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Multilayered organic semiconductors for high performance optoelectronic stimulation of cells

Nano research 2023年第4期16卷 5809-5816页

作者： Aleksandr Markov alexander Gerasimenko Annie-Kermen Boromangnaeva Sofia Shashova Elena Iusupovskaia Ulyana Kurilova Vita Nikitina Irina Suetina Marina Mezentseva Mikhail Savelyev Peter Timashev Dmitry Telyshev Xing-Jie Liang Institute for Bionic Technologies and Engineering I.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia Institute of biomedical Systems National Research University of Electronic TechnologyZelenogradMoscow 124498Russia Chemistry Department Lomonosov Moscow State UniversityLeninskie Gory1/3Moscow 119991Russia Ivanovsky Institute of Virology N.F.Gamaleya National Center of Epidemiology and MicrobiologyMoscow 123098Russia World-Class research center“Digital Biodesign and Personalized Healthcare” I.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia Laboratory of Clinical Smart Nanotechnologies I.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia Institute for Regenerative Medicine I.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia CAS Key Laboratory for biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing 100190China University of Chinese Academy of sciences Beijing 100049China

The efficiency of devices for bioelectronic applications,including cell and tissue stimulation,is heavily dependent on the scale and the performance *** miniaturization of stimulation electrodes,achieving a sufficiently high current pulse to elicit action potentials becomes an *** we report on our approach of vertically stacking organic p-n junctions to create highlyefficient multilayered organic semiconductor(MOS)photostimulation device.A tandem arrangement substantially increases the photovoltage and charge density without sacrificing lateral area,while not exceeding 200-500 nm of *** devices generate 4 times higher voltages and at least double the charge densities over single p-n junction devices,which allow using lower light intensities for *** devices show an outstanding stability in the electrolyte that is extremely important for forthcoming in vivo ***,we have validated MOS devices performance by photostimulating fibroblasts and neuroblasts,and found that using tandem devices leads to more effective action potential *** a result,we obtained up to 4 times enhanced effect in cell growth density using 3 p-n layered *** results corroborate the conclusion that MOS technology not only can achieve parity with state-of-the-art silicon devices,but also can exceed them in miniaturization and performance for biomedical applications.

关键词： bioelectronics organic semiconductors wireless stimulation fibroblasts neuroblastoma cells

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Physics-informed neural networks(PINNs)for fluidmechanics:a review

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Acta Mechanica Sinica 2021年第12期37卷 1727-1738页

作者： Shengze Cai Zhiping Mao Zhicheng Wang Minglang Yin George Em Karniadakis Division of Applied Mathematics Brown UniversityProvidenceRI 02912USA School of Mathematical sciences Xiamen University 361005 China Laboratory of Ocean Energy Utilization of Ministry of Education Dalian University of TechnologyDalian116024China School of Engineering Brown UniversityProvidenceRI 02912USA center for biomedical Engineering Brown UniversityProvidenceRI 02912USA

Despite the significant progress over the last 50 years in simulating flow problems using numerical discretization of the Navier–Stokes equations(NSE),we still cannot incorporate seamlessly noisy data into existing algorithms,mesh-generation is complex,and we cannot tackle high-dimensional problems governed by parametrized ***,solving inverse flow problems is often prohibitively expensive and requires complex and expensive formulations and new computer ***,we review flow physics-informed learning,integrating seamlessly data and mathematical models,and implement them using physics-informed neural networks(PINNs).We demonstrate the effectiveness of PINNs for inverse problems related to three-dimensional wake flows,supersonic flows,and biomedical flows.

关键词： Physics-informed learning PINNs Inverse problems Supersonic flows biomedical flows

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Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy

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Translational Neurodegeneration 2019年第1期8卷 215-229页

作者： Jia-Zhen Wu Mustafa Ardah Caroline Haikal alexander Svanbergsson Meike Diepenbroek Nishant N.Vaikath Wen Li Zhan-You Wang Tiago F.Outeiro Omar M.El-Agnaf Jia-Yi Li Institute of Neuroscience College of Life and Health SciencesNortheastern UniversityShenyangLiaoningChina Department of Biochemistry College of Medicine and Health SciencesUnited Arab Emirates UniversityPO Box 17666Al-AinUnited Arab Emirates Neural Plasticity and Repair Unit Wallenberg Neuroscience CenterDepartment of Experimental Medical ScienceBMC A1022184 LundSweden Neurological Disorders research center Qatar Biomedical Research Institute(QBRI)Hamad Bin Khalifa University(HBKU)Education CityQatar FoundationP.O.Box 5825DohaQatar Institute of Heath sciences China Medical University110112 ShenyangPeople’s Republic of China Key Laboratory of Maternal-Fetal Medicine of Liaoning Province and Key Laboratory of Obstetrics and Gynecology of Higher Education of Liaoning Province Shengjing Hospital of China Medical UniversityShenyangChina Department of Experimental Neurodegeneration Center for Nanoscale Microscopy and Molecular Physiology of the BrainCenter for Biostructural Imaging of NeurodegenerationUniversity Medical Center Göttingen37073 GöttingenGermany Max Planck Institute for Experimental Medicine GöttingenGermany

