检索结果-南通市图书馆

Progress in Natural Science:Materials International 2016年第6期26卷 540-545页

作者： Amgalanbaatar Baldansuren Photon Science Institute EPSRC National EPR FacilitySchool of ChemistryThe University of Manchester

A well-defined, monodisperse Ag6~+ cluster was prepared by mild chemical treatments including aqueous ionexchange, dehydration, oxygen calcination at 673 K and hydrogen reduction 293 K, rather than autoreduction and irradiations with γ-ray and X-ray. H2reduction was proved as a crucial step to form the nanosize cluster with six equivalent silver atoms. Hydrogen isotope exchange and dynamics were probed by epr and HYSCORE to provide information relevant to the cluster geometry, size, charge state and spin state. Desorption experiments result in the deuterium desorption energy of 0.78 eV from the cluster, exceeding the experimental value of 0.38 eV for the single crystal Ag(111) surface. These experiments indicate that the epr-active clusters are in delicate equilibrium with epr-silent clusters.

关键词： Reduced Ag clusters H/D isotope exchange and desorption epr HYSCORE Zeolite A

A new horizon for neuroscience:terahertz biotechnology in brain research

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 309-325页

作者： Zhengping Pu Yu Wu Zhongjie Zhu Hongwei Zhao Donghong Cui Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Kangci Hospital of JiaxingTongxiangZhejiang ProvinceChina Shanghai Synchrotron Radiation facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghaiChina National facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain *** this article,we review the development of terahertz biotechnology and its applications in the field of *** evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin *** vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric *** the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic ***,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical *** review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关键词： biological effect brain neuron neuropsychiatry neuroscience non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology

Tyrosyl radical in haemoglobin and haptoglobin-haemoglobin complex:how does haptoglobin make haemoglobin less toxic?

在线全文

学校读者我要写书评

暂无评论

The Journal of biomedical Research 2020年第4期34卷 281-291页

作者： Dimitri A.Svistunenko Andreea Manole biomedical epr facility School ofLife SciencesUniversity of EssexColchesterEssex CO43SQUK Laboratory of Genetics The Salk Institute for Biological StudiesLa JollaCA 92037USA.

One of the difficulties in creating a blood substitute on the basis of human haemoglobin(Hb) is the toxic nature of Hb when it is outside the safe environment of the red blood *** plasma protein haptoglobin(Hp) takes care of the Hb physiologically leaked into the plasma-it binds Hb and makes it much less toxic while retaining the Hb’s high oxygen transporting *** used Electron Paramagnetic Resonance(epr) spectroscopy to show that the protein bound radical induced by H2O2 in Hb and Hp-Hb complex is formed on the same tyrosine residue(s),but,in the complex,the radical is found in a more hydrophobic environment and decays slower than in unbound Hb,thus mitigating its oxidative *** data obtained in this study might set new directions in engineering blood substitutes for transfusion that would have the oxygen transporting efficiency typical of Hb,but which would be non-toxic.

关键词： blood substitute epr haemoglobin toxicity haptoglobin HBOC protein-bound radical TRSSA

Organic fluorescent probes for live-cell super-resolution imaging

在线全文

学校读者我要写书评

暂无评论

Frontiers of Optoelectronics 2023年第4期16卷 25-36页

作者： Xinxin Duan Meng Zhang Yu‑Hui Zhang Britton Chance Center for biomedical Photonics MoE Key Laboratory for Biomedical PhotonicsAdvanced Biomedical Imaging Facility-Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China

The development of super-resolution technology has made it possible to investigate the ultrastructure of intracellular organelles by fuorescence microscopy,which has greatly facilitated the development of life sciences and *** realize super-resolution imaging of living cells,both advanced imaging systems and excellent fuorescent probes are *** fuorescent probes have good availability,but that is not the case for probes for live-cell super-resolution *** this review,we frst introduce the principles of various super-resolution technologies and their probe requirements,then summarize the existing designs and delivery strategies of super-resolution probes for live-cell imaging,and fnally provide a brief conclusion and overview of the future.

