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Analytical Modeling of Flowrate and Its Maxima in Electrochemical bioelectronics with Drug Delivery Capabilities

Research 2022年第3期2022卷 61-73页

作者： Raudel Avila Yixin Wu Rinaldo Garziera John A.Rogers Yonggang Huang Department of Mechanical Engineering Northwestern UniversityEvanstonIL 60208USA Department of Materials Science and Engineering Northwestern UniversityEvanstonIL 60208USA Querrey Simpson Institute for bioelectronics Northwestern UniversityEvanstonIL 60208USA Dipartimento di Ingegneria ed Architettura Universitàdi ParmaItaly Department of Biomedical Engineering Northwestern UniversityEvanstonIL 60208USA Department of Electrical and Computer Engineering Northwestern UniversityEvanstonIL 60208USA Department of Chemistry Northwestern UniversityEvanstonIL 60208USA Department of Neurological Surgery Northwestern UniversityFeinberg School of MedicineChicagoIL 60611USA Department of Civil and Environmental Engineering Northwestern UniversityEvanstonIL 60208USA

Flowrate control in flexible bioelectronics with targeted drug delivery capabilities is essential to ensure timely and safe *** neuroscience and pharmacogenetics studies in small animals,these flexible bioelectronic systems can be tailored to deliver small drug volumes on a controlled fashion without damaging surrounding tissues from stresses induced by excessively high *** drug delivery process is realized by an electrochemical reaction that pressurizes the internal bioelectronic chambers to deform a flexible polymer membrane that pumps the drug through a network of microchannels implanted in the small *** flowrate temporal profile and global maximum are governed and can be modeled by the ideal gas ***,we obtain an analytical solution that groups the relevant mechanical,fluidic,environmental,and electrochemical terms involved in the drug delivery process into a set of three nondimensional *** unique combinations of these three nondimensional parameters(related to the initial pressure,initial gas volume,and microfluidic resistance)can be used to model the flowrate and scale up the flexible bioelectronic design for experiments in medium and large animal *** analytical solution is divided into(1)a fast variable that controls the maximum flowrate and(2)a slow variable that models the temporal ***,the two variables detail the complete drug delivery process and control using the three nondimensional *** of the analytical model with alternative numerical models shows excellent agreement and validates the analytic modeling *** findings serve as a theoretical framework to design and optimize future flexible bioelectronic systems used in biomedical research,or related medical fields,and analytically control the flowrate and its global maximum for successful drug delivery.

关键词： governed Electrochemical Flow

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Application of graphene vertical field effect to regulation of organic light-emitting transistors

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Chinese Physics B 2020年第5期29卷 473-478页

作者： Hang Song Hao Wu Hai-Yang Lu Zhi-Hao Yang Long Ba State Key Laboratory of bioelectronics Southeast UniversityNanjing 210096China

The luminescence intensity regulation of organic light-emitting transistor(OLED)device can be achieved effectively by the combination of graphene vertical field effect transistor(GVFET)and *** this paper,we fabricate and characterize the graphene vertical field-effect transistor with gate dielectric of ion-gel film,confirming that its current switching ratio reaches up to *** of the property of high light transmittance in ion-gel film,the OLED device prepared with graphene/PEDOT:PSS as composite anode exhibits good optical *** also prepare the graphene vertical organic light-emitting field effect transistor(GVOLEFET)by the combination of GVFET and graphene OLED,analyzing its electrical and optical properties,and confirming that the luminescence intensity can be significantly changed by regulating the gate voltage.

关键词： graphene vertical field effect transistor organic light-emitting transistor ion-gel film gate voltage regulation

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Green photochemical synthesis of fluorescent carbon spheres in-situ enwrapped around Ag nanoparticles

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Science China Chemistry 2015年第4期58卷 634-639页

作者： Wei Ge Xiaoli Liu Jing Ye Qiwei Li Hui Jiang Xuemei Wang State Key Laboratory of bioelectronics (Chien-Shiung Wu Laboratory) Southeast University

Biocompatible carbon-spheres-based nanocomposites exhibit great potential in biomedical and clinical applications. In this contribution we report the first green photochemical synthesis of carbon spheres through in-situ enwrapping around silver nanoparticles(CS–Ag NPs). Since mesoporous carbon spheres can provide the location for combining Ag NPs and other agents, one-step synthesis of glutathione-stabilized CS–Ag NPs could be readily realized by photoreduction. TEM characterization of CS–Ag NPs nanocomposites illustrates that Ag NPs were superbly wrapped inside the carbon spheres and also adhered to the surfaces of the carbon spheres. These porous CS–Ag NPs show excellent fluorescence and effective antibacterial efficiency, exhibiting ideal lengthened activities against Escherichia coli and Staphylococcus aureus compared with bare Ag NPs. The relevant rationale behind it could be attributed to the fact that CS–Ag NPs nanocomposites can provide some excellent niches for the durable and slow release of silver ions. This raises the possibility of promising applications of CS–Ag NPs nanocomposites as excellent antibacterial agents for the efficient monitoring of some disease-related bacteria.

