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Biomass valorization via electrocatalytic carbon–carbon bond cleavage

Journal of Energy Chemistry 2024年第4期91卷 542-578页

作者： Keping Wang Zhenyan Guo Min Zhou Ying Yang Lanyun Li Hu Li Rafael Luque Shunmugavel Saravanamurugan National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide&Agricultural BioengineeringMinistry of EducationState-Local Joint Laboratory for Comprehensive Utilization of BiomassCenter for R&D of Fine ChemicalsGuizhou UniversityGuiyang 550025GuizhouChina Departamento de Quimica Organica Universidad de CordobaCampus de RabanalesEdificio Marie Curie(C-3)Ctra Nnal IVKm.396E-14014 CordobaSpain Laboratory of Bioproduct Chemistry Centre of Innovative and Applied Bioprocessing(CIAB)Mohali 140306PunjabIndia

Renewable electrocatalytic upgrading of biomass feedstocks into valuable chemicals is one of the promising strategies to relieve the pressure of traditional energy-based *** electrocatalytic carbon–carbon bond cleavage of high selectivity,various functionalized molecules,such as organic acids,amides,esters,and nitriles,have great potential to be accessed from ***,it has merely received finite concerns and interests in the *** review first showcases the research progress on the electrocatalytic conversion of lipid/sugar-and lignin-derived molecules(e.g.,glycerol,mesoerythritol,xylose,glucose,1-phenylethanol,and cyclohexanol)into organic acids via specific carbon–carbon bond scission processes,with focus on disclosing reaction mechanisms,recognizing actual active species,and collecting feasible modification *** the guidance of further extensive studies on biomass valorization,organic transformations via a variety of reactions,including decarboxylation,ring-opening,rearrangement,reductive hydrogenation,and carboxylation,are also disclosed for the construction of similar carbon skeletons/*** remaining challenges,prospective applications,and future objectives in terms of biomass conversion are also *** review is expected to provide references to develop renewed electrocatalytic carbon–carbon bond cleavage transformation paths/strategies for biomass upgrading.

关键词： Electrocatalysis Biomass conversion Carbon-carbon bond cleavage Organic acids

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Microbial synthesis of zinc oxide nanoparticles and their potential application as an antimicrobial agent and a feed supplement in animal industry: a review

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Journal of Animal Science and Biotechnology 2019年第4期10卷 851-872页

作者： Hidayat Mohd Yusof Rosfarizan Mohamad Uswatun Hasanah Zaidan Nor’Aini Abdul Rahman Department of Bioprocess Technology Faculty of Biotechnology and Biomolecular SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia bioprocessing and biomanufacturing research centre Faculty of Biotechnology and Biomolecular SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Department of Biochemistry Faculty of Biotechnology and Biomolecular SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia

In recent years, zinc oxide nanoparticles(ZnO NPs) have gained tremendous attention attributed to their unique properties. Notably, evidence has shown that zinc is an important nutrient in living organisms. As such, both prokaryotes and eukaryotes including bacteria, fungi and yeast are exploited for the synthesis of ZnO NPs by using microbial cells or enzyme, protein and other biomolecules compounds in either an intracellular or extracellular route. ZnO NPs exhibit antimicrobial properties, however, the properties of nanoparticles(NPs) are depended upon on their size and shape, which make them specific for various applications. Nevertheless, the desired size and shape of NPs can be obtained through the optimization process of microbes mediated synthesis by manipulating their reaction conditions. It should be noted that ZnO NPs are synthesized by various chemical and physical ***, these methods are expensive and not environmentally friendly. On that account, the microbes mediated synthesis of ZnO NPs have rapidly evolved recently where the microbes are cleaner, eco-friendly, nontoxic and biocompatible as the alternatives to chemical and physical practices. Moreover, zinc in the form of NPs is more effective than their bulk counterparts and thus, they have been explored for many potential applications including in animals industry. Notably, with the advent of multi-drug resistant strains, ZnO NPs have emerged as the potential antimicrobial agents. This is mainly due to their superior properties in combating a broad spectrum of pathogens. Moreover, zinc is known as an essential trace element for most of the biological function in the animal’s body. As such, the applications of ZnO NPs have been reported to significantly enhance the health and production of the farm animals. Thus, this paper reviews the biological synthesis of ZnO NPs by the microbes, the mechanisms of the biological synthesis, parameters for the optimization process and their potential

