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Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease

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Neural Regeneration Research 2025年第7期20卷 2053-2067页

作者： Milica Zeljkovic Jovanovic Jelena Stanojevic Ivana Stevanovic Milica Ninkovic Tihomir V.Ilic Nadezda Nedeljkovic Milorad Dragic laboratory for Neurobiology Department of General Physiology and BiophysicsFaculty of BiologyUniversity of BelgradeBelgradeSerbia Medical Faculty of Military Medical Academy University of DefenceBelgradeSerbia

An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's *** therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in *** transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's ***,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain *** purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated *** with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod ***,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate *** intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate *** with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor *** treatment with prolonged intermittent theta burst stimulation,complete motor recovery was *** improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst *** results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)***

关键词： A_(1)R A_(2A)R adenosine receptors adenosine ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling

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Anti-arthritic effect of Distemonanthus benthamianus extracts against rheumatoid arthritis in rats

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Asian Pacific Journal of Tropical Biomedicine 2022年第10期12卷 411-420页

作者： William Yousseu Nana Ernest Allah Hoki Kwenteh Gilbert Ateufack Eric Gonzal Tsafack Stephanie FloreDjuichou Nguemnang Zenab Linda Fagni Njoya Albert Donatien Atsamo Vanessa Mba Matah Marthe CarineFlore Adjouzem Yacine Karelle Madjo Kouam Elvira Ngoufack Azanze Marius Mbiantcha laboratory of biology and physiology of animal organisms Department of Biology of Animal OrganismsFaculty of ScienceThe University of Douala CameroonP.O.Box 24157DoualaCameroon Research Unit of animal physiology and Phytopharmacology Faculty of ScienceUniversity of DschangDschangCameroon laboratory of animal physiology Faculty of ScienceUniversity of Yaounde IYaoundéCameroon

Objective:To evaluate the anti-arthritic effect of aqueous and methanolic extracts of Distemonanthus ***:Monoarthritis was induced by an injection of 0.3 mL zymosan A(0.9%NaCl,v/v)in the right posterior knee joints of ***,joint diameter and pain threshold were *** was induced by an intracaudal injection of complete Freund’s adjuvant and rats were treated from day 14 post 1st complete Freund’s adjuvant injection until 28 *** clinical,hematological,biochemical and oxidative stress parameters were *** addition,histological analysis of the knee joint was perfomed in both ***:The aqueous and methanolic extracts of Distemonanthus benthamianus at a dose of 500 mg/kg ameliorated zymosan A-induced monoarthritis,as evidenced by reduced joint diameter,increased pain threshold,as well as improved joint *** addition,both extracts of Distemonanthus benthamianus markedly increased body weight and pain threshold,while reducing paw edema in polyarthritic *** also led to a marked decrease in platelets and white blood cells(P<0.05),as well as a significant increase in red blood cells,hemoglobin and hematocrit(P<0.05).The aqueous and methanolic extracts of Distemonanthus benthamianus significantly reduced alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase activities,while increasing serum protein levels(P<0.05)with no significant variation in creatinine ***,both extracts increased catalase and glutathione activities(P<0.05),and inhibited malondialdehyde and nitric oxide production(P<0.01 and P<0.001)in the liver and *** analysis of the joints showed that both extracts triggered tissue ***:Distemonanthus benthamianus could be used as a potential candidate in the treatment of rheumatoid arthritis.

关键词： Distemonanthus benthamianus Rheumatoid arthritis Anti-arthritis Complete Freund’s adjuvant Hyperalgesia Inflammation Oxidative stress

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Ecotoxicological effects of waterborne PFOS exposure on swimming performance and energy expenditure in juvenile goldfish (Carassius auratus)

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Journal of Environmental Sciences 2013年第8期25卷 1672-1679页

作者： Jigang Xia Shijian Fu Zhendong Cao Jianglan Peng Jing Peng Tingting Dai Lili Cheng laboratory of Evolutionary physiology and Behavior Chongqing Key Laboratory of Animal Biology Chongqing Normal University

