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Signal Transduction and Targeted Therapy 2021年第6期6卷 1643-1645页

作者： Ning Meng Dirk Grimm Department of Infectious Diseases/Virology Medical FacultyUniversity of HeidelbergHeidelbergGermany bioquant University of HeidelbergHeidelbergGermany German Center for Infection Research(DZIF)and German Center for Cardiovascular Research(DZHK) partner site HeidelbergHeidelbergGermany

In a new study published in Nature Materials,Liu et al.1 report a novel design of lipid nanoparticles(LNPs)in which multi-tailed ionizable phospholipids(iPhos)constitute the active component,and which facilitates endosomal escape and thus improves delivery of mRNA and/or single-guide(sg)RNA for in vivo gene *** composed of the best-performing iPhos and different helper lipids_zwitterionic lipids,ionizable cationic lipids and permanently cationic lipids-achieved selective organ targeting(SORT)and organ-specific CRISPR-Cas9 gene editing in spleen,liver,and lungs of mice,respectively.

关键词： spleen editing cationic

Two Dimensional Triptycene End-Capping and Its Influence on the Self-Assembly of Quinoxalinophenanthrophenazines

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Chinese Journal of Chemistry 2023年第10期41卷 1198-1208页

作者： Lisa Ro■ Julius Reitemeier Farhad Ghalami Wen-Shan Zhang Jurgen H.Gross Frank Rominger Sven M.Elbert Rasmus Schroder Marcus Elstner Michael Mastalerz Institute of Organic Chemistry Heidelberg UniversityIm Neuenheimer Feld 270D-69120HeidelbergGermany Institute of Physical Chemistry and Theoretical Chemical Chemistry Karlsruhe Institute of TechnologyKaiserstrae 12D-76131KarlsruheGermany bioquant University HeidelbergIm Neuenheimer Feld 267D-69120HeidelbergGermany

In this report we investigated two-dimensionally triptycene end-capped QPPs in terms of their solution and solid-state *** this purpose,a triphenylene based ortho-diamine decorated with two triptycenyl units as well as a phenylene diamine with two non-annulated triptycene units have been *** of condensation reactions with a pyrene-based tetraketone and ortho-diamines yielded a series of QPPs and UV/Vis investigations of the corresponding compounds led to the conclusion,that the QPPs form dimers in solution,which was further supported by ***-crystal X-ray analysis of the triply and quadruply triptycene end-capped QPPs furthermore showed shortπ-π-distances of 3.3-3.4?and a perfect shape match during the dimerization of the triply triptycenyl end-capped QPP making it possible synthon for crystal engineering.

关键词： Triptycene Quinoxalinophenanthrophenazine N-Heteropolycycles Polycyclic aromatic compounds Aggregation

Conserved host-pathogen interactions identify novel treatment options in betacoronavirus infections

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Signal Transduction and Targeted Therapy 2021年第3期6卷 557-559页

作者： Soeren Lukassen Roland Eils Charity-Universitatsmedizin Berlin corporate member of Freie Umversitat BerlinHumboldt-Universitat zu Berlinand Berlin Institute of HealthBerlinGermany Center for Digital Health Berlin Institute of Health(BIH)BerlinGermany Health Data Science Unit Heidelberg University Hospital and BioQuantHeidelbergGermany

In a recent study published in Science,1 Gordon et *** the host-pathogen interactome of the coronaviruses SARS-CoV-1,SARS-CoV-2,and MERS-CoV,all of which caused lethal outbreaks in the past two *** functionally characterize a number of these interactions,leveraging the information to identify promising candidate molecules for drug-repurposing.

关键词： identif interactions treatment

Chemogenetic activation of G12 signaling enhances adipose tissue browning

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Signal Transduction and Targeted Therapy 2023年第9期8卷 3923-3926页

作者： Yuki Ono Ryo Ito Kaito Arai Gurdeep Singh Tsuyoshi Saitoh Robert BRussell Francesco Raimondi Junken Aoki Juro Sakai Asuka Inoue Molecular and Cellular Biochemistry Graduate School of Pharmaceutical SciencesTohoku UniversitySendaiMiyagi 980-8578Japan Division of Molecular Physiology and Metabolism Graduate School of MedicineTohoku UniversitySendaiMiyagi 980-8574Japan bioquant Heidelberg UniversityIm Neuenheimer Feld 26769120 HeidelbergGermany Biochemie Zentrum Heidelberg(BZH) Heidelberg UniversityIm Neuenheimer Feld 32869120 HeidelbergGermany International Institute for Integrative Sleep Medicine(WPI-IIIS) University of Tsukuba1-1-1 TennodaiTsukubaIbaraki 305-8575Japan Graduate School of Comprehensive Human Sciences University of Tsukuba1-1-1 TennodaiTsukubaIbaraki 305-8575Japan Laboratorio di Biologia Bio@SNS Scuola Normale SuperiorePiazza dei Cavalieri 7Pisa 56126Italy Department of Health Chemistry Graduate School of Pharmaceutical SciencesThe University of TokyoBunkyo-kuTokyo 113-0033Japan Division of Metabolic Medicine Research Center for Advanced Science and TechnologyThe University of TokyoMeguro-kuTokyo 153-8904Japan

Dear Editor,Beige adipocytes,which increase energy expenditure by dissipating energy as heat,have gained attention as a therapeutic target for combating obesity.1 Adipocytes express many types of G-protein-coupled receptors(GPCRs),each of which has a unique preference for the Gs,Gi,Gq,and G12 *** the function of Gs-coupledβ-adrenergic receptors in beige adipocyte induction is well established,2 little is known about the function of G12-coupled GPCRs beyond its suppressive roles in white adipocyte maturation.3 In this study,we generated transgenic mice conditionally expressing a G12-coupled designer GPCR using a Cre-loxP system and investigated the potential effects of G12 signaling on adipocyte biology.

关键词： activation gained expressing

Split intein-mediated protein trans-splicing to express large dystrophins

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四川生理科学杂志 2024年第7期46卷 1627-1627页

作者： Hichem Tasfaout Department of Neurology University of Washington School of Medicine Seattle WA USA Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center University of Washington School of Medicine Seattle WA USA Department of Biochemistry University of Washington School of Medicine Seattle WA USA Center for Translational Muscle Research University of Washington Seattle WA USA Department of Bioengineering College of Engineering and School of Medicine University of Washington Seattle WA USA Department of Infectious Diseases/Virology Section Viral Vector Technologies Medical Faculty and Faculty of Engineering Sciences Center for Integrative Infectious Disease Research (CIID) University of Heidelberg Heidelberg Germany bioquant University of Heidelberg Heidelberg Germany German Center for Infection Research (DZIF) and German Center for Cardiovascular Research (DZHK) Heidelberg Germany

Gene replacement using adeno-associated virus(AAV)vectors is a promising therapeutic approach for many diseases1,***,this therapeutic modality is challenged by the packaging capacity of AAVs(approximately 4.7 kilobases)3,limiting its application for disorders involving large coding sequences,such as Duchenne muscular dystrophy,with a 14 kilobase messenger RNA.

关键词： Split bases limiting