Iron metabolism in the mononuclear phagocyte system
Iron metabolism in the mononuclear phagocyte system作者机构：The Key Laboratory of Animal Physiology Biochemistry and Molecular Biology of Hebei Province Hebei Normal University Shijiazhuang 050016 China
出 版 物：《Progress in Natural Science:Materials International》 (自然科学进展·国际材料(英文))
年 卷 期：2008年第18卷第10期
页 面：1197-1202页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种]
基 金：supported by National Natural Science Foundation of China (Grant No.30570957) Natural Science Foundation of Hebei Province (C2006000152,C2006000155) Science Foundation of Hebei Normal University (L2003B15,B200209,B2002010)
主 题：Mononuclear phagocyte system CD 163 Natural resistance-associated macrophage protein 1 Divalent metal transporter 1 HFE Ferroportin 1 Hepcidin
摘 要：The maintenance of body iron homeostasis requires the coordination of multiple regulatory mechanisms of iron *** mononuclear phagocyte system (MPS,composed of monocytes,macrophages,and their precursor cells) is crucial in the maintenance of iron *** of iron is carried out by specialized macrophages via engulfment of aged *** iron stores of macrophages depend on the levels of recovered and exported ***,the molecular mechanisms underlying iron homeostasis in macrophages are poorly *** studies characterizing the function and regulation of natural resistance-associated mac- rophage protein I (Nrampl),divalent metal transporter 1 (DMTI),HLA-linked hemechromatosis gene (HFE),ferroportin 1 (FPNI), and hepcidin are rapidly expanding our knowledge on the molecular level of MPS iron *** studies are deepening our under- standing about the molecular mechanism of iron homeostasis and iron-related diseases.
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