microchip cooling

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Journal of Materials Science & Technology 2022年第26期121卷 256-262页

作者： Zhi-Gang Chen Wei-Di Liu School of Chemistry and Physics Queensland University of TechnologyBrisbaneQLD 4001Australia Australian Institute of biotechnology and nanotechnology the University of QueenslandSt LuciaQLD 4072Australia

With the ever-growing semiconductor and microchip industries,increasing amount and categories of personal electronics have flooded into our daily *** is the key challenge limiting further performance enhancement of the high-speed microchips in *** cooling,a solid-state active cooling method,possesses great potential for localized cooling with the advantages of noise-free,vibration-free,maintenance-free,and liquid-media-free,and can solve the challenge in *** proper material engineering,such as carrier concentration,band engineering,hierarchical architecture engineering,high performance thermoelectric materials with high potential for thermoelectric cooling have been widely *** further proper device design based on state-of-art thermoelectric materials,such as vertical thin film thermoelectric device design,contact interface engineering and thermoelectric and microchip integration,thermoelectric coolers show infinite potentials for finite cooling requirement of microchips.

关键词： Microchip Cooling Thermoelectric Application