Background:Progressive accumulation ofα-synuclein is a key step in the pathological development of Parkinson’s *** protein degradation and increased levels ofα-synuclein may trigger a pathological aggregation in vitro and in *** chaperone-mediated autophagy(CMA)pathway is involved in the intracellular degradation processes ofα-*** of the CMA pathway impairsα-synuclein degradation and causes ***:In the present study,we investigated the effects on the CMA pathway andα-synuclein aggregation using bioactive ingredients(Dihydromyricetin(DHM)and Salvianolic acid B(Sal B))extracted from natural medicinal *** both cell-free and cellular models ofα-synuclein aggregation,after administration of DHM and Sal B,we observed significant inhibition ofα-synuclein accumulation and *** were co-transfected with a Cterminal modifiedα-synuclein(SynT)and synphilin-1,and then treated with DHM(10μM)and Sal B(50μM)16 hours after transfection;levels ofα-synuclein aggregation decreased significantly(68%for DHM and 75%for Sal B).Concomitantly,we detected increased levels of LAMP-1(a marker of lysosomal homeostasis)and LAMP-2A(a key marker of CMA).Immunofluorescence analyses showed increased colocalization between LAMP-1 and LAMP-2A withα-synuclein inclusions after treatment with DHM and Sal *** also found increased levels of LAMP-1 and LAMP-2A both in vitro and in vivo,along with decreased levels ofα-***,DHM and Sal B treatments exhibited anti-inflammatory activities,preventing astroglia-and microglia-mediated neuroinflammation in BAC-α-syn-GFP transgenic ***:Our data indicate that DHM and Sal B are effective in modulatingα-synuclein accumulation and aggregate formation and augmenting activation of CMA,holding potential for the treatment of Parkinson’s disease.

关键词： chaperone-mediated autophagy macroautophagy alpha-synuclein protein aggregation Parkinson disease lysosomal-associated membrane protein

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Deep tissue imaging by enhanced photon collection

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Journal of Innovative Optical Health sciences 2014年第5期7卷 136-144页

作者： Viera Crosignani Sohail Jahid alexander Dvornikov Enrico Gratton Department of biomedical Engineering University of California at IrvineIrvine CA 92697-2715USA

We have developed a two-photon fluorescence microscope capable of imaging up to 4mm inturbid media with micron *** key feature of this instrument is the innovative de-tector,capable of collecting emission photons from a wider surface area of the sample thandetectors in traditional two-photon *** detection scheme is extremely efficient inthe collection of emitted photons scattered by turbid media which allows eight fold increase in theimaging depth when compared with conventional two-photon ***,thissystem also has in-depth fluorescence lifetime imaging microscopy(FLiM)imaging capabilitywhich increases image *** detection scheme captures emission light in a transmissionconfiguration,making it extremely efficient for the detection of second harmonic generation(SHG)signals,which is generally forward *** we present imaging experiments oftissue phantoms and in vivo and ea vivo biological tissue performed with this microscope.

关键词： Deep tissue microscopy fluorescence SHG FLIM

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Intimal pericytes as the second line of immune defence in atherosclerosis

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World Journal of Cardiology 2015年第10期7卷 583-593页

作者： Ekaterina A Ivanova Yuri V Bobryshev alexander N Orekhov Department of Development and Regeneration Biomedical Sciences Group KU LeuveLeuvenBelgium Faculty of Medicine School of Medical Sciences University of New South Wales School of Medicine University of Western Sydney Laboratory of Angiopathology Institute of General Pathology and Pathophysiology Russian Academy of Sciences Institute for Atherosclerosis research Skolkovo Innovative Center Department of Biophysics Faculty of Biology Lomonosov Moscow State University

Inflammation plays an essential role in the development of atherosclerosis. The initiation and growth of atherosclerotic plaques is accompanied by recruitment of inflammatory and precursor cells from the bloodstream and their differentiation towards pro-inflammatory phenotypes. This process is orchestrated by the production of a number of pro-inflammatory cytokines and chemokines. Human arterial intima consists of structurally distinct leaflets, with a proteoglycan-rich layer lying immediately below the endothelial lining. Recent studies reveal the important role of stellate pericyte-like cells(intimal pericytes) populating the proteoglycan-rich layer in the development of atherosclerosis. During the pathologic process, intimal pericytes may participate in the recruitment of inflammatory cells by producing signalling molecules and play a role in the antigen presentation. Intimal pericytes are also involved in lipid accumulation and the formation of foam cells. This review focuses on the role of pericytelike cells in the development of atherosclerotic lesions.