关键词： Animals Antimicrobial Feed supplement Microbial synthesis Nanotechnology Zinc oxide nanoparticles

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research advances on the consolidated bioprocessing of lignocellulosic biomass

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Engineering Microbiology 2024年第2期4卷 91-103页

作者： Zhongye Li Pankajkumar R.Waghmare Lubbert Dijkhuizen Xiangfeng Meng Weifeng Liu State Key Laboratory of Microbial Technology Microbial Technology InstituteShandong UniversityNo.72 Binhai RoadQingdao 266237China CarbExplore research BV Groningenthe Netherlands Microbiology Groningen Biomolecular Sciences and Biotechnology Institute(GBB)University of GroningenGroningenthe Netherlands

Lignocellulosic biomass is an abundant and renewable bioresource for the production of biofuels and biochem-ical *** classical biorefinery process for lignocellulosic degradation and conversion comprises three stages,i.e.,pretreatment,enzymatic saccharification,and ***,the complicated pretreatment process,high cost of cellulase production,and insufficient production performance of fermentation strains have restricted the industrialization of *** bioprocessing(CBP)technology combines the pro-cess of enzyme production,enzymatic saccharification,and fermentation in a single bioreactor using a specific microorganism or a consortium of microbes and represents another approach worth exploring for the production of chemicals from lignocellulosic *** present review summarizes the progress made in research of CBP technology for lignocellulosic biomass *** this review,different CBP strategies in lignocellulose biore-finery are reviewed,including CBP with natural lignocellulose-degrading microorganisms as the chassis,CBP with biosynthetic microorganisms as the chassis,and CBP with microbial co-culturing *** review provides new perspectives and insights on the utilization of low-cost feedstock lignocellulosic biomass for production of biochemicals.

关键词： Lignocellulosic biomass Biorefinery Consolidated bioprocessing Biochemicals

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Parallel mRNA, proteomics and miRNA expression analysis in cell line models of the intestine

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World Journal of Gastroenterology 2017年第41期23卷 7369-7386页

作者： Finbarr O’Sullivan Joanne Keenan Sinead Aherne Fiona O’Neill Colin Clarke Michael Henry Paula Meleady Laura Breen Niall Barron Martin Clynes Karina Horgan Padraig Doolan Richard Murphy National Institute for Cellular Biotechnology Dublin City University National Institute for bioprocessing research & Training Alltech Dunboyne

AIM To identify mi RNA-regulated proteins differentially expressed between Caco2 and HT-29: two principal cell line models of the *** Exponentially growing Caco-2 and HT-29 cells were harvested and prepared for m RNA, mi RNA and proteomic profiling. m RNA microarray profiling analysis was carried out using the Affymetrix Gene Chip Human Gene 1.0 ST array. mi RNA microarray profiling analysis was carried out using the Affymetrix Genechip mi RNA 3.0 array. Quantitative Label-free LC-MS/MS proteomic analysis was performed using a Dionex Ultimate 3000 RSLCnano system coupled to a hybrid linear iontrap/Orbitrap mass spectrometer. Peptide identities were validated in Proteome Discoverer 2.1 and were subsequently imported into Progenesis QI software for further analysis. Hierarchical cluster analysis for all three parallel datasets(mi RNA, proteomics, m RNA) was conducted in the R software environment using the Euclidean distance measure and Ward's clustering algorithm. The prediction of mi RNA and oppositely correlated protein/m RNA interactions was performed using Target Scan 6.1. GO biological process, molecular function and cellular component enrichment analysis was carried out for the DE mi RNA, protein and m RNA lists via the Pathway Studio 11.3 Web interface using their Mammalian *** Differential expression(DE) profiling comparing the intestinal cell lines HT-29 and Caco-2 identified 1795 Genes, 168 Proteins and 160 mi RNAs as DE between the two cell lines. At the gene level, 1084 genes were upregulated and 711 were downregulated in the Caco-2 cell line relative to the HT-29 cell line. At the protein level, 57 proteins were found to be upregulated and 111 downregulated in the Caco-2 cell line relative to the HT-29 cell line. Finally, at the mi RNAs level, 104 were upregulated and 56 downregulated in the Caco-2 cell line relative to the HT-29 cell line. Gene ontology(GO) analysis of the DE m RNA identified cell adhesion, migration and ECM o