关键词： Super-resolution imaging Organic fluorescent dyes-Live-cell imaging Cell-impermeable organic probes

Mechanistic Investigation into the Role of Aluminum Diffusion in the Oxidation Behavior of Cryomilled NiCrAlY Bond Coat

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2016年第1期31卷 35-43页

作者： Kaka MA Xiaochuan TANG Julie M SCHOENUNG Department of Chemical Engineering and Materials Science University of California Davis Genome and biomedical Science facility Genome CenterUniversity of California Davis

High temperature oxidation behavior of the bond coat layer is a critical factor that controls the failure mechanism of thermal barrier coatings（TBCs）.Previous work reveald that TBCs with cryomilled NiCrAlY bond coats exhibited an improved oxidation behavior compared to equivalent TBCs with conventional bond *** cryomilled NiCrAlY bond coats contributed to a slower growth rate of thermally grown oxides（TGO） with a final thinner thickness and enhanced homogeneity in TGO *** better understand the improved oxidation behavior,a mechanistic investigation based on diffusion theory and quantum mechanics is performed to elucidate the role of aluminum diffusion in the oxidation behavior and how the microstructural features of the cryomilled NiCrAlY bond coats,i e,the creation of a thermally stable,uniform distribution of ultrafine Al-rich oxide dispersoids,affect the diffusion kinetics of Al and the migration of free *** is revealed that these Al-rich oxide dispersoids result in a uniform diffusion of Al and slow migration of free electrons within the NiCrAlY bond coat,consequently leading to the improved oxidation behavior.

关键词： nickel alloys coatings oxidation diffusion

Tissue optical clearing for neural regeneration research

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第9期18卷 1940-1941页

作者： Tingting Yu Jianyi Xu Dan Zhu Britton Chance Center for biomedical Photonics-MoE Key Laboratory for biomedical Photonics Wuhan National Laboratory for Optoelectronics-Advanced biomedical Imaging facility Huazhong University of Science and TechnologyWuhanHubei ProvinceChina Optics Valley Laboratory WuhanHubei ProvinceChina

Nerve injury,whether traumatic or degenerative,disrupts the transmission of information in the nervous syste m,leading to *** is widely known that neural regeneration is vital to the restoration of function after nerve ***,outcomes are often limited by the misguidance of axonal regeneration and complex pathological changes in neurons and glia,as well as the longterm denervation of target organs.

关键词： organs neural traumatic

Size-dependent gene delivery of amine-modified silica nanoparticles

在线全文

学校读者我要写书评

暂无评论

Nano Research 2016年第2期9卷 291-305页

作者： Meihua Yu Yuting Niu Jun Zhang Hongwei Zhang Yannan Yang Elena Taran Siddharth Jambhrunkar Wenyi Gu Peter Thorn Chengzhong Yu Australian Institute for Bioengineering and Nanotechnology The University of Queensland Brisbane QLD 4072 Australia Australian National Fabrication facility-QLD Node Brisbane QLD 4072 Australia School of biomedical Sciences The University of Queensland Brisbane QLD 4072 Australia

Silica-based nanoparticles are promising carriers for gene delivery applications. To gain insights into the effect of particle size on gene transfection efficiency, amine-modified monodisperse St6ber spheres （NH2-SS） with diameters of 125, 230, 330, 440, and 570 nm were synthesized. The in vitro transfection efficiencies of NH2-SS for delivering plasmid DNA encoding green fluorescent protein （GFP）（pcDNA3-EGFP, abbreviated as pcDNA, 6.1 kbp） were studied in HEK293T cells. NH2-SS with a diameter of 330 nm （NH2-SS330） showed the highest GFP transfection level compared to NH2-SS particles with other sizes. The transfection efficiency was found as a compromise between the binding capacity and cellular uptake performance of NH2-SS330 and pcDNA conjugates. NH2-SS330 also demonstrated the highest transfection efficiency for plasmid DNA （pDNA） with a bigger size of 8.9 kbp. To our knowledge, this study is the first to demonstrate the significance of particle size for gene transfection efficiency in silica-based gene delivery systems. Our findings are crucial to the rational design of synthetic vectors for gene therapy.