关键词： Atherosclerosis Arteries Intima Immune-inflammator

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Unveiling multimodal hot carrier excitation in plasmonic bimetallic Au@Ag nanostars for photochemistry and SERS sensing

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Nano research 2024年第12期17卷 10355-10362页

作者： Yoel Negrín-Montecelo Amir Elsaidy Jesús Giráldez-Martínez Enrique Carbó-Argibay Zhiming Wang alexander O.Govorov Ramon A.Alvarez-Puebla Miguel A.Correa-Duarte Lucas V.Besteiro Department of Physical and Inorganic Chemistry Universitat Rovira i VirgiliCarrer de Marcel∙líDomingo s/nTarragona 43007Spain Department of chemical engineering Military Technichal CollegeCairo 4393010Egypt CINBIO University of VigoCampus Universitario de VigoLagoas MarcosendeVigo 36310Spain International Iberian Nanotechnology Laboratory Av.Mestre JoséVeiga s/nBraga 4715-330Portugal Institute of Fundamental and Frontier sciences University of Electronic Science and Technology of ChinaChengdu 610054China Department of Physics and Astronomy Ohio UniversityAthensOhio 45701USA ICREA Passeig Lluís Companys 23Barcelona 08010Spain Southern Galicia Institute of Health research(IISGS)and biomedical research Networking center for Mental Health(CIBERSAM) Universidade de VigoVigo 36310Spain

Plasmonic nanostructures stand at the forefront of nanophotonics research,particularly in sensing and energy conversion *** unique ability to confine light energy at the nanoscale makes them indispensable for a wide array of technological *** study of these structures often makes use of different materials and,even more extensively,explores new shapes and configurations to extend our common repertoire of useful nanophotonics *** the creation of bimetallic plasmonic nanostructures combines these two dimensions determining the space of possible plasmonic resonators and opens the possibility of tailoring systems with behavior unavailable to single-metal plasmonic *** this paper,we delve into the exploration of bimetallic systems employing plasmonic *** structures have demonstrated remarkable capabilities for surface-enhanced Raman scattering(SERS)spectroscopy and photochemistry,due to the strong plasmonic response of their peaks,whose disposition following a spherical symmetry makes them largely polarization-and ***,we report the colloidal synthesis of two different water-stable Au@Ag nanostars,explore their performance as photocatalysts and SERS substrates,and provide an in-depth account of their non-trivial physical response.

关键词： hot-electrons field enhancement nanohybrids photocatalysis surface-enhanced Raman scattering(SERS) plasmonics

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Skeletal loading regulates breast cancer-associated osteolysis in a loading intensity-dependent fashion

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Bone research 2020年第2期8卷 238-248页

作者： Yao Fan Aydin Jalali Andy Chen Xinyu Zhao Shengzhi Liu Meghana Teli Yunxia Guo Fangjia Li Junrui Li Amanda Siegel Lianxiang Yang Jing Liu Sungsoo Na Mangilal Agarwal alexander G.Robling Harikrishna Nakshatri Bai-Yan Li Hiroki Yokota Department of Pharmacology School of PharmacyHarbin Medical UniversityHarbin 150081China Department of biomedical Engineering Indiana University Purdue University IndianapolisIndianapolisIN 46202USA Peking Union Medical College Hospital Chinese Academy of Medical SciencesBeijing 100730China Department of Physics Indiana University Purdue University IndianapolisIndianapolisIN 46202USA Department of Mechanical Engineering Oakland UniversityRochesterMI 48309USA Integrative Nanosystems Development Institute Indiana University Purdue University IndianapolisIndianapolisIN 46202USA Department of Anatomy and Cell Biology Indiana University School of MedicineIndianapolisIN 46202USA Indiana center for Musculoskeletal Health Indiana University School of MedicineIndianapolisIN 46202USA Department of Surgery Simon Cancer Research CenterIndiana University School of MedicineIndianapolisIN 46202USA