关键词： Caco-2 HT-29 Microarray Proteomics miRNA Targetscan Gene ontology

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Dendron-polymer hybrid mediated anticancer drug delivery for suppression of mammary cancer

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Journal of Materials Science & Technology 2021年第4期63卷 115-123页

作者： Dayi Pan Xiuli Zheng Miao Chen Qianfeng Zhang Zhiqian Li Zhenyu Duan Qiyong Gong Zhongwei Gu Hu Zhang Kui Luo Huaxi MR research Center(HMRRC) Department of RadiologyFunctional and Molecular Imaging Key Laboratory of Sichuan ProvinceNational Clinical Research Center for GeriatricsState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China Department of Orthodontics West China Hospital of StomatologySichuan UniversityChengdu610041SichuanChina Amegen bioprocessing centre Keck Graduate InstituteCA91711USA

Dendron-polymer-based nanoscale and stimuli-responsive drug delivery systems have shown great promise in tumor-targeting accumulation without significant *** we report a dendronized polymer-doxorubicin(DOX)hybrid(DPDH)with an improved in vivo drug delivery efficiency for cancer therapy compared with a linear polymer-DOX conjugate(LPDC).The in vitro drug release profile of DOX indicates that DPDH displays pH-responsive drug release due to cleavage of hydrazone bonds since a greater amount of DOX is released at pH 5.2 at a faster rate than at pH *** efficiently enters 4 T1 cells and releases DOX to induce cytotoxicity and *** to the dendronzied structure,DPDH has a significantly longer blood circulation time than *** substantially enhances the therapeutic efficacy to suppress tumor growth in a 4 T1 mammary cancer model than LPDC as well as free drug,evidenced from tumor growth inhibition,TUNEL assessment and histological *** of DPDH is also confirmed from hemolysis,body weight shifts during treatment and pathological *** study demonstrates the use of dendronized polymer-DOX hybrids for specific drug molecules is a promising approach for drug delivery.

关键词： cancer analysis. release

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GSH-sensitive polymeric prodrug: Synthesis and loading with photosensitizers as nanoscale chemo-photodynamic anti-cancer nanomedicine

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Acta Pharmaceutica Sinica B 2022年第1期12卷 424-436页

作者： Lei Luo Yiming Qi Hong Zhong Shinan Jiang Hu Zhang Hao Cai Yahui Wu Zhongwei Gu Qiyong Gong Kui Luo Huaxi MR research Center(HMRRC) Department of RadiologyFunctional and Molecular Imaging Key Laboratory of Sichuan ProvinceNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China College of Pharmaceutical Sciences Southwest UniversityChongqing 400716China research Unit of Psychoradiology Chinese Academy of Medical SciencesChengdu 610041China Amgen bioprocessing centre Keck Graduate InstituteClaremontCA 91711USA

Precisely delivering combinational therapeutic agents has become a crucial challenge for anti-tumor treatment. In this study, a novel redox-responsive polymeric prodrug(molecular weight,MW: 93.5 k Da) was produced by reversible addition-fragmentation chain transfer(RAFT) polymerization. The amphiphilic block polymer-doxorubicin(DOX) prodrug was employed to deliver a hydrophobic photosensitizer(PS), chlorin e6(Ce6), and the as-prepared nanoscale system [NPs(Ce6)] was investigated as a chemo-photodynamic anti-cancer agent. The glutathione(GSH)-cleavable disulfide bond was inserted into the backbone of the polymer for biodegradation inside tumor cells, and DOX conjugated onto the polymer with a disulfide bond was successfully released intracellularly. NPs(Ce6) released DOX and Ce6 with their original molecular structures and degraded into segments with low MWs of 41.2 k Da in the presence of GSH. NPs(Ce6) showed a chemo-photodynamic therapeutic effect to kill 4 T1 murine breast cancer cells, which was confirmed from a collapsed cell morphology, a lifted level in the intracellular reactive oxygen species, a reduced viability and induced apoptosis. Moreover, ex vivo fluorescence images indicated that NPs(Ce6) retained in the tumor, and exhibited a remarkable in vivo anticancer efficacy. The combinational therapy showed a significantly increased tumor growth inhibition(TGI,58.53%). Therefore, the redox-responsive, amphiphilic block polymeric prodrug could have a great potential as a chemo-photodynamic anti-cancer agent.