The potential risks of perfluorooctane sulfonate （PFOS） are of increasing ecological concern. Swimming performance is linked to the fitness and health of fish. However, the impacts of PFOS on swimming performance remain largely unknown. We investigated the ecotoxicological effects of acute exposure to PFOS on the swimming performance and energy expenditure of juvenile goldfish （Carassius auratus）. The fish were exposed to a range of PFOS concentrations （0, 0.5, 2, 8 and 32 mg/L） for 48 hr. The spontaneous swimming activity, fast-start swimming performance, critical swimming speed （Ucrit） and active metabolic rate （AMR） of the goldfish were examined after exposure to PFOS. PFOS exposure resulted in remarkable effects on spontaneous activity. Motion distance was reduced, and the proportion of motionless time increased with increasing concentrations of PFOS. However, no significant alterations in the fast-start performance-related kinematic parameters, such as latency time, maximum linear velocity, maximum linear acceleration or escape distance during the first 120 msec after stimulus, were observed after PFOS exposure. Unexpectedly, although PFOS exposure had marked influences on the swimming oxygen consumption rates and AMR of goldfish, the U crit of the goldfish was not significantly affected by PFOS. This may result in a noteworthy increase in the energetic cost of transport. The overall results indicate that, in contrast to spontaneous activity, underlying swimming capabilities are maintained in goldfish after short-term exposure to PFOS, but energy expenditure during the process of swimming is dramatically aggravated.

关键词： perfluorooctane sulfonate (PFOS) spontaneous activity fast-start performance critical swimming speed energy expenditure goldfish

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Cyclophosphamide-induced reproductive toxicity: Beneficial effects of Helichrysum odoratissimum(Asteraceae) in male Wistar rats

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Journal of Integrative Medicine 2019年第5期17卷 366-373页

作者： Pierre Watcho Ismaelle Rosine Mpeck Patrick Brice Deeh Defo Modeste Wankeu-Nya Esther Ngadjui Georges Romeo Bonsou Fozin Pierre Kamtchouing Albert Kamanyi animal physiology and Phytopharmacology laboratory University of DschangP.O. BOX 67DschangCameroon Department of animal organisms biology University of DoualaP.O. BOX 24157DoualaCameroon Department of animal biology and physiology University of YaoundeP.O. BOX 812YaoundeCameroon

Objective: Cyclophosphamide(CP) is commonly used to treat some cancers, but its clinical efficacy is also linked with testicular toxicity. We investigated the effects of aqueous extract(AE) and methanolic extract(ME) of Helichrysum odoratissimum for reducing CP-induced reproductive toxicity in male ***: In addition to a normal control(group 1), drugs or vehicles were administered orally to seven groups(n = 5) of rats that had already received 4-weeks of pre-treatment with CP(5 mg/[kgád], per oral administration);group 2 received CP + distilled water(10 m L/[kgád]);group 3 received CP + 5% tween 80(10 m L/[kgád]);group 4 received CP + clomiphene citrate(0.25 mg/[kgád]);groups 5 and 6 received CP + AE(50 and 100 mg/[kgád]) and groups 7 and 8 received CP + ME(50 and 100 mg/[kgád]). animals were sacrificed on day 15, and body and sexual organ weights, sperm characteristics, testosterone level and testicular histology were ***: The CP-treated group showed a significant reduction(P < 0.001) in the body and seminal vesicle weights, testosterone level, sperm count, sperm motility and sperm viability, but elevated(P < 0.001)sperm morphological abnormalities and testicular structure alterations, compared to the control ***, these detrimental effects of CP were reversed by treatment with H. odoratissimum *** instance, both extracts and all doses of H. odoratissimum significantly increased the sperm count(P < 0.001), sperm motility(AE, 50 mg/kg, P < 0.05;ME, 50 and 100 mg/kg, P < 0.05) and sperm viability(AE, 50 mg/kg, P < 0.001;ME, 50 and 100 mg/kg, P < 0.001) compared to the CP group. H. odoratissimum also improved plasmatic and intratesticular testosterone levels and prevented histological alterations of the ***: H. odoratissimum might be considered as an alternative drug to alleviate/prevent reproductive damage in cancer patients receiving CP chemotherapy.

关键词： Helichrysum odoratissimum Cyclophosphamide Reproductive toxicity Rat

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Aframomum melegueta prevents the ejaculatory complications of propylthiouracil-induced hypothyroidism in sexually experienced male rats: Evidence from intravaginal and fictive ejaculations

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Journal of Integrative Medicine 2019年第5期17卷 359-365页

作者： Francois Xavier Kemka Nguimatio Patrick Brice Deeh Defo Modeste Wankeu-Nya Esther Ngadjui Albert Kamanyi Pierre Kamtchouing Pierre Watcho animal physiology and Phytopharmacology laboratory University of DschangP.O. Box 67DschangCameroon Department of animal organisms biology University of DoualaP.O. Box24157 DoualaCameroon Department of animal biology and physiology University of Yaounde 1P.O. Box 812YaoundeCameroon