Osteocytes are mechanosensitive bone cells, but little is known about their effects on tumor cells in response to mechanical stimulation. We treated breast cancer cells with osteocyte-derived conditioned medium(CM) and fluid flow-treated conditioned medium(FFCM) with 0.25 Pa and 1 Pa shear stress. Notably, CM and FFCM at 0.25 Pa induced the mesenchymal-to-epithelial transition(MET), but FFCM at 1 Pa induced the epithelial-to-mesenchymal transition(EMT). This suggested that the effects of fluid flow on conditioned media depend on flow intensity. Fluorescence resonance energy transfer(FRET)-based evaluation of Src activity and vinculin molecular force showed that osteopontin was involved in EMT and MET switching. A mouse model of tumorinduced osteolysis was tested using dynamic tibia loadings of 1, 2, and 5 N. The low 1 N loading suppressed tumor-induced osteolysis, but this beneficial effect was lost and reversed with loads at 2 and 5 N, respectively. Changing the loading intensities in vivo also led to changes in serum TGFβ levels and the composition of tumor-associated volatile organic compounds in the ***, this study demonstrated the critical role of intensity-dependent mechanotransduction and osteopontin in tumorosteocyte communication, indicating that a biophysical factor can tangibly alter the behaviors of tumor cells in the bone microenvironment.

关键词： breast cancer loading

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Optimization of energy consumption structure based on carbon emission reduction target:A case study in Shandong Province,China

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Chinese Journal of Population,Resources and Environment 2022年第2期20卷 125-135页

作者： Jixiang Liu Haichao Ma Qingsong Wang Shu Tian Yue Xu Yujie Zhang Xueliang Yuan Qiao Ma Yuan Xu Shuo Yang National Engineering Laboratory for Reducing Emissions from Coal Combustion Engineering Research Center of Environmental Thermal Technology of Ministry of EducationShandong Key Laboratory of Energy Carbon Reduction and Resource UtilizationResearch Center for Sustainable DevelopmentSchool of Energy and Power EngineeringShandong UniversityJinanShandong250061China

It is urgent to significantly reduce greenhouse gas emissions to actively deal with global *** paper investigates Shandong Province,a typical province of energy consumption,as the research object,aiming to optimize total energy consumption and consumption structure in the future planning *** paper constructs a methodological system to optimize energy consumption structure in Shandong Province,using a scenario combination of system dynamics(SD)prediction and analysis based on the coupling of key scenario elements affecting different energy consumption from different *** equation modeling and SD sensitivity analysis indicate an overlap between key factors restricting energy *** the key scenario factors can better reflect the internal mechanism of energy consumption *** on this,21 scenarios based on different combinations of the key elements are *** SD prediction and analysis,the most suitable scenario mode for optimizing energy consumption structure in Shandong Province is *** paper provides a suitable development range for the average gross domestic product growth rate,the proportion of secondary industry,energy consumption intensity of secondary industry,and the urbanization rate for Shandong *** paper can provide a reference for similar research and the government in formulating the optimization scheme of energy consumption structure.

关键词： Energy consumption structure System dynamics Structural equation Scenario combination analysis Carbon emissions Optimization research

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Plasma lipidomics reveal systemic changes persistent throughout early life following a childhood burn injury

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Burns & Trauma 2023年第1期11卷 814-824页

作者： Eva Kierath Monique Ryan Elaine Holmes Jeremy K.Nicholson Mark W.Fear Fiona M.Wood Luke Whiley Nicola Gray 无 Australian National Phenome Centre Health Futures InstituteMurdoch UniversityHarry Perkins Institute5 Robin Warren DriveMurdochPerthWA 6150Australia Fiona Wood Foundation Fiona Stanley HospitalFiona Wood FoundationFiona Stanley HospitalLevel 411 Robin Warren DriveMurdochWA 6150Australia Burn injury research unit School of Biomedical SciencesUniversity of Western Australia6 Verdun streetNedlandsWA 6009 Australia Department of Metabolism Digestion and ReproductionFaculty of MedicineImperial College LondonSir Alexander Fleming BuildingSouth KensingtonLondon SW72AZUK Centre for Computational Medicine Health Futures InstituteMurdoch University5 Robin Warren DriveMurdochPerthWA 6150Australia Medical School University of Western AustraliaHarry Perkins InstituteMurdochPerthWA 6150Australia Faculty of Medicine Institute of Global Health InnovationImperial College LondonLevel 1Faculty Building South Kensington CampusLondon SW72AZUK Burns Service of Western Australia WA Department of Health11 Robin Warren driveMurdochWA 6150Australia Perron Institute for Neurological and Translational Science NedlandsWAAustralia