关键词： Stimuli responsiveness Polymeric prodrug Photodynamic therapy Combinational therapy Nanomedicine

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On-site identification of Ophiocordyceps sinensis using multispectral imaging and chemometrics

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International Journal of Agricultural and Biological Engineering 2020年第6期13卷 166-170页

作者： Hongwei Duan Xin Tong Ruxiu Cui Lujia Han Guangqun Huang Laboratory of Biomass and bioprocessing Engineering College of EngineeringChina Agricultural UniversityBeijing 100083China

For the reasonable and effective collection of Ophiocordyceps sinensis,a new method of on-site identification was attempted using a portable multispectral imaging(MSI)*** dimensional(3D)data-cubes of representative Ophiocordyceps sinensis and weeds samples were acquired and pre-processed with standard normal variate transformation(SNV).Principal component analysis(PCA)and simulated annealing particle swarm optimisation(SAPSO)algorithms were used to extract characteristic images and develop the support vector classification(SVC)*** show that the fused feature model of SAPSO-SVC has the best performance,resulting in a recognition accuracy of the prediction set of 96.30%.Moreover,on-site distribution map of Ophiocordyceps sinensis and weeds was created using the spectral feature model of SAPSO-SVC,and the target could be easily identified from the distribution *** work demonstrates the potential for on-site identification of Ophiocordyceps sinensis in the Qinghai-Tibet Plateau using a portable MSI technique combined with the SAPSO-SVC algorithm.

关键词： Ophiocordyceps sinensis MSI SAPSO-SVC On-site distribution map

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Cathepsin B-responsive and gadolinium-labeled branched glycopolymer-PTX conjugate-derived nanotheranostics for cancer treatment

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Acta Pharmaceutica Sinica B 2021年第2期11卷 544-559页

作者： Hao Cai Yufan Xiang Yujun Zeng Zhiqian Li Xiuli Zheng Qiang Luo Hongyan Zhu Qiyong Gong Zhongwei Gu Yanhui Liu Hu Zhang Kui Luo Huaxi MR research Center(HMRRC) Department of Neurosurgeryand Department of RadiologyFunctional and Molecular Imaging Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengdu 610041China Laboratory of Stem Cell Biology West China HospitalSichuan UniversityChengdu 610041China Amgen bioprocessing centre Keck Graduate InstituteClaremontCA 91711USA

Multi-modal therapeutics are emerging for simultaneous diagnosis and treatment of *** carriers are often employed for loading multiple drugs due to their versatility and controlled release of these drugs in response to a tumor specific microenvironment.A theranostic nanomedicine was designed and prepared by complexing a small gadolinium chelate,conjugating a chemotherapeutic drug PTX through a cathepsin B-responsive linker and covalently bonding a fluorescent probe pheophorbide a(Ppa)with a branched *** branched prodrug-based nanosystem was degradable in the tumor microenvironment with overexpressed cathepsin B,and PTX was simultaneously released to exert its therapeutic *** theranostic nanomedicine,branched glycopolymer-PTX-DOTA-Gd,had an extended circulation time,enhanced accumulation in tumors,and excellent biocompatibility with significantly reduced gadolinium ion(Gd3+)retention after 96 h *** imaging contrast up to 24 h post-injection and excellent antitumor efficacy with a tumor inhibition rate more than 90%were achieved from glycopolymer-PTX-DOTA-Gd without obvious systematic *** branched polymeric prodrug-based nanomedicine is very promising for safe and effective diagnosis and treatment of cancer.