Objective: Hypothyroidism has been claimed to generate sexual dysfunctions such as ejaculatory disorders. Aframomum melegueta is an aphrodisiac plant with pro-ejaculatory properties. We investigated the protective effects of aqueous extract(AE) and methanolic extract(ME) of A. melegueta on the ejaculatory function of hypothyroid male ***: Forty sexually experienced male rats were partitioned into 8 groups(5 rats per group) and treated for 28 d as follows: Group 1, Control;Group 2, propylthiouracil(PTU, 10 mg/kg)+ distilled water(DW,10 m L/kg);Group 3, PTU + 5% Tween 80(10 m L/kg);Group 4, PTU + bromocriptine(6 mg/kg);Group 5,PTU + AE(20 mg/kg);Group 6, PTU + AE(100 mg/kg);Group 7, PTU + ME(20 mg/kg), and Group 8,PTU + ME(100 mg/kg). On days 0, 7, 14 and 28 of treatment, each male rat was paired with primed receptive female for measurement of ejaculatory latency time(ELT) and post-ejaculatory interval(PEI) for1.5 h. On day 29, each male rat was urethane-anesthetized and the spinal cord was ***, following urethral/penile stimulations and intravenous injection of dopamine, contractions of the bulbospongiosus muscles and the intraseminal pressure were registered. After these recordings,blood was collected through the catheterization of abdominal artery and plasma was used for thyroidstimulating hormone(TSH), prolactin and testosterone ***: PTU-induced hypothyroidism was characterized by a significant elevation(P < 0.001) of plasmatic TSH and prolactin levels, but a decline(P < 0.001) in plasmatic testosterone, compared to untreated group. ELT, PEI, contractions of the bulbospongiosus muscles and the intraseminal pressure were also altered by PTU treatment. On the contrary, A. melegueta extracts elevated testosterone(AE, 100 mg/kg,P < 0.01;ME, 100 mg/kg, P < 0.05) and decreased prolactin(AE, 100 mg/kg, P < 0.05;ME, 20 mg/kg,P < 0.05) levels, compared to corresponding controls. With regard to DW + PTU group, prolactin concentration wa

关键词： Propylthiouracil Hypothyroidism Ejaculation Bromocriptine Aframomum melegueta

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The methanolic extract ofGuibourtia tessmannii(Caesalpiniaceae)improves sexual parameters in high fat diet-induced obese sexually sluggish rats

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Asian pacific Journal of Reproduction 2017年第5期6卷 202-211页

作者： Patrick Brice Deeh Defo Modeste Wankeu-Nya Esther Ngadjui Georges Romeo Bonsou Fozin Francois Xavier Kemka Albert Kamanyi Pierre Kamtchouing Pierre Watcho animal physiology and Phytopharmacology laboratory University of DschangBox 67 DschangCameroon Department of animal organisms biology University of Douala-Cameroon Department of animal biology and physiology University of Yaoundé1YaoundéCameroon

Objective:To evaluate the effects of the methanolic extract ofGuibourtia tessmannii (G. tesmannii) on sperm parameters, lipid profile and testosterone level in obese ***: A total of 193 male Wistar rats were fed either with palm oil diet (n=185) or standard diet (n=8) for 16 wk. At the end of this feeding period, 90 obese rats were selected and randomly divided into 18 groups of five rats each and treated with distilled water (10 mL/kg), vitamin E (75 mg/kg), clomiphene citrate (2 mg/kg) or methanolic extract ofG. tessmannii (55, 110 or 220 mg/kg) for 7, 21 or 56 d. At the end of each treatment period, sperm parameters, lipid profile and testosterone level were evaluated. Data were analyzed using ANOVA for repeated measures followed by post-hoc Tukey HSD (P<0.05) for multiple ***: Feeding of rats for 16 wk with palm oil diet significantly damaged sperm parameters. The methanolic extract ofG. tesmannii improved sperm viability, motility and normality after 21 or 56 d of treatment. The sperm normality increased significantly in rats treated with the methanolic extract ofG. tesmannii for 7 (110 mg/kg,P<0.01) and 56 d (110 and 220 mg/kg,P<0.05) compared to control group. Triglycerids, total cholesterol, low and very low density lipoproteins cholesterol levels were lower in rats treated with the plant extract for 56 d.G. tesmannii also significantly increased the high density lipoprotein cholesterol and testosterone levels in the plasma after 56 d of ***: The methanolic extract ofG. tesmannii can improve sperm parameters, lipid profile and testosterone level in obese rats. These findings may justify the folkloric use ofG. tesmannii as a reproductive performance enhancer.