关键词： carbon spheres silver nanoparticles CS-Ag NPs nanocomposites antibacterial activity

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Enhancement of Organic Electrolum Inescent Intensity by Doping Hole-Property Polymers

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Chinese Physics Letters 1995年第9期12卷 569-572页

作者： WANG Guangming WU Haiming YUAN Chunwei WEI Yu National Laboratory of Molecular and bioelectronics Southeast UniversityNanjing 210096

Organic electroluminescent(EL)diodes with one-layer poly(3-octylthiophene)(P3OT)and P3OT doped with poly(N-vinylcarbazole)(PVK)(P3OT/PVK)as EL emitting layer sandwiched between indium/tin oxide(lTO)and aluminium electrodes have been fabricated by spin coating onto IT0 *** P3OT/PVK EL diode starts to emit red-orange light at 5 V in our experiment,the luminance and the current for the P3OT/PVK EL diode at bias voltage was compared with those for the only P3OT EL diode,indicating that the PVK dopant has power over the P3OT electroluminescence.

关键词： diode dopant diodes

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Use of packed-fiber solid-phase extraction for sample clean-up and preconcentration of vitamin B_(12) before determination

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Chinese Chemical Letters 2009年第12期20卷 1491-1494页

作者： Fang Fang Xue Jun Kang Zhi Yong Liu Yu Qin Ma Zhong Ze GU State Key Laboratory of bioelectronics Southeast University Nanjing 210096 China

A rapid and simple preconcentration step applying packed-fiber solid-phase extraction columns has been investigated to vitamin B12. The extraction performance of the new method was investigated preliminarily on vitamin functional drink. The analysis used a reversed-phase C18 column, with a photo-diode array detector at 220 nm. The samples were preconcentrated with packed-fiber solid-phase extraction columns. Good linearity was observed in vitamin functional drink. The repeatability of extraction performance, expressed as relative standard deviations, was from 3.5% to 4.3%. The limit of detection （LOD） is 5 ng mL^-1 （S/N = 3）. Finally, the method had been applied for the determination of vitamin B12 in vitamin functional drink.

关键词： Vitamin B12 Nanofibers Packed-fiber solid-phase extraction Preconcentration

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Interface control for pure ultraviolet electroluminescence from nano-ZnO-based heterojunction devices

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Science Bulletin 2018年第1期63卷 38-45页

作者： Daotong You Chunxiang Xu Feifei Qin Zhu Zhu A.Gowri Manohari Wei Xu Jie Zhao Wei Liu State Key Laboratory of bioelectronics School of Biological Science & Medical Engineering Southeast University

Realization of pure and stable ultraviolet electroluminescence(UV EL) of ZnO light-emitting diode(LED)is still a challenging issue, due to complicated defects of intrinsic ZnO and the corresponding device interfaces. In this paper, we demonstrated a simple & feasible method to fabricate n-ZnO/AlN/p-GaN heterojunctions light-emitting devices. First, the vertically aligned ZnO nanorods(NRs) have been prepared as high quality active layer, and the nanostructured heterojunction LED arrays were constructed by directly bonding ZnO NRs onto AlN-coated p-GaN wafer. By optimizing the AlN layer thickness to be 20 nm, a strong and pure ultraviolet emission located at 387 nm can be observed. The energy band alignment of n-ZnO/AlN(20 nm)/p-Ga N heterojunction LED has been studied by using X-ray photoelectron spectroscopy(XPS), the valence band offset between AlN and GaN was calculated to be 0.34 eV. On the other side, the conduction band offset(as large as 3.28 eV) between Al N and ZnO can block the flow of electrons from ZnO top-GaN. Thus, electron-hole recombination takes place in the ZnO layer, and a pure UV EL could be observed. Our results provide a significant approach toward future of pure ultraviolet optoelectronic LEDs.