关键词： Stimuli-responsive Drug delivery Branched glycopolymers Biodegradability Nanomedicine Theranostics

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Polyphenols isolated from Acacia mearnsii bark with anti-inflammatory and carbolytic enzyme inhibitory activities

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Chinese Journal of Natural Medicines 2017年第11期15卷 816-824页

作者： XIONG Jia GRACE Mary H ESPOSITO Debora KOMARNYTSKY Slavko WANG Fei LILA Mary Ann Department of Chemical Engineering Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals Nanjing Forestry University Plants for Human Health Institute Department of Food Bioprocessing and Nutrition Sciences North Carolina State UniversityNorth Carolina Research Campus

The present study was designed to characterize the polyphenols isolated from Acacia mearnsii bark crude extract(B) and fractions(B1-B7) obtained by high-speed counter-current chromatography(HSCCC) and evaluate their anti-inflammatory and carbolytic enzymes(α-glucosidase and α-amylase) inhibitory activities. Fractions B4, B5, B6, B7(total phenolics 850.3, 983.0, 843.9, and 572.5 mg·g^(-1)), respectively; proanthocyanidins 75.7, 90.5, 95.0, and 44.8 mg·g^(-1)), respectively) showed significant activities against reactive oxygen species(ROS), nitric oxide(NO) production, and expression of pro-inflammatory genes interleukin-1β(IL-1β) and inducible nitric oxide synthase(iNOS) in a lipopolysaccharide(LPS)-stimulated mouse macrophage cell line RAW 264.7. All the extracts suppressed α-glucosidase and α-amylase activities, two primary enzymes responsible for carbohydrate digestion. A. mearnsii bark samples possessed significantly stronger inhibitory effects against α-glucosidase enzyme(IC_(50) of 0.4-1.4 μg·mL^(-1)) than the pharmaceutical acarbose(IC_(50) 141.8 μg·mL^(-1))). B6 and B7(IC_(50) 17.6 and 11.7 μg·mL^(-1), respectively) exhibited α-amylase inhibitory activity as efficacious as acarbose(IC_(50) 15.4 μg·mL^(-1))). Moreover, B extract, at 25 μg·mL^(-1), significantly decreased the non-mitochondrial oxidative burst that is often associated with inflammatory response in human monocytic macrophages.

关键词： acacia mearnsii Proanthocyanidins Anti-inflammatory α-Amylase α-Glucosidase

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Methodological issues in the study of intestinal microbiota in irritable bowel syndrome

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World Journal of Gastroenterology 2014年第27期20卷 8821-8836页

作者： Valentina Taverniti Simone Guglielmetti Division of Food Microbiology and bioprocessing Department of Food Environmental and Nutritional Sciences Università degli Studi di Milano 20133 Milan Italy

Irritable bowel syndrome (IBS) is an intestinal functional disorder with the highest prevalence in the industrialized world. The intestinal microbiota (IM) plays a role in the pathogenesis of IBS and is not merely a consequence of this disorder. Previous research efforts have not revealed unequivocal microbiological signatures of IBS, and the experimental results are contradictory. The experimental methodologies adopted to investigate the complex intestinal ecosystem drastically impact the quality and significance of the results. Therefore, to consider the methodological aspects of the research on IM in IBS, we reviewed 29 relevant original research articles identified through a PubMed search using three combinations of keywords: “irritable bowel syndrome + microflora”, “irritable bowel syndrome + microbiota” and “irritable bowel syndrome + microbiome”. For each study, we reviewed the quality and significance of the scientific evidence obtained with respect to the experimental method adopted. The data obtained from each study were compared with all considered publications to identify potential inconsistencies and explain contradictory results. The analytical revision of the studies referenced in the present review has contributed to the identification of microbial groups whose relative abundance significantly alters IBS, suggesting that these microbial groups could be IM signatures for this syndrome. The identification of microbial biomarkers in the IM can be advantageous for the development of new diagnostic tools and novel therapeutic strategies for the treatment of different subtypes of IBS.

关键词： Intestinal dysfunction Irritable bowel syndrome Intestinal microbiota Bifidobacteria New generation DNA sequencing

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