Background:Non-severe paediatric burns can result in poor long-term health *** occurs even in cases with good acute burn-related outcomes,including minimal *** mechanisms that underpin the transition from non-severe burn to sustained negative long-term health impacts are currently ***,sustained metabolic and immune changes have been observed in paediatric burn studies,suggesting these changes may be *** plasma lipidome consists of a rich pool of bioactive metabolites that play critical roles in systemic processes including molecular signalling and *** hypothesised that changes in the plasma lipidome may reflect underlying changes in health status and be linked to long-term health after burn ***:This study analysed the lipidome in children who had previously experienced a non-severe burn,compared to non-injured ***-three participants were recruited between the ages of 5 and 8 years who had experienced a non-severe burn between the ages of 1 and 3 *** samples were also collected from a non-injured,healthy,age and gender matched control group(n=21).Plasma lipids were measured using reversed-phase liquid chromatographymass spectrometery(LC-MS).Results:In total 838 reproducible lipid species from 19 sub-classes passed quality control procedures and progressed to statistical *** of individual lipid metabolites showed significantly higher concentrations of lysophosphatidylethanolamines and phosphatidylethanolamines,and significantly lower concentrations in myristic,palmitic and palmitoleic acids in the plasma of those who had experienced burn injury compared to ***:Long-term changes in the lipid profile may give insight into the mechanisms underlying poor long-term health subsequent to non-severe burn *** work to investigate the relationship between long-term pathology and lipidomic changes may lead to a better understanding of the causes of seconda

关键词： Lipidomics Lipids Burns Trauma Paediatric Children Mass spectrometry

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Effects of Jianpi Jiedu Recipe (健脾解毒方)on Reversion of P-Glycoprotein-Mediated Multidrug Resistance through COX-2 Pathway in Colorectal Cancer

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Chinese Journal of Integrative Medicine 2014年第8期20卷 610-617页

作者：隋华朱惠蓉吴杰 NIKITIN alexander Yu 蔡健锋范忠泽李琦 Department of Medical Oncology Shuguang Hospital&Putuo HospitalShanghai University of Traditional Chinese Medicine Department of Molecular Oncology H.Lee Moffitt Cancer Center and Research InstituteTampaFlorida(33612)USA Department of biomedical sciences Cornell UniversityIthacaNew York(14853-6401)USA Department of Chemistry University of South FloridaTampaFlorida(33620)USA

Objective： To evaluate the underlying mechanism of Jianpi Jiedu Recipe （健脾解毒方, JJR） in the reversion of multidrug resistance concerning colorectal cancer in vitro and in vivo. Methods： Mice were treated orally with JJR at a daily 4.25 g/（***） or injected with vinblastine （VCR） 2.5 mg/（kg day） for 3 weeks after having been inoculated with HCT8N cells; tumor tissues were assayed by hematoxylin and eosin staining. Firstly, the effects of JJR on the expression of cyclooxygenase-2 （COX-2） were tested by real-time polymerase chain reaction （PCR） technique and COX-2 gene silenced by siRNA. Secondly, the variation of intracellular concentration of oxaliplatin （L-OHP） was evaluated by the inductively coupled plasma mass spectroscopy （ICP- MS） in HCT8N and its COX-2 siRNA cells; the concentration of J JR combined with chemotherapeutic drugs and the reverse effect of multidrug resistance （MDR） in HCT8N cells was evaluated by the MTT assay. Thirdly, real-time quantitative PCR and Western blot analysis were used to detect the multidrug resistance gene 1 （MDR1） mRNA and P-gp expression. Results： JJR had an inhibitory effect on the growth of tumors in vivo, and it, in combination with chemotherapeutic drugs, could reverse the drug-resistance of HCT8N cells and increase the sensitivity of HCT8N cells to VCR, DDP, 5-Fu, and THP. ICP-MS results showed that JJR could increase the concentration of drugs in HCT8/V cells （P〈0.01）. Furthermore, it was shown that JJR could reverse drug resistance of colorectal cancer cells by decreasing MDR1 expression and P-gp level via downregulation of COX-2, which has been represented as one of the major mechanisms that contributes to the MDR phenotype （P〈0.01）. Conclusion： JJR reversed multidrug resistance and enhanced the sensitivity to chemotherapy, which could be attributed to the down-regulation of COX-2 in MDRl/P-gp-mediated MDR colorectal cancer after chemotherapy.

关键词： colorectal cancer multidrug resistance P-glycoprotein multidrug resistance gene cyclooxygenase-2 Jianpi Jiedu Recipe Chinese medicine

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