关键词： Guibourtia tessmannii Palm oil diet Sperm parameters Lipid profile Testosterone

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Iron metabolism in the mononuclear phagocyte system

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Progress in Natural Science:Materials International 2008年第10期18卷 1197-1202页

作者： Weina Kong Xianglin Duan Zhenhua Shi Yanzhong Chang The Key laboratory of animal physiology,Biochemistry and Molecular biology of Hebei Province,Hebei Normal University,Shijiazhuang 050016,China The Key laboratory of animal physiology Biochemistry and Molecular Biology of Hebei Province Hebei Normal University Shijiazhuang 050016 China

The maintenance of body iron homeostasis requires the coordination of multiple regulatory mechanisms of iron *** mononuclear phagocyte system (MPS,composed of monocytes,macrophages,and their precursor cells) is crucial in the maintenance of iron *** of iron is carried out by specialized macrophages via engulfment of aged *** iron stores of macrophages depend on the levels of recovered and exported ***,the molecular mechanisms underlying iron homeostasis in macrophages are poorly *** studies characterizing the function and regulation of natural resistance-associated mac- rophage protein I (Nrampl),divalent metal transporter 1 (DMTI),HLA-linked hemechromatosis gene (HFE),ferroportin 1 (FPNI), and hepcidin are rapidly expanding our knowledge on the molecular level of MPS iron *** studies are deepening our under- standing about the molecular mechanism of iron homeostasis and iron-related diseases.

关键词： Mononuclear phagocyte system CD 163 Natural resistance-associated macrophage protein 1 Divalent metal transporter 1 HFE Ferroportin 1 Hepcidin

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Effects of Dracaena arborea(Dracaenaceae) on sexual dysfunction in 4 weeks hyperglycemic male rats

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Asian Pacific Journal of Tropical Medicine 2014年第8期7卷 609-619页

作者： Wankeu-Nya M Watcho P Nguelefack TB Cairo-Juarez M Tapondjou L Kamanyi A animal physiology and Phytopharmacology laboratory Department of Animal BiologyUnivcrsity of DschangP.O.BOX 67 Dschang-Cameroon laboratory of animal biology and physiology Department of Animal Organisms BiologyUniversity of DoualaP.O.BOX 24157Douala-Cameroon Laboratorio de Comportamiento Reproductive Escuela de Medicina Veterinaria y ZootecniaUniversidad Autnoma de Tlaxeala.TlaxealaC.P 90000Mexico Organic Chemistry laboratory Department of chemistryUniversity of DschangP.O.BOX 67 Dschang-Cameroon

Objective:To investigate the effects of Dracaena arborea(***) on the sexual behavior parameters in experienced type-1 diabetic ***:Aqueous and ethanol(100 and 500mg/kg respectively)extracts of dried root barks of *** citrate(1.44 mg/kg),trimethylamine-N-oxide(TMAO,20 mg/kg)and distilled water(110 mL/*** orally administered to 4 weeks streptozolocin-induced diabetic *** latency and frequency(***),intromission latency and frequency(IL,IF) and post-ejaculatory interval(PEI) were measured by ejaculating series during 90 min once a week for 4 *** was determined at the beginning and at the end of the treatment Results:*** did not show any major antihvperglycemic *** to the control group,a significant(P<0.05-0.001)increase in MF and IF was noticed in rats treated with sildenafil citrate(89.71% and 90.07% respectively),aqueous(500 mg/kg.88.08%and 88.749;respectively) and ethanol(100 mg/kg;89.53%and 89.17respectively) extracts of *** after two weeks(series 1) of ***,IL and PEI were significantly(P<0.05-0.001) decreased after 4 weeks of daily treatment[sildenafil citrate(96.***.96.31%and 34.98%),and *** aqueous 500 mg/kg(94.***.94.33% and 66.609;i and ethanol extracts 100 mg/kg(96.***.97.089;and 64.26%)].Conclusions:These aphrodisiac potentials of *** in experienced diabetic rats could be due to the antioxidant and androgenic properties of phenols,*** and sterols revealed in the plant extracts.