关键词： silica nanoparticles gene delivery plasmid DNA particle sizes cellular uptake

Photostimulation of lymphatic clearance ofβ‑amyloid from mouse brain:a new strategy for the therapy of Alzheimer’s disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Optoelectronics 2023年第4期16卷 179-190页

作者： Dongyu Li Hao Lin Silin Sun Shaojun Liu Zhang Liu Yuening He Jingtan Zhu Jianyi Xu Oxana Semyachkina‑Glushkovskaya Tingting Yu Dan Zhu Britton Chance Center for biomedical Photonics-MoE Key Laboratory for biomedical Photonics Wuhan National Laboratory for Optoelectronics-Advanced Biomedical Imaging FacilityHuazhong University of Science and TechnologyWuhan 430074China School of Optical Electronic Information Huazhong University of Science and TechnologyWuhan 430074China Department of Biology Saratov State UniversitySaratov 410012Russia

Alzheimer’s disease(AD)is an age-related neurodegenerative disorder that poses a signifcant burden on socio-economic and healthcare systems ***,the currently available therapy of AD is limited,and new strategies are needed to enhance the clearance ofβ-amyloid(Aβ)protein and improve cognitive ***(PBM)is a noninvasive and efective therapeutic method that has shown promise in treating various brain ***,we demonstrate that 1267-nm PBM signifcantly alleviates cognitive decline in the 5xFAD mouse model of AD and is safe as it does not induce a signifcant increase in cortical ***,with the combination of 3D tissue optical clearing imaging and automatic brain region segmentation,we show that PBM-mediated reductions of Aβplaques in diferent subregions of prefrontal cortex and the hippocampus are *** PBM-induced lymphatic clearance of Aβfrom the brain is associated with improvement of memory and cognitive functions in 5xFAD *** results suggest that the modulation of meningeal lymphatic vessels(MLVs)should play an important role in promoting Aβ***,this pilot study demonstrates that PBM can safely accelerate lymphatic clearance of Aβfrom the brain of 5xFAD mice,promoting improvement of neurocognitive status of AD animals suggesting that PBM can be an efective and bedside therapy for AD.

关键词： Photostimulation-Meningeal lymphatic vessels Amyloid-βclearance Alzheimer's disease

Tissue optical clearing imaging for structural changes of neuromuscular junctions after mice ischemic stroke[Invited]

在线全文

学校读者我要写书评

暂无评论

Chinese Optics Letters 2023年第12期21卷 54-60页

作者：徐健壹戴奕宣昂姚应涛刘少军俞婷婷朱䒟 Britton Chance Center for biomedical Photonics MoE Key Laboratory for Biomedical PhotonicsWuhan National Laboratory for OptoelectronicsAdvanced Biomedical Imaging FacilityHuazhong University of Science and TechnologyWuhan 430074China

Ischemic stroke causes long-term disability and results in motor *** impairments are associated with structural changes in the neuromuscular junction(NMJ),including detailed morphology and three-dimensional(3D)***,previous studies only explored morphological changes of individual NMJs after stroke,which limits the understanding of their role in post-stroke motor ***,we examine 3D distributions and detailed morphology of NMJs in entire mouse muscles after unilateral and bilateral strokes induced by *** results show that 3D distributions and numbers of NMJs do not change after stroke,and severe unilateral stroke causes similar levels of NMJ fragmentation and area enlargement to bilateral *** research provides structural data,deepening the understanding of neuromuscular pathophysiology after stroke.

关键词： tissue optical clearing optical imaging stroke neuromuscular junction

Light sheet fluorescence microscopy: Advancing biological discovery with more dimensions, higher speed, and lower phototoxicity

在线全文

学校读者我要写书评

暂无评论

The Innovation 2024年第5期5卷 29-30页

作者： Yao Zhou Shiqi Mao Peng Fei School of Optical and Electronic Information-Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Advanced biomedical Imaging facility Huazhong University of Science and TechnologyWuhan 430074China

TO SEE THE WORLD IN A GRAIN OF *** microscopy has proved to be essential for seeing life in a grain of a *** epifluorescence microscopes,such as wide-field microscopes and laser scanning confocal microscopes,have been widely used for biology research over the past few *** goal of fluorescence microscopy is to observe the structure and function of cellular events across time and threedimensional(3D)space with spatiotemporal resolution as high as ***,conventional epifluorescence microscopes illuminate the entire 3D volume of the sample while detecting signals only from the 2D focal plane,thereby leading to low photon utilization and high phototoxicity issues that notably prevent high-resolution imaging of live biological specimens(Figure 1A).It becomes increasingly noteworthy that the massively emerging biomedical applications are posing significant challenges to current fluorescence microscopy techniques.

关键词： fluorescence dimensions Figure