关键词： ZnO nanorods AlN insulator layer Interface control Pure ultraviolet light emitting diode Directly bonding

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Tofu-inspired microcarriers from droplet microfluidics for drug delivery

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Science China Chemistry 2019年第1期62卷 87-94页

作者： Han Zhang Yuxiao Liu Jie Wang Changmin Shao Yuanjin Zhao State Key Laboratory of bioelectronics School of Biological Science and Medical Engineering Southeast University

Microcarriers have attracted increasing interests in drug delivery. In order to develop this technique, it is prone to focus on the generation of functional particles through using simple approaches and novel but accessible materials. Here, inspired by the formation mechanism of tofu that through the mixing of soymilk and brine for cross-linking soybean proteins, we present novel soybean protein microcarriers by using microfluidic generation approach for drug delivery. Since the soybean protein droplets are generated by microfluidic emulsification method, the tofu microparticles present highly monodisperse and homogeneous morphologies. Because of the excellent biocompatibility of the soybean protein and the interconnected porous structures throughout the whole microparticles after freeze-drying, various kinds of drugs and active molecules could be absorbed and loaded in the microcarriers, which makes them versatile for drug delivery. It can be anticipated that the microfluidic-generated tofu microcarriers will have great potential in the biomedical field.

关键词： tofu microfluidics microcarrier drug delivery particle droplet

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An insight into the cells' glycans and lectin-glycosensing sites

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Science Bulletin 2016年第2期61卷 108-109页

作者： Chen-Zhong Li Nanobioengineering and bioelectronics Lab Department of Biomedical Engineering Florida International University

Glycosylation produces a diverse and abundant repertoire of glycans that help protein folding and cellular secretion[1].Glycoproteins often sprout sialic acid(alias N-acetyl neuraminic acid,abbreviated as Neu5Ac)at the termini of their N-and O-glycans in a process called sialylation[2].Alterations to the normal function of the glycosylation machinery,including increased branching of N-linked glycans and sialylation,are major hallmarks of cancer ***,increased sialylation on the

关键词：细胞分泌 O-糖链凝集素网站蛋白质折叠唾液酸多聚糖糖基化

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Analysis of nucleosome positioning in promoters of miRNA genes and protein-coding genes

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Chinese Science Bulletin 2010年第22期55卷 2347-2352页

作者： LIU HongDe ZHANG DeJin XIE JianMing YUAN ZhiDong MA Xin LU ZhiYuan GONG LeJun SUN Xiao State Key Laboratory of bioelectronics Southeast University Nanjing 210096 China

Nucleosome positioning in promoters is important for gene transcription regulation. In this paper, with a nucleosome prediction model, curvature profile, the characteristics of nucleosome positioning in promoters are analyzed for miRNA genes and protein-coding genes. In the vicinity of transcription start site (TSS), there is a nucleosome-free region (NFR) followed by a positioned nucleosome at ～200 bp downstream of TSS. A similar characteristic is observed in independent intronic promoters and intergenic promoters, namely, both types of promoters have a longer NFR in 0—-400 bp upstream of TSS. Moreover, transcription factor binding sites (TFBSs) locate in the NFR with a high concentration. However, nucleosome pattern in dependent intronic promoters are like that in protein-coding promoters, with two nucleosomes positioned at -200—-400 bp and -400—-600 bp upstream of TSS. The results indicate nucleosome positioning is probably different in independent miRNA promoters and protein-coding promoters; and positioning seems to be an important factor not only in regulation of protein-coding gene, but also in that of miRNA gene.

关键词：蛋白编码基因基因启动子核小体点定位 RNA基因 miRNA 蛋白质编码转录起始位点

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Advances of multiplex and high throughput biomolecular detection technologies based on encoding microparticles

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Science China Chemistry 2011年第8期54卷 1185-1201页

作者： ZHAO XiangWei, ZHAO YuanJin & GU ZhongZe State Key Laboratory of bioelectronics Southeast University, Nanjing 210096, China 1. State Key Laboratory of bioelectronics Southeast University Nanjing 210096 China

The rapid developments of genomics and proteomics have driven the demand for multiplex and high throughput analysis of large numbers of biomolecules in the fields of medical diagnostics, drug discovery, and environmental monitoring. Encoding the biomolecular binding events is the key technique to fulfill this demand, in which microparticles play the most important roles. This review outlines the development of multiplex and high throughput biodetections, and highlights the most recent advances in the field of encoding microparticles, together with problems that need to be resolved.

关键词： multiplex bioassays multiplex labels encoded microcarrier binding assays high throughput screening

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