关键词： Erectile dysfunction Streptozotocin Diabetes Dracaena arborea Aphrodisiac properties Rats

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In vitro anti-inflammatory,anti-oxidant and in vivo anti-arthritic properties of stem bark extracts from Nauclea pobeguinii(Rubiaceae) in rats

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Asian Pacific Journal of Tropical Biomedicine 2020年第2期10卷 65-77页

作者： Tsafack Eric Gonzal Djuichou Nguemnang Stephanie Flore Atsamo Albert Donatien Nana Yousseu William Tadjoua Tchoumbou Herve Matah Marthe Mba Vanessa Mbiantcha Marius Ateufack Gilbert laboratory of animal physiology and Phytopharmacology Department of Animal BiologyFaculty of ScienceUniversity of DschangP.O.Box 67DschangCameroon laboratory of animal physiology Faculty of ScienceUniversity of Yaounde IPO Box 812YaoundéCameroon

Objective:To explore the immunomodulatory,anti-inflammatory,anti-oxidant and anti-arthritic activity of aqueous and methanolic extracts of Nauclea pobeguinii stem ***:For in vitro assays,the production of reactive oxygen species(chemiluminescence technique),the proliferation of T cells(liquid scintillation counter method),as well as the inhibition of cyclooxygenase,lipoxygenase,protein denaturation,and free radicals[DPPH,ABTS and nitric oxide(NO)inhibition methods]were *** in vivo assays,a polyarthritis model was induced by complete Freund’s adjuvant in *** aqueous and methanolic extracts of Nauclea pobeguinii stem bark were administered orally at 150 and 300 mg/*** 28 days of treatment,the total blood was taken to quantify the hematological parameters and the serum was used to evaluate the biochemical parameters(alanine aminotransferase,aspartate transaminase,phenylalnine ammonialyase,and proteins)and oxidative stress parameters(malondialdehyde,catalase,superoxide dismutase,glutathione and NO),and then the knee joint was removed for histological ***:The extracts of Nauclea pobeguinii significantly reduced the production of intra-and extracellular reactive oxygen species and decreased T cell *** had an inhibitory effect on cyclooxygenase,lipoxygenase,and protein denaturation,and both extracts had antioxidant capacity on DPPH,ABTS and *** extracts alleviated joint inflammation and pain sensitivity after complete Freund’s adjuvant injection,reduced alanine aminotransferase,aspartate transaminase,alkaline phosphatase,NO and malondialdehyde levels,increased protein concentration,superoxide dismutase,catalase and glutathione activity,and restored the cytoarchitecture of the joint after complete Freund’s adjuvant ***:The aqueous and methanolic extracts of Nauclea pobeguinii have immunomodulatory,anti-inflammatory,anti-oxidant and anti-arthritic properties.

关键词： Nauclea pobeguinii Immunomodulation Antioxidant Anti-inflammatory Anti-arthritic

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Acute and Reproductive Toxicity of the Aqueous Extract of the Dry Seeds of <i>Aframomum daniellii </i>on the Female Wistar Rat Strain

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Pharmacology & Pharmacy 2021年第7期12卷 141-153页

作者： Zacharie Nde Modeste Wankeu-Nya Brice L. Koloko Sylvin B. Ateba Marie I. Ngaha Emma F. Bend Paul V. G. Mboumwa Doriane C. Nyonseu Nzeubang Dieudonné Massoma Lembè laboratory of biology and physiology of animal organisms Faculty of Sciences of Douala University Douala Cameroon

This work was designed to investigate the acute and reproductive toxicity activity of the aqueous extract of the dry seeds of Aframomum daniellii on the female rats. The acute toxicity of the aqueous extract of Aframomum daniellii (A. daniellii) was evaluated with 6 female rats which were divided into 2 groups (1 Test group and the Control group) of 3 female rats each. The control group received distilled water (10 mL/kg/po) and the test group received a single dose of extract of A. daniellii at the dose of 2000 mg/kg. The reproductive toxicity was evaluated using 45 adult female rats which were divided into 5 groups. Group I, received distilled water (1 mL/100 g/po, neutral control);group II, received Clomiphene citrate (600 μg/kg/po, positive control);Groups III, IV and V (trials) received aqueous extract of A. daniellii at doses of 100, 200 and 400 mg/kg/po respectively. The animals were treated daily for 14 days. From the 6th day of treatment, the rats were mated with males of proven fertility for 8 days. On day 22, after laparotomy and delivery, the number of implantation sites, corpora lutea, resorption sites and pups were recorded. Concerning the acute toxicity, it was observed that, after the single dose of 2000 mg/kg administration of the aqueous extract of the dry seeds of A. daniellii, no deaths were recorded. Concerning the reproductive toxicity, no implantation and gestation were observed when compared to the control. However, the aqueous extract of A. daniellii caused a significant (p A daniellii is weakly toxic, but could negatively affect some reproductive parameters.

关键词： Acute Toxicity Reproductive Toxicity Female Rats Aframomum daniellii

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